Blebbistatin (BioDeep_00000171966)

   

human metabolite blood metabolite


代谢物信息卡片


3a-hydroxy-6-methyl-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one

化学式: C18H16N2O2 (292.12117159999997)
中文名称: (±)-Blebbistatin
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=CC2=C(C=C1)N=C1N(CCC1(O)C2=O)C1=CC=CC=C1
InChI: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Qihui Fan, Yu Zheng, Xiaochen Wang, Ruipei Xie, Yu Ding, Boyi Wang, Xiaoyu Yu, Ying Lu, Liyu Liu, Yunliang Li, Ming Li, Yuanjin Zhao, Yang Jiao, Fangfu Ye. Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. Angewandte Chemie (International ed. in English). 2021 05; 60(21):11858-11867. doi: 10.1002/anie.202016084. [PMID: 33533087]
  • Máté Gyimesi, Anna Á Rauscher, Sharad Kumar Suthar, Kamirán Á Hamow, Kinga Oravecz, István Lőrincz, Zsolt Borhegyi, Máté T Déri, Ádám F Kiss, Katalin Monostory, Pál Tamás Szabó, Suman Nag, Ivan Tomasic, Jacob Krans, Patrick J Tierney, Mihály Kovács, László Kornya, András Málnási-Csizmadia. Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2. The Journal of pharmacology and experimental therapeutics. 2021 03; 376(3):358-373. doi: 10.1124/jpet.120.000167. [PMID: 33468641]
  • Roberto Alers-Velazquez, Sarah Jacques, Clare Muller, Jennifer Boldt, James Schoelz, Scott Leisner. Cauliflower mosaic virus P6 inclusion body formation: A dynamic and intricate process. Virology. 2021 01; 553(?):9-22. doi: 10.1016/j.virol.2020.10.003. [PMID: 33197754]
  • Andrea Ghisleni, Camilla Galli, Pascale Monzo, Flora Ascione, Marc-Antoine Fardin, Giorgio Scita, Qingsen Li, Paolo Maiuri, Nils C Gauthier. Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse. Nature communications. 2020 10; 11(1):5108. doi: 10.1038/s41467-020-18825-7. [PMID: 33037189]
  • Guangyun Wang, Tiezheng Wang, Yang Hu, Jieman Wang, Yan Wang, Yuanyuan Zhang, Fang Li, Wentao Liu, Yang Sun, Boyang Yu, Junping Kou. NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. Cell death & disease. 2020 06; 11(6):428. doi: 10.1038/s41419-020-2639-1. [PMID: 32513915]
  • Elisabeth C Kugler, Max van Lessen, Stephan Daetwyler, Karishma Chhabria, Aaron M Savage, Vishmi Silva, Karen Plant, Ryan B MacDonald, Jan Huisken, Robert N Wilkinson, Stefan Schulte-Merker, Paul Armitage, Timothy Ja Chico. Cerebrovascular endothelial cells form transient Notch-dependent cystic structures in zebrafish. EMBO reports. 2019 08; 20(8):e47047. doi: 10.15252/embr.201847047. [PMID: 31379129]
  • Andrzej Wróbel, Urszula Doboszewska, Ewa Rechberger, Małgorzata Bańczerowska-Górska, Piotr Czuczwar, Ewa Poleszak, Jarosław Dudka, Piotr Wlaź, Paweł Miotła, Edyta Wlaźlak, Tomasz Rechberger. Blebbistatin, a Myosin II Inhibitor, Exerts Antidepressant-Like Activity and Suppresses Detrusor Overactivity in an Animal Model of Depression Coexisting with Overactive Bladder. Neurotoxicity research. 2019 Jan; 35(1):196-207. doi: 10.1007/s12640-018-9948-5. [PMID: 30155683]
  • Ehsan Sadeghipour, Miguel A Garcia, William James Nelson, Beth L Pruitt. Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion. eLife. 2018 11; 7(?):. doi: 10.7554/elife.39640. [PMID: 30427775]
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  • Jiliang Hu, Somaye Jafari, Yulong Han, Alan J Grodzinsky, Shengqiang Cai, Ming Guo. Size- and speed-dependent mechanical behavior in living mammalian cytoplasm. Proceedings of the National Academy of Sciences of the United States of America. 2017 09; 114(36):9529-9534. doi: 10.1073/pnas.1702488114. [PMID: 28827333]
  • Shohei Tomii, Takumi Akashi, Noboru Ando, Tomoki Tamura, Akira Sakurai, Asami Terada, Asuka Furukawa, Yoshimi Suzuki, Kou Kayamori, Kei Sakamoto, Hironori Ishibashi, Yoshinobu Eishi. Cortical Actin Alteration at the Matrix-Side Cytoplasm in Lung Adenocarcinoma Cells and Its Significance in Invasion. Pathobiology : journal of immunopathology, molecular and cellular biology. 2017; 84(4):171-183. doi: 10.1159/000452838. [PMID: 28002815]
  • Prabuddha Gupta, René Martin, Hans-Joachim Knölker, Deepak Nihalani, Deepak Kumar Sinha. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. PloS one. 2017; 12(7):e0180301. doi: 10.1371/journal.pone.0180301. [PMID: 28678859]
  • Yongliang Wang, Xuefeng Wang. Integrins outside focal adhesions transmit tensions during stable cell adhesion. Scientific reports. 2016 11; 6(?):36959. doi: 10.1038/srep36959. [PMID: 27845380]
  • Jacob Notbohm, Shiladitya Banerjee, Kazage J C Utuje, Bomi Gweon, Hwanseok Jang, Yongdoo Park, Jennifer Shin, James P Butler, Jeffrey J Fredberg, M Cristina Marchetti. Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophysical journal. 2016 Jun; 110(12):2729-2738. doi: 10.1016/j.bpj.2016.05.019. [PMID: 27332131]
  • Somanna A Kollimada, Ankur H Kulkarni, Aniket Ravan, Namrata Gundiah. Advancing Edge Speeds of Epithelial Monolayers Depend on Their Initial Confining Geometry. PloS one. 2016; 11(4):e0153471. doi: 10.1371/journal.pone.0153471. [PMID: 27078632]
  • Andreas Papadopulos, Guillermo A Gomez, Sally Martin, Jade Jackson, Rachel S Gormal, Damien J Keating, Alpha S Yap, Frederic A Meunier. Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature communications. 2015 Feb; 6(?):6297. doi: 10.1038/ncomms7297. [PMID: 25708831]
  • Rachel S Gormal, Tam H Nguyen, Sally Martin, Andreas Papadopulos, Frederic A Meunier. An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Jan; 35(4):1380-9. doi: 10.1523/jneurosci.3228-14.2015. [PMID: 25632116]
  • Christoph Klingner, Anoop V Cherian, Johannes Fels, Philipp M Diesinger, Roland Aufschnaiter, Nicola Maghelli, Thomas Keil, Gisela Beck, Iva M Tolić-Nørrelykke, Mark Bathe, Roland Wedlich-Soldner. Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells. The Journal of cell biology. 2014 Oct; 207(1):107-21. doi: 10.1083/jcb.201402037. [PMID: 25313407]
  • Zhenan Liu, Chin-Han Ho, Frederick Grinnell. The different roles of myosin IIA and myosin IIB in contraction of 3D collagen matrices by human fibroblasts. Experimental cell research. 2014 Aug; 326(2):295-306. doi: 10.1016/j.yexcr.2014.04.013. [PMID: 24768700]
  • Kai Bodo Grimm, Hans Oberleithner, Johannes Fels. Fixed endothelial cells exhibit physiologically relevant nanomechanics of the cortical actin web. Nanotechnology. 2014 May; 25(21):215101. doi: 10.1088/0957-4484/25/21/215101. [PMID: 24786855]
  • Joel R McDade, Daniel E Michele. Membrane damage-induced vesicle-vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin. Human molecular genetics. 2014 Apr; 23(7):1677-86. doi: 10.1093/hmg/ddt557. [PMID: 24203699]
  • Allen Kuan-Liang Chen, Xiaoli Chen, Yu Ming Lim, Shaul Reuveny, Steve Kah Weng Oh. Inhibition of ROCK-myosin II signaling pathway enables culturing of human pluripotent stem cells on microcarriers without extracellular matrix coating. Tissue engineering. Part C, Methods. 2014 Mar; 20(3):227-38. doi: 10.1089/ten.tec.2013.0191. [PMID: 23777438]
  • Juan A Flores, Santiago Balseiro-Gomez, Jose M Cabeza, Jorge Acosta, Pilar Ramirez-Ponce, Eva Ales. A new role for myosin II in vesicle fission. PloS one. 2014; 9(6):e100757. doi: 10.1371/journal.pone.0100757. [PMID: 24959909]
  • Kai Murk, Elena M Blanco Suarez, Louisa M R Cockbill, Paul Banks, Jonathan G Hanley. The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Journal of cell science. 2013 Sep; 126(Pt 17):3873-83. doi: 10.1242/jcs.125146. [PMID: 23843614]
  • Chen Yu, Li Xu, Lii-fang Chen, Ying-jie Guan, Minsoo Kim, Walter L Biffl, Y Eugene Chin. PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change. Immunopharmacology and immunotoxicology. 2013 Feb; 35(1):71-9. doi: 10.3109/08923973.2012.677046. [PMID: 23083320]
  • Justin D Mih, Aleksandar Marinkovic, Fei Liu, Asma S Sharif, Daniel J Tschumperlin. Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. Journal of cell science. 2012 Dec; 125(Pt 24):5974-83. doi: 10.1242/jcs.108886. [PMID: 23097048]
  • Gurunadh R Chichili, Robert C Cail, William Rodgers. Cytoskeletal modulation of lipid interactions regulates Lck kinase activity. The Journal of biological chemistry. 2012 Jul; 287(29):24186-94. doi: 10.1074/jbc.m111.320747. [PMID: 22613726]
  • Tobias Müller, Elisabeth Rumpel, Susanne Hradetzky, Frank Bollig, Henny Wegner, Antje Blumenthal, Andreas Greinacher, Karlhans Endlich, Nicole Endlich. Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Kidney international. 2011 Nov; 80(10):1055-63. doi: 10.1038/ki.2011.256. [PMID: 21849970]
  • Christoph J Burckhardt, Maarit Suomalainen, Philipp Schoenenberger, Karin Boucke, Silvio Hemmi, Urs F Greber. Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure. Cell host & microbe. 2011 Aug; 10(2):105-17. doi: 10.1016/j.chom.2011.07.006. [PMID: 21843868]
  • Athanasios Denelavas, Franziska Weibel, Michael Prummer, Alexander Imbach, Roger G Clerc, Christian M Apfel, Cornelia Hertel. Real-time cellular impedance measurements detect Ca(2+) channel-dependent oscillations of morphology in human H295R adrenoma cells. Biochimica et biophysica acta. 2011 May; 1813(5):754-62. doi: 10.1016/j.bbamcr.2011.01.016. [PMID: 21262275]
  • Herbert B Schiller, Caroline C Friedel, Cyril Boulegue, Reinhard Fässler. Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO reports. 2011 Mar; 12(3):259-66. doi: 10.1038/embor.2011.5. [PMID: 21311561]
  • Raf Ponsaerts, Elke De Vuyst, Mauricio Retamal, Catheleyne D'hondt, Dieter Vermeire, Nan Wang, Humbert De Smedt, Pascale Zimmermann, Bernard Himpens, Johan Vereecke, Luc Leybaert, Geert Bultynck. Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Nov; 24(11):4378-95. doi: 10.1096/fj.09-153007. [PMID: 20634352]
  • Pirjo Spuul, Giuseppe Balistreri, Leevi Kääriäinen, Tero Ahola. Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomes. Journal of virology. 2010 Aug; 84(15):7543-57. doi: 10.1128/jvi.00477-10. [PMID: 20484502]
  • Faiza Waheed, Pam Speight, Glenn Kawai, Qinghong Dan, András Kapus, Katalin Szászi. Extracellular signal-regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase. American journal of physiology. Cell physiology. 2010 Jun; 298(6):C1376-87. doi: 10.1152/ajpcell.00408.2009. [PMID: 20237148]
  • Jin Si, Yan Ge, Shougang Zhuang, Rujun Gong. Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease. Laboratory investigation; a journal of technical methods and pathology. 2010 Mar; 90(3):448-58. doi: 10.1038/labinvest.2009.142. [PMID: 20065948]
  • Sangmyung Rhee, Chin-Han Ho, Frederick Grinnell. Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Experimental cell research. 2010 Jan; 316(2):232-44. doi: 10.1016/j.yexcr.2009.09.021. [PMID: 19796636]
  • Yuhki Yanase, Nicolas Carvou, Michael A Frohman, Shamshad Cockcroft. Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6. The Biochemical journal. 2009 Dec; 425(1):179-93. doi: 10.1042/bj20091122. [PMID: 19845506]
  • Siva A Vanapalli, Yixuan Li, Frieder Mugele, Michel H G Duits. On the origins of the universal dynamics of endogenous granules in mammalian cells. Molecular & cellular biomechanics : MCB. 2009 Dec; 6(4):191-201. doi: ". [PMID: 19899443]
  • Jason P Laliberte, Bernard Moss. Appraising the apoptotic mimicry model and the role of phospholipids for poxvirus entry. Proceedings of the National Academy of Sciences of the United States of America. 2009 Oct; 106(41):17517-21. doi: 10.1073/pnas.0909376106. [PMID: 19805093]
  • Kiyoko Hosaka, Tetsuro Takeda, Noriaki Iino, Michihiro Hosojima, Hiroyoshi Sato, Ryohei Kaseda, Keiko Yamamoto, Asako Kobayashi, Fumitake Gejyo, Akihiko Saito. Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Kidney international. 2009 Jun; 75(12):1308-1315. doi: 10.1038/ki.2009.85. [PMID: 19340093]
  • Charles M Cuerrier, Martin Benoit, Gaétan Guillemette, Fernand Gobeil, Michel Grandbois. Real-time monitoring of angiotensin II-induced contractile response and cytoskeleton remodeling in individual cells by atomic force microscopy. Pflugers Archiv : European journal of physiology. 2009 Apr; 457(6):1361-72. doi: 10.1007/s00424-008-0596-0. [PMID: 18953565]
  • Maya Tanaka, Tatsuya Abe, Yoshitaka Hara. Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts. Journal of cellular physiology. 2009 Apr; 219(1):194-201. doi: 10.1002/jcp.21668. [PMID: 19107843]
  • Khajak Berberian, Alexis J Torres, Qinghua Fang, Kassandra Kisler, Manfred Lindau. F-actin and myosin II accelerate catecholamine release from chromaffin granules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Jan; 29(3):863-70. doi: 10.1523/jneurosci.2818-08.2009. [PMID: 19158310]
  • Guangwei Du, Michael A Frohman. A lipid-signaled myosin phosphatase surge disperses cortical contractile force early in cell spreading. Molecular biology of the cell. 2009 Jan; 20(1):200-8. doi: 10.1091/mbc.e08-06-0555. [PMID: 18946083]
  • F Kent Fulcher, Bethany T Smith, Misty Russ, Yashomati M Patel. Dual role for myosin II in GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Experimental cell research. 2008 Oct; 314(17):3264-74. doi: 10.1016/j.yexcr.2008.08.007. [PMID: 18773891]
  • D Turina, V M Loitto, K Björnström, T Sundqvist, C Eintrei. Propofol causes neurite retraction in neurones. British journal of anaesthesia. 2008 Sep; 101(3):374-9. doi: 10.1093/bja/aen185. [PMID: 18587139]
  • Chung-Lin Chou, Ming-Jiun Yu, Eliza M Kassai, Ryan G Morris, Jason D Hoffert, Susan M Wall, Mark A Knepper. Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct. American journal of physiology. Renal physiology. 2008 Jul; 295(1):F192-201. doi: 10.1152/ajprenal.00011.2008. [PMID: 18417545]
  • Andrei I Ivanov, Ann M Hopkins, G Thomas Brown, Kirsten Gerner-Smidt, Brian A Babbin, Charles A Parkos, Asma Nusrat. Myosin II regulates the shape of three-dimensional intestinal epithelial cysts. Journal of cell science. 2008 Jun; 121(11):1803-14. doi: 10.1242/jcs.015842. [PMID: 18460584]
  • David Cohen, Yuan Tian, Anne Müsch. Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling. Molecular biology of the cell. 2007 Jun; 18(6):2203-15. doi: 10.1091/mbc.e07-02-0095. [PMID: 17409351]
  • Masamitsu Kanada, Akira Nagasaki, Taro Q P Uyeda. Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells. Molecular biology of the cell. 2005 Aug; 16(8):3865-72. doi: 10.1091/mbc.e05-03-0233. [PMID: 15944220]
  • Wayne Chan, German Calderon, Amy L Swift, Jamie Moseley, Shaohua Li, Hiroshi Hosoya, Irwin M Arias, Daniel F Ortiz. Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells. The Journal of biological chemistry. 2005 Jun; 280(25):23741-7. doi: 10.1074/jbc.m502767200. [PMID: 15826951]
  • Paul A Steimle, F Kent Fulcher, Yashomati M Patel. A novel role for myosin II in insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Biochemical and biophysical research communications. 2005 Jun; 331(4):1560-5. doi: 10.1016/j.bbrc.2005.04.082. [PMID: 15883051]
  • Andrei I Ivanov, Dirk Hunt, Markus Utech, Asma Nusrat, Charles A Parkos. Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Molecular biology of the cell. 2005 Jun; 16(6):2636-50. doi: 10.1091/mbc.e05-01-0043. [PMID: 15800060]
  • Minakshi Guha, Mian Zhou, Yu-Li Wang. Cortical actin turnover during cytokinesis requires myosin II. Current biology : CB. 2005 Apr; 15(8):732-6. doi: 10.1016/j.cub.2005.03.042. [PMID: 15854905]
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