1-(2-Methoxyphenyl)piperazine (BioDeep_00000172107)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H16N2O (192.12625659999998)
中文名称: 1-(2-甲氧苯基)哌嗪
谱图信息:
最多检出来源 Mus musculus(blood) 42.31%
分子结构信息
SMILES: COC1=CC=CC=C1N1CCNCC1
InChI: InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:104020
- PubChem: 1346
- HMDB: HMDB0243781
- ChEMBL: CHEMBL9666
- chemspider: 1306
- CAS: 35386-24-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Neelam Kumari, Ankur Kaul, Raunak Varshney, Vinay Kumar Singh, Krishna Srivastava, Sunita Bhagat, Anil Kumar Mishra, Anjani Kumar Tiwari. Synthesis and evaluation of technetium-99m labelled 1-(2-methoxyphenyl)piperazine derivative for single photon emission computed tomography imaging for targeting 5-HT1A.
Bioorganic chemistry.
2021 06; 111(?):104972. doi:
10.1016/j.bioorg.2021.104972. [PMID: 33993020] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - H Tinnerberg, C J Sennbro, B A G Jönsson. Aniline in hydrolyzed urine and plasma--possible biomarkers for phenylisocyanate exposure.
Journal of occupational and environmental hygiene.
2008 Oct; 5(10):629-32. doi:
10.1080/15459620802275411. [PMID: 18666023] - Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A Colabufo, Francesco Berardi, Roberto Perrone. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.
Journal of medicinal chemistry.
2008 Sep; 51(18):5813-22. doi:
10.1021/jm800615e. [PMID: 18800769] - Carl Johan Sennbro, Christian H Lindh, Håkan Tinnerberg, Hans Welinder, Margareta Littorin, Bo A G Jönsson. Biological monitoring of exposure to toluene diisocyanate.
Scandinavian journal of work, environment & health.
2004 Oct; 30(5):371-8. doi:
10.5271/sjweh.825. [PMID: 15534959] - Roland F Staack, Hans H Maurer. Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Dec; 798(2):333-42. doi:
10.1016/j.jchromb.2003.10.004. [PMID: 14643514] - Y Shen, F J Monsma, M A Metcalf, P A Jose, M W Hamblin, D R Sibley. Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
The Journal of biological chemistry.
1993 Aug; 268(24):18200-4. doi:
. [PMID: 8394362] - E Benfenati, S Caccia, F Della Vedova. 1-(o-Methoxyphenyl)piperazine is a metabolite of drugs bearing a methoxyphenylpiperazine side-chain.
The Journal of pharmacy and pharmacology.
1987 Apr; 39(4):312-3. doi:
10.1111/j.2042-7158.1987.tb06275.x. [PMID: 2884299]