E-64d (BioDeep_00000017065)

   


代谢物信息卡片


3-[[[(1S)-3-methyl-1[[(3S-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2S-oxiranecarboxylic acid, ethyl ester

化学式: C17H30N2O5 (342.215461)
中文名称: 阿洛司他丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C
InChI: InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor

同义名列表

3 个代谢物同义名

Aloxistatin; E-64d; 3-[[[(1S)-3-methyl-1[[(3S-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2S-oxiranecarboxylic acid, ethyl ester



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qiu-Hua Gu, Hao Xu, Xin Cao, Xi Cheng, Jun-Ya Jia, Tie-Kun Yan. The protease inhibitor E64d might attenuate the development of experimental anti-glomerular basement membrane disease through regulating the activation of Th1 cells. International immunopharmacology. 2024 Jan; 129(?):111594. doi: 10.1016/j.intimp.2024.111594. [PMID: 38295547]
  • Minho Won, Sunkyung Choi, Seonghye Cheon, Eun-Mi Kim, Taeg Kyu Kwon, Jaewhan Kim, Yong-Eun Kim, Kyung-Cheol Sohn, Gang Min Hur, Kee K Kim. Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition. Cell biology and toxicology. 2021 Sep; ?(?):. doi: 10.1007/s10565-021-09653-6. [PMID: 34523043]
  • Shuai Wang, Rong Guo, Yongxia Su, Chen Yang, Yazhou Guo, Chengjian Tan, Baoyu Zhao. Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells. Chemico-biological interactions. 2021 Feb; 336(?):109319. doi: 10.1016/j.cbi.2020.109319. [PMID: 33186601]
  • Yu-Wei Chou, Li Zhang, Sakthivel Muniyan, Humera Ahmad, Satyendra Kumar, Syed Mahfuzul Alam, Ming-Fong Lin. Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways. PloS one. 2013; 8(4):e61934. doi: 10.1371/journal.pone.0061934. [PMID: 23637932]
  • Yuumi Oh-ye, Yuko Inoue, Yuji Moriyasu. Detecting autophagy in Arabidopsis roots by membrane-permeable cysteine protease inhibitor E-64d and endocytosis tracer FM4-64. Plant signaling & behavior. 2011 Dec; 6(12):1946-9. doi: 10.4161/psb.6.12.18297. [PMID: 22105025]
  • David Kessel, Michael Price, Joseph Caruso, John Reiners. Effects of photodynamic therapy on the endocytic pathway. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2011 Apr; 10(4):491-8. doi: 10.1039/c0pp00276c. [PMID: 21125114]
  • Gregory Hook, Vivian Hook, Mark Kindy. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. Journal of Alzheimer's disease : JAD. 2011; 26(2):387-408. doi: 10.3233/jad-2011-110101. [PMID: 21613740]
  • Kanako Yano, Masaki Hattori, Yuji Moriyasu. A novel type of autophagy occurs together with vacuole genesis in miniprotoplasts prepared from tobacco culture cells. Autophagy. 2007 May; 3(3):215-21. doi: 10.4161/auto.3739. [PMID: 17224627]
  • Sang-Ho Kwon, Harvey Pollard, William B Guggino. Knockdown of NHERF1 enhances degradation of temperature rescued DeltaF508 CFTR from the cell surface of human airway cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2007; 20(6):763-72. doi: 10.1159/000110436. [PMID: 17982258]
  • Kenji Yamada, Kentaro Fuji, Tomoo Shimada, Mikio Nishimura, Ikuko Hara-Nishimura. Endosomal proteases facilitate the fusion of endosomes with vacuoles at the final step of the endocytotic pathway. The Plant journal : for cell and molecular biology. 2005 Mar; 41(6):888-98. doi: 10.1111/j.1365-313x.2005.02349.x. [PMID: 15743452]
  • Yuji Moriyasu, Masaki Hattori, Guang-Yuh Jauh, John C Rogers. Alpha tonoplast intrinsic protein is specifically associated with vacuole membrane involved in an autophagic process. Plant & cell physiology. 2003 Aug; 44(8):795-802. doi: 10.1093/pcp/pcg100. [PMID: 12941871]
  • Steven M Harwood, David A Allen, Alistair M S Chesser, David I New, Martin J Raftery, Muhammad M Yaqoob. Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?. Kidney international. 2003 Mar; 63(3):866-77. doi: 10.1046/j.1523-1755.2003.00823.x. [PMID: 12631067]
  • N J Fardon, R Wilkinson, T H Thomas. Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage. American journal of hypertension. 2001 Sep; 14(9 Pt 1):927-33. doi: 10.1016/s0895-7061(01)02136-7. [PMID: 11587160]
  • R A Dodds, I E James, D Rieman, R Ahern, S M Hwang, J R Connor, S D Thompson, D F Veber, F H Drake, S Holmes, M W Lark, M Gowen. Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2001 Mar; 16(3):478-86. doi: 10.1359/jbmr.2001.16.3.478. [PMID: 11277265]
  • M Ahram, M Sameni, R G Qiu, B Linebaugh, D Kirn, B F Sloane. Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a three-dimensional matrix. Experimental cell research. 2000 Nov; 260(2):292-303. doi: 10.1006/excr.2000.5031. [PMID: 11035924]
  • N Canu, C Barbato, M T Ciotti, A Serafino, L Dus, P Calissano. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Jan; 20(2):589-99. doi: 10.1523/jneurosci.20-02-00589.2000. [PMID: 10632588]
  • K K Tram, S S Murray, D B Lee, E J Murray. PTH-induced osteoblast contraction is mediated by cysteine proteases. Kidney international. 1993 Mar; 43(3):693-9. doi: 10.1038/ki.1993.99. [PMID: 8384280]
  • K Fukushima, Y Kohno, W Osabe, T Suwa, T Satoh. The disposition of loxistatin and metabolites in normal and dystrophic hamsters. Xenobiotica; the fate of foreign compounds in biological systems. 1991 Jan; 21(1):23-31. doi: 10.3109/00498259109039447. [PMID: 2003364]
  • K Fukushima, M Arai, M Tamai, C Yokoo, M Murata, T Suwa, T Satoh. Metabolic fate of loxistatin in rat. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Oct; 20(10):1043-51. doi: 10.3109/00498259009046825. [PMID: 2082594]
  • K Fukushima, M Arai, Y Kohno, T Suwa, T Satoh. An epoxysuccinic acid derivative(loxistatin)-induced hepatic injury in rats and hamsters. Toxicology and applied pharmacology. 1990 Aug; 105(1):1-12. doi: 10.1016/0041-008x(90)90353-v. [PMID: 2392799]
  • W F Chao, M Kai, Y Ohkura. High-performance liquid chromatographic determination of a cysteine protease inhibitor and its ethyl ester in mouse serum and muscle by pre-column fluorescence derivatization. Journal of chromatography. 1990 Mar; 526(1):77-86. doi: 10.1016/s0378-4347(00)82485-8. [PMID: 2341547]
  • M Tamai, S Omura, M Kimura, K Hanada, H Sugita. Prolongation of life span of dystrophic hamster by cysteine proteinase inhibitor, loxistation (EST). Journal of pharmacobio-dynamics. 1987 Nov; 10(11):678-81. doi: 10.1248/bpb1978.10.678. [PMID: 3482108]
  • T Terao, K Mashino, M Takatsu, M Hiraguchi. [Effect of a cysteine protease inhibitor EST on urinary 3-methylhistidine in dystrophic hamsters (BIO 14.6)]. Rinsho shinkeigaku = Clinical neurology. 1986 Nov; 26(11):1218-23. doi: . [PMID: 3549099]
  • L E Ostrowski, A Ahsan, B P Suthar, P Pagast, D L Bain, C Wong, A Patel, R M Schultz. Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis. Cancer research. 1986 Aug; 46(8):4121-8. doi: . [PMID: 3089587]
  • M Tamai, K Matsumoto, S Omura, I Koyama, Y Ozawa, K Hanada. In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64. Journal of pharmacobio-dynamics. 1986 Aug; 9(8):672-7. doi: 10.1248/bpb1978.9.672. [PMID: 3023601]
  • K Komatsu, K Inazuki, J Hosoya, S Satoh. Beneficial effect of new thiol protease inhibitors, epoxide derivatives, on dystrophic mice. Experimental neurology. 1986 Jan; 91(1):23-9. doi: 10.1016/0014-4886(86)90022-1. [PMID: 3940877]
  • A J Barrett, A A Kembhavi, M A Brown, H Kirschke, C G Knight, M Tamai, K Hanada. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. The Biochemical journal. 1982 Jan; 201(1):189-98. doi: 10.1042/bj2010189. [PMID: 7044372]