1,3,4-Thiadiazole (BioDeep_00000172447)
human metabolite blood metabolite
代谢物信息卡片
1,3,4-Thiadiazole
化学式: C2H2N2S (85.99386919999999)
中文名称: 噻二唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NN=CS1
InChI: InChI=1S/C2H2N2S/c1-3-4-2-5-1/h1-2H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bangcan He, Yuzhi Hu, Li Xing, Yishan Qing, Kaini Meng, Wei Zeng, Zhiling Sun, Zhenchao Wang, Wei Xue. Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole.
Journal of agricultural and food chemistry.
2024 May; 72(18):10227-10235. doi:
10.1021/acs.jafc.3c09303. [PMID: 38669314] - Yu Sun, Jie Mu, Yongchen Wang, Chengwei Lü, Li-Wei Zou. Rational synthesis of 1,3,4-thiadiazole based ESIPT-fluorescent probe for detection of Cu2+ and H2S in herbs, wine and fruits.
Analytica chimica acta.
2024 Apr; 1297(?):342379. doi:
10.1016/j.aca.2024.342379. [PMID: 38438245] - Wenliang Zhan, Ran Zhou, Piao Mao, Chunmei Yuan, Tao Zhang, Yi Liu, Jiao Tian, Hua Wang, Wei Xue. Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole.
Molecular diversity.
2024 Apr; 28(2):461-474. doi:
10.1007/s11030-022-10593-4. [PMID: 36964852] - Peng Dai, Jian Jiao, Yufei Li, Peng Teng, Qingqing Wang, Yuchuan Zhu, Weihua Zhang. Novel 5-Sulfonyl-1,3,4-thiadiazole-Substituted Flavonoids as Potential Bactericides and Fungicides: Design, Synthesis, Three-Dimensional Quantitative Structure-Activity Relationship Studies.
Journal of agricultural and food chemistry.
2024 Mar; 72(12):6672-6683. doi:
10.1021/acs.jafc.3c06367. [PMID: 38481361] - Iwona Budziak-Wieczorek, Dominika Kaczmarczyk, Klaudia Rząd, Mariusz Gagoś, Andrzej Stepulak, Beata Myśliwa-Kurdziel, Dariusz Karcz, Karolina Starzak, Gotard Burdziński, Monika Srebro-Hooper, Arkadiusz Matwijczuk. Cooperativity of ESPT and Aggregation-Induced Emission Effects-An Experimental and Theoretical Analysis of a 1,3,4-Thiadiazole Derivative.
International journal of molecular sciences.
2024 Mar; 25(6):. doi:
10.3390/ijms25063352. [PMID: 38542326] - Guoqing Mao, Yao Tian, Jinchao Shi, Changzhou Liao, Weiwei Huang, Yiran Wu, Zhou Wen, Linhua Yu, Xiang Zhu, Junkai Li. Design, Synthesis, Antibacterial, and Antifungal Evaluation of Phenylthiazole Derivatives Containing a 1,3,4-Thiadiazole Thione Moiety.
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020285. [PMID: 38257199] - Huanlin Zheng, Fanglin Wen, Chengzhi Zhang, Rui Luo, Zhibing Wu. Novel 1,3,4-Thiadiazole Derivatives: Synthesis, Antiviral Bioassay and Regulation the Photosynthetic Pathway of Tobacco against TMV Infection.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108881. [PMID: 37240228] - Iwona Budziak-Wieczorek, Lidia Ślusarczyk, Beata Myśliwa-Kurdziel, Martyna Kurdziel, Monika Srebro-Hooper, Izabela Korona-Glowniak, Mariusz Gagoś, Grzegorz Gładyszewski, Andrzej Stepulak, Dariusz Kluczyk, Arkadiusz Matwijczuk. Spectroscopic characterization and assessment of microbiological potential of 1,3,4-thiadiazole derivative showing ESIPT dual fluorescence enhanced by aggregation effects.
Scientific reports.
2022 12; 12(1):22140. doi:
10.1038/s41598-022-26690-1. [PMID: 36550169] - Renxuan Zou, Baoyu Li, Wengui Duan, Guishan Lin, Yucheng Cui. Synthesis of 3-carene-derived nanocellulose/1,3,4-thiadiazole-amide complexes with antifungal activity for plant protection.
Pest management science.
2022 Aug; 78(8):3277-3286. doi:
10.1002/ps.6952. [PMID: 35484724] - Nadezhda Yur'evna Sipkina, Denis Igorevich Sipkin, Igor Pavlovich Yakovlev. Quantification of a New Antifungal Drug Based on 1,3,4-Thiadiazole by HPLC-ESI/MS: Method Development, Validation and Pharmacokinetic Application.
Drug research.
2022 Jan; 72(1):47-52. doi:
10.1055/a-1625-3121. [PMID: 34535039] - Melinda David, Iwona Budziak-Wieczorek, Dariusz Karcz, Monica Florescu, Arkadiusz Matwijczuk. Insight into dual fluorescence effects induced by molecular aggregation occurring in membrane model systems containing 1,3,4-thiadiazole derivatives.
European biophysics journal : EBJ.
2021 Dec; 50(8):1083-1101. doi:
10.1007/s00249-021-01569-7. [PMID: 34515830] - Ting Xu, Wenyue Tian, Qian Zhang, Jiazheng Liu, Zhiyan Liu, Jing Jin, Yong Guo, Li-Ping Bai. Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy.
Bioorganic chemistry.
2021 10; 115(?):105257. doi:
10.1016/j.bioorg.2021.105257. [PMID: 34426156] - Zhibing Wu, Jin Shi, Jixiang Chen, Deyu Hu, Baoan Song. Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel 1,3,4-Thiadiazole Derivatives Containing an Amide Moiety.
Journal of agricultural and food chemistry.
2021 Aug; 69(31):8660-8670. doi:
10.1021/acs.jafc.1c01626. [PMID: 34319116] - Mohammed M S Wassel, Yousry A Ammar, Gameel A M Elhag Ali, Amany Belal, Ahmed B M Mehany, Ahmed Ragab. Development of adamantane scaffold containing 1,3,4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting EGFR.
Bioorganic chemistry.
2021 05; 110(?):104794. doi:
10.1016/j.bioorg.2021.104794. [PMID: 33735711] - Qiong Wu, Hui Cai, Ting Yuan, Shaoyuan Li, Xiuhai Gan, Baoan Song. Novel vanillin derivatives containing a 1,3,4-thiadiazole moiety as potential antibacterial agents.
Bioorganic & medicinal chemistry letters.
2020 05; 30(10):127113. doi:
10.1016/j.bmcl.2020.127113. [PMID: 32199734] - Fayçal Hichri, Amel Omri, Aisha Saad Mana Hossan, Hichem Ben Jannet. Alpha-glucosidase and amylase inhibitory effects of Eruca vesicaria subsp. longirostris essential oils: synthesis of new 1,2,4-triazole-thiol derivatives and 1,3,4-thiadiazole with potential inhibitory activity.
Pharmaceutical biology.
2019 Dec; 57(1):564-570. doi:
10.1080/13880209.2019.1642363. [PMID: 31454271] - Lama A Hamadneh, Dima A Sabbah, Suhair J Hikmat, Luma A Al-Samad, Mariam Hasan, Tariq M Al-Qirim, Imad M Hamadneh, Ammar H Al-Dujaili. Hypolipidemic effect of novel 2,5-bis(4-hydroxybenzylidenamino)-1,3,4-thiadiazole as potential peroxisome proliferation-activated receptor-α agonist in acute hyperlipidemic rat model.
Molecular and cellular biochemistry.
2019 Aug; 458(1-2):39-47. doi:
10.1007/s11010-019-03528-5. [PMID: 30905023] - Vinit Raj, Archana S Bhadauria, Ashok K Singh, Umesh Kumar, Amit Rai, Amit K Keshari, Pranesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Kausar M Ansari, Jawahar L Jat, Sudipta Saha. Novel 1,3,4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling.
Cytokine.
2019 06; 118(?):144-159. doi:
10.1016/j.cyto.2018.03.026. [PMID: 29580751] - Xianghui Ruan, Cheng Zhang, Shichun Jiang, Tao Guo, Rongjiao Xia, Ying Chen, Xu Tang, Wei Xue. Design, Synthesis, and Biological Activity of Novel Myricetin Derivatives Containing Amide, Thioether, and 1,3,4-Thiadiazole Moieties.
Molecules (Basel, Switzerland).
2018 Nov; 23(12):. doi:
10.3390/molecules23123132. [PMID: 30501066] - Amal Smaili, Lalla Aicha Rifai, Siham Esserti, Tayeb Koussa, Fouad Bentiss, Salaheddine Guesmi, Abdelhakim Laachir, Mohamed Faize. Copper complexes of the 1,3,4-thiadiazole derivatives modulate antioxidant defense responses and resistance in tomato plants against fungal and bacterial diseases.
Pesticide biochemistry and physiology.
2017 Nov; 143(?):26-32. doi:
10.1016/j.pestbp.2017.10.002. [PMID: 29183602] - Lu Yu, Xiuhai Gan, Dagui Zhou, Fangcheng He, Song Zeng, Deyu Hu. Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety.
Molecules (Basel, Switzerland).
2017 Apr; 22(4):. doi:
10.3390/molecules22040658. [PMID: 28430149] - Subramani Karthikeyan, Ganesan Bharanidharan, Karthik Ananth Mani, Narasimhan Srinivasan, Manish Kesherwani, Devadasan Velmurugan, Prakasarao Aruna, Singaravelu Ganesan. Determination on the binding of thiadiazole derivative to human serum albumin: a spectroscopy and computational approach.
Journal of biomolecular structure & dynamics.
2017 Mar; 35(4):817-828. doi:
10.1080/07391102.2016.1162751. [PMID: 26999261] - Guanghui Zong, Xiaojing Yan, Jiawei Bi, Rui Jiang, Yinan Qin, Huizhu Yuan, Huizhe Lu, Yanhong Dong, Shuhui Jin, Jianjun Zhang. Synthesis, fungicidal evaluation and 3D-QSAR studies of novel 1,3,4-thiadiazole xylofuranose derivatives.
PloS one.
2017; 12(7):e0181646. doi:
10.1371/journal.pone.0181646. [PMID: 28746366] - Solange C Martins, Danielle Lazarin-Bidóia, Vânia C Desoti, Hugo Falzirolli, Cleuza C da Silva, Tania Ueda-Nakamura, Sueli de O Silva, Celso V Nakamura. 1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress.
Microbes and infection.
2016 Dec; 18(12):787-797. doi:
10.1016/j.micinf.2016.07.007. [PMID: 27484335] - Akanksha Kulshreshtha, Poonam Piplani. Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction.
European journal of medicinal chemistry.
2016 Oct; 122(?):557-573. doi:
10.1016/j.ejmech.2016.06.046. [PMID: 27448914] - Mikhail Krasavin, Alexey Lukin, Nikolay Zhurilo, Alexey Kovalenko, Ihor Zahanich, Sergey Zozulya, Daniel Moore, Irina G Tikhonova. Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold.
Bioorganic & medicinal chemistry.
2016 07; 24(13):2954-2963. doi:
10.1016/j.bmc.2016.04.065. [PMID: 27229618] - Sussan K Ardestani, Fatemeh Poorrajab, Sepideh Razmi, Alireza Foroumadi, Soheila Ajdary, Behnaz Gharegozlou, Mina Behrouzi-Fardmoghadam, Abbas Shafiee. Cell death features induced in Leishmania major by 1,3,4-thiadiazole derivatives.
Experimental parasitology.
2012 Oct; 132(2):116-22. doi:
10.1016/j.exppara.2012.06.002. [PMID: 22959410] - Jignesh Priyakant Raval, Ankur Navinchandra Gandhi, Tarunkumar Nanjibhai Akhaja, Kruti Navinbhai Myangar, Nilesh Hasmukhbhai Patel. Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of new 2-(4-isobutylphenyl)propanoic acid derivatives.
Journal of enzyme inhibition and medicinal chemistry.
2012 Feb; 27(1):110-6. doi:
10.3109/14756366.2011.578743. [PMID: 21612370] - Cr Biju, K Ilango, Manju Prathap, K Rekha. Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity.
Journal of young pharmacists : JYP.
2012 Jan; 4(1):33-7. doi:
10.4103/0975-1483.93576. [PMID: 22523458] - Nevin Turan, M Fatih Topçu, Zuhal Ergin, Suleyman Sandal, Mehmet Tuzcu, Nusret Akpolat, Bayram Yilmaz, Memet Sekerci, Mustafa Karatepe. Pro-oxidant and antiproliferative effects of the 1,3,4-thiadiazole-based Schiff base and its metal complexes.
Drug and chemical toxicology.
2011 Oct; 34(4):369-78. doi:
10.3109/01480545.2011.564177. [PMID: 21714772] - Joshua A Obaleye, Johnson F Adediji, Matthew A Adebayo. Synthesis and biological activities on metal complexes of 2,5-diamino-1,3,4-thiadiazole derived from semicarbazide hydrochloride.
Molecules (Basel, Switzerland).
2011 Jul; 16(7):5861-74. doi:
10.3390/molecules16075861. [PMID: 21750479] - Sadaf J Gilani, Suroor A Khan, Nadeem Siddiqui. Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid.
Bioorganic & medicinal chemistry letters.
2010 Aug; 20(16):4762-5. doi:
10.1016/j.bmcl.2010.06.125. [PMID: 20643545] - Tiffany L Graves, John E Scott. A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity.
Current chemical genomics.
2008 Nov; 2(?):51-61. doi:
10.2174/1875397300802010051. [PMID: 20161844] - Mohammad Amir, Harish Kumar, Sadique A Javed. Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives.
Archiv der Pharmazie.
2007 Nov; 340(11):577-85. doi:
10.1002/ardp.200700065. [PMID: 17924361] - H OTTO. [Effect of the carbonic anhydrase inhibitor 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide (acetazolamide) on citric acid excretion in the urine].
Klinische Wochenschrift.
1958 Jul; 36(13):633-6. doi:
10.1007/bf01480781. [PMID: 13564739] - U REITANO, S BONANNO. [Clearance tests of kidney function in patients treated with 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide (diamox)].
La Riforma medica.
1955 Oct; 69(40):1097-105. doi:
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Minerva medica.
1955 Sep; 46(77):728-9. doi:
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Helvetica paediatrica acta.
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