Resorufin methyl ether (BioDeep_00000017017)
代谢物信息卡片
7-Methoxy-3H-phenoxazin-3-one
化学式: C13H9NO3 (227.0582404)
中文名称: 甲氧基试卤灵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2
InChI: InChI=1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Y Kapelyukh, C J Henderson, N Scheer, A Rode, C R Wolf. Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.
Drug metabolism and disposition: the biological fate of chemicals.
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10.1124/dmd.119.087718. [PMID: 31147315] - Ahmad F Abdull Razis, Manuela Bagatta, Gina R De Nicola, Renato Iori, Nick Plant, Costas Ioannides. Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.
Journal of agricultural and food chemistry.
2012 Jun; 60(22):5556-64. doi:
10.1021/jf3011195. [PMID: 22594452] - Ahmed Faizal Abdull Razis, Gina Rosalinda De Nicola, Eleonora Pagnotta, Renato Iori, Costas Ioannides. 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent.
Archives of toxicology.
2012 Feb; 86(2):183-94. doi:
10.1007/s00204-011-0750-x. [PMID: 21960141] - Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.
International journal of molecular sciences.
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10.3390/ijms13033101. [PMID: 22489144] - Lisa B Helgason, Augustine Arukwe, Geir W Gabrielsen, Mikael Harju, Marit N Hegseth, Eldbjørg S Heimstad, Even H Jørgensen, Anne S Mortensen, Johannes Wolkers. Biotransformation of PCBs in Arctic seabirds: characterization of phase I and II pathways at transcriptional, translational and activity levels.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2010 Jun; 152(1):34-41. doi:
10.1016/j.cbpc.2010.02.009. [PMID: 20176133] - N Konsue, C Ioannides. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Dec; 46(12):3677-83. doi:
10.1016/j.fct.2008.09.046. [PMID: 18929617] - A Messina, V Chirulli, P G Gervasi, V Longo. Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2.
Xenobiotica; the fate of foreign compounds in biological systems.
2008 Dec; 38(12):1453-70. doi:
10.1080/00498250802474437. [PMID: 18949657] - Marie-Estelle Gouze, Joëlle Laffitte, Philippe Pinton, Geneviève Dedieux, Anne Galinier, Jean-Paul Thouvenot, Nicolas Loiseau, Isabelle P Oswald, Pierre Galtier. Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice.
Veterinary research.
2007 Jul; 38(4):635-46. doi:
10.1051/vetres:2007022. [PMID: 17565910] - Suzanne M F Jeurissen, Frank W Claassen, Jaroslav Havlik, Evelien E Bouwmans, Nicole H P Cnubben, Ernst J R Sudhölter, Ivonne M C M Rietjens, Teris A van Beek. Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products.
Journal of chromatography. A.
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10.1016/j.chroma.2006.12.007. [PMID: 17184784] - M Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V Castell, M José Gómez-Lechón. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
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2006 Sep; 34(9):1556-62. doi:
10.1124/dmd.106.009670. [PMID: 16763015] - Masakuni Degawa, Koji Hanaki, Masashi Sekimoto. A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice.
Cancer science.
2006 Jan; 97(1):32-7. doi:
10.1111/j.1349-7006.2006.00140.x. [PMID: 16367918] - Wei-Hung Chan, Wei-Zen Sun, Tzuu-Huei Ueng. Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications.
Journal of toxicology and environmental health. Part A.
2005 Sep; 68(17-18):1581-97. doi:
10.1080/15287390590967522. [PMID: 16076768] - Yune-Fang Ueng, Tung-Hu Tsai, Ming-Jaw Don, Ruei-Ming Chen, Ta-Liang Chen. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats.
The Journal of pharmacy and pharmacology.
2005 Feb; 57(2):227-32. doi:
10.1211/0022357055489. [PMID: 15720787] - Victoria Yoxall, Meera Umachandran, Judith Wilson, Peter Kentish, Costas Ioannides. Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.
Mutagenesis.
2005 Jan; 20(1):23-8. doi:
10.1093/mutage/gei002. [PMID: 15598702] - Y Yang, Y Wu, S Chen, G J Devine, I Denholm, P Jewess, G D Moores. The involvement of microsomal oxidases in pyrethroid resistance in Helicoverpa armigera from Asia.
Insect biochemistry and molecular biology.
2004 Aug; 34(8):763-73. doi:
10.1016/j.ibmb.2004.04.001. [PMID: 15262281] - F Bryce, F Iverson, P Andrews, M Barker, W Cherry, R Mueller, O Pulido, S Hayward, S Fernie, D L Arnold. Effects elicited by toxaphene in the cynomolgus monkey (Macaca fascicularis): a pilot study.
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2001 Mar; 22(3):481-8. doi:
10.1093/carcin/22.3.481. [PMID: 11238190] - P V Nerurkar, S S Park, P E Thomas, R W Nims, R A Lubet. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse.
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