Dibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro- (BioDeep_00000172393)
human metabolite blood metabolite
代谢物信息卡片
tricyclo[10.4.0.0^{2,7}]hexadeca-1(16),2,4,6,12,14-hexaene
化学式: C16H16 (208.1252)
中文名称: 5,6,7,8- 环辛烯
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1CCC2=CC=CC=C2C2=CC=CC=C2C1
InChI: InChI=1S/C16H16/c1-2-8-14-10-4-6-12-16(14)15-11-5-3-9-13(15)7-1/h3-6,9-12H,1-2,7-8H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tae Hwa Lee, Chang Hwa Jung, Dae-Hee Lee. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Dec; 50(12):4239-45. doi:
10.1016/j.fct.2012.08.047. [PMID: 22960133] - Rahul Checker, Raghavendra S Patwardhan, Deepak Sharma, Jisha Menon, Maikho Thoh, Hari N Bhilwade, Tetsuya Konishi, Santosh K Sandur. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB.
Free radical biology & medicine.
2012 Oct; 53(7):1421-30. doi:
10.1016/j.freeradbiomed.2012.08.006. [PMID: 22917978] - Agnieszka Szopa, Halina Ekiert. In vitro cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine)--a potential biotechnological rich source of therapeutically important phenolic acids.
Applied biochemistry and biotechnology.
2012 Apr; 166(8):1941-8. doi:
10.1007/s12010-012-9622-y. [PMID: 22399445] - Si-Yuan Pan, Zhi-Ling Yu, Hang Dong, Chun-Jing Xiang, Wang-Fun Fong, Kam-Ming Ko. Ethanol extract of fructus schisandrae decreases hepatic triglyceride level in mice fed with a high fat/cholesterol diet, with attention to acute toxicity.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):729412. doi:
10.1093/ecam/nep070. [PMID: 19592476] - Si-Yuan Pan, Si-Bao Chen, Hong-Guang Dong, Zhi-Ling Yu, Ji-Cui Dong, Zhi-Xian Long, Wang-Fun Fong, Yi-Fan Han, Kam-Ming Ko. New perspectives on chinese herbal medicine (zhong-yao) research and development.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):403709. doi:
10.1093/ecam/neq056. [PMID: 21785622] - Lenka Brezinová, Helena Vlasínová, Ladislav Havel, Otakar Humpa, Jirí Slanina. Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application.
Biomedical chromatography : BMC.
2010 Sep; 24(9):954-60. doi:
10.1002/bmc.1391. [PMID: 20082284] - MinKyun Na, Tran Manh Hung, Won Keun Oh, Byung Sun Min, Seung Ho Lee, KiHwan Bae. Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis.
Phytotherapy research : PTR.
2010 Jun; 24 Suppl 2(?):S225-8. doi:
10.1002/ptr.3149. [PMID: 20544979] - Hai-Tao Liu, Li-Jia Xu, Yong Peng, Jun-Shan Yang, Xiu-Wei Yang, Pei-Gen Xiao. Complete assignments of 1H and 13C NMR data for new dibenzocyclooctadiene lignans from Kadsura oblongifolia.
Magnetic resonance in chemistry : MRC.
2009 Jul; 47(7):609-12. doi:
10.1002/mrc.2430. [PMID: 19347905] - Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Michael Y Chiang, Shorong-Shii Liou, Ashraf Taha Khalil. Dibenzocyclooctadiene lignans from Kadsura philippinensis.
Phytochemistry.
2009 Jan; 70(1):114-20. doi:
10.1016/j.phytochem.2008.11.005. [PMID: 19108854] - Po Yee Chiu, Hoi Yan Leung, Kam Ming Ko. Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats.
Biological & pharmaceutical bulletin.
2008 Apr; 31(4):602-5. doi:
10.1248/bpb.31.602. [PMID: 18379049] - Jian-Xin Pu, Liu-Meng Yang, Wei-Lie Xiao, Rong-Tao Li, Chun Lei, Xue-Mei Gao, Sheng-Xiong Huang, Sheng-Hong Li, Yong-Tang Zheng, Hao Huang, Han-Dong Sun. Compounds from Kadsura heteroclita and related anti-HIV activity.
Phytochemistry.
2008 Mar; 69(5):1266-72. doi:
10.1016/j.phytochem.2007.11.019. [PMID: 18207206] - Kam Ming Ko, Na Chen, Hoi Yan Leung, Eriol P K Leong, Michel K T Poon, Po Yee Chiu. Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice.
BioFactors (Oxford, England).
2008; 34(4):331-42. doi:
10.3233/bio-2009-1086. [PMID: 19850987] - Si-Yuan Pan, Hang Dong, Zhi-Ling Yu, Xin-Ye Zhao, Chun-Jing Xiang, Hui Wang, Wang-Fun Fong, Kam-Ming Ko. Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice.
The Journal of pharmacy and pharmacology.
2007 Dec; 59(12):1657-62. doi:
10.1211/jpp.59.12.0007. [PMID: 18053327] - Ya-Ching Shen, Yu-Chi Lin, Atallah F Ahmed, Yuan-Bin Cheng, Chia-Ching Liaw, Yao-Haur Kuo. Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis.
Chemical & pharmaceutical bulletin.
2007 Feb; 55(2):280-3. doi:
10.1248/cpb.55.280. [PMID: 17268102] - LiJia Xu, Feng Huang, SiBao Chen, ShiLin Chen, PeiGen Xiao. A new triterpene and dibenzocyclooctadiene lignans from Schisandra propinqua (WALL.) BAILL.
Chemical & pharmaceutical bulletin.
2006 Apr; 54(4):542-5. doi:
10.1248/cpb.54.542. [PMID: 16595961] - Kam-Ming Ko, Brian Y H Lam. Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.
Molecular and cellular biochemistry.
2002 Sep; 238(1-2):181-6. doi:
10.1023/a:1019907316129. [PMID: 12349905] - S Y Pan, Y F Han, P R Carlier, Y P Pang, D H F Mak, B Y H Lam, K M Ko. Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Planta medica.
2002 Mar; 68(3):217-20. doi:
10.1055/s-2002-23145. [PMID: 11914957] - L Opletal, M Krenková, P Havlícková. [Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti.
2001 Jul; 50(4):173-80. doi:
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