2-Hydroxyisobutyrate (BioDeep_00000171435)
Main id: BioDeep_00000003200
human metabolite
代谢物信息卡片
化学式: C4H7O3- (103.0395172)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(natural_products) 1.3%
分子结构信息
SMILES: CC(C)(C(=O)O)O
InChI: InChI=1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)/p-1
描述信息
同义名列表
30 个代谢物同义名
alpha-Hydroxy-alpha-methylpropanoic acid; alpha-Hydroxy-alpha-methylpropionic acid; alpha-Hydroxy-alpha-methylpropanoate; alpha-Hydroxy-alpha-methylpropionate; 2-Hydroxyisobutyric acid, lead salt; a-Hydroxy-a-methylpropionic acid; Α-hydroxy-α-methylpropanoic acid; a-Hydroxy-a-methylpropanoic acid; Α-hydroxy-α-methylpropionic acid; 2-Hydroxy-2-methylpropanoic acid; Lead 2-hydroxyisobutyric acid; alpha-Hydroxyisobutanoic acid; a-Hydroxy-a-methylpropanoate; Α-hydroxy-α-methylpropanoate; Α-hydroxy-α-methylpropionate; a-Hydroxy-a-methylpropionate; 2-Hydroxy-2-methylpropanoate; alpha-Hydroxyisobutyric acid; alpha-Hydroxyisobutanoate; Α-hydroxyisobutanoic acid; a-Hydroxyisobutanoic acid; Α-hydroxyisobutyric acid; 2-HYDROXYISOBUTYRIC ACID; alpha-Hydroxyisobutyrate; a-Hydroxyisobutyric acid; a-Hydroxyisobutanoate; Α-hydroxyisobutanoate; Α-hydroxyisobutyrate; 2-Hydroxyisobutyrate; a-Hydroxyisobutyrate
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:19641
- PubChem: 4277439
- HMDB: HMDB0242161
- chemspider: 3484177
- RefMet: 2-Hydroxyisobutyric acid
- PubChem: 11671
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- 2-methylpropene degradation:
2-methylpropane-1,2-diol + NAD+ ⟶ 2-hydroxy-2-methylpropanal + H+ + NADH - methyl tert-butyl ether degradation:
H+ + NADH + O2 + methyl tert-butyl ether ⟶ tert-butoxymethanol + H2O + NAD+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoyang Chen, Xiabing Li, Pingping Li, Xiaolin Chen, Hao Liu, Junbin Huang, Chaoxi Luo, Tom Hsiang, Lu Zheng. Comprehensive identification of lysine 2-hydroxyisobutyrylated proteins in Ustilaginoidea virens reveals the involvement of lysine 2-hydroxyisobutyrylation in fungal virulence.
Journal of integrative plant biology.
2021 Feb; 63(2):409-425. doi:
10.1111/jipb.13066. [PMID: 33427395] - Tao Sun, Ying Wu, Xueping Wu, Haifeng Ma. Metabolomic profiles investigation on athletes' urine 35 minutes after an 800-meter race.
The Journal of sports medicine and physical fitness.
2017 Jun; 57(6):839-849. doi:
10.23736/s0022-4707.17.06254-5. [PMID: 26699119] - A Miccheli, G Capuani, F Marini, A Tomassini, G Praticò, S Ceccarelli, D Gnani, G Baviera, A Alisi, L Putignani, V Nobili. Urinary (1)H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment.
International journal of obesity (2005).
2015 Jul; 39(7):1118-25. doi:
10.1038/ijo.2015.40. [PMID: 25809828] - Geoffrey A Preidis, Mignon A Keaton, Philippe M Campeau, Brooke C Bessard, Margaret E Conner, Peter J Hotez. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress.
The Journal of nutrition.
2014 Mar; 144(3):273-81. doi:
10.3945/jn.113.183731. [PMID: 24381221] - Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Cho, Jinho Kim, Ho-Sub Lee, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang. ¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats.
Toxicology letters.
2011 Jan; 200(1-2):1-7. doi:
10.1016/j.toxlet.2010.09.020. [PMID: 20932884] - Ana Carolina O Costa, José Luiz da Costa, Fernando G Tonin, Marina F M Tavares, Gustavo Amadeu Micke. Development of a fast capillary electrophoresis method for determination of creatinine in urine samples.
Journal of chromatography. A.
2007 Nov; 1171(1-2):140-3. doi:
10.1016/j.chroma.2007.09.029. [PMID: 17919649] - Kerry A Lucas, Jessica R Filley, Jeremy M Erb, Eric R Graybill, John W Hawes. Peroxisomal metabolism of propionic acid and isobutyric acid in plants.
The Journal of biological chemistry.
2007 Aug; 282(34):24980-9. doi:
10.1074/jbc.m701028200. [PMID: 17580301] - J D Pleil, D Kim, J D Prah, S M Rappaport. Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic model.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2007 Jul; 12(4):331-48. doi:
10.1080/13547500701246334. [PMID: 17564841] - A Amberg, E Rosner, W Dekant. Toxicokinetics of methyl tert-butyl ether and its metabolites in humans after oral exposure.
Toxicological sciences : an official journal of the Society of Toxicology.
2001 May; 61(1):62-7. doi:
10.1093/toxsci/61.1.62. [PMID: 11294975] - A Nihlén, S C Sumner, A Löf, G Johanson. 13C(2)-Labeled methyl tert-butyl ether: toxicokinetics and characterization of urinary metabolites in humans.
Chemical research in toxicology.
1999 Sep; 12(9):822-30. doi:
10.1021/tx980274o. [PMID: 10490504] - A Amberg, E Rosner, W Dekant. Biotransformation and kinetics of excretion of methyl-tert-butyl ether in rats and humans.
Toxicological sciences : an official journal of the Society of Toxicology.
1999 Sep; 51(1):1-8. doi:
10.1093/toxsci/51.1.1. [PMID: 10496672] - R A Dodds, A A Pitsillides, G T Frost. A quantitative cytochemical method for ornithine decarboxylase activity.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
1990 Jan; 38(1):123-7. doi:
10.1177/38.1.2104632. [PMID: 2104632] - Y Shigematsu, M Sudo, T Momoi, Y Inoue, Y Suzuki, J Kameyama. Changing plasma and urinary organic acid levels in a patient with isovaleric acidemia during an attack.
Pediatric research.
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10.1203/00006450-198209000-00013. [PMID: 7133811] - . .
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