GNE-617 (BioDeep_00000017023)

   


代谢物信息卡片


N-{4-[(3,5-Difluorophenyl)sulfonyl]benzyl}imidazo[1,2-A]pyridine-6-Carboxamide

化学式: C21H15F2N3O3S (427.08021440000005)
中文名称: N-[[4-[(3,5-二氟苯基)磺酰基]苯基]甲基]咪唑并[1,2-A]吡啶-6-甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F
InChI: InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)

描述信息

同义名列表

2 个代谢物同义名

N-{4-[(3,5-Difluorophenyl)sulfonyl]benzyl}imidazo[1,2-A]pyridine-6-Carboxamide; GNE-617



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bianca M Liederer, Jonathan Cheong, Kang-Jye Chou, Peter S Dragovich, Hoa Le, Xiaorong Liang, Justin Ly, Sophie Mukadam, Jason Oeh, Deepak Sampath, Leslie Wang, Susan Wong. Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Sep; 49(9):1063-1077. doi: 10.1080/00498254.2018.1528407. [PMID: 30257601]
  • Mark Zak, Bianca M Liederer, Deepak Sampath, Po-Wai Yuen, Kenneth W Bair, Timm Baumeister, Alexandre J Buckmelter, Karl H Clodfelter, Eric Cheng, Lisa Crocker, Bang Fu, Bingsong Han, Guangkun Li, Yen-Ching Ho, Jian Lin, Xiongcai Liu, Justin Ly, Thomas O'Brien, Dominic J Reynolds, Nicholas Skelton, Chase C Smith, Suzanne Tay, Weiru Wang, Zhongguo Wang, Yang Xiao, Lei Zhang, Guiling Zhao, Xiaozhang Zheng, Peter S Dragovich. Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorganic & medicinal chemistry letters. 2015 Feb; 25(3):529-41. doi: 10.1016/j.bmcl.2014.12.026. [PMID: 25556090]
  • Christopher Del Nagro, Yang Xiao, Linda Rangell, Mike Reichelt, Thomas O'Brien. Depletion of the central metabolite NAD leads to oncosis-mediated cell death. The Journal of biological chemistry. 2014 Dec; 289(51):35182-92. doi: 10.1074/jbc.m114.580159. [PMID: 25355314]
  • Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J Buckmelter, Maureen Caligiuri, Karl H Clodfelter, Bingsong Han, Yen-Ching Ho, Nikolai Kley, Jian Lin, Dominic J Reynolds, Geeta Sharma, Chase C Smith, Zhongguo Wang, Peter S Dragovich, Janet Gunzner-Toste, Bianca M Liederer, Justin Ly, Thomas O'Brien, Angela Oh, Leslie Wang, Weiru Wang, Yang Xiao, Mark Zak, Guiling Zhao, Po-Wai Yuen, Kenneth W Bair. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Journal of medicinal chemistry. 2013 Aug; 56(16):6413-33. doi: 10.1021/jm4008664. [PMID: 23859118]