(R)-(+)-Ropivacaine (BioDeep_00000172054)
human metabolite blood metabolite
代谢物信息卡片
N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
化学式: C17H26N2O (274.2045026)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.44%
分子结构信息
SMILES: CCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
InChI: InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
同义名列表
19 个代谢物同义名
N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; 1-Propyl-2,6-dimethyl-2-piperidylcarboxyanilide; Ropivacaine monohydrochloride, (S)-isomer; N-N-Propylpipecolic acid-2,6-xylidide; N-N-Propylpipecolate-2,6-xylidide; 1 Propyl 2,6 pipecoloxylidide; Ropivacaine monohydrochloride; 1-Propyl-2,6-pipecoloxylidide; Ropivacaine hydrochloride; Racemic ropivacaine; (R)-(+)-Ropivacaine; (+-)-Ropivacaine; rac-Ropivacaine; DL-Ropivacaine; Ropivacaine; Naropeine; LEA 103; Naropin; LEA-103
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:60802
- PubChem: 71273
- HMDB: HMDB0243661
- chemspider: 64399
- CAS: 684647-62-9
- CAS: 98626-61-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shen Sun, Yaojun Lu, Fubo Tian, Shaoqiang Huang. Ropivacaine with intraspinal administration alleviates preeclampsia-induced kidney injury via glycocalyx /alpha 7 nicotinic acetylcholine receptor pathway.
Bioengineered.
2022 05; 13(5):13131-13140. doi:
10.1080/21655979.2022.2080365. [PMID: 35635041] - Xiubin Chen, Yueqi Zhang, Xiu Ni, Zhiqiang Liu. Effects of labour analgesia with different concentrations of ropivacaine on maternal body temperature and inflammatory factor: A randomised controlled study.
Anaesthesia, critical care & pain medicine.
2022 04; 41(2):101030. doi:
10.1016/j.accpm.2022.101030. [PMID: 35123105] - Ryan C Dregalla, Yvette Uribe, Marko Bodor. Effect of local anesthetics on platelet physiology and function.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2021 Dec; 39(12):2744-2754. doi:
10.1002/jor.25019. [PMID: 33694196] - Juan Morgaz, David F Latorre, Juan M Serrano-Rodríguez, María M Granados, Juan M Domínguez, J Andrés Fernández-Sarmiento, Setefilla Quiros-Carmona, Rocío Navarrete-Calvo. Preperitoneal ropivacaine infusion versus epidural ropivacaine-morphine for postoperative analgesia in dogs undergoing ovariohysterectomy: a randomized clinical trial.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):935-942. doi:
10.1016/j.vaa.2021.04.009. [PMID: 34561181] - Bruno A Zanfini, Matteo Biancone, Marco Famele, Stefano Catarci, Roberta Lavalle, Luciano Frassanito, Alessandra Piersanti, Cristina Olivieri, Antonio Lanzone, Rosa Draisci, Gaetano Draisci. Comparison of ropivacaine plasma concentration after posterior Quadratus Lumborum Block in Cesarean Section with ropivacaine with epinephrine vs. plane.
Minerva anestesiologica.
2021 09; 87(9):979-986. doi:
10.23736/s0375-9393.21.15354-4. [PMID: 33938678] - Ji-Yeon Bang, Sugeun Nam, Chang-Soon Hwang, Eun-Kyung Lee, Byung-Moon Choi. Population pharmacokinetic analysis of ropivacaine extended-release from a temperature-responsive hydrogel in rats.
Clinical and experimental pharmacology & physiology.
2021 06; 48(6):932-937. doi:
10.1111/1440-1681.13492. [PMID: 33686702] - Vincent Marolf, Keila K Ida, Danuta Siluk, Wiktoria Struck-Lewicka, Michał J Markuszewski, Charlotte Sandersen. Effects of perineural administration of ropivacaine combined with perineural or intravenous administration of dexmedetomidine for sciatic and saphenous nerve blocks in dogs.
American journal of veterinary research.
2021 Jun; 82(6):449-458. doi:
10.2460/ajvr.82.6.449. [PMID: 34032477] - Montiel Jiménez-Fuertes, Dolores C García-Olmo, Sara Puy, Marc Beisani, Francisca Planells, Alba Boldó, Jaime Ruiz-Tovar, Manuel Durán, Damián García-Olmo. Effects of negative-pressure therapy with and without ropivacaine instillation in the early evolution of severe peritonitis in pigs.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2021 Apr; 47(2):597-606. doi:
10.1007/s00068-019-01244-9. [PMID: 31641785] - Kirill Gromov, Stanislas Grassin-Delyle, Nicolai B Foss, Lars Møller Pedersen, Christian S Nielsen, Elodie Lamy, Anders Troelsen, Saik Urien, Henrik Husted. Population pharmacokinetics of ropivacaine used for local infiltration anaesthesia during primary total unilateral and simultaneous bilateral knee arthroplasty.
British journal of anaesthesia.
2021 04; 126(4):872-880. doi:
10.1016/j.bja.2020.11.038. [PMID: 33455802] - Hongfei Chen, Zhousheng Jin, Fangfang Xia, Zhijian Fu. Bupivacaine inhibits a small conductance calcium-activated potassium type 2 channel in human embryonic kidney 293 cells.
BMC pharmacology & toxicology.
2021 03; 22(1):15. doi:
10.1186/s40360-021-00481-2. [PMID: 33712065] - Min Liang, Yijiao Chen, Wenchao Zhu, Dachun Zhou. Efficacy and safety of different doses of ropivacaine for laparoscopy-assisted infiltration analgesia in patients undergoing laparoscopic cholecystectomy: A prospective randomized control trial.
Medicine.
2020 Nov; 99(46):e22540. doi:
10.1097/md.0000000000022540. [PMID: 33181643] - Haikou Yang, Wei Fan, Yong Yang, Jing Zhou, Hao Zhang, Jian Sun, Bo Wang. Application of dexmedetomidine combined with ropivacaine in axillary brachial plexus block in children and its effect on inflammatory factors.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jul; 66(5):73-79. doi:
10.14715/cmb/2020.66.5.14. [PMID: 33040817] - Jung-Taek Hwang, Ji Su Jang, Jae Jun Lee, Dong-Keun Song, Han Na Lee, Do-Young Kim, Sang-Soo Lee, Sung Mi Hwang, Yong-Been Kim, Sanghyeon Lee. Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
2020 Jul; 28(7):2343-2353. doi:
10.1007/s00167-019-05799-3. [PMID: 31773201] - Steve Coppens, Steffen Rex, Steffen Fieuws, Arne Neyrinck, Andre D'Hoore, Geertrui Dewinter. Transmuscular quadratus lumborum (TQL) block for laparoscopic colorectal surgery: study protocol for a double-blind, prospective randomized placebo-controlled trial.
Trials.
2020 Jun; 21(1):581. doi:
10.1186/s13063-020-04525-6. [PMID: 32586361] - Ronggang Zhu, Tingting Du, Hongzhu Gao. Effects of dezocine and ropivacaine infiltration anesthesia on cellular immune function indicators, anesthesia recovery time and pain factors in patients with open liver resection.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jun; 66(3):149-154. doi:
. [PMID: 32538762] - Yar L Yeap, John W Wolfe, Elizabeth Kroepfl, Jonathan Fridell, John A Powelson. Transversus abdominis plane (TAP) block for laparoscopic live donor nephrectomy: Continuous catheter infusion provides no additional analgesic benefit over single-injection ropivacaine.
Clinical transplantation.
2020 06; 34(6):e13861. doi:
10.1111/ctr.13861. [PMID: 32198963] - Elodie Lamy, Fanta Fall, Lisa Boigne, Kirill Gromov, Nicolas Fabresse, Stanislas Grassin-Delyle. Validation according to European and American regulatory agencies guidelines of an LC-MS/MS method for the quantification of free and total ropivacaine in human plasma.
Clinical chemistry and laboratory medicine.
2020 04; 58(5):701-708. doi:
10.1515/cclm-2018-1298. [PMID: 30939109] - Jun Zhang, Tieshuai Liu, Haiyan Zhou, Yue Fei, Xin Yu. The Safety and Efficacy of Ultrasound-Guided Bilateral Dual Transversus Abdominis Plane (BD-TAP) Block in ERAS Program of Laparoscopic Hepatectomy: A Prospective, Randomized, Controlled, Blinded, Clinical Study.
Drug design, development and therapy.
2020; 14(?):2889-2898. doi:
10.2147/dddt.s255385. [PMID: 32764887] - Meng Yin, Zhong-Hua Li, Chen Wang, Ying Li, Hong Zhang, Hui-Bo Du, Zhen-Ao Zhao, Chun-Yu Niu, Zi-Gang Zhao. Stellate Ganglion Blockade repairs Intestinal Mucosal Barrier through suppression of Endoplasmic Reticulum Stress following Hemorrhagic Shock.
International journal of medical sciences.
2020; 17(14):2147-2154. doi:
10.7150/ijms.47662. [PMID: 32922175] - Hai-Yan Zhang, Xiao-Juan Jiang, Qi Li, Xiao-Hong Tang, Tao Zhu. Single-Injection Ultrasound-Guided Thoracic Paravertebral Block versus Local Anesthetic Infiltration in Peritoneal Dialysis Catheter Surgeries: A Randomized Controlled Trial.
Blood purification.
2020; 49(4):426-433. doi:
10.1159/000505259. [PMID: 31927549] - Jing Zhang, Xue-Rong Lin, Yu-Ping Zhang, Li-Min Zhang, Hui-Bo Du, Li-Na Jiang, Zi-Gang Zhao, Chun-Yu Niu. Blockade of Stellate Ganglion Remediates Hemorrhagic Shock-Induced Intestinal Barrier Dysfunction.
The Journal of surgical research.
2019 12; 244(?):69-76. doi:
10.1016/j.jss.2019.06.007. [PMID: 31279996] - Thomas Rössel, Christopher Uhlig, Jörg Pietsch, Stefan Ludwig, Thea Koch, Torsten Richter, Peter Markus Spieth, Stephan Kersting. Effects of regional anesthesia techniques on local anesthetic plasma levels and complications in carotid surgery: a randomized controlled pilot trial.
BMC anesthesiology.
2019 11; 19(1):218. doi:
10.1186/s12871-019-0890-8. [PMID: 31771512] - Mao-Jun Li, Bin-Xiu Wei, Qiu-Xia Deng, Xin Liu, Xiao-Dong Zhu, Ying Zhang. [Effect of preemptive electroacupuncture on pain reactions in primiparous parturients during vaginal delivery].
Zhen ci yan jiu = Acupuncture research.
2019 Oct; 44(10):752-6. doi:
10.13702/j.1000-0607.180873. [PMID: 31657166] - Zhaojun Qin, Chunyan Xiang, Hongbo Li, Tingting Liu, Leyun Zhan, Zhengyuan Xia, Min Zhang, Jianping Lai. The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial.
BMC anesthesiology.
2019 10; 19(1):181. doi:
10.1186/s12871-019-0859-7. [PMID: 31604428] - Rakesh V Sondekoppam, Vishal Uppal, Jonathan Brookes, Sugantha Ganapathy. Bilateral Thoracic Paravertebral Blocks Compared to Thoracic Epidural Analgesia After Midline Laparotomy: A Pragmatic Noninferiority Clinical Trial.
Anesthesia and analgesia.
2019 09; 129(3):855-863. doi:
10.1213/ane.0000000000004219. [PMID: 31425230] - Jane Hayden, Anil Gupta, Sven-Egron Thörn, Pontus Thulin, Linda Block, Jonatan Oras. Does intraperitoneal ropivacaine reduce postoperative inflammation? A prospective, double-blind, placebo-controlled pilot study.
Acta anaesthesiologica Scandinavica.
2019 09; 63(8):1048-1054. doi:
10.1111/aas.13410. [PMID: 31206591] - Carolina C Rennó, Juliana Z B Papini, Cintia Maria Saia Cereda, Elizabeth Martinez, Victor Angelo Montalli, Eneida de Paula, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Giovana Radomille Tofoli. Preclinical Evaluation of Ropivacaine in 2 Liposomal Modified Systems.
Anesthesia and analgesia.
2019 08; 129(2):387-396. doi:
10.1213/ane.0000000000003837. [PMID: 30303863] - Qin Fang, Yong-le Li, Ming-Yang Cai, Wei Huang, Chao Yuan, Xiang-Nan Chen. [Efficacy of Ropivacaine injection at acupoints for labor analgesia and its effect on breastfeeding and serum prolactin].
Zhen ci yan jiu = Acupuncture research.
2019 Jun; 44(6):434-8. doi:
10.13702/j.1000-0607.190009. [PMID: 31368267] - Milan Patel, Andreia Z Chignalia, Ayman Isbatan, Nikhil Bommakanti, Randal O Dull. Ropivacaine inhibits pressure-induced lung endothelial hyperpermeability in models of acute hypertension.
Life sciences.
2019 Apr; 222(?):22-28. doi:
10.1016/j.lfs.2019.02.053. [PMID: 30822427] - Tatsuo Maeyashiki, Jae-Hwi Jang, Florian Janker, Yoshito Yamada, Ilhan Inci, Walter Weder, Tobias Piegeler, Wolfgang Jungraithmayr. The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation.
Lung.
2019 04; 197(2):217-226. doi:
10.1007/s00408-019-00197-5. [PMID: 30739218] - Jennifer M Crawford, John A Loadsman, Kenny Xf Yang, Peter Ca Kam. Adding low concentrations of clonidine to ropivacaine for transversus abdominis plane blocks does not reduce plasma ropivacaine levels, suggesting a lack of vasoconstrictor effect.
Anaesthesia and intensive care.
2019 Mar; 47(2):134-140. doi:
10.1177/0310057x19838731. [PMID: 31070463] - Purnima Narasimhan, Lokesh Kashyap, V K Mohan, Mahesh Kumar Arora, Dilip Shende, Maddur Srinivas, Seema Kashyap, Sayan Nath, Puneet Khanna. Comparison of caudal epidural block with paravertebral block for renal surgeries in pediatric patients: A prospective randomised, blinded clinical trial.
Journal of clinical anesthesia.
2019 Feb; 52(?):105-110. doi:
10.1016/j.jclinane.2018.09.007. [PMID: 30243061] - Singh Mathuria Kaushal-Deep, Mehershree Lodhi, Afzal Anees, Shehtaj Khan, Mohammad Amanullah Khan. Randomised prospective study of using intraoperative, intraincisional and intraperitoneal ropivacaine for the early discharge of post-laparoscopic cholecystectomy patients as a day case in a cost-effective way in government setup of low-income and middle-income countries: Opening new horizons.
Postgraduate medical journal.
2019 Feb; 95(1120):78-84. doi:
10.1136/postgradmedj-2018-135662. [PMID: 31015318] - Yanbing Wang, Jian Cheng, Liu Yang, Jingjing Wang, Hao Liu, Zhongzhu Lv. Ropivacaine for Intercostal Nerve Block Improves Early Postoperative Cognitive Dysfunction in Patients Following Thoracotomy for Esophageal Cancer.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):460-465. doi:
10.12659/msm.912328. [PMID: 30647402] - Hao-Wen Kao, Yi-Yu Lin, Walter J Gwathney, Keelung Hong. Formulation and evaluation of multilamellar vesicles ropivacaine in pain management.
International journal of nanomedicine.
2019; 14(?):7891-7901. doi:
10.2147/ijn.s215952. [PMID: 31632006] - Sietske M K Bakker, Maaike G E Fenten, Daan J Touw, Bart J F van den Bemt, Petra J C Heesterbeek, Gert-Jan Scheffer, Rudolf Stienstra. Pharmacokinetics of 400 mg Locally Infiltrated Ropivacaine After Total Knee Arthroplasty Without Perioperative Tourniquet Use.
Regional anesthesia and pain medicine.
2018 Oct; 43(7):699-704. doi:
10.1097/aap.0000000000000816. [PMID: 29905628] - Mazaher Ahmadi, Mohammad Mahdi Moein, Tayyebeh Madrakian, Abbas Afkhami, Soleiman Bahar, Mohamed Abdel-Rehim. Reduced graphene oxide as an efficient sorbent in microextraction by packed sorbent: Determination of local anesthetics in human plasma and saliva samples utilizing liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):177-182. doi:
10.1016/j.jchromb.2018.07.036. [PMID: 30077098] - Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky. Population Pharmacokinetic-Pharmacodynamic Modeling of Ropivacaine in Spinal Anesthesia.
Clinical pharmacokinetics.
2018 09; 57(9):1135-1147. doi:
10.1007/s40262-017-0617-2. [PMID: 29236228] - Mark C Kendall. Re: Choi et al.: Effect of Intercostal Nerve Block and Nephrostomy Tract Infiltration With Ropivacaine on Postoperative Pain Control After Tubeless Percutaneous Nephrolithotomy: A Prospective, Randomized, and Case-controlled Trial (Urology 2018;114:49-55).
Urology.
2018 09; 119(?):162. doi:
10.1016/j.urology.2018.05.038. [PMID: 29908217] - Wei Dai, Yao Lu, Jia Liu, Lili Tang, Bin Mei, Xuesheng Liu. Ultrasound-guided left lateral transversus abdominis plane block combined with rectus sheath block in peritoneal dialysis catheter placement.
Journal of anesthesia.
2018 08; 32(4):645-648. doi:
10.1007/s00540-018-2528-2. [PMID: 29978298] - Zi Li, Xiao Hong Tang, Qi Li, Wen-Juan Zhang, Tian Tao, Tao Zhu. Ultrasound-Guided Oblique Sub-Costal Transversus Abdominis Plane Block as the Principal Anesthesia Technique in Peritoneal Dialysis Catheter Implantation and Plasma Ropivacaine Concentration Evaluation in ESRD Patients: A Prospective, Randomized, Double-Blinded, Controlled Trial.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2018 May; 38(3):192-199. doi:
10.3747/pdi.2017.00222. [PMID: 29848599] - Reuben J Miller, Andrew J Cameron, Julian Dimech, Robert J Orec, Nicholas J Lightfoot. Plasma Ropivacaine Concentrations Following Local Infiltration Analgesia in Total Knee Arthroplasty: A Pharmacokinetic Study to Determine Safety Following Fixed-Dose Administration.
Regional anesthesia and pain medicine.
2018 May; 43(4):347-351. doi:
10.1097/aap.0000000000000727. [PMID: 29369957] - Xiang-Nan Chen, Shi-Hui Yang, Hui-Rui Lin, Ning-Ning Chen, Chen-Lu Su, Wei Huang. [Efficacy of ropivacaine injection at acupoints for labor analgesia and its effect on cortisol level in parturients].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2018 Apr; 38(4):502-504. doi:
NULL. [PMID: 29735455] - J Tang, S Y Zhang, F J Lu, W H Qin, Y S Shi. [The application of combining low dose naloxone with ropivacaine in supraclavicular brachial plexus block].
Zhonghua yi xue za zhi.
2017 Dec; 97(48):3787-3791. doi:
10.3760/cma.j.issn.0376-2491.2017.48.007. [PMID: 29325337] - Joo-Hyun Jun, Gaab-Soo Kim, Jeong Jin Lee, Justin S Ko, Sung Joo Kim, Pil Hyun Jeon. Comparison of intrathecal morphine and surgical-site infusion of ropivacaine as adjuncts to intravenous patient-controlled analgesia in living-donor kidney transplant recipients.
Singapore medical journal.
2017 Nov; 58(11):666-673. doi:
10.11622/smedj.2017077. [PMID: 28805236] - Zhi Yuen Beh, Mohd Shahnaz Hasan. Ultrasound-guided costoclavicular approach infraclavicular brachial plexus block for vascular access surgery.
The journal of vascular access.
2017 Sep; 18(5):e57-e61. doi:
10.5301/jva.5000720. [PMID: 28478621] - Matthias Desmet, Kris Vermeylen, Imré Van Herreweghe, Laurence Carlier, Filiep Soetens, Stijn Lambrecht, Kathleen Croes, Hans Pottel, Marc Van de Velde. A Longitudinal Supra-Inguinal Fascia Iliaca Compartment Block Reduces Morphine Consumption After Total Hip Arthroplasty.
Regional anesthesia and pain medicine.
2017 May; 42(3):327-333. doi:
10.1097/aap.0000000000000543. [PMID: 28059869] - Takahiro Tamura, Shoichi Mori, Atsushi Mori, Masahiko Ando, Shuichi Yokota, Yasuyuki Shibata, Kimitoshi Nishiwaki. A randomized controlled trial comparing paravertebral block via the surgical field with thoracic epidural block using ropivacaine for post-thoracotomy pain relief.
Journal of anesthesia.
2017 Apr; 31(2):263-270. doi:
10.1007/s00540-017-2307-5. [PMID: 28116506] - M G E Fenten, S M K Bakker, D J Touw, B J F van den Bemt, G J Scheffer, P J C Heesterbeek, R Stienstra. Pharmacokinetics of 400 mg ropivacaine after periarticular local infiltration analgesia for total knee arthroplasty.
Acta anaesthesiologica Scandinavica.
2017 Mar; 61(3):338-345. doi:
10.1111/aas.12849. [PMID: 28066882] - Vedat Eljezi, Etienne Imhoff, Daniel Bourdeaux, Bruno Pereira, Mehdi Farhat, Pierre Schoeffler, Kasra Azarnoush, Christian Dualé. Bilateral sternal infusion of ropivacaine and length of stay in ICU after cardiac surgery with increased respiratory risk: A randomised controlled trial.
European journal of anaesthesiology.
2017 Feb; 34(2):56-65. doi:
10.1097/eja.0000000000000564. [PMID: 27977439] - Xavier Capdevila, Sebastien Moulard, Christian Plasse, Jean-Luc Peshaud, Nicolas Molinari, Christophe Dadure, Sophie Bringuier. Effectiveness of Epidural Analgesia, Continuous Surgical Site Analgesia, and Patient-Controlled Analgesic Morphine for Postoperative Pain Management and Hyperalgesia, Rehabilitation, and Health-Related Quality of Life After Open Nephrectomy: A Prospective, Randomized, Controlled Study.
Anesthesia and analgesia.
2017 01; 124(1):336-345. doi:
10.1213/ane.0000000000001688. [PMID: 27918333] - Massimo Allegri, Martina Ornaghi, Catherine E Ferland, Dario Bugada, Yash Meghani, Serena Calcinati, Manuela De Gregori, Federica Lovisari, Krishnaprabha Radhakrishnan, Maria Cusato, Stefano Scalia Catenacci, Marta Somaini, Guido Fanelli, Pablo Ingelmo. Peritoneal Nebulization of Ropivacaine during Laparoscopic Cholecystectomy: Dose Finding and Pharmacokinetic Study.
Pain research & management.
2017; 2017(?):4260702. doi:
10.1155/2017/4260702. [PMID: 28316464] - Maya Keplinger, Peter Marhofer, Wolfgang Klug, Birgit Reiter, Thomas Stimpfl, Stephan C Kettner, Lena Korf, Markus Zeitlinger, Daniela Marhofer, Lydia Triffterer. Feasibility and pharmacokinetics of caudal blockade in children and adolescents with 30-50 kg of body weight.
Paediatric anaesthesia.
2016 Nov; 26(11):1053-1059. doi:
10.1111/pan.12972. [PMID: 27397645] - Yukitoshi Niiyama, Takatoshi Yotsuyanagi, Michiaki Yamakage. Continuous wound infiltration with 0.2\% ropivacaine versus a single intercostal nerve block with 0.75\% ropivacaine for postoperative pain management after reconstructive surgery for microtia.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2016 Oct; 69(10):1445-9. doi:
10.1016/j.bjps.2016.05.009. [PMID: 27350268] - Akito Tsukinaga, Tomoya Irie, Kazuhiro Uchimoto, Tetsuya Miyashita, Takahisa Goto. [A Case of Combined Spinal-Epidural Anesthesia for Cesarean Section in a Patient with Right Heart Failure due to Supravalvular Pulmonary Stenosis after Jatene Operation].
Masui. The Japanese journal of anesthesiology.
2016 10; 65(10):1031-1033. doi:
NULL. [PMID: 30358281] - A M-H Ho, M K Karmakar, S K Ng, S Wan, C S H Ng, R H L Wong, S K C Chan, G M Joynt. Local anaesthetic toxicity after bilateral thoracic paravertebral block in patients undergoing coronary artery bypass surgery.
Anaesthesia and intensive care.
2016 09; 44(5):615-9. doi:
10.1177/0310057x1604400502. [PMID: 27608346] - Pauline Dureau, Beny Charbit, Nathalie Nicolas, Dan Benhamou, Jean-Xavier Mazoit. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study.
Anesthesiology.
2016 09; 125(3):474-83. doi:
10.1097/aln.0000000000001230. [PMID: 27404223] - Matthias Flury, Dominik Rickenbacher, Hans-Kaspar Schwyzer, Christian Jung, Marco M Schneider, Katharina Stahnke, Jörg Goldhahn, Laurent Audigé. Does Pure Platelet-Rich Plasma Affect Postoperative Clinical Outcomes After Arthroscopic Rotator Cuff Repair? A Randomized Controlled Trial.
The American journal of sports medicine.
2016 Aug; 44(8):2136-46. doi:
10.1177/0363546516645518. [PMID: 27184542] - Huaijiang Wang, Liandi Li, Chengshi Xu, Xiangdong Qu, Zhijun Qu, Geng Wang. The efficacy of simultaneous bilateral axillary brachial plexus block under the guidance of neurostimulator or ultrasound: a prospective study.
Journal of anesthesia.
2016 08; 30(4):596-602. doi:
10.1007/s00540-016-2193-2. [PMID: 27255448] - C Stoetzer, T Doll, T Stueber, C Herzog, F Echtermeyer, F Greulich, C Rudat, A Kispert, F Wegner, A Leffler. Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Jun; 389(6):625-36. doi:
10.1007/s00210-016-1231-9. [PMID: 27000037] - Yehuda Ginosar, Simon Haroutounian, Leonid Kagan, Michael Naveh, Arnon Aharon, Elyad M Davidson. Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers.
Anesthesia and analgesia.
2016 May; 122(5):1673-80. doi:
10.1213/ane.0000000000001217. [PMID: 27057798] - Elyad M Davidson, Simon Haroutounian, Leonid Kagan, Michael Naveh, Arnon Aharon, Yehuda Ginosar. A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs.
Anesthesia and analgesia.
2016 May; 122(5):1663-72. doi:
10.1213/ane.0000000000001200. [PMID: 27057797] - C Adami, D Casoni, F Noussitou, U Rytz, C Spadavecchia. Addition of magnesium sulphate to ropivacaine for spinal analgesia in dogs undergoing tibial plateau levelling osteotomy.
Veterinary journal (London, England : 1997).
2016 Mar; 209(?):163-8. doi:
10.1016/j.tvjl.2015.11.017. [PMID: 26831174] - Lisa K Mouzi, Olivia Adams, Germaine Cuff, Elaan Lukasiewicz, Elise Champeil, Arthur Atchabahian. Plasma concentrations of ropivacaine following ultrasound-guided or nerve-stimulator-guided femoral nerve block: A prospective randomised study.
Anaesthesia, critical care & pain medicine.
2016 Feb; 35(1):45-48. doi:
10.1016/j.accpm.2015.08.002. [PMID: 26681523] - Qiang Ni, Wurong Chen, Lei Tong, Jue Cao, Chao Ji. Preparation of novel biodegradable ropivacaine microspheres and evaluation of their efficacy in sciatic nerve block in mice.
Drug design, development and therapy.
2016; 10(?):2499-506. doi:
10.2147/dddt.s110742. [PMID: 27536071] - Tomohiro Chaki, Shigekazu Sugino, Piotr K Janicki, Yoshiya Ishioka, Yosuke Hatakeyama, Tomo Hayase, Miki Kaneuchi-Yamashita, Naonori Kohri, Michiaki Yamakage. Efficacy and Safety of a Lidocaine and Ropivacaine Mixture for Scalp Nerve Block and Local Infiltration Anesthesia in Patients Undergoing Awake Craniotomy.
Journal of neurosurgical anesthesiology.
2016 Jan; 28(1):1-5. doi:
10.1097/ana.0000000000000149. [PMID: 25493926] - Zi Wang, Haizhen Huang, Shaozhong Yang, Shanshan Huang, Jingxuan Guo, Qi Tang, Feng Qi. Long-term effect of ropivacaine nanoparticles for sciatic nerve block on postoperative pain in rats.
International journal of nanomedicine.
2016; 11(?):2081-90. doi:
10.2147/ijn.s101563. [PMID: 27274236] - Sophia L Markantonis, Aikaterini Melemeni, Marina Markidou, Stefania Irene Haikali, Vangelis Karalis, Argyro Fassoulaki. Ropivacaine, Interleukin-6 and Tumor Necrosis Factor Alpha Plasma Levels during Intermittent Epidural and Continuous Wound Infusion of Ropivacaine for Analgesia after Hysterectomy or Myomectomy: An Observational Study.
Pharmacology.
2016; 98(5-6):294-298. doi:
10.1159/000448758. [PMID: 27631634] - S Yu Sichkar, I I Afukov, O V Koshko, N V Yeliseeva. [THE USE OF 20\% LIPOFUNDIN INFUSIONS AT THE APPEARANCE OF TOXIC PROPERTIES OF ROPIVACAINE 2 MG/ML IN CHILD 1.5 MONTHS AT THE POSTOPERATIVE PERIOD WITH EPIDURAL ANALGESIA].
Anesteziologiia i reanimatologiia.
2016 Jan; 61(1):51-4. doi:
NULL. [PMID: 27192857] - V Shoshiashvili, A Tataradze, L Beglarishvili, L Managadze, A Chkhotua. INFLUENCE OF TYPE OF ANESTHESIA ON HEMODYNAMIC PARAMETERS AND OUTCOME OF DIALYSIS ARTERIOVENOUS FISTULA OPERATIONS.
Georgian medical news.
2015 Dec; ?(249):20-7. doi:
NULL. [PMID: 26719545] - Francesco Iadaresta, Carlo Crescenzi, Ahmad Amini, Anders Colmsjö, Hirsh Koyi, Mohamed Abdel-Rehim. Application of graphitic sorbent for online microextraction of drugs in human plasma samples.
Journal of chromatography. A.
2015 Nov; 1422(?):34-42. doi:
10.1016/j.chroma.2015.10.025. [PMID: 26499973] - Andreas Koköfer, Jürgen Nawratil, Thomas K Felder, Ottokar Stundner, Nina Mader, Peter Gerner. Ropivacaine 0.375\% vs. 0.75\% with prilocaine for intermediate cervical plexus block for carotid endarterectomy: A randomised trial.
European journal of anaesthesiology.
2015 Nov; 32(11):781-9. doi:
10.1097/eja.0000000000000243. [PMID: 25782662] - Ibrahim S Farid, Elizabeth J Kendrick, Mark J Adamczyk, Nancy R Lukas, Eric Z Massanyi. Perioperative Analgesic Management of Newborn Bladder Exstrophy Repair Using a Directly Placed Tunneled Epidural Catheter with 0.1\% Ropivacaine.
A & A case reports.
2015 Oct; 5(7):112-4. doi:
10.1213/xaa.0000000000000191. [PMID: 26402021] - Dario Bugada, Manuela De Gregori, Christian Compagnone, Carolina Muscoli, Ferdinando Raimondi, Silvia Bettinelli, Maria Antonietta Avanzini, Lorenzo Cobianchi, Andrea Peloso, Marco Baciarello, Concetta Dagostino, Luigino A Giancotti, Sara Ilari, Filomena Lauro, Stefania Grimaldi, Ennio Tasciotti, Massimo Fini, Gloria M R Saccani Jotti, Tiziana Meschi, Guido Fanelli, Massimo Allegri. Continuous wound infusion of local anesthetic and steroid after major abdominal surgery: study protocol for a randomized controlled trial.
Trials.
2015 Aug; 16(?):357. doi:
10.1186/s13063-015-0874-z. [PMID: 26272452] - Magdalena Karas-Trzeciak, Tomasz Grabowski, Bogumila Woloszczuk-Gebicka, Beata Borucka. Fentanyl with ropivacaine infusion for postoperative pain relief in infants and children. Kinetics of epidural fentanyl.
Paediatric anaesthesia.
2015 Aug; 25(8):818-823. doi:
10.1111/pan.12648. [PMID: 25904383] - Luciano Perotti, Maria Cusato, Pablo Ingelmo, Thekla Larissa Niebel, Marta Somaini, Francesca Riva, Carmine Tinelli, José De Andrés, Guido Fanelli, Antonio Braschi, Mario Regazzi, Massimo Allegri. A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial.
Anesthesia and analgesia.
2015 Aug; 121(2):348-56. doi:
10.1213/ane.0000000000000775. [PMID: 25977992] - A S Brydone, R Souvatzoglou, M Abbas, D G Watson, D A McDonald, A M Gill. Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty.
Anaesthesia.
2015 Jul; 70(7):784-90. doi:
10.1111/anae.13017. [PMID: 25708670] - Alexander P Schwoerer, Hanno Scheel, Patrick Friederich. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels.
Anesthesia and analgesia.
2015 Jun; 120(6):1226-34. doi:
10.1213/ane.0000000000000646. [PMID: 25692452] - François Gaudreault, Pierre Drolet, Michel Fallaha, France Varin. Modeling the anesthetic effect of ropivacaine after a femoral nerve block in orthopedic patients: a population pharmacokinetic-pharmacodynamic analysis.
Anesthesiology.
2015 May; 122(5):1010-20. doi:
10.1097/aln.0000000000000631. [PMID: 25790027] - Verônica Batista de Albuquerque, Marcelo Augusto de Araújo, Gabriel Thadeu Nogueira Martins Ferreira, Mariana Werneck Fonseca, André Moreira Martins Arruda, Lu ShiChen, Valéria Nobre Leal de Souza Oliva. Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg(-1) in bitches undergoing epidural anesthesia.
Acta cirurgica brasileira.
2015 Mar; 30(3):222-38. doi:
10.1590/s0102-8650201500300000010. [PMID: 25790012] - Ehab Farag, Maged N Guirguis, Mada Helou, Jarrod E Dalton, Fallon Ngo, Michael Ghobrial, Jerome O'Hara, John Seif, Venkatesh Krishnamurthi, David Goldfarb. Continuous transversus abdominis plane block catheter analgesia for postoperative pain control in renal transplant.
Journal of anesthesia.
2015 Feb; 29(1):4-8. doi:
10.1007/s00540-014-1855-1. [PMID: 24898186] - Kazuya Toju, Katsunori Shiraishi, Takahiro Hakozaki, Tsuyoshi Isosu, Masahiro Murakawa. Plasma ropivacaine concentration following ultrasound-guided subcostal transversus abdominis plane block in adults.
Journal of anesthesia.
2015 Feb; 29(1):146-8. doi:
10.1007/s00540-014-1864-0. [PMID: 24935748] - Shizuko Kosugi, Saori Hashiguchi, Daisuke Nishimura, Hiroyuki Seki, Takeshi Suzuki, Nobuyuki Katori, Hiroshi Morisaki. Neurolysis targeting both the aorticorenal ganglia and lumbar sympathetic plexus for kidney tumor-related pain.
Pain medicine (Malden, Mass.).
2015 Jan; 16(1):202-3. doi:
10.1111/pme.12596. [PMID: 25339575] - M Hübler, M C Planitz, O Vicent. Early pharmacokinetic of ropivacaine without epinephrine after injection into the psoas compartment.
British journal of anaesthesia.
2015 Jan; 114(1):130-5. doi:
10.1093/bja/aeu363. [PMID: 25303987] - Sarika K Kumar, Vasanth Rao, Raymond G Morris, Richard W Watts, Ian S Westley. Ropivacaine (total and unbound) and AGP concentrations after transversus abdominis plane block for analgesia after abdominal surgery.
Therapeutic drug monitoring.
2014 Dec; 36(6):759-64. doi:
10.1097/ftd.0000000000000091. [PMID: 24819972] - F Affas, S Eksborg, P Wretenberg, C Olofsson, N Stephanson, C-O Stiller. Plasma concentration of ketorolac after local infiltration analgesia in hip arthroplasty.
Acta anaesthesiologica Scandinavica.
2014 Oct; 58(9):1140-5. doi:
10.1111/aas.12371. [PMID: 25078268] - Shan-Wu Feng, Shi-Qin Xu, Li Ma, Cai-Juan Li, Xian Wang, Hong-Mei Yuan, Fu-Zhou Wang, Xiao-Feng Shen, Zheng-Nian Ding. Regular intermittent bolus provides similar incidence of maternal fever compared with continuous infusion during epidural labor analgesia.
Saudi medical journal.
2014 Oct; 35(10):1237-42. doi:
NULL. [PMID: 25316469] - Fatin Affas, Staffan Eksborg, Per Wretenberg, Christina Olofsson, Carl-Olav Stiller. Ropivacaine pharmacokinetics after local infiltration analgesia in hip arthroplasty.
Anesthesia and analgesia.
2014 Oct; 119(4):996-999. doi:
10.1213/ane.0000000000000364. [PMID: 25025588] - Caio J X Abimussi, Thais M Menegheti, Juliana T Wagatsuma, Beatriz P Floriano, André M M Arruda, Paulo S P dos Santos, Valéria N L S Oliva. Tumescent local anesthesia with ropivacaine in different concentrations in bitches undergoing mastectomy: plasma concentration and post-operative analgesia.
Veterinary anaesthesia and analgesia.
2014 Sep; 41(5):516-25. doi:
10.1111/vaa.12178. [PMID: 24835303] - Bogumila Woloszczuk-Gebicka, Tomasz Grabowski, Beata Borucka, Magdalena Karas-Trzeciak. Pharmacokinetics of sufentanil administered with 0.2\% ropivacaine as a continuous epidural infusion for postoperative pain relief in infants.
Paediatric anaesthesia.
2014 Sep; 24(9):962-7. doi:
10.1111/pan.12440. [PMID: 24824135] - Yingjie Zhai, Xiaoye Yang, Lili Zhao, Zimin Wang, Guangxi Zhai. Lipid nanocapsules for transdermal delivery of ropivacaine: in vitro and in vivo evaluation.
International journal of pharmaceutics.
2014 Aug; 471(1-2):103-11. doi:
10.1016/j.ijpharm.2014.05.035. [PMID: 24858383] - Masato Kitayama, Morito Wada, Hiroshi Hashimoto, Tsuyoshi Kudo, Chihiro Yakoshi, Kazuyoshi Hirota. Plasma ropivacaine concentrations after ultrasound-guided transversus abdominis plane block for open retropubic prostatectomy.
Journal of anesthesia.
2014 Aug; 28(4):576-9. doi:
10.1007/s00540-013-1763-9. [PMID: 24347034] - D T Baptista-Hon, F M Robertson, G B Robertson, S J Owen, G W Rogers, E L Lydon, N H Lee, T G Hales. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function.
British journal of anaesthesia.
2014 Jul; 113 Suppl 1(?):i39-i48. doi:
10.1093/bja/aeu104. [PMID: 24852501] - Dolores M McKeen, Ronald B George, John Colin Boyd, Victoria M Allen, Aaron Pink. Transversus abdominis plane block does not improve early or late pain outcomes after Cesarean delivery: a randomized controlled trial.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2014 Jul; 61(7):631-40. doi:
10.1007/s12630-014-0162-5. [PMID: 24764186] - Venkat R R Mantha, Harsha K Nair, Raman Venkataramanan, Yuan Yue Gao, Krzysztof Matyjaszewski, Hongchen Dong, Wenwen Li, Doug Landsittel, Elan Cohen, William R Lariviere. Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.
Anesthesia and analgesia.
2014 Jun; 118(6):1355-62. doi:
10.1213/ane.0000000000000175. [PMID: 24722259] - Lyubov Chaykovska, Linus Blohmé, Dieter Mayer, Steffen Gloekler, Zoran Rancic, Christian A P Schmidt, Roberto Tunesi, Frank Veith, Mario Lachat, Dominique Bettex. Paraincisional subcutaneous infusion of ropivacaine after open abdominal vascular surgery shows significant advantages.
Annals of vascular surgery.
2014 May; 28(4):837-44. doi:
10.1016/j.avsg.2013.11.019. [PMID: 24456863] - A M Gill, N B Scott, M Abbas, D G Watson, K Place, D A McDonald. Ropivacaine plasma levels following local infiltration analgesia for primary total hip arthroplasty.
Anaesthesia.
2014 Apr; 69(4):368-73. doi:
10.1111/anae.12559. [PMID: 24641643] - Devanand Mangar, Rachel A Karlnoski, Collin J Sprenker, Katheryne L Downes, Narrene Taffe, Robert Wainwright, Kenneth Gustke, Thomas L Bernasek, Enrico Camporesi. Knee strength retention and analgesia with continuous perineural fentanyl infusion after total knee replacement: randomized controlled trial.
Journal of anesthesia.
2014 Apr; 28(2):214-21. doi:
10.1007/s00540-013-1700-y. [PMID: 23978948] - Emile Calenda, Jean Marc Baste, Ridha Hajjej, Eric Danielou, Christophe Peillon. Toxic plasma concentration of ropivacaine after a paravertebral block in a patient suffering from severe hypoalbuminemia.
Journal of clinical anesthesia.
2014 Mar; 26(2):149-51. doi:
10.1016/j.jclinane.2013.11.008. [PMID: 24565501]