6-Hydroxynorketamine (BioDeep_00000171996)

   

human metabolite blood metabolite


代谢物信息卡片


Cyclohexanone, 2-amino-2-(2-chlorophenyl)-6-hydroxy-

  化学式: C12H14ClNO2 (239.0713)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O
InChI: InChI=1S/C12H14ClNO2/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16/h1-2,4-5,10,15H,3,6-7,14H2


描述信息

同义名列表

5 个代谢物同义名

Cyclohexanone, 2-amino-2-(2-chlorophenyl)-6-hydroxy-; 2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one; 6-Hydroxynorketamine, (2S-cis)-isomer; 6-Hydroxynorketamine, (+-)-isomer; 6-Hydroxynorketamine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lichao Ye, Xueling Xiao, Yuanyuan Xu, Chen Zheng, Si Chen, Tao Luo, Zhenlong Li, Yuze Du, Yilin Yuan, Linyi Li, Bo Liu, Wei Qin, Dylan Chou. Prelimbic cortex miR-34a contributes to (2R,6R)-hydroxynorketamine-mediated antidepressant-relevant actions. Neuropharmacology. 2022 05; 208(?):108984. doi: 10.1016/j.neuropharm.2022.108984. [PMID: 35131296]
  • Jaclyn N Highland, Patrick J Morris, Kylie M Konrath, Lace M Riggs, Natalie R Hagen, Panos Zanos, Chris F Powels, Ruin Moaddel, Craig J Thomas, Amy Q Wang, Todd D Gould. Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines. ACS chemical neuroscience. 2022 02; 13(4):510-523. doi: 10.1021/acschemneuro.1c00761. [PMID: 35113535]
  • Jaclyn N Highland, Cristan A Farmer, Panos Zanos, Jacqueline Lovett, Carlos A Zarate, Ruin Moaddel, Todd D Gould. Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans. Journal of psychopharmacology (Oxford, England). 2022 02; 36(2):170-182. doi: 10.1177/02698811211064922. [PMID: 34971525]
  • Michael Weiss, Werner Siegmund. Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged-Release Ketamine With Emphasis on 2,6-Hydroxynorketamines. Clinical pharmacology in drug development. 2022 02; 11(2):194-206. doi: 10.1002/cpdd.993. [PMID: 34265182]
  • Michael F Grunebaum, Hanga C Galfalvy, Tse-Hwei Choo, Michelle S Parris, Ainsley K Burke, Raymond F Suckow, Thomas B Cooper, J John Mann. Ketamine metabolite pilot study in a suicidal depression trial. Journal of psychiatric research. 2019 10; 117(?):129-134. doi: 10.1016/j.jpsychires.2019.08.005. [PMID: 31415914]
  • Zhongwei Xiong, Yuko Fujita, Kai Zhang, Yaoyu Pu, Lijia Chang, Min Ma, Jincao Chen, Kenji Hashimoto. Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model. Behavioural brain research. 2019 08; 368(?):111904. doi: 10.1016/j.bbr.2019.111904. [PMID: 30980851]
  • Jaclyn N Highland, Patrick J Morris, Panos Zanos, Jacqueline Lovett, Soumita Ghosh, Amy Q Wang, Carlos A Zarate, Craig J Thomas, Ruin Moaddel, Todd D Gould. Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine. Journal of psychopharmacology (Oxford, England). 2019 01; 33(1):12-24. doi: 10.1177/0269881118812095. [PMID: 30488740]
  • Jun-Ichi Yamaguchi, Hidetoh Toki, Youge Qu, Chun Yang, Hiroyuki Koike, Kenji Hashimoto, Akiko Mizuno-Yasuhira, Shigeyuki Chaki. (2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 08; 43(9):1900-1907. doi: 10.1038/s41386-018-0084-y. [PMID: 29802366]
  • Tuomas O Lilius, Hanna Viisanen, Viljami Jokinen, Mikko Niemi, Eija A Kalso, Pekka V Rauhala. Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine. Basic & clinical pharmacology & toxicology. 2018 May; 122(5):481-488. doi: 10.1111/bcpt.12941. [PMID: 29171155]
  • Friederike A Sandbaumhüter, Regula Theurillat, Rima N Bektas, Annette P N Kutter, Regula Bettschart-Wolfensberger, Wolfgang Thormann. Pharmacokinetics of ketamine and three metabolites in Beagle dogs under sevoflurane vs. medetomidine comedication assessed by enantioselective capillary electrophoresis. Journal of chromatography. A. 2016 Oct; 1467(?):436-444. doi: 10.1016/j.chroma.2016.07.060. [PMID: 27485149]
  • Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel, Dave A Luckenbaugh, Nancy E Brutsche, Lobna Ibrahim, Carlos A Zarate, Donald E Mager, Irving W Wainer. Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression. British journal of clinical pharmacology. 2012 Aug; 74(2):304-14. doi: 10.1111/j.1365-2125.2012.04198.x. [PMID: 22295895]