1,3-Benzodioxole (BioDeep_00000172423)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1,2-(Methylenedioxy)benzene

化学式: C7H6O2 (122.0367776)
中文名称: 1,2-亚甲二氧基苯, 1,3-苯并二氧杂环戊烯
谱图信息: 最多检出来源 Homo sapiens(blood) 95.24%

分子结构信息

SMILES: C1OC2=CC=CC=C2O1
InChI: InChI=1S/C7H6O2/c1-2-4-7-6(3-1)8-5-9-7/h1-4H,5H2

描述信息

同义名列表

10 个代谢物同义名

1,2-(Methylenedioxy)benzene; 1,2-Methylenedioxybenzene; 3,4-Methylenedioxybenzene; Methylene dioxybenzene; Methylenedioxybenzene; 2H-1,3-Benzodioxole; 1,3-Benzodioxole; 1,3-Dioxaindan; benzodioxole; 1,3-Benzodioxole



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mariza Severina de Lima Silva, Marcilene Souza da Silva, Rômulo Carlos Dantas da Cruz, Bruno de Oliveira Veras, Ivone Antonia de Souza, Rafael Matos Ximenes, Thiago Mendonça de Aquino, Alexandre José da Silva Góes. Biological evaluation of 1,3-benzodioxole acids points to 3,4-(methylenedioxy) cinnamic acid as a potential larvicide against Aedes aegypti (Diptera: Culicidae). Experimental parasitology. 2024 Jan; 256(?):108657. doi: 10.1016/j.exppara.2023.108657. [PMID: 38043764]
  • Ning Xu, Wenli Bao, Jiletu Xin, Hua Xiao, Jiaqi Yu, Liang Xu. A New 1,3-Benzodioxole Compound from Hypecoum erectum and Its Antioxidant Activity. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196657. [PMID: 36235194]
  • Cassandra Yong, Shane M Devine, Anne-Catherine Abel, Stefan D Tomlins, Divya Muthiah, Xuexin Gao, Richard Callaghan, Michel O Steinmetz, Andrea E Prota, Ben Capuano, Peter J Scammells. 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. ChemMedChem. 2021 09; 16(18):2882-2894. doi: 10.1002/cmdc.202100363. [PMID: 34159741]
  • Yun-Dong Xie, Yan-Hong Xu, Ji-Ping Liu, Bin Wang, Yong-Heng Shi, Wei Wang, Xiao-Ping Wang, Meng Sun, Xin-Ya Xu, Xiao-Li Bian. 1,3-Benzodioxole-based fibrate derivatives as potential hypolipidemic and hepatoprotective agents. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):127898. doi: 10.1016/j.bmcl.2021.127898. [PMID: 33684440]
  • Kelly E Wood, Matthew D Krasowski. An Infant with a Prolonged Sympathomimetic Toxidrome after Lisdexamfetamine Dimesylate Ingestion. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2016 12; 12(4):402-405. doi: 10.1007/s13181-016-0560-x. [PMID: 27277955]
  • Ye Zhang, Yuan-Lu Cui, Li-Na Gao, Heng-Li Jiang. Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate. International journal of biological macromolecules. 2013 Aug; 59(?):363-71. doi: 10.1016/j.ijbiomac.2013.04.074. [PMID: 23664937]
  • R M Hartley, J Peng, G A Fest, S Dakshanamurthy, D E Frantz, M L Brown, S L Mooberry. Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site. Molecular pharmacology. 2012 Mar; 81(3):431-9. doi: 10.1124/mol.111.075838. [PMID: 22169850]
  • Roberto Parise-Filho, Michelli Pastrello, Carla Emygdio Pereira Camerlingo, Gisele Juni Silva, Leonardo Aguiar Agostinho, Thaís de Souza, Fátima Maria Motter Magri, Roberto Rodrigues Ribeiro, Carlos Alberto Brandt, Michelle Carneiro Polli. The anti-inflammatory activity of dillapiole and some semisynthetic analogues. Pharmaceutical biology. 2011 Nov; 49(11):1173-9. doi: 10.3109/13880209.2011.575793. [PMID: 22014265]
  • Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorganic & medicinal chemistry letters. 2010 Nov; 20(21):6242-5. doi: 10.1016/j.bmcl.2010.08.100. [PMID: 20850301]
  • Motilal Maiti, Gopinatha Suresh Kumar. Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer. Journal of nucleic acids. 2010; 2010(?):. doi: 10.4061/2010/593408. [PMID: 20814427]
  • Se-Woong Oh, Dae-Hoon Kim, Jong-Ryul Ha, Dae-Yong Kim. Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats. Biological & pharmaceutical bulletin. 2009 Aug; 32(8):1364-70. doi: 10.1248/bpb.32.1364. [PMID: 19652375]
  • Hernán Laurentin, Astrid Ratzinger, Petr Karlovsky. Relationship between metabolic and genomic diversity in sesame (Sesamum indicum L.). BMC genomics. 2008 May; 9(?):250. doi: 10.1186/1471-2164-9-250. [PMID: 18510719]
  • Prerna N Domadia, Anirban Bhunia, J Sivaraman, Sanjay Swarup, Debjani Dasgupta. Berberine targets assembly of Escherichia coli cell division protein FtsZ. Biochemistry. 2008 Mar; 47(10):3225-34. doi: 10.1021/bi7018546. [PMID: 18275156]
  • Megan Hogan, James Claffey, Eoin Fitzpatrick, Thomas Hickey, Clara Pampillón, Matthias Tacke. Synthesis and cytotoxicity studies of titanocene C analogues. Metal-based drugs. 2008; 2008(?):754358. doi: 10.1155/2008/754358. [PMID: 18274663]
  • B Marongiu, A Maxia, A Piras, S Porcedda, E Tuveri, M J Gonçalves, C Cavaleiro, L Salgueiro. Isolation of Crithmum maritimum L. volatile oil by supercritical carbon dioxide extraction and biological assays. Natural product research. 2007 Nov; 21(13):1145-50. doi: 10.1080/14786410600911616. [PMID: 17987493]
  • Gurdip Singh, Palanisamy Marimuthu, Carola S de Heluani, Cesar A N Catalan. Antioxidant and biocidal activities of Carum nigrum (seed) essential oil, oleoresin, and their selected components. Journal of agricultural and food chemistry. 2006 Jan; 54(1):174-81. doi: 10.1021/jf0518610. [PMID: 16390196]
  • Luisa Ugolini, Isabella Della Noce, Paolo Trincia, Valerio Borzatta, Sandro Palmieri. Benzodioxole derivatives as negative effectors of plant proteases. Journal of agricultural and food chemistry. 2005 Sep; 53(19):7494-501. doi: 10.1021/jf0580418. [PMID: 16159178]
  • Suresh Walia, Supradeep Saha, Balraj S Parmar. Liquid chromatographic method for the analysis of two plant based insecticide synergists dillapiole and dihydrodillapiole. Journal of chromatography. A. 2004 Aug; 1047(2):229-33. doi: 10.1016/j.chroma.2004.07.009. [PMID: 15460253]
  • Roland F Staack, Hans H Maurer. New designer drug 1-(3,4-methylenedioxybenzyl) piperazine (MDBP): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry. Journal of mass spectrometry : JMS. 2004 Mar; 39(3):255-61. doi: 10.1002/jms.556. [PMID: 15039932]
  • M C Dumasia. Identification of some N-hydroxylated metabolites of (+/-)-3,4-methylenedioxymethamphetamine in horse urine by gas chromatography-mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Oct; 33(10):1013-25. doi: 10.1080/00498250310001602766. [PMID: 14555338]
  • Z S Zhao, S Khan, P J O'Brien. The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. Chemico-biological interactions. 1997 Dec; 108(1-2):107-18. doi: 10.1016/s0009-2797(97)00103-8. [PMID: 9463524]
  • J P Wynn, A Kendrick, C Ratledge. Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme. Lipids. 1997 Jun; 32(6):605-10. doi: 10.1007/s11745-997-0077-1. [PMID: 9208389]
  • Z S Zhao, P J O'Brien. The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. Toxicology and applied pharmacology. 1996 Oct; 140(2):411-21. doi: 10.1006/taap.1996.0238. [PMID: 8887459]