1,1,1,2,3,3,3-Heptafluoropropane (BioDeep_00000172331)
human metabolite blood metabolite
代谢物信息卡片
1,1,1,2,3,3,3-Heptafluoropropane
化学式: C3HF7 (169.996647)
中文名称: 七氟丙烷
谱图信息:
最多检出来源 Mus musculus(blood) 22.58%
分子结构信息
SMILES: C(C(F)(F)F)(C(F)(F)F)F
InChI: InChI=1S/C3HF7/c4-1(2(5,6)7)3(8,9)10/h1H
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 67940
- HMDB: HMDB0244037
- ChEMBL: CHEMBL2104472
- Wikipedia: 1,1,1,2,3,3,3-Heptafluoropropane
- chemspider: 61257
- CAS: 431-89-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Edward M Kerwin, Tony Marrs, Mary Z Luo, Jack Y Zhang. Pharmacokinetic Study of Epinephrine Hydrofluoroalkane (Primatene MIST) Metered-Dose Inhaler.
Journal of aerosol medicine and pulmonary drug delivery.
2020 10; 33(5):282-287. doi:
10.1089/jamp.2019.1577. [PMID: 32423275] - Amira Sa Said, Salahdein AbuRuz, Henry Chrystyn. Bioavailability of Beclometasone From Two HFA-BDP Formulations With a Spacer.
Respiratory care.
2019 Oct; 64(10):1222-1230. doi:
10.4187/respcare.06689. [PMID: 31138731] - William J Anderson, Philip M Short, Peter A Williamson, Arvind Manoharan, Brian J Lipworth. The inverse agonist propranolol confers no corticosteroid-sparing activity in mild-to-moderate persistent asthma.
Clinical science (London, England : 1979).
2014 12; 127(11):635-43. doi:
10.1042/cs20140249. [PMID: 24938324] - Ole D Wolthers, Ewan G Walters. Short-term lower leg growth in 5- to 11-year-old asthmatic children using beclomethasone dipropionate inhalers with chlorofluorocarbon or hydrofluoroalkane propellants: a 9-week, open-label, randomized, crossover, noninferiority study.
Clinical therapeutics.
2011 Aug; 33(8):1069-76. doi:
10.1016/j.clinthera.2011.06.015. [PMID: 21784529] - Yanjun Zhao, Marc B Brown, Stuart A Jones. The topical delivery of benzoyl peroxide using elegant dynamic hydrofluoroalkane foams.
Journal of pharmaceutical sciences.
2010 Mar; 99(3):1384-98. doi:
10.1002/jps.21933. [PMID: 19798761] - Hao-Ying Li, Peter C Seville. Novel pMDI formulations for pulmonary delivery of proteins.
International journal of pharmaceutics.
2010 Jan; 385(1-2):73-8. doi:
10.1016/j.ijpharm.2009.10.032. [PMID: 19854252] - Yanjun Zhao, Marc B Brown, Stuart A Jones. The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams.
International journal of pharmaceutics.
2010 Jan; 383(1-2):277-84. doi:
10.1016/j.ijpharm.2009.09.029. [PMID: 19772905] - Celestine Juliet Po, Saumya Subhash Chandran, Nazma Syed, K Raghu Naidu, Manoj Rathod, Ameet Sule, Amar Lulla, Shrinivas Purandare. Comparative bioavailability of two hydrofluoroalkane formulations of formoterol fumarate both delivered by pressurised metered dose inhaler.
Arzneimittel-Forschung.
2010; 60(2):81-6. doi:
10.1055/s-0031-1296253. [PMID: 20329656] - Ruediger Nave, Rolf Herzog, Aziz Laurent, Mark A Wingertzahn. Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healthy volunteers.
Clinical therapeutics.
2009 Dec; 31(12):2988-99. doi:
10.1016/j.clinthera.2009.12.002. [PMID: 20110036] - Yanjun Zhao, Mojgan Moddaresi, Stuart A Jones, Marc B Brown. A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2009 Aug; 72(3):521-8. doi:
10.1016/j.ejpb.2009.03.002. [PMID: 19303438] - Jean Bousquet, Gianluigi Poli, Daniela Acerbi, Raffaella Monno, Steven Ramael, Fabrice Nollevaux. Systemic exposure and implications for lung deposition with an extra-fine hydrofluoroalkane beclometasone dipropionate/formoterol fixed combination.
Clinical pharmacokinetics.
2009; 48(6):347-58. doi:
10.2165/00003088-200948060-00001. [PMID: 19650674] - Josh D Engstrom, Jasmine M Tam, Maria A Miller, Robert O Williams, Keith P Johnston. Templated open flocs of nanorods for enhanced pulmonary delivery with pressurized metered dose inhalers.
Pharmaceutical research.
2009 Jan; 26(1):101-17. doi:
10.1007/s11095-008-9707-z. [PMID: 18758922] - Kenneth Tripp, William K McVicar, Parameswaran Nair, Jonathan Corren, Warren W Pleskow, Elizabeth Goodwin, Rudolf A Baumgartner, John P Hanrahan. A cumulative dose study of levalbuterol and racemic albuterol administered by hydrofluoroalkane-134a metered-dose inhaler in asthmatic subjects.
The Journal of allergy and clinical immunology.
2008 Sep; 122(3):544-9. doi:
10.1016/j.jaci.2008.06.015. [PMID: 18692886] - Kenneth T Kim, Henry Milgrom, Y Kellie Yoon, Arden L Levy, Paul Matz, Michael J Welch, Anthony Cahn, David A Collins, Steven Kathman, Rashmi Mehta, Sheng-Fang Su, Robert L Kunka. Systemic exposure and urinary cortisol effects of fluticasone propionate formulated with hydrofluoroalkane in 4- to 11-year-olds with asthma.
Journal of clinical pharmacology.
2008 Jan; 48(1):108-16. doi:
10.1177/0091270007309704. [PMID: 18094223] - O D Wolthers. Short-term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydrofluoroalkane-134a.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2006 Dec; 17(8):613-9. doi:
10.1111/j.1399-3038.2006.00460.x. [PMID: 17121590] - Yasmeen Khan, Yufei Tang, Guenther Hochhaus, Jonathan J Shuster, Terry Spencer, Sarah Chesrown, Leslie Hendeles. Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask.
The Journal of pediatrics.
2006 Dec; 149(6):793-7. doi:
10.1016/j.jpeds.2006.08.022. [PMID: 17137894] - Paul Y Qaqundah, Robert W Sugerman, Elaina Ceruti, Jorge Fernando Maspero, Joseph F Kleha, Catherine A Scott, Wei Wu, Rashmi Mehta, Courtney Crim. Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre-school-age children with asthma: a randomized, double-blind, placebo-controlled study.
The Journal of pediatrics.
2006 Nov; 149(5):663-670. doi:
10.1016/j.jpeds.2006.07.045. [PMID: 17095339] - Takahide Teramoto, Toshiyuki Fukao, Yoshiko Tomita, Yoshiaki Terauchi, Kaori Hosoi, Eiko Matsui, Minako Aoki, Naomi Kondo, Haruki Mikawa. Pharmacokinetics of beclomethasone dipropionate in an hydrofluoroalkane-134a propellant system in Japanese children with bronchial asthma.
Allergology international : official journal of the Japanese Society of Allergology.
2006 Sep; 55(3):317-20. doi:
10.2332/allergolint.55.317. [PMID: 17075274] - Yong-hong Liao, Xian-ming Zeng. [Advances in studies of pressurized metered dose formulations containing hydrofluoroalkane propellants].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Mar; 41(3):197-202. doi:
". [PMID: 16758987] - Tom C Fardon, Patricia Burns, Martyn L Barnes, Brian J Lipworth. A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2006 Mar; 96(3):422-30. doi:
10.1016/s1081-1206(10)60909-x. [PMID: 16597076] - William R Lumry, Michael M Conway, Craig F LaForce, David S Pearlman, Catherine A Scott, Nancy E Herje, Wei W Wu, Courtney Crim. Fluticasone propionate hydrofluoroalkane inhalation aerosol in patients receiving inhaled corticosteroids.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2006 Jan; 96(1):51-9. doi:
10.1016/s1081-1206(10)61040-x. [PMID: 16440533] - Jacob L Pinnas, Michael J Noonan, Steven F Weinstein, Paul Chervinsky, Catherine A Scott, Nancy E Herje, Wei Wu, Courtney Crim. Fluticasone propionate HFA-134a pressurized metered-dose inhaler in adolescents and adults with moderate to severe asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2005 Dec; 42(10):865-71. doi:
10.1080/02770900500371294. [PMID: 16393726] - Yong-Hong Liao, Marc B Brown, Stuart A Jones, Tahir Nazir, Gary P Martin. The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers.
International journal of pharmaceutics.
2005 Nov; 304(1-2):29-39. doi:
10.1016/j.ijpharm.2005.07.013. [PMID: 16181753] - Rodger Kempsford, Malcolm Handel, Rashmi Mehta, Mariza De Silva, Peter Daley-Yates. Comparison of the systemic pharmacodynamic effects and pharmacokinetics of salmeterol delivered by CFC propellant and non-CFC propellant metered dose inhalers in healthy subjects.
Respiratory medicine.
2005 Apr; 99 Suppl A(?):S11-9. doi:
10.1016/j.rmed.2004.11.005. [PMID: 15777604] - C M Houghton, S J Langley, S D Singh, J Holden, A P Monici Preti, D Acerbi, G Poli, A Woodcock. Comparison of bronchoprotective and bronchodilator effects of a single dose of formoterol delivered by hydrofluoroalkane and chlorofluorocarbon aerosols and dry powder in a double blind, placebo-controlled, crossover study.
British journal of clinical pharmacology.
2004 Oct; 58(4):359-66. doi:
10.1111/j.1365-2125.2004.02172.x. [PMID: 15373928] - Thomas E Tarara, Michael S Hartman, Howard Gill, Alan A Kennedy, Jeffry G Weers. Characterization of suspension-based metered dose inhaler formulations composed of spray-dried budesonide microcrystals dispersed in HFA-134a.
Pharmaceutical research.
2004 Sep; 21(9):1607-14. doi:
10.1023/b:pham.0000041455.13980.f1. [PMID: 15497686] - Louis-Philippe Boulet, André Cartier, Pierre Ernst, Pierre Larivée, Michel Laviolette. Safety and efficacy of HFA-134a beclomethasone dipropionate extra-fine aerosol over six months.
Canadian respiratory journal.
2004 Mar; 11(2):123-30. doi:
10.1155/2004/823084. [PMID: 15045043] - O Holz, I Zühlke, M Einhaus, L Welker, F Kanniess, D Branscheid, M Nakashima, L I Harrison, R A Jörres, K Richter, H Magnussen. Direct measurement of BDP and 17-BMP in bronchial and peripheral lung tissue after inhalation of HFA- vs CFC-driven aerosols.
Pulmonary pharmacology & therapeutics.
2004; 17(4):233-8. doi:
10.1016/j.pupt.2004.04.004. [PMID: 15219268] - I Grzelewska-Rzymowska, J Malolepszy, M de Molina, K Sladek, J Zarkovice, Z Siergiejko. Equivalent asthma control and systemic safety of inhaled budesonide delivered via HFA-134a or CFC propellant in a broad range of doses.
Respiratory medicine.
2003 Nov; 97 Suppl D(?):S10-9. doi:
10.1016/j.rmed.2003.10.004. [PMID: 14753247] - E Vastagh, P Kuna, P Calistruc, M A Bogdan. Efficacy and safety of inhaled budesonide delivered once or twice daily via HFA-134a in mild to moderate persistent asthma in adult patients. Comparison with budesonide CFC.
Respiratory medicine.
2003 Nov; 97 Suppl D(?):S20-8. doi:
10.1016/j.rmed.2003.10.001. [PMID: 14753248] - Anjuli Nayak, Robert Lanier, Steven Weinstein, Patti Stampone, Michael Welch. Efficacy and safety of beclomethasone dipropionate extrafine aerosol in childhood asthma: a 12-week, randomized, double-blind, placebo-controlled study.
Chest.
2002 Dec; 122(6):1956-65. doi:
10.1378/chest.122.6.1956. [PMID: 12475833] - V Vondra, K Sladek, J Kotasová, M Terl, A Rossetti, L Cantini. A new HFA-134a propellant in the administration of inhaled BDP via the Jet spacer: controlled clinical trial vs the conventional CFC.
Respiratory medicine.
2002 Oct; 96(10):784-9. doi:
10.1053/rmed.2002.1348. [PMID: 12412977] - G P Currie, S J Fowler, A M Wilson, E J Sims, L C Orr, B J Lipworth. Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma.
Thorax.
2002 Oct; 57(10):865-8. doi:
10.1136/thorax.57.10.865. [PMID: 12324672] - Stephen J Langley, Janet Holden, Alison Derham, Paul Hedgeland, Raj K Sharma, Ashley Woodcock. Fluticasone propionate via the Diskhaler or hydrofluoroalkane-134a metered-dose inhaler on methacholine-induced airway hyperresponsiveness.
Chest.
2002 Sep; 122(3):806-11. doi:
10.1378/chest.122.3.806. [PMID: 12226017] - J Bousquet, L Cantini. Clinical studies in asthmatics with a new non-extra fine HFA formulation of beclometasone dipropionate (BDP Modulite).
Respiratory medicine.
2002 Aug; 96 Suppl D(?):S17-27. doi:
10.1016/s0954-6111(02)80020-8. [PMID: 12201078] - A Woodcock, D Acerbi, G Poli. Modulite technology: pharmacodynamic and pharmacokinetic implications.
Respiratory medicine.
2002 Aug; 96 Suppl D(?):S9-15. doi:
10.1016/s0954-6111(02)80019-1. [PMID: 12201080] - Stephen J Fowler, Graeme P Currie, Brian J Lipworth. Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone.
The Journal of allergy and clinical immunology.
2002 Jun; 109(6):929-35. doi:
10.1067/mai.2002.123869. [PMID: 12063520] - Arno Nolting, Suryanarayana Sista, Wattanaporn Abramowitz. Single-dose study to compare the pharmacokinetics of HFA flunisolide and CFC flunisolide.
Journal of pharmaceutical sciences.
2002 Feb; 91(2):424-32. doi:
10.1002/jps.10030. [PMID: 11835202] - P B Anderson, S J Langley, P Mooney, J Jones, R Addlestone, A Rossetti, L Cantini. Equivalent efficacy and safety of a new HFA-134a formulation of BDP compared with the conventional CFC in adult asthmatics.
Journal of investigational allergology & clinical immunology.
2002; 12(2):107-13. doi:
. [PMID: 12371526] - A Nolting, S Sista, W Abramowitz. Flunisolide HFA vs flunisolide CFC: pharmacokinetic comparison in healthy volunteers.
Biopharmaceutics & drug disposition.
2001 Dec; 22(9):373-82. doi:
10.1002/bdd.274. [PMID: 11870676] - R Lizio, M Damm, A W Sarlikiotis, H H Bauer, C M Lehr. Low-temperature micronization of a peptide drug in fluid propellant: case study cetrorelix.
AAPS PharmSciTech.
2001 Jul; 2(3):E12. doi:
10.1208/pt020312. [PMID: 14727871] - P Fireman, B M Prenner, W Vincken, M Demedts, S J Mol, R M Cohen. Long-term safety and efficacy of a chlorofluorocarbon-free beclomethasone dipropionate extrafine aerosol.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2001 May; 86(5):557-65. doi:
10.1016/s1081-1206(10)62905-5. [PMID: 11379808] - S J Fowler, A M Wilson, E A Griffiths, B J Lipworth. Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube.
Chest.
2001 Apr; 119(4):1018-20. doi:
10.1378/chest.119.4.1018. [PMID: 11296163] - P H Hirst, G R Pitcairn, J C Richards, S Rohatagi, M S Gillen, S P Newman. Deposition and pharmacokinetics of an HFA formulation of triamcinolone acetonide delivered by pressurized metered dose inhaler.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.
2001; 14(2):155-65. doi:
10.1089/08942680152484090. [PMID: 11681648] - H Worth, J F Muir, W R Pieters. Comparison of hydrofluoroalkane-beclomethasone dipropionate Autohaler with budesonide Turbuhaler in asthma control.
Respiration; international review of thoracic diseases.
2001; 68(5):517-26. doi:
10.1159/000050561. [PMID: 11694816] - J Richards, P Hirst, G Pitcairn, S Mahashabde, W Abramowitz, A Nolting, S P Newman. Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.
2001; 14(2):197-208. doi:
10.1089/08942680152484126. [PMID: 11681651] - A P Perruchoud, B Lundback, M Yigla, A P Sykes. Clinical efficacy and safety of fluticasone propionate 1 mg per day administered via a HFA 134a pressurized metered dose inhaler to patients with moderate to severe asthma. International study group.
Respiratory medicine.
2000 Jun; 94 Suppl B(?):S35-41. doi:
NULL. [PMID: 10919684] - H Magnussen. Equivalent asthma control after dose reduction with HFA-134a beclomethasone solution aerosol. Comparative Inhaled Steroid Investigation Group (CISIG).
Respiratory medicine.
2000 Jun; 94(6):549-55. doi:
10.1053/rmed.1999.0772. [PMID: 10921758] - A B Tonnel, J Bons, M Legendre, A Prud'Homme, B Bugnas, I Evano-Celli, A M Stuart. Clinical efficacy and safety of fluticasone propionate 250 microg twice daily administered via a HFA 134a pressurized metered dose inhaler to patients with mild to moderate asthma. French study group.
Respiratory medicine.
2000 Jun; 94 Suppl B(?):S29-34. doi:
NULL. [PMID: 10919683] - J G Ayres, A B Millar, A P Sykes. Clinical efficacy and safety of fluticasone propionate 1 mg twice daily administered via a HFA 134a pressurized metered dose inhaler to patients with severe asthma. U.K. study group.
Respiratory medicine.
2000 Jun; 94 Suppl B(?):S42-50. doi:
NULL. [PMID: 10919685] - R Kunka, S Andrews, M Pimazzoni, S Callejas, L Ziviani, L Squassante, P T Daley-Yates. From hydrofluoroalkane pressurized metered dose inhalers (pMDIs) and comparability with chlorofluorocarbon pMDIs.
Respiratory medicine.
2000 Jun; 94 Suppl B(?):S10-6. doi:
NULL. [PMID: 10919680] - D Argenti, B Shah, D Heald. A study comparing the clinical pharmacokinetics, pharmacodynamics, and tolerability of triamcinolone acetonide HFA-134a metered-dose inhaler and budesonide dry-powder inhaler following inhalation administration.
Journal of clinical pharmacology.
2000 May; 40(5):516-26. doi:
10.1177/00912700022009134. [PMID: 10806605] - P C Seville, C Simons, G Taylor, P A Dickinson. Prodrug to probe solution HFA pMDI formulation and pulmonary esterase activity.
International journal of pharmaceutics.
2000 Feb; 195(1-2):13-6. doi:
10.1016/s0378-5173(99)00352-x. [PMID: 10675676] - I S Farmer, M Middle, J Savic, V L Perri, M J Herdman. Therapeutic equivalence of inhaled beclomethasone dipropionate with CFC and non-CFC (HFA 134a) propellants both delivered via the Easibreathe inhaler for the treatment of paediatric asthma.
Respiratory medicine.
2000 Jan; 94(1):57-63. doi:
10.1053/rmed.1999.0678. [PMID: 10714480] - A E Mackie, J E McDowall, P Ventresca, A Bye, C Falcoz, P T Daley-Yates. Systemic exposure to fluticasone propionate administered via metered-dose inhaler containing chlorofluorocarbon or hydrofluoroalkane propellant.
Clinical pharmacokinetics.
2000; 39 Suppl 1(?):17-22. doi:
10.2165/00003088-200039001-00003. [PMID: 11140429] - L Borgström. The pharmacokinetics of inhaled hydrofluoroalkane formulations.
The Journal of allergy and clinical immunology.
1999 Dec; 104(6):S246-9. doi:
10.1016/s0091-6749(99)70040-0. [PMID: 10588984] - B J Lipworth, C M Jackson. Pharmacokinetics of chlorofluorocarbon and hydrofluoroalkane metered-dose inhaler formulations of beclomethasone dipropionate.
British journal of clinical pharmacology.
1999 Dec; 48(6):866-8. doi:
10.1046/j.1365-2125.1999.00098.x. [PMID: 10594492] - A M Wilson, E J Sims, L C Orr, B J Lipworth. Differences in lung bioavailability between different propellants for fluticasone propionate.
Lancet (London, England).
1999 Oct; 354(9187):1357-8. doi:
10.1016/s0140-6736(99)03581-3. [PMID: 10533870] - J Milanowski, J Qualtrough, V L Perrin. Inhaled beclomethasone (BDP) with non-CFC propellant (HFA 134a) is equivalent to BDP-CFC for the treatment of asthma.
Respiratory medicine.
1999 Apr; 93(4):245-51. doi:
10.1016/s0954-6111(99)90020-3. [PMID: 10464888] - L I Harrison, G L Colice, D Donnell, I Soria, R Dockhorn. Adrenal effects and pharmacokinetics of CFC-free beclomethasone dipropionate: a 14-day dose-response study.
The Journal of pharmacy and pharmacology.
1999 Mar; 51(3):263-9. doi:
10.1211/0022357991772439. [PMID: 10344626] - R O Williams, J Liu. Formulation of a protein with propellant HFA 134a for aerosol delivery.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
1999 Jan; 7(2):137-44. doi:
10.1016/s0928-0987(98)00015-3. [PMID: 9845798] - J P Seale, L I Harrison. Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics.
Respiratory medicine.
1998 Jun; 92 Suppl A(?):9-15. doi:
10.1016/s0954-6111(98)90212-8. [PMID: 9850358] - P J Thompson, R J Davies, W F Young, A B Grossman, D Donnell. Safety of hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol.
Respiratory medicine.
1998 Jun; 92 Suppl A(?):33-9. doi:
10.1016/s0954-6111(98)90215-3. [PMID: 9850361] - R J Davies, P Stampone, B J O'Connor. Hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol provides equivalent asthma control to chlorofluorocarbon beclomethasone dipropionate at approximately half the total daily dose.
Respiratory medicine.
1998 Jun; 92 Suppl A(?):23-31. doi:
10.1016/s0954-6111(98)90214-1. [PMID: 9850360] - D G Tinkelman, E R Bleecker, J Ramsdell, B P Ekholm, N M Klinger, G L Colice, H B Slade. Proventil HFA and ventolin have similar safety profiles during regular use.
Chest.
1998 Feb; 113(2):290-6. doi:
10.1378/chest.113.2.290. [PMID: 9498941] - U Köster, D Mayer, H M Deger, W DeKant. Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Aug; 24(8):906-10. doi:
. [PMID: 8869827] - L I Harrison, D Donnell, J L Simmons, B P Ekholm, K M Cooper, P J Wyld. Twenty-eight-day double-blind safety study of an HFA-134a inhalation aerosol system in healthy subjects.
The Journal of pharmacy and pharmacology.
1996 Jun; 48(6):596-600. doi:
10.1111/j.2042-7158.1996.tb05980.x. [PMID: 8832493] - L I Harrison, A Cline, T M Wells, J P Jacobson, K M Cooper, S F Chang, J R Nelson, B P Ekholm, J Morganroth. Systemic concentrations of salbutamol and HFA-134a after inhalation of salbutamol sulfate in a chlorofluorocarbon-free system.
Therapeutic drug monitoring.
1996 Jun; 18(3):240-4. doi:
10.1097/00007691-199606000-00004. [PMID: 8738762] - E C Kleerup, D P Tashkin, A C Cline, B P Ekholm. Cumulative dose-response study of non-CFC propellant HFA 134a salbutamol sulfate metered-dose inhaler in patients with asthma.
Chest.
1996 Mar; 109(3):702-7. doi:
10.1378/chest.109.3.702. [PMID: 8617079] - D Donnell, L I Harrison, S Ward, N M Klinger, B P Ekholm, K M Cooper, I Porietis, J McEwen. Acute safety of the CFC-free propellant HFA-134a from a pressurized metered dose inhaler.
European journal of clinical pharmacology.
1995; 48(6):473-7. doi:
10.1007/bf00194337. [PMID: 8582466]