1-Phenylpiperazine (BioDeep_00000172293)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


Phenylpiperazine monohydrochloride

化学式: C10H14N2 (162.1156924)
中文名称: 1-苯基哌嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCN1)C1=CC=CC=C1
InChI: InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

描述信息

D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs

同义名列表

8 个代谢物同义名

Phenylpiperazine monohydrochloride; Phenylpiperazine dihydrochloride; Phenylpiperazine dihydrobromide; Phenylpiperazine hydrochloride; N-Phenylpiperazine; 1-PHENYLPIPERAZINE; Phenylpiperazine; 1-Phenylpiperazine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Junjun Huang, Shihao Song, Shuo Zhao, Xiuyun Sun, Zijie Wang, Xiaorong Huang, Qing Xiao, Yinyue Deng. Anti-virulence activity of novel (1-heteroaryloxy-2-hydroxypropyl)- phenylpiperazine derivatives against both wild-type and clinical drug-resistant Candida albicans strains. Microbial biotechnology. 2023 01; 16(1):116-127. doi: 10.1111/1751-7915.14169. [PMID: 36404587]
  • Iva Zonjić, Marijana Radić Stojković, Ivo Crnolatac, Ana Tomašić Paić, Silvia Pšeničnik, Aleksey Vasilev, Meglena Kandinska, Mihail Mondeshki, Stanislav Baluschev, Katharina Landfester, Ljubica Glavaš-Obrovac, Marijana Jukić, Juran Kralj, Anamaria Brozovic, Lucija Horvat, Lidija-Marija Tumir. Styryl dyes with N-Methylpiperazine and N-Phenylpiperazine Functionality: AT-DNA and G-quadruplex binding ligands and theranostic agents. Bioorganic chemistry. 2022 10; 127(?):105999. doi: 10.1016/j.bioorg.2022.105999. [PMID: 35809513]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • C S Johnson, C R Stansfield, V R Hassan, E Kolbe, H K Partington, D C Kappatos, R F Somerville. The phenomenon of para-Fluorophenylpiperazine (pFPP) in combination with the synthetic cannabinoid AMB-FUBINACA in seized plant material in New Zealand. Forensic science international. 2020 Feb; 307(?):110107. doi: 10.1016/j.forsciint.2019.110107. [PMID: 31951949]
  • V Stuettgen, D J Brayden. Investigations of Piperazine Derivatives as Intestinal Permeation Enhancers in Isolated Rat Intestinal Tissue Mucosae. The AAPS journal. 2020 01; 22(2):33. doi: 10.1208/s12248-020-0416-9. [PMID: 31989362]
  • Sandra Šegan, Jelena Penjišević, Vladimir Šukalović, Deana Andrić, Dušanka Milojković-Opsenica, Slađana Kostić-Rajačić. Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy)phenylpiperazine dopamine D2 ligands. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):146-153. doi: 10.1016/j.jchromb.2019.06.006. [PMID: 31200246]
  • Sarka Pospisilova, Pavlina Marvanova, Jakub Treml, Agnes M Moricz, Peter G Ott, Petr Mokry, Klara Odehnalova, Ondrej Sedo, Alois Cizek, Josef Jampilek. Activity of N-Phenylpiperazine Derivatives Against Bacterial and Fungal Pathogens. Current protein & peptide science. 2019; 20(11):1119-1129. doi: 10.2174/1389203720666190913114041. [PMID: 31518219]
  • Chad S Cummings, Katherine Fein, Hironobu Murata, Rebecca L Ball, Alan J Russell, Kathryn A Whitehead. ATRP-grown protein-polymer conjugates containing phenylpiperazine selectively enhance transepithelial protein transport. Journal of controlled release : official journal of the Controlled Release Society. 2017 06; 255(?):270-278. doi: 10.1016/j.jconrel.2017.04.035. [PMID: 28455168]
  • Randy L Luciano, Mark A Perazella. Nephrotoxic effects of designer drugs: synthetic is not better!. Nature reviews. Nephrology. 2014 Jun; 10(6):314-24. doi: 10.1038/nrneph.2014.44. [PMID: 24662435]
  • William C Motel, Jason R Healy, Eddy Viard, Buddy Pouw, Kelly Martin, Rae R Matsumoto, Andrew Coop. Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. Bioorganic & medicinal chemistry letters. 2013 Dec; 23(24):6920-6922. doi: 10.1016/j.bmcl.2013.09.038. [PMID: 24211020]
  • Kasper Severinsen, Johan F Kraft, Heidi Koldsø, Katrine A Vinberg, Richard B Rothman, John S Partilla, Ove Wiborg, Bruce Blough, Birgit Schiøtt, Steffen Sinning. Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters. ACS chemical neuroscience. 2012 Sep; 3(9):693-705. doi: 10.1021/cn300040f. [PMID: 23019496]
  • Leo J Schep, Robin J Slaughter, J Allister Vale, D Michael G Beasley, Paul Gee. The clinical toxicology of the designer "party pills" benzylpiperazine and trifluoromethylphenylpiperazine. Clinical toxicology (Philadelphia, Pa.). 2011 Mar; 49(3):131-41. doi: 10.3109/15563650.2011.572076. [PMID: 21495881]
  • Adina T Michael-Titus, Monika Albert, Gregory J Michael, Thomas Michaelis, Takashi Watanabe, Jens Frahm, Olga Pudovkina, Marieke G C van der Hart, Mayke B Hesselink, Eberhard Fuchs, Boldizsár Czéh. SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. European journal of pharmacology. 2008 Nov; 598(1-3):43-50. doi: 10.1016/j.ejphar.2008.09.006. [PMID: 18822282]
  • Carina M Jung, Thomas M Heinze, Joanna Deck, Ruth Strakosha, John B Sutherland. Transformation of N-phenylpiperazine by mixed cultures from a municipal wastewater treatment plant. Applied and environmental microbiology. 2008 Oct; 74(19):6147-50. doi: 10.1128/aem.00516-08. [PMID: 18676696]
  • Daniela J Conrado, Hugo Verli, Gilda Neves, Carlos Alberto Manssour Fraga, Eliezer J Barreiro, Stela Maris Kuze Rates, Teresa Dalla Costa. Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype. The Journal of pharmacy and pharmacology. 2008 Jun; 60(6):699-707. doi: 10.1211/jpp.60.6.0004. [PMID: 18498705]
  • Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Olga Cruz-Lopez, Mojgan Aghazadeh Tabrizi, Allan R Moorman, Stefania Gessi, Eleonora Fogli, Valeria Sacchetto, Pier Andrea Borea. From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor. Journal of medicinal chemistry. 2007 Jul; 50(15):3706-15. doi: 10.1021/jm070443e. [PMID: 17585854]
  • Leandro Tasso, Gilda Neves, Ricardo Menegatti, Carlos Alberto Manssour Fraga, Eliezer Barreiro, Vera Eifler-Lima, Stela Maris Kuze Rates, Teresa Dalla Costa. Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2005 Oct; 26(2):194-202. doi: 10.1016/j.ejps.2005.06.002. [PMID: 16076552]
  • Roland F Staack, Denis S Theobald, Hans H Maurer. Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry. Therapeutic drug monitoring. 2004 Aug; 26(4):441-9. doi: 10.1097/00007691-200408000-00015. [PMID: 15257075]
  • L Tasso, G Neves, R Menegatti, C A M Fraga, E J Barreiro, V L Eifler-Lima, S M K Rates, Teresa Dalla Costa. Validated HPLC method for determination of LASSBio-581, a new heterocyclic N-phenylpiperazine derivative, in rat plasma. Journal of pharmaceutical and biomedical analysis. 2003 Dec; 33(5):1127-33. doi: 10.1016/s0731-7085(03)00407-2. [PMID: 14656603]
  • Cailean Clarkson, Chitalu C Musonda, Kelly Chibale, William E Campbell, Peter Smith. Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity. Bioorganic & medicinal chemistry. 2003 Oct; 11(20):4417-22. doi: 10.1016/s0968-0896(03)00491-7. [PMID: 13129578]
  • Pier Giovanni Baraldi, Maria del Carmen Nuñez, Anna Morelli, Simonetta Falzoni, Francesco Di Virgilio, Romeo Romagnoli. Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. Journal of medicinal chemistry. 2003 Apr; 46(8):1318-29. doi: 10.1021/jm021049d. [PMID: 12672232]
  • María J Núñez, Maravillas Rivas, Pilar Riveiro, Juan Suárez, José Balboa, Luis A Núñez, Manuel Rey-Méndez, Manuel Freire-Garabal. Effects of nefazodone on voluntary ethanol consumption induced by isolation stress in young and aged rats. Pharmacology, biochemistry, and behavior. 2002 Oct; 73(3):689-96. doi: 10.1016/s0091-3057(02)00875-4. [PMID: 12151045]
  • J C Bloomer, H F Boyd, D M Hickey, R J Ife, C A Leach, C H Macphee, K J Milliner, I L Pinto, D A Rawlings, S A Smith, I G Stansfield, S J Stanway, M A Taylor, C J Theobald, C M Whittaker. 1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2). Bioorganic & medicinal chemistry letters. 2001 Jul; 11(14):1925-9. doi: 10.1016/s0960-894x(01)00346-8. [PMID: 11459662]
  • G Cascio, E Manghisi, R Porta, G Fregnan. N-phenylpiperazine derivatives with hypocholesterolemic activity. Journal of medicinal chemistry. 1985 Jun; 28(6):815-8. doi: 10.1021/jm00383a021. [PMID: 4009605]