1,3-Dicyclohexylurea (BioDeep_00000172431)

   

human metabolite blood metabolite


代谢物信息卡片


1,3-Dicyclohexylurea

化学式: C13H24N2O (224.18885339999997)
中文名称: N,N’-二环己基脲
谱图信息: 最多检出来源 Homo sapiens(blood) 53.98%

分子结构信息

SMILES: C1CCC(CC1)NC(=O)NC1CCCCC1
InChI: InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)

描述信息

同义名列表

4 个代谢物同义名

1,3-Dicyclohexylurea; N,N-dicyclohexylurea; dicyclohexylurea; DCU compound



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ebtesam Saad Al-Sheddi, Mai Mohammad Al-Oqail, Quaiser Saquib, Maqsood Ahmed Siddiqui, Javed Musarrat, Abdulaziz Ali Al-Khedhairy, Nida Nayyar Farshori. Novel all trans-retinoic Acid derivatives: cytotoxicity, inhibition of cell cycle progression and induction of apoptosis in human cancer cell lines. Molecules (Basel, Switzerland). 2015 May; 20(5):8181-97. doi: 10.3390/molecules20058181. [PMID: 25961160]
  • L Mark Hall, Lowell H Hall, Tzipporah M Kertesz, Dennis W Hill, Thomas R Sharp, Edward Z Oblak, Ying W Dong, David S Wishart, Ming-Hui Chen, David F Grant. Development of Ecom₅₀ and retention index models for nontargeted metabolomics: identification of 1,3-dicyclohexylurea in human serum by HPLC/mass spectrometry. Journal of chemical information and modeling. 2012 May; 52(5):1222-37. doi: 10.1021/ci300092s. [PMID: 22489687]
  • Po-Chang Chiang, Yingqing Ran, Kang-Jye Chou, Yong Cui, Harvey Wong. Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery. Nanoscale research letters. 2011 Jun; 6(1):413. doi: 10.1186/1556-276x-6-413. [PMID: 21711942]
  • Shuangtao Ma, Dachun Yang, De Li, Bing Tang, Yongjian Yang. Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36. Lipids in health and disease. 2011 Apr; 10(?):53. doi: 10.1186/1476-511x-10-53. [PMID: 21486455]
  • Yuangang Zu, Qi Zhao, Xiuhua Zhao, Shuchong Zu, Li Meng. Process optimization for the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design method. International journal of nanomedicine. 2011; 6(?):3429-41. doi: 10.2147/ijn.s27157. [PMID: 22267927]
  • V S Velingkar, D R Jain, D C Ahire. Spacer/Linker based synthesis and biological evaluation of mutual prodrugs as antiinflammatory agents. Indian journal of pharmaceutical sciences. 2010 Sep; 72(5):632-6. doi: 10.4103/0250-474x.78535. [PMID: 21694998]
  • Houli Jiang, Angela G Zhu, Magdalena Mamczur, Christophe Morisseau, Bruce D Hammock, John R Falck, John C McGiff. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. The Journal of pharmacology and experimental therapeutics. 2008 Jul; 326(1):330-7. doi: 10.1124/jpet.107.134858. [PMID: 18445784]
  • Sarbani Ghosh, Po-Chang Chiang, Jan L Wahlstrom, Hideji Fujiwara, Jon G Selbo, Steven L Roberds. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic & clinical pharmacology & toxicology. 2008 May; 102(5):453-8. doi: 10.1111/j.1742-7843.2008.00213.x. [PMID: 18312493]
  • Xiang Fang, Shanming Hu, Bingkun Xu, Gary D Snyder, Shawn Harmon, Jianrong Yao, Yi Liu, Bhavani Sangras, J R Falck, Neal L Weintraub, Arthur A Spector. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. American journal of physiology. Heart and circulatory physiology. 2006 Jan; 290(1):H55-63. doi: 10.1152/ajpheart.00427.2005. [PMID: 16113065]
  • Xiang Fang, Neal L Weintraub, Ryan B McCaw, Shanming Hu, Shawn D Harmon, James B Rice, Bruce D Hammock, Arthur A Spector. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American journal of physiology. Heart and circulatory physiology. 2004 Dec; 287(6):H2412-20. doi: 10.1152/ajpheart.00527.2004. [PMID: 15284062]
  • Asia N Rasheed, Fatma U Afifi, Mayadeh Shaedah, Mutasem O Taha. Investigation of the active constituents of Portulaca oleraceae L. (Portulacaceae) growing in Jordan. Pakistan journal of pharmaceutical sciences. 2004 Jan; 17(1):37-45. doi: ". [PMID: 16414585]
  • X Fang, T L Kaduce, N L Weintraub, S Harmon, L M Teesch, C Morisseau, D A Thompson, B D Hammock, A A Spector. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. The Journal of biological chemistry. 2001 May; 276(18):14867-74. doi: 10.1074/jbc.m011761200. [PMID: 11278979]
  • Z Yu, F Xu, L M Huse, C Morisseau, A J Draper, J W Newman, C Parker, L Graham, M M Engler, B D Hammock, D C Zeldin, D L Kroetz. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation research. 2000 Nov; 87(11):992-8. doi: 10.1161/01.res.87.11.992. [PMID: 11090543]