1,2,3-Thiadiazole (BioDeep_00000172390)
human metabolite blood metabolite
代谢物信息卡片
1,2,3-Thiadiazole
化学式: C2H2N2S (85.99386919999999)
中文名称: 1,2,3-噻二唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CSN=N1
InChI: InChI=1S/C2H2N2S/c1-2-5-4-3-1/h1-2H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xing-Hai Liu, Li Pan, Jian-Quan Weng, Cheng-Xia Tan, Yong-Hong Li, Bao-Lei Wang, Zheng-Ming Li. Synthesis, structure, and biological activity of novel (oxdi/tri)azoles derivatives containing 1,2,3-thiadiazole or methyl moiety.
Molecular diversity.
2012 May; 16(2):251-60. doi:
10.1007/s11030-011-9352-z. [PMID: 22249419] - Ahsan Raza, Aamer Saeed, Aliya Ibrar, Muhammad Muddassar, Aftab Ahmed Khan, Jamshed Iqbal. Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors.
ISRN pharmacology.
2012; 2012(?):707932. doi:
10.5402/2012/707932. [PMID: 22966467] - Michael Hothorn, Tsegaye Dabi, Joanne Chory. Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.
Nature chemical biology.
2011 Oct; 7(11):766-8. doi:
10.1038/nchembio.667. [PMID: 21964459] - Alexander W Schüttelkopf, Ludovic Gros, David E Blair, Julie A Frearson, Daan M F van Aalten, Ian H Gilbert. Acetazolamide-based fungal chitinase inhibitors.
Bioorganic & medicinal chemistry.
2010 Dec; 18(23):8334-40. doi:
10.1016/j.bmc.2010.09.062. [PMID: 21044846] - Le Zhang, Jie Wang, Guo-Nian Zhu, Lai Su. Pubertal exposure to thiodiazole copper inhibits thyroid function in juvenile female rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2010 Mar; 62(2):163-9. doi:
10.1016/j.etp.2009.03.005. [PMID: 19375902] - Le Zhang, Jie Wang, Guo N Zhu. Pubertal exposure to bismerthlazol inhibits thyroid function in juvenile female rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2009 Sep; 61(5):453-9. doi:
10.1016/j.etp.2008.10.011. [PMID: 19070471] - Zhijin Fan, Zugui Shi, Haike Zhang, Xiufeng Liu, Lili Bao, Lin Ma, Xiang Zuo, Qinxiang Zheng, Na Mi. Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
Journal of agricultural and food chemistry.
2009 May; 57(10):4279-86. doi:
10.1021/jf8031364. [PMID: 21314199] - Tiffany L Graves, John E Scott. A high throughput serum paraoxonase assay for discovery of small molecule modulators of PON1 activity.
Current chemical genomics.
2008 Nov; 2(?):51-61. doi:
10.2174/1875397300802010051. [PMID: 20161844] - Can Sungur, Sarah Miller, Johann Bergholz, Rebecca C Hoye, Ronald G Brisbois, Paul Overvoorde. The small molecule 2-furylacrylic acid inhibits auxin-mediated responses in Arabidopsis thaliana.
Plant & cell physiology.
2007 Dec; 48(12):1693-701. doi:
10.1093/pcp/pcm141. [PMID: 17942448] - Peter Stanetty, Martin Turner, Marko D Mihovilovic. Synthesis of pyrrolo[2,3-d][1,2,3]thiadiazole-6-carboxylates via the Hurd-Mori reaction. Investigating the effect of the N-protecting group on the cyclization.
Molecules (Basel, Switzerland).
2005 Feb; 10(2):367-75. doi:
10.3390/10020367. [PMID: 18007307] - Mohd Amir, Shikha Kumar. Anti-inflammatory and gastro sparing activity of some new indomethacin derivatives.
Archiv der Pharmazie.
2005 Jan; 338(1):24-31. doi:
10.1002/ardp.200400891. [PMID: 15674801] - Yuuki Koide, Akira Tatsui, Takeshi Hasegawa, Akira Murakami, Shoji Satoh, Hideki Yamada, Shin-ichi Kazayama, Atsuo Takahashi. Identification of a stable chymase inhibitor using a pharmacophore-Based database search.
Bioorganic & medicinal chemistry letters.
2003 Jan; 13(1):25-9. doi:
10.1016/s0960-894x(02)00853-3. [PMID: 12467610] - Lee Jia, Hong Wong, Cesario Cerna, Steve D Weitman. Effect of nanonization on absorption of 301029: ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry.
Pharmaceutical research.
2002 Aug; 19(8):1091-6. doi:
10.1023/a:1019829622088. [PMID: 12240933] - H Wong, L Jia, J B Camden, S D Weitman. Liquid chromatography-mass spectrometry assay of a thiadiazole derivative in mice: application to pharmacokinetic studies.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Dec; 765(1):55-62. doi:
10.1016/s0378-4347(01)00403-0. [PMID: 11817310] - A B Fawzi, D Macdonald, L L Benbow, A Smith-Torhan, H Zhang, B C Weig, G Ho, D Tulshian, M E Linder, M P Graziano. SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.
Molecular pharmacology.
2001 Jan; 59(1):30-7. doi:
10.1124/mol.59.1.30. [PMID: 11125021]