AGK2 (BioDeep_00000017085)
代谢物信息卡片
化学式: C23H13Cl2N3O2 (433.0384778)
中文名称: 2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
InChI: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
描述信息
AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 μM, respectively.
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:94578
- KEGG: C74569
- PubChem: 2130404
- Metlin: METLIN45470
- ChEMBL: CHEMBL224864
- CAS: 2711817-72-8
- CAS: 304896-28-4
- PMhub: MS000237699
- medchemexpress: HY-100578
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yeon-Yong Kim, Gayeong Hur, Seung Woong Lee, Seung-Jae Lee, Soyoung Lee, Sang-Hyun Kim, Mun-Chual Rho. AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway.
Pharmacological research.
2020 09; 159(?):105027. doi:
10.1016/j.phrs.2020.105027. [PMID: 32565308] - Hai-Bo Yu, Hui Jiang, Sheng-Tao Cheng, Zhong-Wen Hu, Ji-Hua Ren, Juan Chen. AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo.
International journal of medical sciences.
2018; 15(12):1356-1364. doi:
10.7150/ijms.26125. [PMID: 30275764] - Fang-Fang He, Ren-Yu You, Chen Ye, Chun-Tao Lei, Hui Tang, Hua Su, Chun Zhang. Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(2):451-460. doi:
10.1159/000488613. [PMID: 29614506] - Yan Wang, Yu Mu, Xiaorui Zhou, Huaixue Ji, Xing Gao, Wen Wen Cai, Qiuhua Guan, Tie Xu. SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion.
Apoptosis : an international journal on programmed cell death.
2017 Apr; 22(4):519-530. doi:
10.1007/s10495-016-1341-3. [PMID: 28078537] - Teng Ai, Daniel J Wilson, Swati S More, Jiashu Xie, Liqiang Chen. 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.
Journal of medicinal chemistry.
2016 Apr; 59(7):2928-41. doi:
10.1021/acs.jmedchem.5b01376. [PMID: 26982234] - Huaqing Cui, Zeeshan Kamal, Teng Ai, Yanli Xu, Swati S More, Daniel J Wilson, Liqiang Chen. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
Journal of medicinal chemistry.
2014 Oct; 57(20):8340-57. doi:
10.1021/jm500777s. [PMID: 25275824] - Murugavel Ponnusamy, Xiaoxu Zhou, Yanli Yan, Jinhua Tang, Evelyn Tolbert, Ting C Zhao, Rujun Gong, Shougang Zhuang. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.
The Journal of pharmacology and experimental therapeutics.
2014 Aug; 350(2):243-56. doi:
10.1124/jpet.113.212076. [PMID: 24833701]