1,2-Dioctanoylglycerol (BioDeep_00000172372)
human metabolite blood metabolite
代谢物信息卡片
1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
化学式: C19H36O5 (344.2563)
中文名称: 二辛酸甘油酯
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC
InChI: InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3
描述信息
C78276 - Agent Affecting Digestive System or Metabolism
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 1323
- HMDB: HMDB0244086
- ChEMBL: CHEMBL24609
- chemspider: 1283
- CAS: 36354-80-0
- CAS: 1069-87-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Michelle A Lum, Carter J Barger, Alice H Hsu, Olga V Leontieva, Adrian R Black, Jennifer D Black. Protein Kinase Cα (PKCα) Is Resistant to Long Term Desensitization/Down-regulation by Prolonged Diacylglycerol Stimulation.
The Journal of biological chemistry.
2016 Mar; 291(12):6331-46. doi:
10.1074/jbc.m115.696211. [PMID: 26769967] - Chiara Ghezzi, Ernest M Wright. Regulation of the human Na+-dependent glucose cotransporter hSGLT2.
American journal of physiology. Cell physiology.
2012 Aug; 303(3):C348-54. doi:
10.1152/ajpcell.00115.2012. [PMID: 22673616] - Hetal N Prajapati, Damon M Dalrymple, Abu T M Serajuddin. A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development.
Pharmaceutical research.
2012 Jan; 29(1):285-305. doi:
10.1007/s11095-011-0541-3. [PMID: 21861203] - Christian Winter, Nicole B Kampik, Luca Vedovelli, Florina Rothenberger, Teodor G Paunescu, Paul A Stehberger, Dennis Brown, Hubert John, Carsten A Wagner. Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.
American journal of physiology. Cell physiology.
2011 Nov; 301(5):C1251-61. doi:
10.1152/ajpcell.00076.2011. [PMID: 21832245] - Günther Raspotnig, Hans-Jörg Leis. Wearing a raincoat: exocrine secretions contain anti-wetting agents in the oribatid mite, Liacarus subterraneus (Acari: Oribatida).
Experimental & applied acarology.
2009 Mar; 47(3):179-90. doi:
10.1007/s10493-008-9212-4. [PMID: 19005767] - Shawn Hopewell, Nihar R Pandey, Ayesha Misquith, Erin Twomey, Daniel L Sparks. Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion.
Metabolism: clinical and experimental.
2008 Dec; 57(12):1677-84. doi:
10.1016/j.metabol.2008.07.023. [PMID: 19013290] - Chuan Wang, Uyenlinh L Mirshahi, Boyi Liu, Zhanfeng Jia, Tooraj Mirshahi, Hailin Zhang. Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.
Molecular pharmacology.
2008 Apr; 73(4):1185-94. doi:
10.1124/mol.107.043067. [PMID: 18202303] - Hideyuki Takahashi, Hideo Namiki. Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
The Biochemical journal.
2007 Jul; 405(2):331-40. doi:
10.1042/bj20070299. [PMID: 17373912] - Shinichi Meguro, Noriko Osaki, Koji Onizawa, Noriyuki Yajima, Tadashi Hase, Noboru Matsuo, Ichiro Tokimitsu. Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2007 Jul; 45(7):1165-72. doi:
10.1016/j.fct.2006.12.024. [PMID: 17306914] - Paola Capuano, Desa Bacic, Marcel Roos, Serge M Gisler, Gerti Stange, Jürg Biber, Brigitte Kaissling, Edward J Weinman, Shirish Shenolikar, Carsten A Wagner, Heini Murer. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
American journal of physiology. Cell physiology.
2007 Feb; 292(2):C927-34. doi:
10.1152/ajpcell.00126.2006. [PMID: 16987995] - Johnny Näsman, Genevieve Bart, Kim Larsson, Lauri Louhivuori, Hanna Peltonen, Karl E O Akerman. The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Oct; 26(42):10658-66. doi:
10.1523/jneurosci.2609-06.2006. [PMID: 17050705] - Helena Stensman, Arathi Raghunath, Christer Larsson. Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol.
The Journal of biological chemistry.
2004 Sep; 279(39):40576-83. doi:
10.1074/jbc.m405560200. [PMID: 15277524] - L R Quinlan, S Faherty, M T Kane. Phospholipase C and protein kinase C involvement in mouse embryonic stem-cell proliferation and apoptosis.
Reproduction (Cambridge, England).
2003 Jul; 126(1):121-31. doi:
10.1530/rep.0.1260121. [PMID: 12814354] - Johannes C Lenz, H Peter Reusch, Nadine Albrecht, Günter Schultz, Michael Schaefer. Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells.
The Journal of cell biology.
2002 Oct; 159(2):291-302. doi:
10.1083/jcb.200203048. [PMID: 12391024] - Carole L Baron, Vivek Malhotra. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane.
Science (New York, N.Y.).
2002 Jan; 295(5553):325-8. doi:
10.1126/science.1066759. [PMID: 11729268] - P Masiello, M Novelli, M Bombara, V Fierabracci, S Vittorini, M Prentki, E Bergamini. The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets.
Metabolism: clinical and experimental.
2002 Jan; 51(1):110-4. doi:
10.1053/meta.2002.28969. [PMID: 11782881] - A Y Andreeva, E Krause, E C Müller, I E Blasig, D I Utepbergenov. Protein kinase C regulates the phosphorylation and cellular localization of occludin.
The Journal of biological chemistry.
2001 Oct; 276(42):38480-6. doi:
10.1074/jbc.m104923200. [PMID: 11502742] - Y Tesfai, H M Brereton, G J Barritt. A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
The Biochemical journal.
2001 Sep; 358(Pt 3):717-26. doi:
10.1042/0264-6021:3580717. [PMID: 11535132] - G Pietig, T Mehrens, J R Hirsch, I Cetinkaya, H Piechota, E Schlatter. Properties and regulation of organic cation transport in freshly isolated human proximal tubules.
The Journal of biological chemistry.
2001 Sep; 276(36):33741-6. doi:
10.1074/jbc.m104617200. [PMID: 11447227] - L Sek, C J Porter, W N Charman. Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis.
Journal of pharmaceutical and biomedical analysis.
2001 Jun; 25(3-4):651-61. doi:
10.1016/s0731-7085(00)00528-8. [PMID: 11377046] - B Haidar, S Mott, B Boucher, C Y Lee, M Marcil, J Genest. Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts.
Journal of lipid research.
2001 Feb; 42(2):249-57. doi:
10.1016/s0022-2275(20)31686-2. [PMID: 11181755] - J K Jackon, C Tudan, H M Burt. The involvement of phospholipase C in crystal induced human neutrophil activation.
The Journal of rheumatology.
2000 Dec; 27(12):2877-85. doi:
NULL. [PMID: 11128680] - M Gekle, S Mildenberger, C Sauvant, D Bednarczyk, S H Wright, W H Dantzler. Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine.
The American journal of physiology.
1999 08; 277(2):F251-6. doi:
10.1152/ajprenal.1999.277.2.f251. [PMID: 10444580] - Z Schwartz, V L Sylvia, D Curry, M H Luna, D D Dean, B D Boyan. Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes.
Endocrinology.
1999 Jul; 140(7):2991-3002. doi:
10.1210/endo.140.7.6801. [PMID: 10385391] - I C Forster, M Traebert, M Jankowski, G Stange, J Biber, H Murer. Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes.
The Journal of physiology.
1999 Jun; 517 ( Pt 2)(?):327-40. doi:
10.1111/j.1469-7793.1999.0327t.x. [PMID: 10332085] - A T Tool, M Blom, D Roos, A J Verhoeven. Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils.
The Biochemical journal.
1999 May; 340 ( Pt 1)(?):95-101. doi:
10.1042/bj3400095. [PMID: 10229663] - K Suzuki, H Namiki. Phorbol 12-myristate 13-acetate induced cell death of porcine peripheral blood polymorphonuclear leucocytes.
Cell structure and function.
1998 Dec; 23(6):367-72. doi:
10.1247/csf.23.367. [PMID: 10206739] - K Nobe, Y Sakai, K Momose. Alternations of diacylglycerol kinase in streptozotocin-induced diabetic rats.
Cellular signalling.
1998 Jul; 10(7):465-71. doi:
10.1016/s0898-6568(97)00172-1. [PMID: 9754714] - V L Sylvia, Z Schwartz, D B Curry, Z Chang, D D Dean, B D Boyan. 1,25(OH)2D3 regulates protein kinase C activity through two phospholipid-dependent pathways involving phospholipase A2 and phospholipase C in growth zone chondrocytes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1998 Apr; 13(4):559-69. doi:
10.1359/jbmr.1998.13.4.559. [PMID: 9556056] - H Kurota, M Yamaguchi. Inhibitory effect of calcium-binding protein regucalcin on protein kinase C activity in rat renal cortex cytosol.
Biological & pharmaceutical bulletin.
1998 Apr; 21(4):315-8. doi:
10.1248/bpb.21.315. [PMID: 9586564] - E Oancea, M N Teruel, A F Quest, T Meyer. Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.
The Journal of cell biology.
1998 Feb; 140(3):485-98. doi:
10.1083/jcb.140.3.485. [PMID: 9456311] - G I Gorodeski, J Goldfarb. Seminal fluid factor increases the resistance of the tight junctional complex of cultured human cervical epithelium CaSki cells.
Fertility and sterility.
1998 Feb; 69(2):309-17. doi:
10.1016/s0015-0282(97)00471-8. [PMID: 9496347] - H Rösner, G Vacun. Organotypic spinal cord culture in serum-free fibrin gel: a new approach to study three-dimensional neurite outgrowth and of neurotoxicity testing: Effects of modulating the actin and tubulin dynamics and protein kinase activities.
Journal of neuroscience methods.
1997 Dec; 78(1-2):93-103. doi:
10.1016/s0165-0270(97)00132-5. [PMID: 9497005] - X Yang, L Sun, J Gabbeta, A K Rao. Platelet activation with combination of ionophore A23187 and a direct protein kinase C activator induces normal secretion in patients with impaired receptor mediated secretion and abnormal signal transduction.
Thrombosis research.
1997 Nov; 88(3):317-28. doi:
10.1016/s0049-3848(97)00261-2. [PMID: 9526952] - J N Larocca, M Farooq, W T Norton. Induction of oligodendrocyte apoptosis by C2-ceramide.
Neurochemical research.
1997 Apr; 22(4):529-34. doi:
10.1023/a:1027332415877. [PMID: 9130266] - D D Loo, J R Hirsch, H K Sarkar, E M Wright. Regulation of the mouse retinal taurine transporter (TAUT) by protein kinases in Xenopus oocytes.
FEBS letters.
1996 Sep; 392(3):250-4. doi:
10.1016/0014-5793(96)00823-x. [PMID: 8774855] - J T Deeney, B A Cunningham, S Chheda, K Bokvist, L Juntti-Berggren, K Lam, H M Korchak, B E Corkey, P O Berggren. Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release.
The Journal of biological chemistry.
1996 Jul; 271(30):18154-60. doi:
10.1074/jbc.271.30.18154. [PMID: 8663368] - J R Hirsch, D D Loo, E M Wright. Regulation of Na+/glucose cotransporter expression by protein kinases in Xenopus laevis oocytes.
The Journal of biological chemistry.
1996 Jun; 271(25):14740-6. doi:
10.1074/jbc.271.25.14740. [PMID: 8663046] - W J Gelsema, O F van den Brink, H van den Bosch. Benzoolysis of diacylglycerophosphocholines: dephosphorylation and sequential formation of isomeric reaction products.
Journal of lipid research.
1996 Jun; 37(6):1224-33. doi:
10.1016/s0022-2275(20)39152-5. [PMID: 8808757] - K Heiskanen, M Ruotsalainen, K Savolainen. Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes.
Toxicology.
1995 Dec; 104(1-3):113-21. doi:
10.1016/0300-483x(95)03153-7. [PMID: 8560489] - K Törnquist, M Pasternack, K Kaila. Sphingosine derivatives inhibit depolarization-evoked calcium entry in rat GH4C1 cells.
Endocrinology.
1995 Nov; 136(11):4894-902. doi:
10.1210/endo.136.11.7588222. [PMID: 7588222] - S E Gordon, J Downing-Park, B Tam, A L Zimmerman. Diacylglycerol analogs inhibit the rod cGMP-gated channel by a phosphorylation-independent mechanism.
Biophysical journal.
1995 Aug; 69(2):409-17. doi:
10.1016/s0006-3495(95)79913-1. [PMID: 8527654] - R C Drisdel, S R Mack, R A Anderson, L J Zaneveld. Purification and partial characterization of acrosome reaction inhibiting glycoprotein from human seminal plasma.
Biology of reproduction.
1995 Jul; 53(1):201-8. doi:
10.1095/biolreprod53.1.201. [PMID: 7669849] - M Mizobuchi, T R Downs, L A Frohman. Growth hormone-releasing hormone immunoreactivity in mouse placenta, maternal blood, and amniotic fluid: molecular characterization and secretion from primary cell cultures in vitro.
Endocrinology.
1995 Apr; 136(4):1731-6. doi:
10.1210/endo.136.4.7895684. [PMID: 7895684] - J R Apgar. Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization.
Molecular biology of the cell.
1995 Jan; 6(1):97-108. doi:
10.1091/mbc.6.1.97. [PMID: 7749199] - R L Brandão, N M de Magalhães-Rocha, R Alijo, J Ramos, J M Thevelein. Possible involvement of a phosphatidylinositol-type signaling pathway in glucose-induced activation of plasma membrane H(+)-ATPase and cellular proton extrusion in the yeast Saccharomyces cerevisiae.
Biochimica et biophysica acta.
1994 Aug; 1223(1):117-24. doi:
10.1016/0167-4889(94)90080-9. [PMID: 8061044] - T G Brock, K Nagaprakash, D I Margolis, J E Smolen. Modeling degranulation with liposomes: effect of lipid composition on membrane fusion.
The Journal of membrane biology.
1994 Aug; 141(2):139-48. doi:
10.1007/bf00238247. [PMID: 7807516] - S Grabski, X G Xie, J F Holland, M Schindler. Lipids trigger changes in the elasticity of the cytoskeleton in plant cells: a cell optical displacement assay for live cell measurements.
The Journal of cell biology.
1994 Aug; 126(3):713-26. doi:
10.1083/jcb.126.3.713. [PMID: 8045935] - S E Mau, T Saermark, H Vilhardt. Translocation of protein kinase C isozymes in lactotroph-enriched rat anterior pituitary cell cultures: differential effects of substance P and phorbol ester.
Journal of molecular endocrinology.
1994 Jun; 12(3):293-302. doi:
10.1677/jme.0.0120293. [PMID: 7522460] - A F Quest, E S Bardes, R M Bell. A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.
The Journal of biological chemistry.
1994 Jan; 269(4):2953-60. doi:
. [PMID: 8300627] - E Urcelay, N Butta, C G Manchón, G Ciprés, A M Requero, M S Ayuso, R Parrilla. Role of protein kinase-C in the alpha 1-adrenoceptor-mediated responses of perfused rat liver.
Endocrinology.
1993 Nov; 133(5):2105-15. doi:
10.1210/endo.133.5.8404660. [PMID: 8404660] - Y Sistina, M Lin, K E Mate, J C Rodger. Induction of the marsupial sperm acrosome reaction in vitro by treatment with diacylglycerols.
Journal of reproduction and fertility.
1993 Nov; 99(2):335-41. doi:
10.1530/jrf.0.0990335. [PMID: 8107014] - J W Park, B M Babior. Effects of diacylglycerol on the activation and kinetics of the respiratory burst oxidase in a cell-free system from human neutrophils: evidence that diacylglycerol may regulate nucleotide uptake by a GTP-binding protein.
Archives of biochemistry and biophysics.
1993 Oct; 306(1):119-24. doi:
10.1006/abbi.1993.1488. [PMID: 8215391] - M S Balda, L Gonzalez-Mariscal, K Matter, M Cereijido, J M Anderson. Assembly of the tight junction: the role of diacylglycerol.
The Journal of cell biology.
1993 Oct; 123(2):293-302. doi:
10.1083/jcb.123.2.293. [PMID: 8408213] - K Krämer, A Markwitan, J Pallauf. Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade.
Zeitschrift fur Ernahrungswissenschaft.
1993 Sep; 32(3):176-86. doi:
10.1007/bf01610728. [PMID: 8237077] - N Laminski, K Hammond, A Meyers. The effect of protein kinase C modulators on endogenous protein phosphorylation in primate kidney.
Biochemistry and molecular biology international.
1993 Aug; 30(5):959-67. doi:
NULL. [PMID: 8220244] - D J MacEwan, R Mitchell, M S Johnson, F J Thomson, E M Lutz, R A Clegg, K Connor. Evidence that protein kinase C alpha has reduced affinity towards 1,2-dioctanoyl-sn-glycerol: the effects of lipid activators on phorbol ester binding and kinase activity.
European journal of pharmacology.
1993 Jun; 246(1):9-18. doi:
10.1016/0922-4106(93)90003-r. [PMID: 8354345] - J Ohanian, A Izzard, M Littlewood, A Heagerty. Regulation of diacylglycerol metabolism by vasoconstrictor hormones in intact small arteries.
Circulation research.
1993 Jun; 72(6):1163-71. doi:
10.1161/01.res.72.6.1163. [PMID: 8495546] - I Teitelbaum. Protein kinase C inhibits arginine vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism.
The American journal of physiology.
1993 Feb; 264(2 Pt 2):F216-20. doi:
10.1152/ajprenal.1993.264.2.f216. [PMID: 8383449] - N Takuwa, W Zhou, M Kumada, Y Takuwa. Activators of protein kinase C induce p34cdc2 histone H1 kinase stimulation in Swiss 3T3 fibroblasts.
Biochemical and biophysical research communications.
1992 Nov; 188(3):1084-9. doi:
10.1016/0006-291x(92)91342-n. [PMID: 1445345] - A Nanda, A Gukovskaya, J Tseng, S Grinstein. Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation.
The Journal of biological chemistry.
1992 Nov; 267(32):22740-6. doi:
10.1016/s0021-9258(18)50010-7. [PMID: 1331065] - J W Park, B M Babior. The translocation of respiratory burst oxidase components from cytosol to plasma membrane is regulated by guanine nucleotides and diacylglycerol.
The Journal of biological chemistry.
1992 Oct; 267(28):19901-6. doi:
NULL. [PMID: 1328185] - A Shariff, E J Luna. Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes.
Science (New York, N.Y.).
1992 Apr; 256(5054):245-7. doi:
10.1126/science.1373523. [PMID: 1373523] - G P Downey, C K Chan, P Lea, A Takai, S Grinstein. Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
The Journal of cell biology.
1992 Feb; 116(3):695-706. doi:
10.1083/jcb.116.3.695. [PMID: 1370499] - I Neveu, F Jehan, R Houlgatte, D Wion, P Brachet. Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C.
Brain research.
1992 Jan; 570(1-2):316-22. doi:
10.1016/0006-8993(92)90596-2. [PMID: 1617422] - A Nanda, S Grinstein. Protein kinase C activates an H+ (equivalent) conductance in the plasma membrane of human neutrophils.
Proceedings of the National Academy of Sciences of the United States of America.
1991 Dec; 88(23):10816-20. doi:
10.1073/pnas.88.23.10816. [PMID: 1720552] - C A Molina, C L Ashendel. Tumor promoter 12-O-tetradecanoylphorbol-13-acetate and sn-1,2-dioctanoylglycerol increase the phosphorylation of protein kinase C in cells.
Cancer research.
1991 Sep; 51(17):4624-30. doi:
NULL. [PMID: 1873807] - A J Mendez, J F Oram, E L Bierman. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol.
The Journal of biological chemistry.
1991 Jun; 266(16):10104-11. doi:
NULL. [PMID: 1645339] - L M Boland, A C Allen, R Dingledine. Inhibition by bradykinin of voltage-activated barium current in a rat dorsal root ganglion cell line: role of protein kinase C.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1991 Apr; 11(4):1140-9. doi:
10.1523/jneurosci.11-04-01140.1991. [PMID: 2010809] - J T Reston, S Gould-Fogerite, R J Mannino. Potentiation of DNA mediated gene transfer in NIH3T3 cells by activators of protein kinase C.
Biochimica et biophysica acta.
1991 Feb; 1088(2):270-6. doi:
10.1016/0167-4781(91)90063-r. [PMID: 1900439] - M R Elstad, T M McIntyre, S M Prescott, G A Zimmerman. Protein kinase C regulates the synthesis of platelet-activating factor by human monocytes.
American journal of respiratory cell and molecular biology.
1991 Feb; 4(2):148-55. doi:
10.1165/ajrcmb/4.2.148. [PMID: 1846746] - K Tomita, H Nonoguchi, F Marumo. Inhibition of fluid transport by endothelin through protein kinase C in collecting duct of rats.
Contributions to nephrology.
1991; 95(?):207-15. doi:
10.1159/000420661. [PMID: 1666990] - J Kadota, G J Cianciolo, R Snyderman. A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.
Microbiology and immunology.
1991; 35(6):443-59. doi:
10.1111/j.1348-0421.1991.tb01575.x. [PMID: 1921761] - K E Mate, J C Rodger. Stability of the acrosome of the brush-tailed possum (Trichosurus vulpecula) and tammar wallaby (Macropus eugenii) in vitro and after exposure to conditions and agents known to cause capacitation or acrosome reaction of eutherian spermatozoa.
Journal of reproduction and fertility.
1991 Jan; 91(1):41-8. doi:
10.1530/jrf.0.0910041. [PMID: 1847424] - C Godson, B A Weiss, P A Insel. Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells.
The Journal of biological chemistry.
1990 May; 265(15):8369-72. doi:
10.1016/s0021-9258(19)38894-5. [PMID: 2341388] - J H Lowe, C L Huang, H E Ives. Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors.
The Journal of biological chemistry.
1990 May; 265(13):7188-94. doi:
10.1016/s0021-9258(19)39097-0. [PMID: 2158991] - J T French, T H Welsh. In vitro modulation of porcine Leydig cell steroidogenesis by phorbol-12-myristate-13-acetate and 1,2-dioctanoylglycerol.
Acta endocrinologica.
1990 Jan; 122(1):101-6. doi:
10.1530/acta.0.1220101. [PMID: 2305601] - P M Larsen, S M Wolniak. 1,2-Dioctanoylglycerol accelerates or retards mitotic progression in Tradescantia stamen hair cells as a function of the time of its addition.
Cell motility and the cytoskeleton.
1990; 16(3):190-203. doi:
10.1002/cm.970160306. [PMID: 2163772] - G Ginsburg, A R Kimmel. Inositol trisphosphate and diacylglycerol can differentially modulate gene expression in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Dec; 86(23):9332-6. doi:
10.1073/pnas.86.23.9332. [PMID: 2556709] - H M Sheu, Y Kitajima, H Yaoita. Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration.
Experimental cell research.
1989 Nov; 185(1):176-90. doi:
10.1016/0014-4827(89)90047-5. [PMID: 2509226] - W Siess, E G Lapetina. Platelet aggregation induced by alpha 2-adrenoceptor and protein kinase C activation. A novel synergism.
The Biochemical journal.
1989 Oct; 263(2):377-85. doi:
10.1042/bj2630377. [PMID: 2574568] - R C Smart, K J Mills, L A Hansen, A H Conney. Synthetic lipid second messenger sn-1,2-didecanoylglycerol: a complete tumor promoter in mouse skin.
Cancer research.
1989 Aug; 49(16):4455-8. doi:
. [PMID: 2743335] - R J Gillies, R Martinez, J M Sneider, P B Hoyer. Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells.
Journal of cellular physiology.
1989 Apr; 139(1):125-30. doi:
10.1002/jcp.1041390118. [PMID: 2540207] - P M Larsen, T L Chen, S M Wolniak. Quin2-induced metaphase arrest in stamen hair cells can be reversed by 1,2-dioctanoylglycerol but not by 1,3-dioctanoylglycerol.
European journal of cell biology.
1989 Apr; 48(2):212-9. doi:
. [PMID: 2743997] - A Ortiz, J Villalaín, J C Gómez-Fernández. Interaction of diacylglycerols with phosphatidylcholine vesicles as studied by differential scanning calorimetry and fluorescence probe depolarization.
Biochemistry.
1988 Dec; 27(25):9030-6. doi:
10.1021/bi00425a022. [PMID: 3233220] - W R Huckle, C A McArdle, P M Conn. Differential sensitivity of agonist- and antagonist-occupied gonadotropin-releasing hormone receptors to protein kinase C activators. A marker for receptor activation.
The Journal of biological chemistry.
1988 Mar; 263(7):3296-302. doi:
NULL. [PMID: 2830280] - W S Lynn, A Tweedale, M W Cloyd. Human immunodeficiency virus (HIV-1) cytotoxicity: perturbation of the cell membrane and depression of phospholipid synthesis.
Virology.
1988 Mar; 163(1):43-51. doi:
10.1016/0042-6822(88)90232-2. [PMID: 3126600] - M Baum, S R Hays. Phorbol myristate acetate and dioctanoylglycerol inhibit transport in rabbit proximal convoluted tubule.
The American journal of physiology.
1988 Jan; 254(1 Pt 2):F9-14. doi:
10.1152/ajprenal.1988.254.1.f9. [PMID: 2827521] - S R Hays, M Baum, J P Kokko. Effects of protein kinase C activation on sodium, potassium, chloride, and total CO2 transport in the rabbit cortical collecting tubule.
The Journal of clinical investigation.
1987 Dec; 80(6):1561-70. doi:
10.1172/jci113242. [PMID: 3680514] - D T Chu, D K Granner. The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.
The Journal of biological chemistry.
1986 Dec; 261(36):16848-53. doi:
. [PMID: 3023368] - J G Hovis, D J Stumpo, D L Halsey, P J Blackshear. Effects of mitogens on ornithine decarboxylase activity and messenger RNA levels in normal and protein kinase C-deficient NIH-3T3 fibroblasts.
The Journal of biological chemistry.
1986 Aug; 261(22):10380-6. doi:
10.1016/s0021-9258(18)67535-0. [PMID: 3733713] - J Eichberg, P N de Graan, L H Schrama, W H Gispen. Dioctanoylglycerol and phorbol diesters enhance phosphorylation of phosphoprotein B-50 in native synaptic plasma membranes.
Biochemical and biophysical research communications.
1986 May; 136(3):1007-12. doi:
10.1016/0006-291x(86)90433-x. [PMID: 2941012] - J G Muir, A W Murray. Mimicry of phorbol ester responses by diacylglycerols. Differential effects on phosphatidylcholine biosynthesis, cell-cell communication and epidermal growth factor binding.
Biochimica et biophysica acta.
1986 Feb; 885(2):176-84. doi:
10.1016/0167-4889(86)90086-8. [PMID: 3484975] - G R Guy, J Gordon, R H Michell, G Brown. Synergism between diacylglycerols and calcium ionophore in the induction of human B cell proliferation mimics the inositol lipid polyphosphate breakdown signals induced by crosslinking surface immunoglobulin.
Biochemical and biophysical research communications.
1985 Aug; 131(1):484-91. doi:
10.1016/0006-291x(85)91828-5. [PMID: 2994665]
