(2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone (BioDeep_00000171700)
human metabolite blood metabolite
代谢物信息卡片
(2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone
化学式: C22H22IN3O3 (503.0705852)
中文名称: (R,S)-3-(2-碘-5-硝基苯甲酰)-1-(1-甲基-2-哌啶甲基)-1H-吲哚
谱图信息:
最多检出来源 Homo sapiens(blood) 87.5%
分子结构信息
SMILES: CN1CCCCC1CN1C=C(C(=O)C2=C(I)C=CC(=C2)[N+]([O-])=O)C2=CC=CC=C12
InChI: InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 10141893
- HMDB: HMDB0242472
- ChEMBL: CHEMBL408430
- chemspider: 8317404
- CAS: 444912-48-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feier Zeng, Abbie Wade, Kade Harbert, Shrina Patel, Joshua S Holley, Cornelia K Dehghanpuor, Thomas Hopwood, Silvia Marino, Antonia Sophocleous, Aymen I Idris. Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation.
Scientific reports.
2024 03; 14(1):5782. doi:
10.1038/s41598-024-56220-0. [PMID: 38461339] - Wenhua Liu, Changgong Chen, Xingjian Gu, Li Zhang, Xiang Mao, Zili Chen, Luyuan Tao. AM1241 alleviates myocardial ischemia-reperfusion injury in rats by enhancing Pink1/Parkin-mediated autophagy.
Life sciences.
2021 May; 272(?):119228. doi:
10.1016/j.lfs.2021.119228. [PMID: 33607150] - Yafeng Wu, Run Ma, Cuizhen Long, Yuanhui Shu, Ping He, Yan Zhou, Yining Xiang, Yuping Wang. The protective effect of cannabinoid type II receptor agonist AM1241 on ConA-induced liver injury in mice via mitogen-activated protein kinase signalling pathway.
International journal of immunopathology and pharmacology.
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Fundamental & clinical pharmacology.
2020 Feb; 34(1):80-90. doi:
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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2017 Nov; 25(11):841-846. doi:
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American journal of therapeutics.
2016 Nov; 23(6):e1484-e1492. doi:
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British journal of pharmacology.
2016 Apr; 173(7):1128-42. doi:
10.1111/bph.13056. [PMID: 25537025] - Xiang Li, Dong Han, Zuhong Tian, Beilei Gao, Miaomiao Fan, Congye Li, Xiujuan Li, Yabin Wang, Sai Ma, Feng Cao. Activation of Cannabinoid Receptor Type II by AM1241 Ameliorates Myocardial Fibrosis via Nrf2-Mediated Inhibition of TGF-β1/Smad3 Pathway in Myocardial Infarction Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(4):1521-36. doi:
10.1159/000447855. [PMID: 27614871] - David R Janero, Alexandros Makriyannis. Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems.
ACS chemical neuroscience.
2014 Nov; 5(11):1097-106. doi:
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Life sciences.
2013 Mar; 92(8-9):482-91. doi:
10.1016/j.lfs.2012.06.019. [PMID: 22749867] - Carol A Paronis, Ganesh A Thakur, Shama Bajaj, Spyros P Nikas, V Kiran Vemuri, Alexandros Makriyannis, Jack Bergman. Diuretic effects of cannabinoids.
The Journal of pharmacology and experimental therapeutics.
2013 Jan; 344(1):8-14. doi:
10.1124/jpet.112.199331. [PMID: 23019138] - Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhang. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists.
Prostaglandins & other lipid mediators.
2013 Jan; 100-101(?):1-14. doi:
10.1016/j.prostaglandins.2012.11.003. [PMID: 23219970] - Federica Barutta, Fabiana Piscitelli, Silvia Pinach, Graziella Bruno, Roberto Gambino, Maria Pia Rastaldi, Gennaro Salvidio, Vincenzo Di Marzo, Paolo Cavallo Perin, Gabriella Gruden. Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy.
Diabetes.
2011 Sep; 60(9):2386-96. doi:
10.2337/db10-1809. [PMID: 21810593] - Shuxian Jiang, Meritxell Alberich-Jorda, Radoslaw Zagozdzon, Kalindi Parmar, Yigong Fu, Peter Mauch, Naheed Banu, Alexandros Makriyannis, Daniel G Tenen, Shalom Avraham, Jerome E Groopman, Hava Karsenty Avraham. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.
Blood.
2011 Jan; 117(3):827-38. doi:
10.1182/blood-2010-01-265082. [PMID: 21063029] - Andrea De Gottardi, Laurent Spahr, Florence Ravier-Dall'Antonia, Antoine Hadengue. Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.
Liver international : official journal of the International Association for the Study of the Liver.
2010 Nov; 30(10):1482-9. doi:
10.1111/j.1478-3231.2010.02298.x. [PMID: 20602678] - Ying-Ying Yang, Han-Chieh Lin. Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis.
Liver international : official journal of the International Association for the Study of the Liver.
2010 Nov; 30(10):1397-9. doi:
10.1111/j.1478-3231.2010.02352.x. [PMID: 20860563] - Betty B Yao, Gin Hsieh, Anthony V Daza, Yihong Fan, George K Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A Hooker, Madhavi Pai, Erica J Wensink, Anita K Salyers, Prasant Chandran, Chang Z Zhu, Chengmin Zhong, Keith Ryther, Megan E Gallagher, Chih-Liang Chin, Ann E Tovcimak, Vincent P Hradil, Gerard B Fox, Michael J Dart, Prisca Honore, Michael D Meyer. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.
The Journal of pharmacology and experimental therapeutics.
2009 Jan; 328(1):141-51. doi:
10.1124/jpet.108.145011. [PMID: 18931146] - Hiroshi Ohta, Tomoko Ishizaka, Makoto Tatsuzuki, Mitsukane Yoshinaga, Izumi Iida, Tomomi Yamaguchi, Yasumitsu Tomishima, Nobuko Futaki, Yoshihisa Toda, Shuji Saito. Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action.
Bioorganic & medicinal chemistry.
2008 Feb; 16(3):1111-24. doi:
10.1016/j.bmc.2007.10.087. [PMID: 18006322] - Armen N Akopian, Nikita B Ruparel, Amol Patwardhan, Kenneth M Hargreaves. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Jan; 28(5):1064-75. doi:
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