l-685,458 (BioDeep_00000017119)
代谢物信息卡片
化学式: C39H52N4O6 (672.3887)
中文名称:
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O
InChI: InChI=1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32+,33+,34-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Emily G Hicks, Sylvie E Kandel, Jed N Lampe. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors.
Bioorganic & medicinal chemistry letters.
2022 06; 66(?):128732. doi:
10.1016/j.bmcl.2022.128732. [PMID: 35427739] - C Campos-Estrada, B Riquelme, M Vergara, C Altamirano, M F Cavieres. In vitro Notch-mediated adjuvant immunogenic potency is induced by combining QS-21 and MPL in a co-culture model of PBMC and HUVEC cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Oct; 68(?):104947. doi:
10.1016/j.tiv.2020.104947. [PMID: 32679256] - Zeyu Zeng, Lei Wang, Weihui Ma, Rongying Zheng, Hong Zhang, Xinxin Zeng, Hui Zhang, Weixi Zhang. Inhibiting the Notch signaling pathway suppresses Th17-associated airway hyperresponsiveness in obese asthmatic mice.
Laboratory investigation; a journal of technical methods and pathology.
2019 12; 99(12):1784-1794. doi:
10.1038/s41374-019-0294-x. [PMID: 31409887] - Zhi-Ying Yang, Jian-Ming Li, Ling Xiao, Lin Mou, Yan Cai, He Huang, Xue-Gang Luo, Xiao-Xin Yan. [(3) H]-L685,458 binding sites are abundant in multiple peripheral organs in rats: implications for safety assessment of putative γ-secretase targeting drugs.
Basic & clinical pharmacology & toxicology.
2014 Dec; 115(6):518-26. doi:
10.1111/bcpt.12271. [PMID: 24861611] - Robyn M Carey, Jan K Blusztajn, Barbara E Slack. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin.
BMC cell biology.
2011 May; 12(?):20. doi:
10.1186/1471-2121-12-20. [PMID: 21586144] - Elodie Ristorcelli, Evelyne Beraud, Sylvie Mathieu, Dominique Lombardo, Alain Verine. Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.
International journal of cancer.
2009 Sep; 125(5):1016-26. doi:
10.1002/ijc.24375. [PMID: 19405120] - Robyn A Sharples, Laura J Vella, Rebecca M Nisbet, Ryan Naylor, Keyla Perez, Kevin J Barnham, Colin L Masters, Andrew F Hill. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2008 May; 22(5):1469-78. doi:
10.1096/fj.07-9357com. [PMID: 18171695] - Rohini Polavarapu, Jie An, Chen Zhang, Manuel Yepes. Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death.
The American journal of pathology.
2008 May; 172(5):1355-62. doi:
10.2353/ajpath.2008.070975. [PMID: 18403601] - Ingrid G Haas, Marcus Frank, Nathalie Véron, Rolf Kemler. Presenilin-dependent processing and nuclear function of gamma-protocadherins.
The Journal of biological chemistry.
2005 Mar; 280(10):9313-9. doi:
10.1074/jbc.m412909200. [PMID: 15611067] - Jiong Chun, Ye Ingrid Yin, Guangli Yang, Leonid Tarassishin, Yue-Ming Li. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors.
The Journal of organic chemistry.
2004 Oct; 69(21):7344-7. doi:
10.1021/jo0486948. [PMID: 15471490] - A Petit, A Pasini, C Alves Da Costa, E Ayral, J F Hernandez, C Dumanchin-Njock, C J Phiel, P Marambaud, S Wilk, M Farzan, P Fulcrand, J Martinez, D Andrau, F Checler. JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.
Journal of neuroscience research.
2003 Nov; 74(3):370-7. doi:
10.1002/jnr.10747. [PMID: 14598313] - Daizo Murakami, Isamu Okamoto, Osamu Nagano, Yoshiaki Kawano, Taisuke Tomita, Takeshi Iwatsubo, Bart De Strooper, Eiji Yumoto, Hideyuki Saya. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene.
2003 Mar; 22(10):1511-6. doi:
10.1038/sj.onc.1206298. [PMID: 12629514] - H Steiner, E Winkler, M S Shearman, R Prywes, C Haass. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Neurobiology of disease.
2001 Aug; 8(4):717-22. doi:
10.1006/nbdi.2001.0405. [PMID: 11493036] - J L Martys-Zage, S H Kim, B Berechid, S J Bingham, S Chu, J Sklar, J Nye, S S Sisodia. Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Journal of molecular neuroscience : MN.
2000 Dec; 15(3):189-204. doi:
10.1385/jmn:15:3:189. [PMID: 11303783]
