3-(4-{[5-Fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid (BioDeep_00000017042)
代谢物信息卡片
3-(4-{[5-Fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid
化学式: C23H21FO3 (364.14746479999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)C2=C(C=C(C=C2)F)COC3=CC=C(C=C3)CCC(=O)O
InChI: InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Seiji Kitajima, Kazuhiro Sakamoto, Motonaka Kuroda. Effects of TUG-891, a potent GPR120 agonist, on the physical and oral lipid- coating properties, and secretion of saliva.
Physiology & behavior.
2023 06; 265(?):114160. doi:
10.1016/j.physbeh.2023.114160. [PMID: 36934827] - Anna Kiepura, Kamila Stachyra, Anna Wiśniewska, Katarzyna Kuś, Klaudia Czepiel, Maciej Suski, Magdalena Ulatowska-Białas, Marcin Surmiak, Rafał Olszanecki. The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype.
International journal of molecular sciences.
2021 Sep; 22(18):. doi:
10.3390/ijms22189772. [PMID: 34575934] - Tian-Tian Wei, Le-Tian Yang, Fan Guo, Si-Bei Tao, Lu Cheng, Rong-Shuang Huang, Liang Ma, Ping Fu. Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy.
Acta pharmacologica Sinica.
2021 Feb; 42(2):252-263. doi:
10.1038/s41401-020-00520-4. [PMID: 32948825] - Yu-Feng Zhao, Xiao-Cheng Li, Xiang-Yan Liang, Yan-Yan Zhao, Rong Xie, Li-Jun Zhang, Xiao-Chun Zhang, Chen Chen. GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization.
Endocrinology.
2020 10; 161(10):. doi:
10.1210/endocr/bqaa157. [PMID: 32877513] - Jiping Yi, Bin Chen, Yongzheng Bao, Jingyu Wang. Simultaneous determination of TUG-891 and its metabolites in rat plasma using LC-HRMS with application to preclinical pharmacokinetic study.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4870. doi:
10.1002/bmc.4870. [PMID: 32346871] - Zhuo Huang, Fan Guo, Zijing Xia, Yan Liang, Song Lei, Zhouke Tan, Liang Ma, Ping Fu. Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jun; 126(?):110056. doi:
10.1016/j.biopha.2020.110056. [PMID: 32145589] - Babar Murtaza, Aziz Hichami, Amira S Khan, Bharat Shimpukade, Trond Ulven, Mehmet Hakan Ozdener, Naim A Khan. Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice.
Journal of lipid research.
2020 02; 61(2):133-142. doi:
10.1194/jlr.ra119000142. [PMID: 31806728] - Li Wang, Xu Ren, Xue-Fei Tian, Xiao-Li Cheng, Yan-Yan Zhao, Qiu-Yan Li, Zhao-Yang Duan, Li-Fang Tian, Zhao Chen, Jia-Mei Lu, Xiang-Yan Liang, Yu-Feng Zhao, Rong-Guo Fu. Protective effects of GPR120 agonist-programmed macrophages on renal interstitial fibrosis in unilateral ureteral obstruction (UUO) rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Sep; 117(?):109172. doi:
10.1016/j.biopha.2019.109172. [PMID: 31261028] - Maaike Schilperoort, Andrea D van Dam, Geerte Hoeke, Irina G Shabalina, Anthony Okolo, Aylin C Hanyaloglu, Lea H Dib, Isabel M Mol, Natarin Caengprasath, Yi-Wah Chan, Sami Damak, Anne Reifel Miller, Tamer Coskun, Bharat Shimpukade, Trond Ulven, Sander Kooijman, Patrick Cn Rensen, Mark Christian. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.
EMBO molecular medicine.
2018 03; 10(3):. doi:
10.15252/emmm.201708047. [PMID: 29343498] - Zheng Li, Xue Xu, Gang Li, Xiaoting Fu, Yanzhi Liu, Yufeng Feng, Mingyan Wang, Yunting Ouyang, Jing Han. Improving metabolic stability with deuterium: The discovery of GPU-028, a potent free fatty acid receptor 4 agonists.
Bioorganic & medicinal chemistry.
2017 12; 25(24):6647-6652. doi:
10.1016/j.bmc.2017.10.040. [PMID: 29100735] - Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, Charles W Emala. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology.
2015 Nov; 309(9):L970-82. doi:
10.1152/ajplung.00041.2015. [PMID: 26342087] - Bo Gao, Qiang Huang, Qiang Jie, Wei-Guang Lu, Long Wang, Xiao-Jie Li, Zhen Sun, Ya-Qian Hu, Li Chen, Bao-Hua Liu, Jian Liu, Liu Yang, Zhuo-Jing Luo. GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs.
Scientific reports.
2015 Sep; 5(?):14080. doi:
10.1038/srep14080. [PMID: 26365922]