(+)-Butaclamol (BioDeep_00000171504)
human metabolite blood metabolite
代谢物信息卡片
化学式: C25H31NO (361.2405516)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 66.67%
分子结构信息
SMILES: CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O
InChI: InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Francesca R Buttarelli, Alessandra Fanciulli, Clelia Pellicano, Francesco E Pontieri. The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders.
Current neuropharmacology.
2011 Jun; 9(2):278-88. doi:
10.2174/157015911795596612. [PMID: 22131937] - Sylwia Lukasiewicz, Agnieszka Polit, Sylwia Kędracka-Krok, Krzysztof Wędzony, Marzena Maćkowiak, Marta Dziedzicka-Wasylewska. Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptors.
Biochimica et biophysica acta.
2010 Dec; 1803(12):1347-58. doi:
10.1016/j.bbamcr.2010.08.010. [PMID: 20831885] - Raluca-Ioana Stefan-van Staden, Nontete Suzan Nhlapo, Jacobus Frederick van Staden, Hassan Y Aboul-Enein. Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.
Combinatorial chemistry & high throughput screening.
2010 Sep; 13(8):690-3. doi:
10.2174/138620710791920301. [PMID: 20426737] - Stéphane Bastianetto, Marc Danik, Françoise Mennicken, Sylvain Williams, Rémi Quirion. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
BMC neuroscience.
2006 Mar; 7(?):28. doi:
10.1186/1471-2202-7-28. [PMID: 16573831] - Brian F O'Dowd, Xiaodong Ji, Mohammad Alijaniaram, Ryan D Rajaram, Michael M C Kong, Asim Rashid, Tuan Nguyen, Susan R George. Dopamine receptor oligomerization visualized in living cells.
The Journal of biological chemistry.
2005 Nov; 280(44):37225-35. doi:
10.1074/jbc.m504562200. [PMID: 16115864] - Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.
BMC biology.
2004 Oct; 2(?):22. doi:
10.1186/1741-7007-2-22. [PMID: 15473914] - Hassan Y Aboul-Enein, Mohamed M Hefnawy. Chiral analysis of butaclamol enantiomers in human plasma by HPLC using a macrocyclic antibiotic (vancomycin) chiral stationary phase and solid phase extraction.
Chirality.
2004 Mar; 16(3):147-52. doi:
10.1002/chir.20001. [PMID: 14770410] - K M Dewar, T A Reader. Specific [3H]SCH23390 binding to dopamine D1 receptors in cerebral cortex and neostriatum: role of disulfide and sulfhydryl groups.
Journal of neurochemistry.
1989 Feb; 52(2):472-82. doi:
10.1111/j.1471-4159.1989.tb09145.x. [PMID: 2463335] - R T Curnow, E J Rayfield, D T George, T V Zenser, F R DeRubertis. Altered hepatic glycogen metabolism and glucoregulatory hormones during sepsis.
The American journal of physiology.
1976 May; 230(5):1296-1301. doi:
10.1152/ajplegacy.1976.230.5.1296. [PMID: 5897] - M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1975 Sep; 71(6):609-29. doi:
NULL. [PMID: 281]