FICZ (BioDeep_00000017078)
代谢物信息卡片
5,11-Dihydroindolo[3,2-b]carbazole-6-carbaldehyde
化学式: C19H12N2O (284.0949582)
中文名称: 6-甲酰基吲哚并(3
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C3=CC4=C(C5=CC=CC=C5N4)C(=C3N2)C=O
InChI: InChI=1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
描述信息
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94466
- KEGG: C73318
- PubChem: 1863
- Metlin: METLIN43424
- ChEMBL: CHEMBL472031
- CAS: 172922-91-7
- CAS: 229020-82-0
- PMhub: MS000239388
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Romain Vial, Stéphane Poitevin, Nathalie McKay, Stéphane Burtey, Claire Cerini. Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23042369. [PMID: 35216489] - Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal.
Scientific reports.
2021 08; 11(1):16629. doi:
10.1038/s41598-021-96109-w. [PMID: 34404832] - Laura Wrzosek, Dragos Ciocan, Cindy Hugot, Madeleine Spatz, Margot Dupeux, Camille Houron, Vanessa Lievin-Le Moal, Virginie Puchois, Gladys Ferrere, Nicolas Trainel, Françoise Mercier-Nomé, Sylvere Durand, Guido Kroemer, Cosmin Sebastian Voican, Patrick Emond, Marjolène Straube, Harry Sokol, Gabriel Perlemuter, Anne-Marie Cassard. Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury.
Gut.
2021 07; 70(7):1299-1308. doi:
10.1136/gutjnl-2020-321565. [PMID: 33004548] - Hsueh-Chun Wang, Kwei-Yan Liu, Li-Ting Wang, Shih-Hsien Hsu, Shao-Chun Wang, Shau-Ku Huang. Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Human cell.
2021 May; 34(3):785-799. doi:
10.1007/s13577-021-00491-6. [PMID: 33683656] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Sibei Tao, Fan Guo, Qian Ren, Jing Liu, Tiantian Wei, Lingzhi Li, Liang Ma, Ping Fu. Activation of aryl hydrocarbon receptor by 6-formylindolo[3,2-b]carbazole alleviated acute kidney injury by repressing inflammation and apoptosis.
Journal of cellular and molecular medicine.
2021 01; 25(2):1035-1047. doi:
10.1111/jcmm.16168. [PMID: 33280241] - Christopher R Manzella, Max Ackerman, Megha Singhal, Alexander L Ticho, Justin Ceh, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gill. Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2020 Feb; 54(1):126-141. doi:
10.33594/000000209. [PMID: 32017483] - Xiaoqi Yang, Haoran Liu, Tao Ye, Chen Duan, Peng Lv, Xiaoliang Wu, Jianhe Liu, Kehua Jiang, Hongyan Lu, Huan Yang, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye. AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization.
Theranostics.
2020; 10(26):12011-12025. doi:
10.7150/thno.51144. [PMID: 33204326] - Kyohei Sumida, Makiko Kawana, Emi Kouno, Tomoo Itoh, Shuhei Takano, Tomoya Narawa, Robert H Tukey, Ryoichi Fujiwara. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia.
Molecular pharmacology.
2013 Nov; 84(5):679-86. doi:
10.1124/mol.113.088112. [PMID: 23950218] - Saori Morino-Koga, Hiroshi Uchi, Gaku Tsuji, Masakazu Takahara, Junboku Kajiwara, Teruaki Hirata, Masutaka Furue. Reduction of CC-chemokine ligand 5 by aryl hydrocarbon receptor ligands.
Journal of dermatological science.
2013 Oct; 72(1):9-15. doi:
10.1016/j.jdermsci.2013.04.031. [PMID: 23810773] - V A Kostyuk, A I Potapovich, D Lulli, A Stancato, C De Luca, S Pastore, L Korkina. Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers.
Current medicinal chemistry.
2013; 20(7):869-79. doi:
. [PMID: 23210792] - Daniel V Iwamoto, Chad M Kurylo, Kelly M Schorling, Wade H Powell. Induction of cytochrome P450 family 1 mRNAs and activities in a cell line from the frog Xenopus laevis.
Aquatic toxicology (Amsterdam, Netherlands).
2012 Jun; 114-115(?):165-72. doi:
10.1016/j.aquatox.2012.02.028. [PMID: 22446828] - Vladimir Kostyuk, Alla Potapovich, Andrea Stancato, Chiara De Luca, Daniela Lulli, Saveria Pastore, Liudmila Korkina. Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes.
PloS one.
2012; 7(8):e44472. doi:
10.1371/journal.pone.0044472. [PMID: 22952984] - Alla I Potapovich, Daniela Lulli, Paolo Fidanza, Vladimir A Kostyuk, Chiara De Luca, Saveria Pastore, Liudmila G Korkina. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway.
Toxicology and applied pharmacology.
2011 Sep; 255(2):138-49. doi:
10.1016/j.taap.2011.06.007. [PMID: 21756928] - Emma Wincent, Nahid Amini, Sandra Luecke, Hansruedi Glatt, Jan Bergman, Carlo Crescenzi, Agneta Rannug, Ulf Rannug. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.
The Journal of biological chemistry.
2009 Jan; 284(5):2690-2696. doi:
10.1074/jbc.m808321200. [PMID: 19054769] - Erica J Reschly, Ni Ai, William J Welsh, Sean Ekins, Lee R Hagey, Matthew D Krasowski. Ligand specificity and evolution of liver X receptors.
The Journal of steroid biochemistry and molecular biology.
2008 May; 110(1-2):83-94. doi:
10.1016/j.jsbmb.2008.02.007. [PMID: 18395439]