GSK 650394 (BioDeep_00000017021)

   


代谢物信息卡片


2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

化学式: C25H22N2O2 (382.1681)
中文名称: 2-环戊基-4-(5-苯基-1H-吡咯并[2,3-B]吡啶-3-基)苯甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O
InChI: InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

描述信息

同义名列表

2 个代谢物同义名

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid; GSK 650394



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Oak Z Chi, Antonio Chiricolo, Xia Liu, Nikhil Patel, Estela Jacinto, Harvey R Weiss. Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption. Neuroscience letters. 2021 09; 762(?):136143. doi: 10.1016/j.neulet.2021.136143. [PMID: 34332027]
  • Agustina P Bertolin, Florian Weissmann, Jingkun Zeng, Viktor Posse, Jennifer C Milligan, Berta Canal, Rachel Ulferts, Mary Wu, Lucy S Drury, Michael Howell, Rupert Beale, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase. The Biochemical journal. 2021 07; 478(13):2425-2443. doi: 10.1042/bcj20210200. [PMID: 34198323]
  • Reggie Hui-Chao Lee, Mychal S Grames, Celeste Yin-Chieh Wu, Chih-Feng Lien, Alexandre Couto E Silva, HarLee E Possoit, Garrett A Clemons, Cristiane T Citadin, Jake T Neumann, Donatella Pastore, Davide Lauro, David Della-Morte, Hung Wen Lin. Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest. American journal of physiology. Heart and circulatory physiology. 2020 11; 319(5):H1044-H1050. doi: 10.1152/ajpheart.00399.2020. [PMID: 32946263]
  • Valentina Ranzuglia, Ilaria Lorenzon, Ilenia Pellarin, Maura Sonego, Alessandra Dall'Acqua, Sara D'Andrea, Sara Lovisa, Ilenia Segatto, Michela Coan, Jerry Polesel, Diego Serraino, Patrizia Sabatelli, Paola Spessotto, Barbara Belletti, Gustavo Baldassarre, Monica Schiappacassi. Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells. Oncogene. 2020 10; 39(40):6370-6386. doi: 10.1038/s41388-020-01433-6. [PMID: 32848212]
  • Zohreh Hosseinzadeh, Stefan Hauser, Yogesh Singh, Lisann Pelzl, Stefanie Schuster, Yamini Sharma, Philip Höflinger, Nefeli Zacharopoulou, Christos Stournaras, Daniel L Rathbun, Eberhart Zrenner, Ludger Schöls, Florian Lang. Decreased Na+/K+ ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients. Scientific reports. 2020 05; 10(1):8391. doi: 10.1038/s41598-020-64845-0. [PMID: 32439941]
  • Zheng Zhang, Qian Xu, Chao Song, Baoguo Mi, Honghua Zhang, Honglei Kang, Huiyong Liu, Yunlong Sun, Jia Wang, Zhuowei Lei, Hanfeng Guan, Feng Li. Serum- and Glucocorticoid-inducible Kinase 1 is Essential for Osteoclastogenesis and Promotes Breast Cancer Bone Metastasis. Molecular cancer therapeutics. 2020 02; 19(2):650-660. doi: 10.1158/1535-7163.mct-18-0783. [PMID: 31694887]
  • Zhiyuan Tang, Qin Shen, Hao Xie, Zhu Zhou, Guanglin Shi, Caixin Zhang, Anaz Mohammed, Yi Wu, Songshi Ni, Xiaoyu Zhou. Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and γ-ray irradiation was elucidated. Oncology reports. 2018 Mar; 39(3):1505-1515. doi: 10.3892/or.2018.6181. [PMID: 29328462]
  • Haoxun Wang, Chenchang Liu, Guofeng You. The activity of organic anion transporter-3: Role of dexamethasone. Journal of pharmacological sciences. 2018 Feb; 136(2):79-85. doi: 10.1016/j.jphs.2017.12.011. [PMID: 29422382]
  • Haoxun Wang, Guofeng You. SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3. Biopharmaceutics & drug disposition. 2017 Nov; 38(8):449-457. doi: 10.1002/bdd.2085. [PMID: 28608480]
  • William C Valinsky, Anna Jolly, Perrine Miquel, Rhian M Touyz, Alvin Shrier. Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7). The Journal of biological chemistry. 2016 09; 291(38):20163-72. doi: 10.1074/jbc.m116.735175. [PMID: 27466368]
  • Insun Kook, Clinton Jones. The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infection. Virus research. 2016 08; 222(?):106-112. doi: 10.1016/j.virusres.2016.06.007. [PMID: 27297663]
  • Li Zhang, Jia Liu, Yanchun Liu, Yaguang Xu, Xiufen Zhao, Jun Qian, Bin Sun, Changying Xing. Fluvastatin inhibits the expression of fibronectin in human peritoneal mesothelial cells induced by high-glucose peritoneal dialysis solution via SGK1 pathway. Clinical and experimental nephrology. 2015 Jun; 19(3):336-42. doi: 10.1007/s10157-014-0991-0. [PMID: 24942605]
  • Joseph Burgon, Anne L Robertson, Pranvera Sadiku, Xingang Wang, Edward Hooper-Greenhill, Lynne R Prince, Paul Walker, Emily E Hoggett, Jonathan R Ward, Stuart N Farrow, William J Zuercher, Philip Jeffrey, Caroline O Savage, Philip W Ingham, Adam F Hurlstone, Moira K B Whyte, Stephen A Renshaw. Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. Journal of immunology (Baltimore, Md. : 1950). 2014 Feb; 192(4):1796-805. doi: 10.4049/jimmunol.1300087. [PMID: 24431232]
  • Jennifer M Bomberger, Bonita A Coutermarsh, Roxanna L Barnaby, J Denry Sato, M Christine Chapline, Bruce A Stanton. Serum and glucocorticoid-inducible kinase1 increases plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval. PloS one. 2014; 9(2):e89599. doi: 10.1371/journal.pone.0089599. [PMID: 24586903]
  • Judith G Alamares-Sapuay, Luis Martinez-Gil, Silke Stertz, Matthew S Miller, Megan L Shaw, Peter Palese. Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. Journal of virology. 2013 May; 87(10):6020-6. doi: 10.1128/jvi.01258-12. [PMID: 23487453]
  • Hsien-Yu Peng, Gin-Den Chen, Cheng-Yuan Lai, Ming-Chun Hsieh, Tzer-Bin Lin. Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Mar; 33(12):5227-40. doi: 10.1523/jneurosci.4452-12.2013. [PMID: 23516288]
  • Werner J Geldenhuys, Phani K Talasila, Prabodh Sadana. Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening. Bioorganic & medicinal chemistry letters. 2012 Sep; 22(17):5675-8. doi: 10.1016/j.bmcl.2012.06.096. [PMID: 22858098]
  • Sheela V Thomas, Paru P Kathpalia, Madhumitha Rajagopal, Carol Charlton, Jianning Zhang, Douglas C Eaton, My N Helms, Alan C Pao. Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1. The Journal of biological chemistry. 2011 Sep; 286(37):32074-85. doi: 10.1074/jbc.m111.278283. [PMID: 21784856]
  • Paul Bamborough, Murray J Brown, John A Christopher, Chun-wa Chung, Geoff W Mellor. Selectivity of kinase inhibitor fragments. Journal of medicinal chemistry. 2011 Jul; 54(14):5131-43. doi: 10.1021/jm200349b. [PMID: 21699136]
  • Morag K Mansley, Stuart M Wilson. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. British journal of pharmacology. 2010 Oct; 161(3):571-88. doi: 10.1111/j.1476-5381.2010.00898.x. [PMID: 20880397]
  • Marlys Hammond, David G Washburn, H Tram Hoang, Sharada Manns, James S Frazee, Hiroko Nakamura, Jaclyn R Patterson, Walter Trizna, Charlene Wu, Leonard M Azzarano, Rakesh Nagilla, Melanie Nord, Rebecca Trejo, Martha S Head, Baoguang Zhao, Angela M Smallwood, Kendra Hightower, Nicholas J Laping, Christine G Schnackenberg, Scott K Thompson. Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors. Bioorganic & medicinal chemistry letters. 2009 Aug; 19(15):4441-5. doi: 10.1016/j.bmcl.2009.05.051. [PMID: 19497745]
  • Andrea B Sherk, Daniel E Frigo, Christine G Schnackenberg, Jeffrey D Bray, Nicholas J Laping, Walter Trizna, Marlys Hammond, Jaclyn R Patterson, Scott K Thompson, Dmitri Kazmin, John D Norris, Donald P McDonnell. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer research. 2008 Sep; 68(18):7475-83. doi: 10.1158/0008-5472.can-08-1047. [PMID: 18794135]