(1R)-1,3-Bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-4,5-dihydroxycyclohexane-1-carboxylic acid (BioDeep_00000171592)

   

human metabolite blood metabolite


代谢物信息卡片


(1R)-1,3-Bis[3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-4,5-dihydroxycyclohexane-1-carboxylic acid

化学式: C25H24O12 (516.1268)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 2.56%

分子结构信息

SMILES: O=C(C=Cc1ccc(O)c(O)c1)OC1CC(OC(=O)C=Cc2ccc(O)c(O)c2)(C(=O)O)CC(O)C1O
InChI: InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Rei Uranishi, Raju Aedla, Doaa H M Alsaadi, Dongxing Wang, Ken Kusakari, Hirotaka Osaki, Koji Sugimura, Takashi Watanabe. Evaluation of Environmental Factor Effects on the Polyphenol and Flavonoid Content in the Leaves of Chrysanthemum indicum L. and Its Habitat Suitability Prediction Mapping. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050927. [PMID: 38474439]
  • Pu Zhang, Kewei Rong, Jiadong Guo, Lei Cui, Keyu Kong, Chen Zhao, Huan Yang, Hongtao Xu, An Qin, Peixiang Ma, Xiao Yang, Jie Zhao. Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 165(?):115252. doi: 10.1016/j.biopha.2023.115252. [PMID: 37536034]
  • Chang Ho Yoon, Hyun-Jae Jang, Jin Suk Ryu, Jung Hwa Ko, Kyung-Seop Ahn, Sei-Ryang Oh, Jang-Hee Oh, Jin Ho Chung, Joo Youn Oh. 1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface. The ocular surface. 2023 Jun; 29(?):469-479. doi: 10.1016/j.jtos.2023.06.016. [PMID: 37390940]
  • Cheng-Wei Lu, Tzu-Yu Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Neurochemistry international. 2023 May; 167(?):105537. doi: 10.1016/j.neuint.2023.105537. [PMID: 37164158]
  • Chun-Yong Sun, Le-Le Yang, Pan Zhao, Pei-Zheng Yan, Jia Li, Dong-Sheng Zhao. Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment. Hereditas. 2022 Dec; 159(1):44. doi: 10.1186/s41065-022-00256-7. [PMID: 36451177]
  • Changgui Wu, Shaohua Chen, Yang Liu, Bo Kong, Wei Yan, Tao Jiang, Hao Tian, Zhaoyi Liu, Qi Shi, Yongjun Wang, Qianqian Liang, Xiaobing Xi, Hao Xu. Cynarin suppresses gouty arthritis induced by monosodium urate crystals. Bioengineered. 2022 05; 13(5):11782-11793. doi: 10.1080/21655979.2022.2072055. [PMID: 35546047]
  • Kateryna Murlanova, Netanela Cohen, Anna Pinkus, Liudmila Vinnikova, Mikhail Pletnikov, Michael Kirby, Jonathan Gorelick, Elyashiv Drori, Albert Pinhasov. Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract. Scientific reports. 2022 03; 12(1):3647. doi: 10.1038/s41598-022-04840-9. [PMID: 35256610]
  • Rong Li, Mingfang Tao, Ting Wu, Zhang Zhuo, Tingting Xu, Siyi Pan, Xiaoyun Xu. A promising strategy for investigating the anti-aging effect of natural compounds: a case study of caffeoylquinic acids. Food & function. 2021 Sep; 12(18):8583-8593. doi: 10.1039/d1fo01383a. [PMID: 34338272]
  • Reham Wagdy, Reham M Abdelkader, Ahmed H El-Khatib, Michael W Linscheid, Nabila Hamdi, Heba Handoussa. Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L. Journal of food science. 2019 May; 84(5):1012-1022. doi: 10.1111/1750-3841.14587. [PMID: 31017668]
  • Nuramina Mamat, Xue Ying Lu, Maidina Kabas, Haji Akber Aisa. Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd. International journal of molecular medicine. 2018 Nov; 42(5):2665-2675. doi: 10.3892/ijmm.2018.3861. [PMID: 30226537]
  • Yankun Chen, Xi Chen, Ganggang Luo, Xu Zhang, Fang Lu, Liansheng Qiao, Wenjing He, Gongyu Li, Yanling Zhang. Discovery of Potential Inhibitors of Squalene Synthase from Traditional Chinese Medicine Based on Virtual Screening and In Vitro Evaluation of Lipid-Lowering Effect. Molecules (Basel, Switzerland). 2018 Apr; 23(5):. doi: 10.3390/molecules23051040. [PMID: 29710800]
  • Zineb Hakkou, Alexandre Maciuk, Veronique Leblais, Nour Elhouda Bouanani, Hassane Mekhfi, Mohammed Bnouham, Mohammed Aziz, Abderrahime Ziyyat, Abdur Rauf, Taibi Ben Hadda, Usama Shaheen, Seema Patel, Rodolphe Fischmeister, Abdelkhaleq Legssyer. Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):62-69. doi: 10.1016/j.biopha.2017.06.015. [PMID: 28623784]
  • Przemysław Sitarek, Ewa Skała, Monika Toma, Marzena Wielanek, Janusz Szemraj, Tomasz Skorski, Adam J Białas, Tomasz Sakowicz, Tomasz Kowalczyk, Maciej Radek, Halina Wysokińska, Tomasz Śliwiński. Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells. Pathology oncology research : POR. 2017 Jul; 23(3):679-687. doi: 10.1007/s12253-016-0170-6. [PMID: 28032310]
  • Zhe Wang, Shixi Wang, Baoli Qin. An LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and 1-O-acetylbritannilactone in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Mar; 31(3):. doi: 10.1002/bmc.3811. [PMID: 27518585]
  • Jing Tong, Qi-Gui Mo, Bing-Xin Ma, Lan-Lan Ge, Gao Zhou, You-Wei Wang. The protective effects of Cichorium glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro. Food & function. 2017 Jan; 8(1):209-219. doi: 10.1039/c6fo01531j. [PMID: 27966724]
  • Maryam Salami, Mehdi Rahimmalek, Mohammad Hossein Ehtemam. Inhibitory effect of different fennel (Foeniculum vulgare) samples and their phenolic compounds on formation of advanced glycation products and comparison of antimicrobial and antioxidant activities. Food chemistry. 2016 Dec; 213(?):196-205. doi: 10.1016/j.foodchem.2016.06.070. [PMID: 27451172]
  • L X Chen, D J Hu, S C Lam, L Ge, D Wu, J Zhao, Z R Long, W J Yang, B Fan, S P Li. Comparison of antioxidant activities of different parts from snow chrysanthemum (Coreopsis tinctoria Nutt.) and identification of their natural antioxidants using high performance liquid chromatography coupled with diode array detection and mass spectrometry and 2,2'-azinobis(3-ethylbenzthiazoline-sulfonic acid)diammonium salt-based assay. Journal of chromatography. A. 2016 Jan; 1428(?):134-42. doi: 10.1016/j.chroma.2015.10.037. [PMID: 26521095]
  • Meryem Topal, Hulya Gocer, Fevzi Topal, Pınar Kalin, Leyla Polat Köse, İlhami Gülçin, Kader C Çakmak, Murat Küçük, Lokman Durmaz, Ahmet C Gören, Saleh H Alwasel. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). Journal of enzyme inhibition and medicinal chemistry. 2016; 31(2):266-75. doi: 10.3109/14756366.2015.1018244. [PMID: 25792498]
  • Wen-Zheng Ju, Yang Zhao, Fang Liu, Ting Wu, Jun Zhang, Shi-Jia Liu, Ling Zhou, Guo-Liang Dai, Ning-Ning Xiong, Zhu-Yuan Fang. Clinical tolerability and pharmacokinetics of Erigerontis hydroxybenzene injection: results of a randomized phase I study in healthy Chinese volunteers. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Feb; 22(2):319-25. doi: 10.1016/j.phymed.2014.11.014. [PMID: 25765839]
  • Shah Hussain, Cornelia Pezzei, Yüksel Güzel, Matthias Rainer, Christian W Huck, Günther K Bonn. Zirconium silicate assisted removal of residual proteins after organic solvent deproteinization of human plasma, enhancing the stability of the LC-ESI-MS response for the bioanalysis of small molecules. Analytica chimica acta. 2014 Dec; 852(?):284-92. doi: 10.1016/j.aca.2014.09.014. [PMID: 25441909]
  • Y V Vereshchagina, V P Bulgakov, V P Grigorchuk, V G Rybin, G N Veremeichik, G K Tchernoded, T Y Gorpenchenko, O G Koren, N H T Phan, N T Minh, L T Chau, Y N Zhuravlev. The rolC gene increases caffeoylquinic acid production in transformed artichoke cells. Applied microbiology and biotechnology. 2014 Sep; 98(18):7773-80. doi: 10.1007/s00253-014-5869-2. [PMID: 24938208]
  • Hosakatte Niranjana Murthy, Yun-Soo Kim, So-Young Park, Kee-Yoeup Paek. Biotechnological production of caffeic acid derivatives from cell and organ cultures of Echinacea species. Applied microbiology and biotechnology. 2014 Sep; 98(18):7707-17. doi: 10.1007/s00253-014-5962-6. [PMID: 25077780]
  • Veronika Petruľová, Zuzana Dučaiová, Miroslav Repčák. Short-term UV-B dose stimulates production of protective metabolites in Matricaria chamomilla leaves. Photochemistry and photobiology. 2014 Sep; 90(5):1061-8. doi: 10.1111/php.12300. [PMID: 24913599]
  • Ning Xia, Andrea Pautz, Ursula Wollscheid, Gisela Reifenberg, Ulrich Förstermann, Huige Li. Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. Molecules (Basel, Switzerland). 2014 Mar; 19(3):3654-68. doi: 10.3390/molecules19033654. [PMID: 24662080]
  • Zhi-Yu Zhang, Duan-Yun Si, Xiu-Lin Yi, Chang-Xiao Liu. Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1. Chinese journal of natural medicines. 2014 Feb; 12(2):131-8. doi: 10.1016/s1875-5364(14)60021-2. [PMID: 24636064]
  • Giuseppe Colla, Youssef Rouphael, Mariateresa Cardarelli, Eva Svecova, Elvira Rea, Luigi Lucini. Effects of saline stress on mineral composition, phenolic acids and flavonoids in leaves of artichoke and cardoon genotypes grown in floating system. Journal of the science of food and agriculture. 2013 Mar; 93(5):1119-27. doi: 10.1002/jsfa.5861. [PMID: 22936423]
  • Kil Sun Yoo, Eun Jin Lee, Daniel Leskovar, Bhimanagouda S Patil. Development of an automated method for Folin-Ciocalteu total phenolic assay in artichoke extracts. Journal of food science. 2012 Dec; 77(12):C1279-84. doi: 10.1111/j.1750-3841.2012.02973.x. [PMID: 23163965]
  • Maha Ahmed Aboul-Ela, Abdalla Mohamed El-Lakany, Safa Mohamed Shams Eldin, Hala Mostafa Hammoda. A new validated HPTLC method for quantitative determination of 1, 5-dicaffeoylquinic acid in Inula crithmoides roots. Pakistan journal of pharmaceutical sciences. 2012 Oct; 25(4):721-5. doi: ". [PMID: 23009986]
  • A Angelini, R Di Pietro, L Centurione, M L Castellani, P Conti, E Porreca, F Cuccurullo. Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells. Journal of biological regulators and homeostatic agents. 2012 Jul; 26(3):495-504. doi: . [PMID: 23034269]
  • Zheng Sun, Jingnan Chen, Jinyu Ma, Yue Jiang, Mingfu Wang, Guixing Ren, Feng Chen. Cynarin-rich sunflower (Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. Journal of agricultural and food chemistry. 2012 Mar; 60(12):3260-5. doi: 10.1021/jf300737y. [PMID: 22394088]
  • Donatella Negro, Vincenzo Montesano, Sabrina Grieco, Pasquale Crupi, Giulio Sarli, Antonino De Lisi, Gabriella Sonnante. Polyphenol compounds in artichoke plant tissues and varieties. Journal of food science. 2012 Feb; 77(2):C244-52. doi: 10.1111/j.1750-3841.2011.02531.x. [PMID: 22251096]
  • Maksymilian Kulza, Katarzyna Malinowska, Anna Woźniak, Monika Seńczuk-Przybyłowska, Gerard Nowak, Ewa Florek. [Development and validation of method for the determination of cynarin, luteolin in plasma]. Przeglad lekarski. 2012; 69(10):987-91. doi: . [PMID: 23421076]
  • Paula N Brown, Michael Chan, Lori Paley, Joseph M Betz. Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension. Journal of AOAC International. 2011 Sep; 94(5):1400-10. doi: 10.5740/jaoacint.11-142. [PMID: 22165004]
  • Shan Qin, Xuesen Wen. [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jun; 36(11):1474-7. doi: 10.4268/cjcmm20111115. [PMID: 22779181]
  • Katharina Franziska Pirker, Bernard Albert Goodman. Caffeoylquinic acid derived free radicals identified during antioxidant reactions of bitter tea (Ilex latifolia and Ilex kudincha). Food & function. 2010 Dec; 1(3):262-8. doi: 10.1039/c0fo00085j. [PMID: 21776475]
  • Jianglin Liu, Guifang Dou, Xiaona Dong, Dan Yuan, Xiwei Ji, Zhuona Wu, ZhiYun Meng. An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. Biomedical chromatography : BMC. 2010 Sep; 24(9):935-40. doi: 10.1002/bmc.1388. [PMID: 20058327]
  • A Sannia. [Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms]. Minerva gastroenterologica e dietologica. 2010 Jun; 56(2):93-9. doi: ". [PMID: 20485248]
  • Rosalia Ferracane, Giulia Graziani, Monica Gallo, Vincenzo Fogliano, Alberto Ritieni. Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. Journal of pharmaceutical and biomedical analysis. 2010 Jan; 51(2):399-404. doi: 10.1016/j.jpba.2009.03.018. [PMID: 19375261]
  • E J Verspohl, M Ploch, T Windeck, M Klaes, T Schmidt, K Bauer. Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Nov; 15(11):1002-9. doi: 10.1016/j.phymed.2008.02.011. [PMID: 18424104]
  • Ruolan Gu, Guifang Dou, Jing Wang, Junxing Dong, Zhiyun Meng. Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):85-91. doi: 10.1016/j.jchromb.2006.12.055. [PMID: 17267301]
  • Mitja Krizman, Dea Baricevic, Mirko Prosek. Determination of phenolic compounds in fennel by HPLC and HPLC-MS using a monolithic reversed-phase column. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(2):481-5. doi: 10.1016/j.jpba.2006.07.029. [PMID: 16930913]
  • B Benedek, N Geisz, W Jäger, T Thalhammer, B Kopp. Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2006 Nov; 13(9-10):702-6. doi: 10.1016/j.phymed.2005.10.005. [PMID: 16303291]
  • Susan J Murch, Sriyani E Peiris, Wendy L Shi, S M A Zobayed, Praveen K Saxena. Genetic diversity in seed populations of Echinacea purpurea controls the capacity for regeneration, route of morphogenesis and phytochemical composition. Plant cell reports. 2006 Jun; 25(6):522-32. doi: 10.1007/s00299-006-0118-5. [PMID: 16477405]
  • Guo-Chung Dong, Ping-Hsien Chuang, Michael D Forrest, Yi-Chen Lin, Hueih Min Chen. Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method. Journal of medicinal chemistry. 2006 Mar; 49(6):1845-54. doi: 10.1021/jm0509039. [PMID: 16539370]
  • B Yang, Z Y Meng, L P Yan, J X Dong, L B Zou, Z M Tang, G F Dou. Pharmacokinetics and metabolism of 1,5-dicaffeoylquinic acid in rats following a single intravenous administration. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(2):417-22. doi: 10.1016/j.jpba.2005.06.037. [PMID: 16143483]
  • Bo Yang, Zhiyun Meng, Junxing Dong, Liangping Yan, Libo Zou, Zhongming Tang, Guifang Dou. Metabolic profile of 1,5-dicaffeoylquinic acid in rats, an in vivo and in vitro study. Drug metabolism and disposition: the biological fate of chemicals. 2005 Jul; 33(7):930-6. doi: 10.1124/dmd.104.002154. [PMID: 15802385]
  • E Speroni, R Cervellati, P Govoni, S Guizzardi, C Renzulli, M C Guerra. Efficacy of different Cynara scolymus preparations on liver complaints. Journal of ethnopharmacology. 2003 Jun; 86(2-3):203-11. doi: 10.1016/s0378-8741(03)00076-x. [PMID: 12738088]
  • I Koubaa, M Damak. A new dilignan from Cynara cardunculus. Fitoterapia. 2003 Feb; 74(1-2):18-22. doi: 10.1016/s0367-326x(02)00300-3. [PMID: 12628389]
  • Ari Tolonen, Topi Joutsamo, Sampo Mattlla, Terttu Kämäräinen, Jorma Jalonen. Identification of isomeric dicaffeoylquinic acids from Eleutherococcus senticosus using HPLC-ESI/TOF/MS and 1H-NMR methods. Phytochemical analysis : PCA. 2002 Nov; 13(6):316-28. doi: 10.1002/pca.663. [PMID: 12494749]
  • Shannon E Binns, John F Livesey, John T Arnason, Bernard R Baum. Phytochemical variation in echinacea from roots and flowerheads of wild and cultivated populations. Journal of agricultural and food chemistry. 2002 Jun; 50(13):3673-87. doi: 10.1021/jf011439t. [PMID: 12059142]
  • Magali Laasonen, Tero Wennberg, Tuulikki Harmia-Pulkkinen, Heikki Vuorela. Simultaneous analysis of alkamides and caffeic acid derivatives for the identification of Echinacea purpurea, Echinacea angustifolia, Echinacea pallida and Parthenium integrifolium roots. Planta medica. 2002 Jun; 68(6):572-4. doi: 10.1055/s-2002-32561. [PMID: 12094312]
  • F Pérez-García, T Adzet, S Cañigueral. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free radical research. 2000 Nov; 33(5):661-5. doi: 10.1080/10715760000301171. [PMID: 11200096]
  • A Carnat, A Heitz, D Fraisse, A P Carnat, J L Lamaison. Major dicaffeoylquinic acids from Artemisia vulgaris. Fitoterapia. 2000 Sep; 71(5):587-9. doi: 10.1016/s0367-326x(00)00163-5. [PMID: 11449516]
  • T Wesołowska, E Szmatłoch, D Wira, J Pieczul-Mróz, J Gregorczyk. [Phospholipid fractions and free fatty acids in the serum of patients with hypertriglyceridemia treated with 1,5-dicaffeequinine acid]. Przeglad lekarski. 1986; 43(7):527-30. doi: NULL. [PMID: 3775065]
  • O Palacz, D Czepita, J Wójcicki. [Electroretinographic investigations in subjects in chronic exposure to carbon disulphide: III. Cynarex effect on ERG related to blood lipid pattern (author's transl)]. Klinika oczna. 1981 Apr; 83(4-5):223-5. doi: ". [PMID: 6895532]
  • M Woyke, H Cwajda, J Wójcicki, K Kośmider. [Platelet aggregation in workers chronically exposed to carbon disulfide and subjected to prophylactic treatment with Cynarex]. Medycyna pracy. 1981; 32(4):261-4. doi: ". [PMID: 6895541]
  • G Vorberg. [Cynarix. Therapeutic experiences with Cynarix in disorders of fat metabolism in general practice]. ZFA. Zeitschrift fur Allgemeinmedizin. 1980 Sep; 56(25):1598-602. doi: ". [PMID: 6893780]
  • W Scheffler, W Schwartzkopff. Frequently used lipid-lowering drugs having no guaranteed effect. Artery. 1980; 8(2):120-7. doi: ". [PMID: 6893927]