Ferrostatin-1 (Fer-1) (BioDeep_00000017076)
代谢物信息卡片
Ethyl 3-amino-4-(cyclohexylamino)benzoate
化学式: C15H22N2O2 (262.1681192)
中文名称: Ferrostatin-1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N
InChI: InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:173086
- KEGG: C74788
- PubChem: 4068248
- ChEMBL: CHEMBL3633556
- CAS: 347174-05-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinfu Zhou, Jianping Tang, Chenran Zhang, Guilin Li, Xinpei Lin, Sining Liao, Jinying Luo, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Wenya Shao, Hong Hu, Liangpu Xu, Siying Wu, Huangyuan Li. ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
Free radical biology & medicine.
2024 Aug; 220(?):271-287. doi:
10.1016/j.freeradbiomed.2024.05.014. [PMID: 38734267] - Yi He, Xingbo Wang, Siqi Chen, Hanshen Luo, Bo Huo, Xian Guo, Rui Li, Yue Chen, Xin Yi, Xiang Wei, Ding-Sheng Jiang. SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells.
Free radical biology & medicine.
2024 Jul; 219(?):49-63. doi:
10.1016/j.freeradbiomed.2024.04.220. [PMID: 38608823] - Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system.
Free radical biology & medicine.
2024 Jun; 218(?):26-40. doi:
10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172] - Yanwei Wang, Jingru Qiu, Hua Yan, Nan Zhang, Shixuan Gao, Ning Xu, Cuiyan Wang, Haiyan Lou. The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice.
Archives of toxicology.
2024 Jun; 98(6):1781-1794. doi:
10.1007/s00204-024-03697-3. [PMID: 38573338] - Yuanyuan Chen, Zhaohua Liu, Hongmei Chen, Yi Wen, Lang Fan, Man Luo. Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Biochimica et biophysica acta. Molecular basis of disease.
2024 Jun; 1870(5):167182. doi:
10.1016/j.bbadis.2024.167182. [PMID: 38653359] - Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation.
Journal of pharmacological sciences.
2024 Jun; 155(2):44-51. doi:
10.1016/j.jphs.2024.04.001. [PMID: 38677785] - Qianjie Yang, Yutong Xia, Kuangqi Chen, Yinhao Wang, Dongjie Song, Jiru Zhu, Jianping Tong, Ye Shen. Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro.
Journal of photochemistry and photobiology. B, Biology.
2024 Jun; 255(?):112908. doi:
10.1016/j.jphotobiol.2024.112908. [PMID: 38663336] - Bicheng Li, Minqiao Lu, Hui Wang, Siqi Sheng, Shuyuan Guo, Jia Li, Ye Tian. Macrophage Ferroptosis Promotes MMP2/9 Overexpression Induced by Hemin in Hemorrhagic Plaque.
Thrombosis and haemostasis.
2024 Jun; 124(6):568-580. doi:
10.1055/a-2173-3602. [PMID: 37696298] - Jia-Jia Liu, Xue Zhang, Bang-Lan Cai, Man-Man Qi, Yong-Bin Chi, Bin Peng, Deng-Hai Zhang. Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells.
Journal of integrative medicine.
2024 May; 22(3):286-294. doi:
10.1016/j.joim.2024.03.007. [PMID: 38565435] - Lihe Lu, Yuanzhi Ye, Yajun Chen, Liyun Feng, Jiali Huang, Qingchun Liang, Zirong Lan, Qianqian Dong, Xiaoyu Liu, Yining Li, Xiuli Zhang, Jing-Song Ou, An Chen, Jianyun Yan. Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2024 Apr; 38(7):e23592. doi:
10.1096/fj.202302570r. [PMID: 38581243] - Chao Hou, Bing Zhong, Shuo Gu, Yunyan Wang, Lu Ji. Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis.
Aging.
2024 Mar; 16(7):5987-6007. doi:
10.18632/aging.205684. [PMID: 38536018] - Fabien Segui, Boutaina Daher, Célia Gotorbe, Jacques Pouyssegur, Vincent Picco, Milica Vucetic. Revealing the Ferroptotic Phenotype of Medulloblastoma.
Journal of visualized experiments : JoVE.
2024 Mar; ?(205):. doi:
10.3791/66645. [PMID: 38557602] - Jing Zhang, Jun Jiang, Bingqing Wang, Yue Wang, Yaoyao Qian, Jinmeng Suo, Yiming Li, Zhiyong Peng. SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
International immunopharmacology.
2024 Mar; 129(?):111564. doi:
10.1016/j.intimp.2024.111564. [PMID: 38320352] - Yalei Cao, Zirun Jin, Yu Xi, Jianxing Cheng, Zishui Fang, Qiancheng Zhao, Jiaming Weng, Jun Zhu, Yanlin Tang, Zhe Zhang, Hui Jiang. Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction.
Free radical biology & medicine.
2024 Mar; 214(?):193-205. doi:
10.1016/j.freeradbiomed.2024.02.006. [PMID: 38369075] - Ruijiao Lin, Zijie Jia, Hongbing Chen, Hongli Xiong, Cunhao Bian, Xin He, Bi Wei, Junfeng Fu, Minzhu Zhao, Jianbo Li. Ferrostatin‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat.
Toxicology.
2024 Mar; 503(?):153767. doi:
10.1016/j.tox.2024.153767. [PMID: 38437911] - Akane Suda, Banlanjo Abdulaziz Umaru, Yui Yamamoto, Hiroki Shima, Yuriko Saiki, Yijun Pan, Liang Jin, Jiaqi Sun, Yi Ling Clare Low, Chitose Suzuki, Takaaki Abe, Kazuhiko Igarashi, Toru Furukawa, Yuji Owada, Yoshiteru Kagawa. Polyunsaturated fatty acids-induced ferroptosis suppresses pancreatic cancer growth.
Scientific reports.
2024 02; 14(1):4409. doi:
10.1038/s41598-024-55050-4. [PMID: 38388563] - Liangzhen Xie, Zewei Zhao, Hao Xia, Shuang Su, Liwei He, Zhaohui Huang, Yongchun Li, Mingjian Gao, Jun Chen, Jian Peng, Yunjun Ruan. A novel tsRNA-5008a promotes ferroptosis in cardiomyocytes that causes atrial structural remodeling predisposed to atrial fibrillation.
Experimental cell research.
2024 Feb; 435(2):113923. doi:
10.1016/j.yexcr.2024.113923. [PMID: 38190870] - Hidenobu Kojima, Hirofumi Hirao, Kentaro Kadono, Takahiro Ito, Siyuan Yao, Taylor Torgerson, Kenneth J Dery, Hiroaki Kitajima, Takahiro Ogawa, Fady M Kaldas, Douglas G Farmer, Jerzy W Kupiec-Weglinski. Cold stress-induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes.
JCI insight.
2024 Feb; 9(3):. doi:
10.1172/jci.insight.174354. [PMID: 38329125] - Si Chen, Jian-Jun Gao, Yu-Jia Liu, Zhi-Wei Mo, Fang-Yuan Wu, Zuo-Jun Hu, Yue-Ming Peng, Xiao-Qin Zhang, Zhen-Sheng Ma, Ze-Long Liu, Jian-Yun Yan, Zhi-Jun Ou, Yan Li, Jing-Song Ou. The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3.
Journal of lipid research.
2024 02; 65(2):100499. doi:
10.1016/j.jlr.2024.100499. [PMID: 38218337] - Mengran Wang, Tingting Xuan, Haining Li, Jing An, Tianhui Hao, Jiang Cheng. Protective effect of FXN overexpression on ferroptosis in L-Glu-induced SH-SY5Y cells.
Acta histochemica.
2024 Jan; 126(1):152135. doi:
10.1016/j.acthis.2024.152135. [PMID: 38266318] - Fengping Chen, Jiexia Lu, Biaolin Zheng, Nan Yi, Chunxiao Xie, Feiran Chen, Dafu Wei, Haixing Jiang, Shanyu Qin. Artesunate Inhibits the Growth of Insulinoma Cells via SLC7A11/ GPX4-mediated Ferroptosis.
Current pharmaceutical design.
2024; 30(3):230-239. doi:
10.2174/0113816128289372240105041038. [PMID: 38243946] - Jinfu Zhou, Xinpei Lin, Sining Liao, Guilin Li, Jianping Tang, Jinying Luo, Chenran Zhang, Siying Wu, Liangpu Xu, Huangyuan Li. Ferroptosis contributes to hemolytic hyperbilirubinemia‑induced brain damage in vivo and in vitro.
Molecular medicine reports.
2023 Dec; 28(6):. doi:
10.3892/mmr.2023.13123. [PMID: 37937619] - Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz Hassannia, Tom Vanden Berghe, Koen Augustyns. Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors.
Trends in pharmacological sciences.
2023 12; 44(12):902-916. doi:
10.1016/j.tips.2023.08.012. [PMID: 37770317] - Yu-Ting Wu, Guo-Yong Zhang, Yue Hua, Hui-Jie Fan, Xin Han, Hong-Lin Xu, Guang-Hong Chen, Bin Liu, Ling-Peng Xie, Ying-Chun Zhou. Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.
The Journal of pharmacy and pharmacology.
2023 Nov; 75(11):1467-1477. doi:
10.1093/jpp/rgad080. [PMID: 37738327] - Wei Wang, Lijiang Zhou, Xinyu Zhang, Zheng Li. Mollugin suppresses proliferation and drives ferroptosis of colorectal cancer cells through inhibition of insulin-like growth factor 2 mRNA binding protein 3/glutathione peroxidase 4 axis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115427. doi:
10.1016/j.biopha.2023.115427. [PMID: 37677963] - Yuqi Liu, Xinyi Zhang, Yumeng Cao, Xia Chen, Jiali Zhu, Yun Zou. Ferrostatin-1 Ameliorated Oxidative Lipid Damage in LPS-induced Acute Lung Injury.
The Journal of surgical research.
2023 10; 290(?):266-275. doi:
10.1016/j.jss.2023.05.006. [PMID: 37321147] - Deqian Kong, Yue Liu, Li Li, Huajun Wang, Ke Li, Guangying Zheng. Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating GPX4 and ferroptosis.
Chemico-biological interactions.
2023 Sep; 383(?):110684. doi:
10.1016/j.cbi.2023.110684. [PMID: 37648051] - Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis.
Chemico-biological interactions.
2023 Sep; ?(?):110713. doi:
10.1016/j.cbi.2023.110713. [PMID: 37716422] - Shuquan Lv, Huajun Li, Tianyu Zhang, Xiuhai Su, Wenjuan Sun, Qinghai Wang, Lixin Wang, Nana Feng, Shufang Zhang, Yuansong Wang, Huantian Cui. San-Huang-Yi-Shen capsule ameliorates diabetic nephropathy in mice through inhibiting ferroptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Sep; 165(?):115086. doi:
10.1016/j.biopha.2023.115086. [PMID: 37418978] - Ting Ye, Wei Yang, Tielei Gao, Xue Yu, Tianzuo Chen, Yan Yang, Jinxiang Guo, Quanfeng Li, Hong Li, Liming Yang. Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction.
Free radical biology & medicine.
2023 09; 206(?):143-161. doi:
10.1016/j.freeradbiomed.2023.06.019. [PMID: 37392951] - Jiawei Song, Yihang Chen, Yufei Chen, Siyuan Wang, Zhaojie Dong, Xinming Liu, Xueting Li, Zhenzhou Zhang, Lanlan Sun, Jiuchang Zhong. Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling.
Journal of cardiovascular translational research.
2023 Aug; ?(?):. doi:
10.1007/s12265-023-10423-4. [PMID: 37603208] - Narandulam Usukhbayar, Shota Uesugi, Ken-Ichi Kimura. 3,6-Epidioxy-1,10-bisaboladiene and sulfasalazine synergistically induce ferroptosis-like cell death in human breast cancer cell lines.
Bioscience, biotechnology, and biochemistry.
2023 Aug; ?(?):. doi:
10.1093/bbb/zbad117. [PMID: 37604790] - Huiqing Wang, Yao Zhou, Mingpei Zhao, Lianghong Yu, Yuanxiang Lin, Dezhi Kang. Ferrostatin-1 attenuates brain injury in animal model of subarachnoid hemorrhage via phospholipase A2 activity of PRDX6.
Neuroreport.
2023 08; 34(12):606-616. doi:
10.1097/wnr.0000000000001931. [PMID: 37395228] - Lucas P Gartzke, Koen D W Hendriks, Femke Hoogstra-Berends, Christian P Joschko, Anne-Lise Strandmoe, Pieter C Vogelaar, Guido Krenning, Robert H Henning. Inhibition of Ferroptosis Enables Safe Rewarming of HEK293 Cells following Cooling in University of Wisconsin Cold Storage Solution.
International journal of molecular sciences.
2023 Jun; 24(13):. doi:
10.3390/ijms241310939. [PMID: 37446116] - Lai-Bo Yin, Zhi-Wei Li, Jing-Ling Wang, Lei Wang, Liang Hou, Si-Yuan Hu, Huan Chen, Pan Luo, Xiao-Bin Cui, Jia-Long Zhu. Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis.
Chemical biology & drug design.
2023 Jun; ?(?):. doi:
10.1111/cbdd.14281. [PMID: 37291716] - Dorian M Cheff, Chuying Huang, Karoline C Scholzen, Radosveta Gencheva, Michael H Ronzetti, Qing Cheng, Matthew D Hall, Elias S J Arnér. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.
Redox biology.
2023 06; 62(?):102703. doi:
10.1016/j.redox.2023.102703. [PMID: 37087975] - Hongyu Li, Boying Wang, Sheng Wu, Shuying Dong, Guojun Jiang, Yingying Huang, Xuhui Tong, Meiling Yu. Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53.
Chemico-biological interactions.
2023 Jun; 378(?):110479. doi:
10.1016/j.cbi.2023.110479. [PMID: 37088170] - Wei Li, Chang Liu, Sichuan Wang, Naifeng Liu. Neutrophil membrane biomimetic delivery system (Ptdser-NM-Lipo/Fer-1) designed for targeting atherosclerosis therapy.
IET nanobiotechnology.
2023 May; ?(?):. doi:
10.1049/nbt2.12137. [PMID: 37183611] - Jia Ma, Jiaqi Wang, Chenjie Ma, Qian Cai, Shuang Wu, Wenfeng Hu, Jiali Yang, Jing Xue, Juan Chen, Xiaoming Liu. Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance.
Toxicology.
2023 05; 490(?):153514. doi:
10.1016/j.tox.2023.153514. [PMID: 37075931] - Yan Wang, Yue Zhang, Jinglong Xue, Leqiang Gao, Xiangyang Li, Moxuan Zhao, Dong Zhao, Xianqing Zhou. Ferroptosis mediates decabromodiphenyl ether-induced liver damage and inflammation.
Ecotoxicology and environmental safety.
2023 Apr; 255(?):114771. doi:
10.1016/j.ecoenv.2023.114771. [PMID: 36921498] - Yong-Il Cheon, Ji Min Kim, Sung-Chan Shin, Hyung-Sik Kim, Jin-Choon Lee, Gi Cheol Park, Eui-Suk Sung, Minhyung Lee, Byung-Joo Lee. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats.
Aging.
2023 04; 15(7):2418-2432. doi:
10.18632/aging.204641. [PMID: 37036468] - Dan Huang, Xin Dong, Jianzhe Li, Yudan Chen, Ying Zhou, Qingjie Chen, Yuewen Sun. Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism.
Medical oncology (Northwood, London, England).
2023 Mar; 40(5):132. doi:
10.1007/s12032-023-02000-1. [PMID: 36977862] - Li-Da Chen, Ya-Ping Huang, Ji-Zhi Chen, Jie-Feng Huang, Qiao-Zhen Xu, Gong-Ping Chen, Qi-Chang Lin. Nrf2 plays protective role during intermittent hypoxia-induced ferroptosis in rat liver (BRL-3A) cells.
Sleep & breathing = Schlaf & Atmung.
2023 Mar; ?(?):. doi:
10.1007/s11325-023-02801-8. [PMID: 36856923] - Qiumin Xie, Yanting Sun, Hao Xu, Tangtian Chen, Han Xiang, Huiwen Liu, Rui Wang, Bin Tan, Qin Yi, Jie Tian, Jing Zhu. Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis.
Archives of biochemistry and biophysics.
2023 03; 736(?):109535. doi:
10.1016/j.abb.2023.109535. [PMID: 36708941] - Yuhua Chen, Wei He, Hong Wei, Cuicui Chang, Lingjian Yang, Jiao Meng, Tianlin Long, Quanhua Xu, Chi Zhang. Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia/reperfusion injury.
CNS neuroscience & therapeutics.
2023 Feb; ?(?):. doi:
10.1111/cns.14130. [PMID: 36852441] - Bo Zhang, Qi Hou, Xiaoli Zhang, Yiming Ma, Junhu Yuan, Shuai Li, Xinhua Zhao, Li Sun, Hongying Wang, Hui Zheng. Anesthetic propofol inhibits ferroptosis and aggravates distant cancer metastasis via Nrf2 upregulation.
Free radical biology & medicine.
2023 02; 195(?):298-308. doi:
10.1016/j.freeradbiomed.2022.12.092. [PMID: 36586453] - Yufei Chen, Xueting Li, Siyuan Wang, Ran Miao, Jiuchang Zhong. Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases.
Nutrients.
2023 Jan; 15(3):. doi:
10.3390/nu15030591. [PMID: 36771298] - Xiaoying Guo, Yu Hao, Huiying Ma, Hai Li, Liping Li, Fengmei Yan, Jing Huang, Ling Li. The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells.
The Journal of toxicological sciences.
2023; 48(5):299-310. doi:
10.2131/jts.48.299. [PMID: 37121744] - Milica Markelic, Ana Stancic, Tamara Saksida, Ilijana Grigorov, Dragica Micanovic, Ksenija Velickovic, Vesna Martinovic, Nevena Savic, Andjelija Gudelj, Vesna Otasevic. Defining the ferroptotic phenotype of beta cells in type 1 diabetes and its inhibition as a potential antidiabetic strategy.
Frontiers in endocrinology.
2023; 14(?):1227498. doi:
10.3389/fendo.2023.1227498. [PMID: 37600723] - M A Conde, N P Alza, M I Funk, A Maniscalchi, O N Benzi Juncos, I Berge, R M Uranga, G A Salvador. α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors.
Oxidative medicine and cellular longevity.
2023; 2023(?):5803323. doi:
10.1155/2023/5803323. [PMID: 37113744] - Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He. GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS.
Journal of advanced research.
2023 01; 43(?):205-218. doi:
10.1016/j.jare.2022.02.016. [PMID: 36585109] - Chao-Qun Liu, Xiao-Yong Liu, Pei-Wen Ouyang, Qun Liu, Xiao-Mei Huang, Fan Xiao, Yu-Hong Cui, Qing Zhou, Hong-Wei Pan. Ferrostatin-1 attenuates pathological angiogenesis in oxygen-induced retinopathy via inhibition of ferroptosis.
Experimental eye research.
2023 01; 226(?):109347. doi:
10.1016/j.exer.2022.109347. [PMID: 36502924] - Xuedong Yin, Qiaoling Yang, Hongjing Li, Yulin Kang, Zhiling Li. Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides.
Drug design, development and therapy.
2023; 17(?):283-295. doi:
10.2147/dddt.s392813. [PMID: 36756189] - Yanxiu Zhao, Binhua Jiang, Dinghui Huang, Juxiang Lou, Guoshun Li, Jianqi Liu, Fuhui Duan, Yuan Yuan, Xiaoyan Su. Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins.
PeerJ.
2023; 11(?):e15786. doi:
10.7717/peerj.15786. [PMID: 37701828] - Yuanzhi Ye, An Chen, Li Li, Qingchun Liang, Siyi Wang, Qianqian Dong, Mingwei Fu, Zirong Lan, Yining Li, Xiaoyu Liu, Jing-Song Ou, Lihe Lu, Jianyun Yan. Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification.
Kidney international.
2022 12; 102(6):1259-1275. doi:
10.1016/j.kint.2022.07.034. [PMID: 36063875] - Xue-Ting Li, Jia-Wei Song, Zhen-Zhou Zhang, Mi-Wen Zhang, Li-Rong Liang, Ran Miao, Ying Liu, Yi-Hang Chen, Xiao-Yan Liu, Jiu-Chang Zhong. Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Free radical biology & medicine.
2022 11; 193(Pt 1):459-473. doi:
10.1016/j.freeradbiomed.2022.10.320. [PMID: 36334846] - Zengxin Jiang, Hao Wang, Guobin Qi, Chang Jiang, Kangning Chen, Zuoqin Yan. Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study.
IUBMB life.
2022 11; 74(11):1052-1069. doi:
10.1002/iub.2656. [PMID: 35638167] - Sheng Zhang, Shuai Cao, Heng Zhou, Limin Li, Qing Hu, Xiuhong Mao, Shen Ji. Realgar-induced nephrotoxicity via ferroptosis in mice.
Journal of applied toxicology : JAT.
2022 11; 42(11):1843-1853. doi:
10.1002/jat.4362. [PMID: 35803278] - Shuang Guan, Ranran Zhang, Yanan Zhao, Zhuoqun Meng, Jing Lu. 1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Environmental toxicology.
2022 Oct; 37(10):2515-2528. doi:
10.1002/tox.23615. [PMID: 35870111] - Xuezhong Wang, Zilin Liu, Puji Peng, Ziheng Gong, Jun Huang, Hao Peng. Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Chemico-biological interactions.
2022 Oct; 366(?):110148. doi:
10.1016/j.cbi.2022.110148. [PMID: 36084724] - Kailin Yang, Liuting Zeng, Xiao Yuan, Shanshan Wang, Anqi Ge, Hao Xu, Jinsong Zeng, Jinwen Ge. The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113611. doi:
10.1016/j.biopha.2022.113611. [PMID: 36081288] - Jinna Xie, Zehua Ye, Lei Li, Yuqi Xia, Run Yuan, Yuan Ruan, Xiangjun Zhou. Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Molecular medicine reports.
2022 08; 26(2):. doi:
10.3892/mmr.2022.12772. [PMID: 35703358] - Rongli Sun, Manman Liu, Kai Xu, Yunqiu Pu, Jiawei Huang, Jinyan Liu, Juan Zhang, Lihong Yin, Yuepu Pu. Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway.
Chemico-biological interactions.
2022 Aug; 362(?):110004. doi:
10.1016/j.cbi.2022.110004. [PMID: 35661779] - Xing Peng, Qingyun Tan, Leiming Wu, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu. Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.
Journal of natural products.
2022 07; 85(7):1808-1815. doi:
10.1021/acs.jnatprod.2c00352. [PMID: 35796002] - Lucía Martín-Saiz, Juan Guerrero-Mauvecin, Diego Martín-Sanchez, Olatz Fresnedo, Manuel J Gómez, Susana Carrasco, Pablo Cannata-Ortiz, Alberto Ortiz, José A Fernandez, Ana B Sanz. Ferrostatin-1 modulates dysregulated kidney lipids in acute kidney injury.
The Journal of pathology.
2022 07; 257(3):285-299. doi:
10.1002/path.5882. [PMID: 35152438] - Dongning Li, Chengzhu Song, Jie Zhang, Xiaoyan Zhao. ROS and iron homeostasis dependent ferroptosis play a vital role in 5-Fluorouracil induced cardiotoxicity in vitro and in vivo.
Toxicology.
2022 02; 468(?):153113. doi:
10.1016/j.tox.2022.153113. [PMID: 35101590] - Shan-Shan Xie, Yan Deng, Sheng-Lan Guo, Jia-Quan Li, Ying-Chuan Zhou, Juan Liao, Dan-Dan Wu, Wei-Fang Lan. Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation.
Scientific reports.
2022 02; 12(1):3056. doi:
10.1038/s41598-022-06848-7. [PMID: 35197507] - Xinhao Zhang, Liping Jiang, Huangben Chen, Sen Wei, Kun Yao, Xiance Sun, Guang Yang, Lijie Jiang, Cong Zhang, Ningning Wang, Yan Wang, Xiaofang Liu. Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Toxicology.
2022 01; 465(?):153048. doi:
10.1016/j.tox.2021.153048. [PMID: 34813903] - Fan Zhang, Hualong Zhen, Hengshun Cheng, Fengying Hu, Yunfei Jia, Binbin Huang, Minmin Jiang. Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice.
Frontiers in cell and developmental biology.
2022; 10(?):1014243. doi:
10.3389/fcell.2022.1014243. [PMID: 36438553] - Nan Yang, Yunxiao Shang. Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells.
Oxidative medicine and cellular longevity.
2022; 2022(?):9657933. doi:
10.1155/2022/9657933. [PMID: 35154576] - Hongfei Ge, Xingsen Xue, Jishu Xian, Linbo Yuan, Long Wang, Yongjie Zou, Jun Zhong, Zhouyang Jiang, Jiantao Shi, Tunan Chen, Hong Su, Hua Feng, Shengli Hu. Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury.
Molecular neurobiology.
2022 Jan; 59(1):161-176. doi:
10.1007/s12035-021-02571-y. [PMID: 34635980] - Yi Lyu, Xue-Ke Ren, Can-Can Guo, Zhao-Fei Li, Jin-Ping Zheng. Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
The Journal of toxicological sciences.
2022; 47(12):519-529. doi:
10.2131/jts.47.519. [PMID: 36450496] - Peng-Wei Ma, Wei-Long Wang, Jia-Wei Chen, Hao Yuan, Pei-Heng Lu, Wei Gao, Xue-Rui Ding, Yu-Qiang Lun, Rui Liang, Zu-Hong He, Qian Yang, Lian-Jun Lu. Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis.
Oxidative medicine and cellular longevity.
2022; 2022(?):3373828. doi:
10.1155/2022/3373828. [PMID: 36531206] - Yun Tang, Haojun Luo, Qiong Xiao, Li Li, Xiang Zhong, Jiong Zhang, Fang Wang, Guisen Li, Li Wang, Yi Li. Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis.
Renal failure.
2021 Dec; 43(1):1551-1560. doi:
10.1080/0886022x.2021.2003208. [PMID: 34791966] - Xiaoyan Meng, Wenjing Huang, Weiwei Mo, Tingting Shu, Haoqiang Yang, Haibo Ning. ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy.
Bioengineered.
2021 12; 12(2):11610-11621. doi:
10.1080/21655979.2021.1994707. [PMID: 34666603] - Meiling Yu, Zhuoheng Lin, Xiaoxue Tian, Shiyu Chen, Xinling Liang, Min Qin, Qian Zhu, Yuanyuan Wu, Shilong Zhong. Downregulation of Cx43 reduces cisplatin-induced acute renal injury by inhibiting ferroptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112672. doi:
10.1016/j.fct.2021.112672. [PMID: 34785303] - Zheng Xiao, Bin Kong, Jin Fang, Tianyou Qin, Chang Dai, Wei Shuai, He Huang. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction.
Bioengineered.
2021 12; 12(2):9367-9376. doi:
10.1080/21655979.2021.2001913. [PMID: 34787054] - Xiaoqin Zhang, Linda Xiaoyan Li, Hao Ding, Vicente E Torres, Chen Yu, Xiaogang Li. Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2759-2776. doi:
10.1681/asn.2021040460. [PMID: 34716241] - Zhijun Meng, Hongping Liang, Jianli Zhao, Jia Gao, Caihong Liu, Xinliang Ma, Jing Liu, Bin Liang, Xiangying Jiao, Jimin Cao, Yajing Wang. HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis.
Life sciences.
2021 Nov; 284(?):119935. doi:
10.1016/j.lfs.2021.119935. [PMID: 34508760] - Bingquan Jian, Jiaqi Pang, Hao Xiong, Weijian Zhang, Ting Zhan, Zhongwu Su, Hanqing Lin, Huasong Zhang, Wuhui He, Yiqing Zheng. Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Toxicology letters.
2021 Oct; 350(?):249-260. doi:
10.1016/j.toxlet.2021.07.010. [PMID: 34302894] - Junxuan Xu, Si Liu, Zilu Cui, Xingyu Wang, Tingting Ning, Tiange Wang, Nan Zhang, Sian Xie, Li Min, Shutian Zhang, Chunnan Liang, Shengtao Zhu. Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis.
Biochemical and biophysical research communications.
2021 10; 573(?):48-54. doi:
10.1016/j.bbrc.2021.08.018. [PMID: 34388454] - Jingjing Du, Lishuang Wang, Xiaoming Huang, Na Zhang, Ze Long, You Yang, Fangfang Zhong, Bowen Zheng, Wenjian Lan, Wanjun Lin, Wenzhe Ma. Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153551. doi:
10.1016/j.phymed.2021.153551. [PMID: 33827043] - Junting Xiao, Shanshan Zhang, Baijie Tu, Xuejun Jiang, Shuqun Cheng, Qianghu Tang, Jun Zhang, Xia Qin, Bin Wang, Zhen Zou, Chengzhi Chen. Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 May; 151(?):112114. doi:
10.1016/j.fct.2021.112114. [PMID: 33722599] - Jumpei Ito, Shigemiki Omiya, Mara-Camelia Rusu, Hiromichi Ueda, Tomokazu Murakawa, Yohei Tanada, Hajime Abe, Kazuki Nakahara, Michio Asahi, Manabu Taneike, Kazuhiko Nishida, Ajay M Shah, Kinya Otsu. Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice.
eLife.
2021 02; 10(?):. doi:
10.7554/elife.62174. [PMID: 33526170] - Lulu Sun, Hongliang Dong, Weiqun Zhang, Nan Wang, Na Ni, Xuelian Bai, Naiguo Liu. Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition Are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms.
DNA and cell biology.
2021 Feb; 40(2):172-183. doi:
10.1089/dna.2020.5730. [PMID: 33351681] - Xiaohong Zhang, Mengxin Tian, Xin Li, Chunyan Zheng, Ailian Wang, Jundong Feng, Xiaodan Hu, Shuquan Chang, Haiqian Zhang. Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice.
International journal of radiation biology.
2021; 97(4):464-473. doi:
10.1080/09553002.2021.1876956. [PMID: 33464146] - Bing Hu, Yunsheng Liu, Xiaozhu Chen, Jianjun Zhao, Jinghong Han, Hongsong Dong, Qingyin Zheng, Guohui Nie. Ferrostatin-1 protects auditory hair cells from cisplatin-induced ototoxicity in vitro and in vivo.
Biochemical and biophysical research communications.
2020 12; 533(4):1442-1448. doi:
10.1016/j.bbrc.2020.10.019. [PMID: 33109343] - Jingjing Liu, Hui He, Jing Wang, Xiaoping Guo, Hongkun Lin, Huimin Chen, Chunjie Jiang, Li Chen, Ping Yao, Yuhan Tang. Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis.
Toxicology.
2020 12; 445(?):152584. doi:
10.1016/j.tox.2020.152584. [PMID: 33017621] - Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, Alice Haumont, Isadora Lenoël, Peter K Stys, Samuel David. Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2020 11; 40(48):9327-9341. doi:
10.1523/jneurosci.1749-20.2020. [PMID: 33106352] - Yuan Zhong, Fei Tian, Huanxin Ma, Huihan Wang, Wei Yang, Zhuogang Liu, Aijun Liao. FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.
Life sciences.
2020 Nov; 260(?):118077. doi:
10.1016/j.lfs.2020.118077. [PMID: 32810509] - Jingjing Lu, Feng Xu, Hong Lu. LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53.
Life sciences.
2020 Nov; 260(?):118305. doi:
10.1016/j.lfs.2020.118305. [PMID: 32827544] - Yiran Sun, Libo He, Taoyu Wang, Wan Hua, Huan Qin, Jingjin Wang, Li Wang, Wanqin Gu, Tingting Li, Na Li, Xinanbei Liu, Fang Chen, Lin Tang. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Molecular neurobiology.
2020 Nov; 57(11):4628-4641. doi:
10.1007/s12035-020-02049-3. [PMID: 32770451] - Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki. Emerging roles of ferroptosis in liver pathophysiology.
Archives of pharmacal research.
2020 Oct; 43(10):985-996. doi:
10.1007/s12272-020-01273-8. [PMID: 33079307] - Honglin Mei, Liping Zhao, Wen Li, Zhiwei Zheng, Dongmei Tang, Xiaoling Lu, Yingzi He. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity.
Journal of cellular and molecular medicine.
2020 10; 24(20):12065-12081. doi:
10.1111/jcmm.15839. [PMID: 32929878] - Dan Li, Chunjie Jiang, Guibin Mei, Ying Zhao, Li Chen, Jingjing Liu, Yuhan Tang, Chao Gao, Ping Yao. Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes.
Nutrients.
2020 Sep; 12(10):. doi:
10.3390/nu12102954. [PMID: 32992479] - Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W C Yu, Ninib Baryawno, Elizabeth W Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B Sykes, Mark A Keibler, Sudeshna Das, John N Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J Logan, Stuart Schreiber, Gregory Stephanopoulos, William B Rizzo, David T Scadden. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Blood.
2020 09; 136(11):1303-1316. doi:
10.1182/blood.2019001808. [PMID: 32458004] - Sen Wei, Tianming Qiu, Ningning Wang, Xiaofeng Yao, Liping Jiang, Xue Jia, Ye Tao, Jingyuan Zhang, Yuhan Zhu, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun. Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.
Environmental research.
2020 09; 188(?):109824. doi:
10.1016/j.envres.2020.109824. [PMID: 32593899] - Yingying Yu, Li Jiang, Hao Wang, Zhe Shen, Qi Cheng, Pan Zhang, Jiaming Wang, Qian Wu, Xuexian Fang, Lingyan Duan, Shufen Wang, Kai Wang, Peng An, Tuo Shao, Raymond T Chung, Shusen Zheng, Junxia Min, Fudi Wang. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Blood.
2020 08; 136(6):726-739. doi:
10.1182/blood.2019002907. [PMID: 32374849] - Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li, Rong-Rong He. Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro.
Bioscience, biotechnology, and biochemistry.
2020 Aug; 84(8):1621-1628. doi:
10.1080/09168451.2020.1763155. [PMID: 32419644]