[3H]Rosiglitazone (BioDeep_00000172088)
human metabolite blood metabolite
代谢物信息卡片
4-hydroxy-5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-2,3-dihydro-1,3-thiazol-2-one
化学式: C18H19N3O3S (357.1147)
中文名称:
谱图信息:
最多检出来源 Mus musculus(not specific) 7.14%
分子结构信息
SMILES: CN(CCOC1=CC=C(C=C1)CC2=C(NC(=O)S2)O)C3=CC=CC=N3
InChI: InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Thamilvaani Manaharan, Cheng Hwee Ming, Uma D Palanisamy. Syzygium aqueum leaf extract and its bioactive compounds enhances pre-adipocyte differentiation and 2-NBDG uptake in 3T3-L1 cells.
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Endocrinology.
2012 Nov; 153(11):5222-30. doi:
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Diabetes, obesity & metabolism.
2012 Nov; 14(11):973-82. doi:
10.1111/j.1463-1326.2012.01601.x. [PMID: 22443197] - David J Semple, Sunil Bhandari, Anne-Marie L Seymour. Uremic cardiomyopathy is characterized by loss of the cardioprotective effects of insulin.
American journal of physiology. Renal physiology.
2012 Nov; 303(9):F1275-86. doi:
10.1152/ajprenal.00048.2012. [PMID: 22914780] - Vasudeva Rao Avupati, Rajendra Prasad Yejella, Annapurna Akula, Girija Sankar Guntuku, Bhagya Raju Doddi, Venkata Rao Vutla, Suvarna Ratna Anagani, Lakshmana Santhi Adimulam, Aruna Kumar Vyricharla. Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(20):6442-50. doi:
10.1016/j.bmcl.2012.08.052. [PMID: 22981328] - Brian R Hoffmann, Mohamed F El-Mansy, Daniel S Sem, Andrew S Greene. Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.
Journal of medicinal chemistry.
2012 Oct; 55(19):8260-71. doi:
10.1021/jm301204r. [PMID: 22970990] - T Basturk, A Unsal, T Ulas, Y Koc, T Sakaci, E Ahbap, F Borlu. Effects of rosiglitazone treatment on insulin resistance and TNF-alpha levels in patients with chronic kidney disease: a prospective study.
European review for medical and pharmacological sciences.
2012 Oct; 16(11):1519-24. doi:
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Fundamental & clinical pharmacology.
2012 Oct; 26(5):621-31. doi:
10.1111/j.1472-8206.2011.00960.x. [PMID: 21692847] - Harish Kumar Bishnoi, Nanjaian Mahadevan, Pitchai Balakumar. The combined strategy with PPARα agonism and AT₁ receptor antagonism is not superior relative to their individual treatment approach in preventing the induction of nephropathy in the diabetic rat.
Pharmacological research.
2012 Oct; 66(4):349-56. doi:
10.1016/j.phrs.2012.07.001. [PMID: 22796657] - O Gealekman, N Guseva, K Gurav, A Gusev, C Hartigan, M Thompson, S Malkani, S Corvera. Effect of rosiglitazone on capillary density and angiogenesis in adipose tissue of normoglycaemic humans in a randomised controlled trial.
Diabetologia.
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European journal of pharmacology.
2012 Sep; 691(1-3):261-7. doi:
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Archives of pharmacal research.
2012 Sep; 35(9):1655-64. doi:
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Biochemical pharmacology.
2012 Sep; 84(5):692-700. doi:
10.1016/j.bcp.2012.05.021. [PMID: 22732454] - Caroline Dart. Selective block of K(ATP) channels: why the anti-diabetic sulphonylureas and rosiglitazone have more in common than we thought.
British journal of pharmacology.
2012 Sep; 167(1):23-5. doi:
10.1111/j.1476-5381.2012.01990.x. [PMID: 22506686] - Arjunan Sundaresan, Ranganathan Harini, Kodukkur Viswanathan Pugalendi. Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice.
General physiology and biophysics.
2012 Sep; 31(3):323-33. doi:
10.4149/gpb_2012_037. [PMID: 23047945] - Mian Zeng, Xiao-mei Huang, Wan-mei He, Hu Chen, Yu-jie Jiang. [The effects of rosiglitazone combined ceftazidime on peroxisome proliferator activated receptor γ activity and interleukin in septic rats].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2012 Sep; 24(9):550-3. doi:
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Journal of ethnopharmacology.
2012 Aug; 143(1):347-54. doi:
10.1016/j.jep.2012.06.050. [PMID: 22776833] - Hale Sayan-Ozacmak, Veysel Haktan Ozacmak, Figen Barut, Ewa Jakubowska-Dogru. Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion.
Neurochemistry international.
2012 Aug; 61(3):287-90. doi:
10.1016/j.neuint.2012.05.011. [PMID: 22609374] - Di Li, Guan-liang Wang, Meng-ya Shan, Jia-han Liu, Lin Wang, De-zeng Zhu. [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2012 Aug; 10(8):886-93. doi:
10.3736/jcim20120809. [PMID: 22883405] - Hany M El-Bassossy, Shaymaa M Abo-Warda, Ahmed Fahmy. Rosiglitazone, a peroxisome proliferator-activated receptor γ stimulant, abrogates diabetes-evoked hypertension by rectifying abnormalities in vascular reactivity.
Clinical and experimental pharmacology & physiology.
2012 Aug; 39(8):643-9. doi:
10.1111/j.1440-1681.2012.05724.x. [PMID: 22594672] - R Gutman, M Barnea, L Haviv, N Chapnik, O Froy. Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice.
International journal of obesity (2005).
2012 Aug; 36(8):1131-4. doi:
10.1038/ijo.2011.215. [PMID: 22064158] - Niraj M Bhatt, Meenal Chavda, Dipali Desai, Rishit Zalawadia, Vaibhav B Patel, Vinod Burade, Anita K Sharma, Pawan K Singal, Sarita Gupta. Cardioprotective and antihypertensive effects of Enicostemma littorale Blume extract in fructose-fed rats.
Canadian journal of physiology and pharmacology.
2012 Aug; 90(8):1065-73. doi:
10.1139/y2012-055. [PMID: 22784355] - Wenchao Hu, Qian Yu, Jie Zhang, Demin Liu. Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of Chemerin and ChemR23 in the kidney of streptozotocin-induced diabetic rats.
Inflammation.
2012 Aug; 35(4):1287-93. doi:
10.1007/s10753-012-9440-y. [PMID: 22350950] - Julio Cesar Fraulob, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda. Beneficial effects of rosuvastatin on insulin resistance, adiposity, inflammatory markers and non-alcoholic fatty liver disease in mice fed on a high-fat diet.
Clinical science (London, England : 1979).
2012 Aug; 123(4):259-70. doi:
10.1042/cs20110373. [PMID: 22420611] - Tsun-Yung Kuo, Chuen-Lin Huang, Jung-Mou Yang, Wei-Jung Huang, Nai-Kuei Huang, Yue-Wen Chen, Ren-Jye Lin, Ying-Chen Yang. The role of ribosylated-BSA in regulating PC12 cell viability.
Cell biology and toxicology.
2012 Aug; 28(4):255-67. doi:
10.1007/s10565-012-9220-3. [PMID: 22543687] - Xiaobing Qu, Shuiping Zhao, Jie Gao, Min Hu, Lini Dong, Xiangyu Zhang. [Reduced expression and secretion of apolipoprotein M in fat-fed, streptozotocin-diabetic rats is partially reversed by an artificial ligand of PPARγ].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2012 Aug; 37(8):796-801. doi:
10.3969/j.issn.1672-7347.2012.08.007. [PMID: 22954914] - Himanshu Naik, Jing-Tao Wu, Robert Palmer, Lachy McLean. The effects of febuxostat on the pharmacokinetic parameters of rosiglitazone, a CYP2C8 substrate.
British journal of clinical pharmacology.
2012 Aug; 74(2):327-35. doi:
10.1111/j.1365-2125.2012.04182.x. [PMID: 22242967] - Emilie Distel, Graziella Penot, Thomas Cadoudal, Irène Balguy, Sylvie Durant, Chantal Benelli. Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats.
Biochimie.
2012 Aug; 94(8):1660-7. doi:
10.1016/j.biochi.2012.04.014. [PMID: 22575275] - Gyeong-Min Do, Un Ju Jung, Hae-Jin Park, Eun-Young Kwon, Seon-Min Jeon, Robin A McGregor, Myung-Sook Choi. Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice.
Molecular nutrition & food research.
2012 Aug; 56(8):1282-91. doi:
10.1002/mnfr.201200067. [PMID: 22715031] - Yingzi Liu, Haoran Liu, Jiansong Zhang. Total saponins of Cornus officinalis Sieb. ameliorates the endothelium dependent relaxation of mesenteric artery by regulating nitric oxide release in streptozotocin-induced diabetic rats.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2012 Aug; 37(8):757-64. doi:
10.3969/j.issn.1672-7347.2012.08.001. [PMID: 22954908] - Piruthivi Sukumar, Alicia Sedo, Jing Li, Lesley A Wilson, David O'Regan, Jonathan D Lippiat, Karen E Porter, Mark T Kearney, Justin F X Ainscough, David J Beech. Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.
Circulation research.
2012 Jul; 111(2):191-200. doi:
10.1161/circresaha.112.270751. [PMID: 22668831] - I-Chih Chen, Wen-Huang Lee, Ting-Hsing Chao, Yi-Heng Li, Wei-Chuan Tsai, Hsien-An Pan, Shih-Ya Tseng, Ju-Yi Chen. Effects of rosiglitazone on the cardiovascular profile in postmenopausal women without diabetes mellitus: interplay of thiazolidinediones and hormone therapy.
Menopause (New York, N.Y.).
2012 Jul; 19(7):812-9. doi:
10.1097/gme.0b013e3182400ec0. [PMID: 22415569] - Liang Ma, Jinying Chen, Xiaolin Liang, Caifei Xie, Chongyang Deng, Li Huang, Aihua Peng, Yuanquan Wei, Lijuan Chen. Synthesis and evaluation of 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of non-alcoholic fatty liver disease.
Archiv der Pharmazie.
2012 Jul; 345(7):517-24. doi:
10.1002/ardp.201100413. [PMID: 22532295] - Enkhzaya Davaa, Jeong-Sook Park. Formulation parameters influencing the physicochemical characteristics of rosiglitazone-loaded cationic lipid emulsion.
Archives of pharmacal research.
2012 Jul; 35(7):1205-13. doi:
10.1007/s12272-012-0711-9. [PMID: 22864743] - Lin Wang, Guan-liang Wang, Jia-han Liu, Di Li, De-zeng Zhu, Liang-neng Wu. [Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2012 Jul; 10(7):793-9. doi:
10.3736/jcim20120710. [PMID: 22805086] - Daniel L Hertz, Christine M Walko, Arlene S Bridges, J Heyward Hull, Jill Herendeen, Kristan Rollins, Paul B Watkins, E Claire Dees. Pilot study of rosiglitazone as an in vivo probe of paclitaxel exposure.
British journal of clinical pharmacology.
2012 Jul; 74(1):197-200. doi:
10.1111/j.1365-2125.2012.04165.x. [PMID: 22680343] - George A Chressanthis, Pratap Khedkar, Nitin Jain, Prashant Poddar, Michael G Seiders. Can access limits on sales representatives to physicians affect clinical prescription decisions? A study of recent events with diabetes and lipid drugs.
Journal of clinical hypertension (Greenwich, Conn.).
2012 Jul; 14(7):435-46. doi:
10.1111/j.1751-7176.2012.00651.x. [PMID: 22747616] - Inayat ur Rahman, Muhammad Idrees, Mohammad Salman, Rooh Ullah Khan, M I Khan, Fazli Amin, Naeem Ullah Jan. A comparison of the effect of glitazones on serum sialic acid in patients with type 2 diabetes.
Diabetes & vascular disease research.
2012 Jul; 9(3):238-40. doi:
10.1177/1479164111428629. [PMID: 22067722] - Zhixin Guo, Zhihong Qin, Rong Zhang, Jiawei Li, Yan Yin. Effect of rosiglitazone on the expression of cardiac adiponectin receptors and NADPH oxidase in type 2 diabetic rats.
European journal of pharmacology.
2012 Jun; 685(1-3):116-25. doi:
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The New England journal of medicine.
2012 Jun; 366(24):2247-56. doi:
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Biochemical and biophysical research communications.
2012 Jun; 422(3):423-8. doi:
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Current molecular pharmacology.
2012 Jun; 5(2):264-71. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 Jun; 341(3):617-25. doi:
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European journal of internal medicine.
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Cardiovascular drugs and therapy.
2012 Jun; 26(3):195-204. doi:
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Current molecular pharmacology.
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Journal of lipid research.
2012 Jun; 53(6):1117-25. doi:
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Cardiovascular & hematological agents in medicinal chemistry.
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British journal of pharmacology.
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Molecular endocrinology (Baltimore, Md.).
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Cardiovascular research.
2012 Jun; 94(3):537-44. doi:
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Journal of physiology and biochemistry.
2012 Jun; 68(2):263-9. doi:
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Indian journal of pharmacology.
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Bulletin of experimental biology and medicine.
2012 May; 153(1):54-6. doi:
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Acta physiologica (Oxford, England).
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Journal of pharmaceutical sciences.
2012 May; 101(5):1659-71. doi:
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The Journal of pharmacy and pharmacology.
2012 May; 64(5):719-26. doi:
10.1111/j.2042-7158.2012.01462.x. [PMID: 22471368] - Jing-Quan Zheng, Kun Wang, Dee Pei, Yen-Lin Chen, Yen-Lin Chang, Chun-Hsien Hsu, Tsan-Ming Huang, Mei-Yu Lin, Pao-Ying Lin, Jiunn-Diann Lin. Improvement of abnormal liver enzymes after rosiglitazone treatment in Chinese type 2 diabetes.
Indian journal of pharmacology.
2012 May; 44(3):372-6. doi:
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Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2012 Apr; 44(4):306-11. doi:
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Kidney international.
2012 Apr; 81(7):698-706. doi:
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Journal of endocrinological investigation.
2012 Apr; 35(4):365-71. doi:
10.3275/7739. [PMID: 21597316] - Antonio Cittadini, Raffaele Napoli, Maria Gaia Monti, Domenica Rea, Salvatore Longobardi, Paolo Antonio Netti, Marion Walser, Mariateresa Samà, Gianluca Aimaretti, Jörgen Isgaard, Luigi Saccà. Metformin prevents the development of chronic heart failure in the SHHF rat model.
Diabetes.
2012 Apr; 61(4):944-53. doi:
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Recent patents on cardiovascular drug discovery.
2012 Apr; 7(1):33-41. doi:
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Acta neuropathologica.
2012 Apr; 123(4):587-600. doi:
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Neurobiology of aging.
2012 Apr; 33(4):835.e13-30. doi:
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American journal of physiology. Endocrinology and metabolism.
2012 Apr; 302(7):E788-99. doi:
10.1152/ajpendo.00337.2011. [PMID: 22275753] - Wijtske Annema, Uwe Jf Tietge. Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.
Nutrition & metabolism.
2012 Mar; 9(1):25. doi:
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Nutrition (Burbank, Los Angeles County, Calif.).
2012 Mar; 28(3):294-9. doi:
10.1016/j.nut.2011.06.009. [PMID: 21996045] - Xiuhua Sun, Yunan Tang, Xiaobing Tan, Qiong Li, Wei Zhong, Xinguo Sun, Wei Jia, Craig J McClain, Zhanxiang Zhou. Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Mar; 302(5):G548-57. doi:
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Nutrition, metabolism, and cardiovascular diseases : NMCD.
2012 Mar; 22(3):167-75. doi:
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Molecular biology reports.
2012 Mar; 39(3):2665-75. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2012 Mar; 32(3):677-85. doi:
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Indian journal of endocrinology and metabolism.
2012 Mar; 16 Suppl 1(?):S110-3. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Mar; 50(3-4):575-82. doi:
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American journal of physiology. Renal physiology.
2012 Mar; 302(5):F540-51. doi:
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Diabetes/metabolism research and reviews.
2012 Mar; 28(3):258-67. doi:
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Nutrition & metabolism.
2012 Feb; 9(?):13. doi:
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Regulatory peptides.
2012 Feb; 174(1-3):18-25. doi:
10.1016/j.regpep.2011.11.004. [PMID: 22120832] - Karin M Slivkoff-Clark, Anthony P James, John Cl Mamo. The chronic effects of fish oil with exercise on postprandial lipaemia and chylomicron homeostasis in insulin resistant viscerally obese men.
Nutrition & metabolism.
2012 Feb; 9(?):9. doi:
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Cell.
2012 Feb; 148(3):556-67. doi:
10.1016/j.cell.2011.11.062. [PMID: 22304921] - Gaurang Patel, Gitanjali Kher, Ambikanandan Misra. Preparation and evaluation of hepatic stellate cell selective, surface conjugated, peroxisome proliferator-activated receptor-gamma ligand loaded liposomes.
Journal of drug targeting.
2012 Feb; 20(2):155-65. doi:
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European review for medical and pharmacological sciences.
2012 Feb; 16(2):166-75. doi:
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Bone.
2012 Feb; 50(2):499-509. doi:
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Diabetes, obesity & metabolism.
2012 Feb; 14(2):181-6. doi:
10.1111/j.1463-1326.2011.01510.x. [PMID: 21955403] - Iván P Uray, Jennifer M Rodenberg, Reid P Bissonnette, Powel H Brown, Michael A Mancini. Cancer-preventive rexinoid modulates neutral lipid contents of mammary epithelial cells through a peroxisome proliferator-activated receptor γ-dependent mechanism.
Molecular pharmacology.
2012 Feb; 81(2):228-38. doi:
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Biomedical and environmental sciences : BES.
2012 Feb; 25(1):46-52. doi:
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Cardiovascular diabetology.
2012 Jan; 11(?):11. doi:
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Chemistry Central journal.
2012 Jan; 6(1):9. doi:
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Cardiovascular diabetology.
2012 Jan; 11(?):6. doi:
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Bioorganic & medicinal chemistry.
2012 Jan; 20(2):1060-75. doi:
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BMC public health.
2012 Jan; 12(?):23. doi:
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BMJ (Clinical research ed.).
2012 Jan; 344(?):d7771. doi:
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Life sciences.
2012 Jan; 90(1-2):30-8. doi:
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PloS one.
2012; 7(4):e34614. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Jan; 35(1):48-54. doi:
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PloS one.
2012; 7(4):e36224. doi:
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