1-Benzylimidazole (BioDeep_00000172160)

   

human metabolite blood metabolite


代谢物信息卡片


1-benzyl-1H-imidazole

化学式: C10H10N2 (158.084394)
中文名称: 1-苄基咪唑
谱图信息: 最多检出来源 Mus musculus(blood) 29.36%

分子结构信息

SMILES: C(N1C=CN=C1)C1=CC=CC=C1
InChI: InChI=1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2

描述信息

D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

同义名列表

3 个代谢物同义名

1-benzyl-1H-imidazole; N-Benzylimidazole; 1-Benzylimidazole



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism. European journal of medicinal chemistry. 2021 May; 217(?):113379. doi: 10.1016/j.ejmech.2021.113379. [PMID: 33756126]
  • Morris D Faiman, Swetha Kaul, Shaheen A Latif, Todd D Williams, Craig E Lunte. S-(N, N-diethylcarbamoyl)glutathione (carbamathione), a disulfiram metabolite and its effect on nucleus accumbens and prefrontal cortex dopamine, GABA, and glutamate: a microdialysis study. Neuropharmacology. 2013 Dec; 75(?):95-105. doi: 10.1016/j.neuropharm.2013.07.007. [PMID: 23891816]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Karen A Atkinson, Elena E Beretta, Janice A Brown, Mayda Castrodad, Yue Chen, Judith M Cosgrove, Ping Du, John Litchfield, Michael Makowski, Kelly Martin, Thomas J McLellan, Constantin Neagu, David A Perry, David W Piotrowski, Claire M Steppan, Richard Trilles. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorganic & medicinal chemistry letters. 2011 Mar; 21(6):1621-5. doi: 10.1016/j.bmcl.2011.01.113. [PMID: 21324691]
  • Adnan A Elfarra, Renee J Krause. S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant. The Journal of pharmacology and experimental therapeutics. 2007 Jun; 321(3):1095-101. doi: 10.1124/jpet.107.120444. [PMID: 17347324]
  • Silvia Diani-Moore, Fotini Papachristou, Erin Labitzke, Arleen B Rifkind. Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Drug metabolism and disposition: the biological fate of chemicals. 2006 Aug; 34(8):1376-85. doi: 10.1124/dmd.106.009498. [PMID: 16714371]
  • J Wang, S Grisle, D Schlenk. Effects of salinity on aldicarb toxicity in juvenile rainbow trout (Oncorhynchus mykiss) and striped bass (Morone saxatilis x chrysops). Toxicological sciences : an official journal of the Society of Toxicology. 2001 Dec; 64(2):200-7. doi: 10.1093/toxsci/64.2.200. [PMID: 11719702]
  • J Hoskins, G Shenfield, M Murray, A Gross. Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems. 2001 Jul; 31(7):387-97. doi: 10.1080/00498250110055488. [PMID: 11531003]
  • M G Pike, D C Mays, D W Macomber, J J Lipsky. Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes. Drug metabolism and disposition: the biological fate of chemicals. 2001 Feb; 29(2):127-32. doi: . [PMID: 11159801]
  • P Rothenbach, R H Turnage, J Iglesias, A Riva, L Bartula, S I Myers. Downstream effects of splanchnic ischemia-reperfusion injury on renal function and eicosanoid release. Journal of applied physiology (Bethesda, Md. : 1985). 1997 Aug; 83(2):530-6. doi: 10.1152/jappl.1997.83.2.530. [PMID: 9262449]
  • J C Davila, P J Davis, D Acosta. Changes in glutathione and cellular energy as potential mechanisms of papaverine-induced hepatotoxicity in vitro. Toxicology and applied pharmacology. 1991 Mar; 108(1):28-36. doi: 10.1016/0041-008x(91)90265-g. [PMID: 2006504]
  • J L Reyes, E Meléndez, B A Escalante, M C Namorado. Effect of synthesis inhibitors of thromboxane A2 and prostaglandin E2 on the regulation of sodium and water. The Journal of pharmacology and experimental therapeutics. 1989 Nov; 251(2):694-9. doi: NULL. [PMID: 2810118]
  • G F Grauer, C A Culham, R R Dubielzig, S K Presto, T D Oberley, C B Thomas, R B Grieve. Effects of a specific thromboxane synthetase inhibitor on development of experimental Dirofilaria immitis immune complex glomerulonephritis in the dog. Journal of veterinary internal medicine. 1988 Oct; 2(4):192-200. doi: 10.1111/j.1939-1676.1988.tb00316.x. [PMID: 2976425]
  • J Magdalou, M Totis, A F Boiteux-Antoine, S Fournel-Gigleux, G Siest, L Schladt, F Oesch. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver. Biochemical pharmacology. 1988 Sep; 37(17):3297-304. doi: 10.1016/0006-2952(88)90642-9. [PMID: 2840913]
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