(2-Acetyloxy-3-hydroxypropyl) (E)-octadec-9-enoate (BioDeep_00000171687)
human metabolite blood metabolite
代谢物信息卡片
(2-Acetyloxy-3-hydroxypropyl) (e)-octadec-9-enoic acid
化学式: C23H42O5 (398.30320820000003)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 94.74%
分子结构信息
SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCC(CO)OC(C)=O
InChI: InChI=1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Susanne Fiedler, Ursula Storch, Serap Erdogmus, Thomas Gudermann, Michael Mederos Y Schnitzler, Alexander Dietrich. Small Fluorescein Arsenical Hairpin-Based Förster Resonance Energy Transfer Analysis Reveals Changes in Amino- to Carboxyl-Terminal Interactions upon OAG Activation of Classical Transient Receptor Potential 6.
Molecular pharmacology.
2019 07; 96(1):90-98. doi:
10.1124/mol.119.115949. [PMID: 31171574] - Cory Wilson, Stuart E Dryer. A mutation in TRPC6 channels abolishes their activation by hypoosmotic stretch but does not affect activation by diacylglycerol or G protein signaling cascades.
American journal of physiology. Renal physiology.
2014 May; 306(9):F1018-25. doi:
10.1152/ajprenal.00662.2013. [PMID: 24598806] - Karin M Streifel, James Miller, Rola Mouneimne, Ronald B Tjalkens. Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes.
Neurotoxicology.
2013 Jan; 34(?):160-6. doi:
10.1016/j.neuro.2012.10.014. [PMID: 23131343] - Paolo Ariano, Simona Dalmazzo, Grzegorz Owsianik, Bernd Nilius, Davide Lovisolo. TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons.
Cell calcium.
2011 Jun; 49(6):387-94. doi:
10.1016/j.ceca.2011.03.007. [PMID: 21511334] - Jie Li, Zhi-Zhong Xie, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan. Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice.
European journal of pharmacology.
2011 Feb; 652(1-3):104-10. doi:
10.1016/j.ejphar.2010.11.017. [PMID: 21122802] - Tamera K Bardell, Eric L Barker. Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells.
Neurochemistry international.
2010 Aug; 57(1):76-83. doi:
10.1016/j.neuint.2010.05.002. [PMID: 20466028] - Wayne I DeHaven, Bertina F Jones, John G Petranka, Jeremy T Smyth, Takuro Tomita, Gary S Bird, James W Putney. TRPC channels function independently of STIM1 and Orai1.
The Journal of physiology.
2009 May; 587(Pt 10):2275-98. doi:
10.1113/jphysiol.2009.170431. [PMID: 19332491] - Peng Tu, Christiane Kunert-Keil, Silke Lucke, Heinrich Brinkmeier, Alexandre Bouron. Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Journal of neurochemistry.
2009 Jan; 108(1):126-38. doi:
10.1111/j.1471-4159.2008.05752.x. [PMID: 19094061] - Kristy L Houck, Todd E Fox, Lakshman Sandirasegarane, Mark Kester. Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling.
American journal of physiology. Heart and circulatory physiology.
2008 Oct; 295(4):H1657-68. doi:
10.1152/ajpheart.00141.2008. [PMID: 18723771] - Rachel Ross, Penny Y T Wang, Madhu Chari, Carol K L Lam, Liora Caspi, Hiraku Ono, Evan D Muse, Xiaosong Li, Roger Gutierrez-Juarez, Peter E Light, Gary J Schwartz, Luciano Rossetti, Tony K T Lam. Hypothalamic protein kinase C regulates glucose production.
Diabetes.
2008 Aug; 57(8):2061-5. doi:
10.2337/db08-0206. [PMID: 18511848] - Christoffer Löf, Tomas Blom, Kid Törnquist. Overexpression of TRPC3 reduces the content of intracellular calcium stores in HEK-293 cells.
Journal of cellular physiology.
2008 Jul; 216(1):245-52. doi:
10.1002/jcp.21396. [PMID: 18431718] - Tarik Smani, Tina Patel, Victoria M Bolotina. Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.
American journal of physiology. Cell physiology.
2008 Jun; 294(6):C1499-508. doi:
10.1152/ajpcell.00365.2007. [PMID: 18434622] - Loïc Lemonnier, Mohamed Trebak, James W Putney. Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate.
Cell calcium.
2008 May; 43(5):506-14. doi:
10.1016/j.ceca.2007.09.001. [PMID: 17942152] - Hua Zhang, Ryuji Inoue, Juan Shi, Xiao-hang Jin, Yun-qing Li. Synergistic actions of diacylglycerol and inositol 1,4,5 trisphosphate for Ca2+-dependent inactivation of TRPC7 channel.
Acta pharmacologica Sinica.
2008 Jan; 29(1):90-7. doi:
10.1111/j.1745-7254.2008.00721.x. [PMID: 18158870] - Wei Zhang, Edgar Zitron, Meike Hömme, Lars Kihm, Christian Morath, Daniel Scherer, Stephan Hegge, Dierk Thomas, Claus P Schmitt, Martin Zeier, Hugo Katus, Christoph Karle, Vedat Schwenger. Aquaporin-1 channel function is positively regulated by protein kinase C.
The Journal of biological chemistry.
2007 Jul; 282(29):20933-40. doi:
10.1074/jbc.m703858200. [PMID: 17522053] - Tom Litjens, Than Nguyen, Joel Castro, Edoardo C Aromataris, Lynette Jones, Greg J Barritt, Grigori Y Rychkov. Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells.
The Biochemical journal.
2007 Jul; 405(2):269-76. doi:
10.1042/bj20061762. [PMID: 17432954] - C M Peppiatt-Wildman, A P Albert, S N Saleh, W A Large. Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes.
The Journal of physiology.
2007 May; 580(Pt.3):755-64. doi:
10.1113/jphysiol.2006.126656. [PMID: 17303636] - Carolina Kirchheimer, Carlos F Mendez, Andrea Acquier, Susana Nowicki. Role of 20-HETE in D1/D2 dopamine receptor synergism resulting in the inhibition of Na+-K+-ATPase activity in the proximal tubule.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1435-42. doi:
10.1152/ajprenal.00176.2006. [PMID: 17264308] - Jérémy Fauconnier, Johanna T Lanner, Ariane Sultan, Shi-Jin Zhang, Abram Katz, Joseph D Bruton, Håkan Westerblad. Insulin potentiates TRPC3-mediated cation currents in normal but not in insulin-resistant mouse cardiomyocytes.
Cardiovascular research.
2007 Jan; 73(2):376-85. doi:
10.1016/j.cardiores.2006.10.018. [PMID: 17156765] - S N Saleh, A P Albert, C M Peppiatt, W A Large. Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.
The Journal of physiology.
2006 Dec; 577(Pt 2):479-95. doi:
10.1113/jphysiol.2006.119305. [PMID: 16973707] - Agnes C L Martin, Dermot M F Cooper. Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8.
Molecular pharmacology.
2006 Aug; 70(2):769-77. doi:
10.1124/mol.106.025213. [PMID: 16723496] - Mark Estacion, William G Sinkins, Stephen W Jones, Milana A B Applegate, William P Schilling. Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability.
The Journal of physiology.
2006 Apr; 572(Pt 2):359-77. doi:
10.1113/jphysiol.2005.103143. [PMID: 16439426] - Efrat Eliyahu, Nataly Shtraizent, Alina Tsaadon, Ruth Shalgi. Association between myristoylated alanin-rich C kinase substrate (MARCKS) translocation and cortical granule exocytosis in rat eggs.
Reproduction (Cambridge, England).
2006 Feb; 131(2):221-31. doi:
10.1530/rep.1.00794. [PMID: 16452716] - Jean-Philippe Lievremont, Takuro Numaga, Guillermo Vazquez, Loïc Lemonnier, Yuji Hara, Emiko Mori, Mohamed Trebak, Stephen E Moss, Gary S Bird, Yasuo Mori, James W Putney. The role of canonical transient receptor potential 7 in B-cell receptor-activated channels.
The Journal of biological chemistry.
2005 Oct; 280(42):35346-51. doi:
10.1074/jbc.m507606200. [PMID: 16123040] - Christina Hörnig, Dana Albert, Lutz Fischer, Michael Hörnig, Olof Rådmark, Dieter Steinhilber, Oliver Werz. 1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain.
The Journal of biological chemistry.
2005 Jul; 280(29):26913-21. doi:
10.1074/jbc.m500068200. [PMID: 15923196] - Marisa J Wainszelbaum, María L Belaunzarán, Estela M Lammel, Mónica Florin-Christensen, Jorge Florin-Christensen, Elvira L D Isola. Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.
The Biochemical journal.
2003 Nov; 375(Pt 3):705-12. doi:
10.1042/bj20021907. [PMID: 12887332] - M Tateyama, J Kurokawa, C Terrenoire, I Rivolta, R S Kass. Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels.
Circulation.
2003 Jul; 107(25):3216-22. doi:
10.1161/01.cir.0000070936.65183.97. [PMID: 12796143] - Olivier Mignen, Jill L Thompson, Trevor J Shuttleworth. Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels.
The Journal of biological chemistry.
2003 Mar; 278(12):10174-81. doi:
10.1074/jbc.m212536200. [PMID: 12522216] - Efrat Eliyahu, Ruth Shalgi. A role for protein kinase C during rat egg activation.
Biology of reproduction.
2002 Jul; 67(1):189-95. doi:
10.1095/biolreprod67.1.189. [PMID: 12080017] - Y Tesfai, H M Brereton, G J Barritt. A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein.
The Biochemical journal.
2001 Sep; 358(Pt 3):717-26. doi:
10.1042/0264-6021:3580717. [PMID: 11535132] - Z Su, P Csutora, D Hunton, R L Shoemaker, R B Marchase, J E Blalock. A store-operated nonselective cation channel in lymphocytes is activated directly by Ca(2+) influx factor and diacylglycerol.
American journal of physiology. Cell physiology.
2001 May; 280(5):C1284-92. doi:
10.1152/ajpcell.2001.280.5.c1284. [PMID: 11287342] - Y Isohama, M Kanemaru, H Kai, K Takahama, T Miyata. Interaction between beta-adrenergic signaling and protein kinase C increases cytoplasmic Ca2+ in alveolar type II cells.
Life sciences.
2001 Apr; 68(21):2361-71. doi:
10.1016/s0024-3205(01)01028-1. [PMID: 11350007] - M I Zhang, R G O'Neil. Kinetics of activation of a PKC-regulated epithelial calcium channel.
Cell calcium.
2001 Apr; 29(4):263-75. doi:
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2001 Jan; 280(2):435-9. doi:
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