9H-Purine-9-butanoic acid, 6-amino-alpha-hydroxy-, methyl ester (BioDeep_00000017048)
代谢物信息卡片
化学式: C10H13N5O3 (251.10183480000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C(CCN1C=NC2=C(N=CN=C21)N)O
InChI: InChI=1S/C10H13N5O3/c1-18-10(17)6(16)2-3-15-5-14-7-8(11)12-4-13-9(7)15/h4-6,16H,2-3H2,1H3,(H2,11,12,13)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shu-Hui Fan, Yuan Chang, Xiao-Yu Xiong, Mai Xiang, Wen-Long Yuan, Xiao-Qian Yang, Wen-Hui Wei, Li Chen, Meng-Nan Cheng, Feng-Hua Zhu, Shi-Jun He, Jian-Ping Zuo, Ze-Min Lin. Reversible SAHH inhibitor ameliorates MIA-induced osteoarthritis of rats through suppressing MEK/ERK pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 170(?):115975. doi:
10.1016/j.biopha.2023.115975. [PMID: 38070246] - Chun-Mei Wu, Jia-Wen Mao, Jin-Zhi Zhu, Can-Can Xie, Jia-Ying Yao, Xiao-Qian Yang, Mai Xiang, Yi-Fan He, Xiao Tong, Dilinaer Litifu, Xiao-Yu Xiong, Meng-Nan Cheng, Feng-Hua Zhu, Shi-Jun He, Ze-Min Lin, Jian-Ping Zuo. DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway.
Acta pharmacologica Sinica.
2024 Jan; 45(1):166-179. doi:
10.1038/s41401-023-01146-y. [PMID: 37605050] - Li Chen, Zemin Lin, Yuting Liu, Shiqi Cao, Yueteng Huang, Xiaoqian Yang, Fenghua Zhu, Wei Tang, Shijun He, Jianping Zuo. DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters.
International immunopharmacology.
2021 Feb; 91(?):107334. doi:
10.1016/j.intimp.2020.107334. [PMID: 33412493] - Shijun He, Xing Liu, Zemin Lin, Yuting Liu, Lei Gu, Hu Zhou, Wei Tang, Jianping Zuo. Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage.
Arthritis research & therapy.
2019 01; 21(1):40. doi:
10.1186/s13075-019-1820-3. [PMID: 30696480] - Ze-Min Lin, Meng Ma, Heng Li, Qing Qi, Yu-Ting Liu, Yu-Xi Yan, Yun-Fu Shen, Xiao-Qian Yang, Feng-Hua Zhu, Shi-Jun He, Wei Tang, Jian-Ping Zuo. Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17.
Pharmacological research.
2018 03; 129(?):443-452. doi:
10.1016/j.phrs.2017.11.012. [PMID: 29155016] - Shi-jun He, Ze-min Lin, Yan-wei Wu, Bing-xin Bai, Xiao-qian Yang, Pei-lan He, Feng-hua Zhu, Wei Tang, Jian-ping Zuo. Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response.
Acta pharmacologica Sinica.
2014 Feb; 35(2):219-29. doi:
10.1038/aps.2013.167. [PMID: 24374810] - Virginie Tardif, Yulia Manenkova, Michael Berger, Kasper Hoebe, Jian-Ping Zuo, Chong Yuan, Dwight H Kono, Argyrios N Theofilopoulos, Brian R Lawson. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.).
2013 May; 147(2):133-43. doi:
10.1016/j.clim.2013.02.018. [PMID: 23583916]