Ibogamine (BioDeep_00000171750)

human metabolite blood metabolite natural product

代谢物信息卡片

6,9-Methano-5H-pyrido[1,2:1,2]azepino[4,5-b]indole, 7-ethyl-6,6a,7,8,9,10,12,13-octahydro-, [6R-(6alpha,6abeta,7beta,9alpha)]-

化学式: C19H24N2 (280.1939384)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1CC2CC3C1N(C2)CCC1=C3NC2=CC=CC=C12
InChI: InChI=1S/C19H24N2/c1-2-13-9-12-10-16-18-15(7-8-21(11-12)19(13)16)14-5-3-4-6-17(14)20-18/h3-6,12-13,16,19-20H,2,7-11H2,1H3

描述信息

同义名列表

3 个代谢物同义名

6,9-Methano-5H-pyrido[1,2:1,2]azepino[4,5-b]indole, 7-ethyl-6,6a,7,8,9,10,12,13-octahydro-, [6R-(6alpha,6abeta,7beta,9alpha)]-; 17-ethyl-3,13-diazapentacyclo[13.3.1.0²,¹⁰.0⁴,⁹.0¹³,¹⁸]nonadeca-2(10),4,6,8-tetraene; Ibogamine

数据库引用编号

6 个数据库交叉引用编号

PubChem: 500053
HMDB: HMDB0242533
Wikipedia: Ibogamine
LOTUS: LTS0030139
LOTUS: LTS0179415
wikidata: Q104667254

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

4056 - Apocynaceae: LTS0030139
2759 - Eukaryota: LTS0030139
9606 - Homo sapiens: -
3398 - Magnoliopsida: LTS0030139
35493 - Streptophyta: LTS0030139
52860 - Tabernaemontana: LTS0030139
761054 - Tabernaemontana calcarea: 10.1021/NP020548E
761054 - Tabernaemontana calcarea: LTS0030139
141615 - Tabernaemontana citrifolia: 10.1002/HLCA.19820650729
141615 - Tabernaemontana citrifolia: LTS0030139
52861 - Tabernaemontana divaricata: 10.1021/NP060344O
52861 - Tabernaemontana divaricata: 10.1039/B301167D
52861 - Tabernaemontana divaricata: LTS0030139
58023 - Tracheophyta: LTS0030139
33090 - Viridiplantae: LTS0030139

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Felix Krengel, Marco V Mijangos, Marisol Reyes-Lezama, Ricardo Reyes-Chilpa. Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican Tabernaemontana Species (Apocynaceae). Chemistry & biodiversity. 2019 Jul; 16(7):e1900175. doi: 10.1002/cbdv.201900175. [PMID: 31095891]
Hong-Mei Chen, Yu-Ting Yang, Hong-Xiang Li, Zhi-Xing Cao, Xiao-Mei Dan, Ling Mei, Da-Le Guo, Chuan-Xia Song, Yu Dai, Jia Hu, Yun Deng. Cytotoxic monoterpenoid indole alkaloids isolated from the barks of Voacanga africana Staph. Natural product research. 2016; 30(10):1144-9. doi: 10.1080/14786419.2015.1046132. [PMID: 26140390]
Cédric Mazoyer, Jérémy Carlier, Alexandra Boucher, Michel Péoc'h, Catherine Lemeur, Yvan Gaillard. Fatal case of a 27-year-old male after taking iboga in withdrawal treatment: GC-MS/MS determination of ibogaine and ibogamine in iboga roots and postmortem biological material. Journal of forensic sciences. 2013 Nov; 58(6):1666-72. doi: 10.1111/1556-4029.12250. [PMID: 23919354]
Tamara Antonio, Steven R Childers, Richard B Rothman, Christina M Dersch, Christine King, Martin Kuehne, William G Bornmann, Amy J Eshleman, Aaron Janowsky, Eric R Simon, Maarten E A Reith, Kenneth Alper. Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation. PloS one. 2013; 8(10):e77262. doi: 10.1371/journal.pone.0077262. [PMID: 24204784]
Christopher W Jenks. Extraction studies of Tabernanthe iboga and Voacanga africana. Natural product letters. 2002 Feb; 16(1):71-6. doi: 10.1080/1057563029001/4881. [PMID: 11942686]