(+)-2-Amino-7-phosphonoheptanoic acid (BioDeep_00000171501)

   

human metabolite blood metabolite


代谢物信息卡片


2-Amino-7-phosphonoheptanoic acid, (+-)-isomer

化学式: C7H16NO5P (225.0766056)
中文名称: DL-2-氨基-7-膦酰己酸
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C(CCC(C(=O)O)N)CCP(=O)(O)O
InChI: InChI=1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

14 个代谢物同义名

2-Amino-7-phosphonoheptanoic acid, (+-)-isomer; 2-Amino-7-phosphonoheptanoic acid, (S)-isomer; 2-Amino-7-phosphonoheptanoic acid, (R)-isomer; (+--)-2-Amino-7-phosphonoheptanoic acid; (+)-2-Amino-7-phosphonoheptanoic acid; 2-amino-7-phosphonoheptanoic acid; (+)-2-Amino-7-phosphonoheptanoate; 2-Amino-7-phosphoheptanoic acid; 2-Amino-7-phosphonoheptanoate; AP-7 compound; AP-7 (drug); DL-AP7; D-AP7; AP-7



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Gwladys Temkou Ngoupaye, Elisabeth Ngo Bum, Germain Sotoing Taiwe, Fleur Clarisse Okomolo Moto, Emmanuel Talla. Antidepressant properties of aqueous macerate from Gladiolus dalenii corms. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2014; 11(1):53-61. doi: ". [PMID: 24653553]
  • Rodrigo C A de Menezes, Dmitry V Zaretsky, Sumit Sarkar, Marco A P Fontes, Joseph A Dimicco. Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Sep; 295(3):R881-90. doi: 10.1152/ajpregu.00181.2008. [PMID: 18650321]
  • P Couratier, J Hugon, P Sindou, J M Vallat, M Dumas. Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Lancet (London, England). 1993 Jan; 341(8840):265-8. doi: 10.1016/0140-6736(93)92615-z. [PMID: 8093916]
  • R Trullas, P Skolnick. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. European journal of pharmacology. 1990 Aug; 185(1):1-10. doi: 10.1016/0014-2999(90)90204-j. [PMID: 2171955]
  • R P Compton, W F Hood, J B Monahan. Determination of the pharmacokinetics of 2-amino-7-phosphonoheptanoate in rat plasma and cerebrospinal fluid. Neuroscience letters. 1988 Feb; 84(3):339-44. doi: 10.1016/0304-3940(88)90532-0. [PMID: 3352960]
  • J W Ferkany, J T Coyle. Specific binding of [3H]+/- 2-amino-7-phosphono heptanoic acid to rat brain membranes in vitro. Life sciences. 1983 Sep; 33(13):1295-305. doi: 10.1016/0024-3205(83)90011-5. [PMID: 6136884]
  • A G Chapman, J F Collins, B S Meldrum, E Westerberg. Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]heptanoic acid, into mouse brain. Neuroscience letters. 1983 May; 37(1):75-80. doi: 10.1016/0304-3940(83)90507-4. [PMID: 6877661]