1,3-Dioxolane (BioDeep_00000172438)

   

human metabolite blood metabolite


代谢物信息卡片


Glycol methylene ether

化学式: C3H6O2 (74.0367776)
中文名称: 1,3-二氧五环
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1COCO1
InChI: InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2

描述信息

D009676 - Noxae > D009153 - Mutagens

同义名列表

5 个代谢物同义名

Glycol methylene ether; 1,3-Dioxacyclopentane; 1,3-Dioxolane; Formal glycol; dioxolane



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li-Jing Min, Han Wang, Joanna Bajsa-Hirschel, Chen-Sheng Yu, Bin Wang, Meng-Meng Yao, Liang Han, Charles L Cantrell, Stephen O Duke, Na-Bo Sun, Xing-Hai Liu. Novel Dioxolane Ring Compounds for the Management of Phytopathogen Diseases as Ergosterol Biosynthesis Inhibitors: Synthesis, Biological Activities, and Molecular Docking. Journal of agricultural and food chemistry. 2022 Apr; 70(14):4303-4315. doi: 10.1021/acs.jafc.2c00541. [PMID: 35357135]
  • Michael M Gaschler, Alexander A Andia, Hengrui Liu, Joleen M Csuka, Brisa Hurlocker, Christopher A Vaiana, Daniel W Heindel, Dylan S Zuckerman, Pieter H Bos, Eduard Reznik, Ling F Ye, Yulia Y Tyurina, Annie J Lin, Mikhail S Shchepinov, Amy Y Chan, Eveliz Peguero-Pereira, Maksim A Fomich, Jacob D Daniels, Andrei V Bekish, Vadim V Shmanai, Valerian E Kagan, Lara K Mahal, K A Woerpel, Brent R Stockwell. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nature chemical biology. 2018 05; 14(5):507-515. doi: 10.1038/s41589-018-0031-6. [PMID: 29610484]
  • Christine Hinz, Maceler Aldrovandi, Charis Uhlson, Lawrence J Marnett, Hilary J Longhurst, Timothy D Warner, Saydul Alam, David A Slatter, Sarah N Lauder, Keith Allen-Redpath, Peter W Collins, Robert C Murphy, Christopher P Thomas, Valerie B O'Donnell. Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid. The Journal of biological chemistry. 2016 Jun; 291(26):13448-64. doi: 10.1074/jbc.m115.700609. [PMID: 27129261]
  • Kazuhiro Yamada, Yuko Yoshizawa, Keimei Oh. Synthesis of 2RS,4RS-1-[2-phenyl-4-[2-(2-trifluromethoxy-phenoxy)-ethyl]-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole derivatives as potent inhibitors of brassinosteroid biosynthesis. Molecules (Basel, Switzerland). 2012 Apr; 17(4):4460-73. doi: 10.3390/molecules17044460. [PMID: 22504831]
  • Chi-Chi Peng, Wei Shi, Justin D Lutz, Kent L Kunze, Jun O Liu, Wendel L Nelson, Nina Isoherranen. Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):426-35. doi: 10.1124/dmd.111.042739. [PMID: 22106171]
  • Shasikala Narayan, Debra L Wyatt, David S Crumrine, Samuel Cukierman. Proton transfer in water wires in proteins: modulation by local constraint and polarity in gramicidin a channels. Biophysical journal. 2007 Sep; 93(5):1571-9. doi: 10.1529/biophysj.107.109231. [PMID: 17496018]
  • C Rétho, F Blanchard. Determination of 3-chloropropane-1,2-diol as its 1,3-dioxolane derivative at the microg kg-1 level: application to a wide range of foods. Food additives and contaminants. 2005 Dec; 22(12):1189-97. doi: 10.1080/02652030500197680. [PMID: 16356881]
  • Liang-Zhong Xu, Shu-Sheng Zhang, Shu-Yan Niu, Yong-Qi Qin, Xue-Mei Li, Kui Jiao. Synthesis and biological activities of novel triazole compounds containing 1,3-dioxolane rings. Molecules (Basel, Switzerland). 2004 Nov; 9(11):913-21. doi: 10.3390/91100913. [PMID: 18007492]
  • Santiago Olivella, Albert Solé. Mechanism of 1,3-migration in allylperoxyl radicals: computational evidence for the formation of a loosely bound radical-dioxygen complex. Journal of the American Chemical Society. 2003 Sep; 125(35):10641-50. doi: 10.1021/ja030171e. [PMID: 12940748]
  • Ching-Hsing Yu, Samuel Cukierman, Régis Pomès. Theoretical study of the structure and dynamic fluctuations of dioxolane-linked gramicidin channels. Biophysical journal. 2003 Feb; 84(2 Pt 1):816-31. doi: 10.1016/s0006-3495(03)74901-7. [PMID: 12547766]
  • C M de Godoy, S Cukierman. Modulation of proton transfer in the water wire of dioxolane-linked gramicidin channels by lipid membranes. Biophysical journal. 2001 Sep; 81(3):1430-8. doi: 10.1016/s0006-3495(01)75798-0. [PMID: 11509357]
  • E P Quigley, D S Crumrine, S Cukierman. Gating and permeation in ion channels formed by gramicidin A and its dioxolane-linked dimer in Na(+) and Cs(+) solutions. The Journal of membrane biology. 2000 Apr; 174(3):207-12. doi: 10.1007/s002320001045. [PMID: 10758174]
  • E P Quigley, P Quigley, D S Crumrine, S Cukierman. The conduction of protons in different stereoisomers of dioxolane-linked gramicidin A channels. Biophysical journal. 1999 Nov; 77(5):2479-91. doi: 10.1016/s0006-3495(99)77084-0. [PMID: 10545350]
  • E P Quigley, A J Emerick, D S Crumrine, S Cukierman. Attenuation of proton currents by methanol in a dioxolane-linked gramicidin A channel in different lipid bilayers. Biophysical journal. 1998 Dec; 75(6):2811-20. doi: 10.1016/s0006-3495(98)77724-0. [PMID: 9826603]
  • S Cukierman, E P Quigley, D S Crumrine. Proton conduction in gramicidin A and in its dioxolane-linked dimer in different lipid bilayers. Biophysical journal. 1997 Nov; 73(5):2489-502. doi: 10.1016/s0006-3495(97)78277-8. [PMID: 9370442]
  • T Wun, T G Paglieroni, N A Lachant. Desmopressin stimulates the expression of P-selectin on human platelets in vitro. The Journal of laboratory and clinical medicine. 1995 Oct; 126(4):401-9. doi: . [PMID: 7561450]