1,2-Diethyl-3-hydroxypyridin-4-one (BioDeep_00000172360)

   

human metabolite blood metabolite


代谢物信息卡片


1,2-diethyl-3-hydroxy-1,4-dihydropyridin-4-one

化学式: C9H13NO2 (167.09462380000002)
中文名称: 1,2-二乙基-3-羟基吡啶-4(1H)-酮
谱图信息: 最多检出来源 Homo sapiens(blood) 85.71%

分子结构信息

SMILES: CCC1=C(C(=O)C=CN1CC)O
InChI: InChI=1S/C9H13NO2/c1-3-7-9(12)8(11)5-6-10(7)4-2/h5-6,12H,3-4H2,1-2H3

描述信息

D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents

同义名列表

2 个代谢物同义名

1,2-diethyl-3-hydroxy-1,4-dihydropyridin-4-one; 1,2-diethyl-3-hydroxypyridin-4-one



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jin Hyen Baek, Chad E N Reiter, Dominador J Manalo, Paul W Buehler, Robert C Hider, Abdu I Alayash. Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochimica et biophysica acta. 2011 Apr; 1809(4-6):262-8. doi: 10.1016/j.bbagrm.2011.04.010. [PMID: 21558026]
  • S L Lu, I Gosriwatana, D Y Liu, Z D Liu, A I Mallet, R C Hider. Biliary and urinary metabolic profiles of 1,2-diethyl-3-hydroxypyridin-4-one (CP94) in the rat. Drug metabolism and disposition: the biological fate of chemicals. 2000 Aug; 28(8):873-9. doi: NULL. [PMID: 10901694]
  • H Cable, J B Lloyd. Cellular uptake and release of two contrasting iron chelators. The Journal of pharmacy and pharmacology. 1999 Feb; 51(2):131-4. doi: 10.1211/0022357991772231. [PMID: 10217310]
  • R Choudhury, S Singh. Effect of iron overload on the metabolism and urinary recovery of 3-hydroxypyridin-4-one chelating agents in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1995 Mar; 23(3):314-20. doi: . [PMID: 7628295]
  • R D Abeysinghe, B L Ellis, J B Porter. Platelet labelling with indium-hydroxypyridinone and indium-hydroxypyranone complexes. European journal of nuclear medicine. 1994 Oct; 21(10):1141-7. doi: 10.1007/bf00181071. [PMID: 7828625]
  • R O Epemolu, R Ackerman, J B Porter, R C Hider, L A Damani, S Singh. HPLC determination of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide conjugate [CP94-GLUC] in serum and urine of thalassaemic patients. Journal of pharmaceutical and biomedical analysis. 1994 Jul; 12(7):923-30. doi: 10.1016/0731-7085(94)e0027-x. [PMID: 7981322]
  • J R Boelaert, J Van Cutsem, M de Locht, Y J Schneider, R R Crichton. Deferoxamine augments growth and pathogenicity of Rhizopus, while hydroxypyridinone chelators have no effect. Kidney international. 1994 Mar; 45(3):667-71. doi: 10.1038/ki.1994.89. [PMID: 8196268]
  • J B Porter, R D Abeysinghe, K P Hoyes, C Barra, E R Huehns, P N Brooks, M P Blackwell, M Araneta, G Brittenham, S Singh. Contrasting interspecies efficacy and toxicology of 1,2-diethyl-3-hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site. British journal of haematology. 1993 Sep; 85(1):159-68. doi: 10.1111/j.1365-2141.1993.tb08660.x. [PMID: 8251385]
  • A Hartley, C Rice-Evans. The chelation of nonheme iron within sickle erythrocytes by the hydroxypyridinone chelator CP094. Archives of biochemistry and biophysics. 1992 Sep; 297(2):377-82. doi: 10.1016/0003-9861(92)90687-r. [PMID: 1497355]
  • R J Bergeron, R R Streiff, J Wiegand, G Luchetta, E A Creary, H H Peter. A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferoxamine. Blood. 1992 Apr; 79(7):1882-90. doi: NULL. [PMID: 1558978]
  • S Singh, R O Epemolu, P S Dobbin, G S Tilbrook, B L Ellis, L A Damani, R C Hider. Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones. Drug metabolism and disposition: the biological fate of chemicals. 1992 Mar; 20(2):256-61. doi: NULL. [PMID: 1352218]
  • S Zevin, G Link, R W Grady, R C Hider, H H Peter, C Hershko. Origin and fate of iron mobilized by the 3-hydroxypyridin-4-one oral chelators: studies in hypertransfused rats by selective radioiron probes of reticuloendothelial and hepatocellular iron stores. Blood. 1992 Jan; 79(1):248-53. doi: NULL. [PMID: 1728313]
  • C Hershko, G Link, A Pinson, H H Peter, P Dobbin, R C Hider. Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture. Blood. 1991 May; 77(9):2049-53. doi: ". [PMID: 2018841]
  • V Eybl, D Caisová, J Koutenský, G J Kontoghiorghes. Influence of iron chelators, 1,2-dialkyl-3-hydroxypyridin-4-ones, on the lipid peroxidation and glutathione level in the liver of mice. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 1991; 14(?):185-7. doi: 10.1007/978-3-642-74936-0_37. [PMID: 1805729]