4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide (BioDeep_00000017016)

   


代谢物信息卡片


4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide

化学式: C23H27F3N4O3 (464.2035148)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
InChI: InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)

描述信息

同义名列表

1 个代谢物同义名

4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Liubing Hu, Yan Wang, Zui Chen, Liangshun Fu, Sheng Wang, Xinyue Zhang, Pengchao Zhang, Xueping Lu, Huiyang Jie, Manmei Li, Yifei Wang, Zhong Liu. Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway. Oxidative medicine and cellular longevity. 2019; 2019(?):9675450. doi: 10.1155/2019/9675450. [PMID: 31019655]
  • Xiao Wang, Shaoxiang Wang, Yuting Liu, Dane Huang, Kai Zheng, Yi Zhang, Xiaoyan Wang, Qiuying Liu, Depo Yang, Yifei Wang. Comparative effects of SNX-7081 and SNX-2112 on cell cycle, apoptosis and Hsp90 client proteins in human cancer cells. Oncology reports. 2015 Jan; 33(1):230-8. doi: 10.3892/or.2014.3552. [PMID: 25334086]
  • Wei Liu, Hongming Liu, Hua Sun, Dong Dong, Zhiguo Ma, Yifei Wang, Baojian Wu. Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Xenobiotica; the fate of foreign compounds in biological systems. 2014 May; 44(5):455-64. doi: 10.3109/00498254.2013.853849. [PMID: 24191862]
  • Francois Lamoureux, Christian Thomas, Min-Jean Yin, Hidetoshi Kuruma, Ladan Fazli, Martin E Gleave, Amina Zoubeidi. A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Apr; 17(8):2301-13. doi: 10.1158/1078-0432.ccr-10-3077. [PMID: 21349995]
  • Q Q Zhai, G Q Gong, Z Liu, Y Luo, M Xia, G W Xing, X F You, Y F Wang. Preclinical pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2011 Mar; 65(2):132-6. doi: 10.1016/j.biopha.2010.12.009. [PMID: 21227627]
  • Qian-Qian Zhai, Guo-Qin Gong, Yong Luo, Qing-Duan Wang, Min Xia, Guo-Wen Xing, Yi-Cheng Li, Jin-Hua Jiang, Zhong Liu, Qiu-Ying Liu, Yi-Fei Wang. Determination of SNX-2112, a selective Hsp90 inhibitor, in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. Journal of pharmaceutical and biomedical analysis. 2010 Dec; 53(4):1048-52. doi: 10.1016/j.jpba.2010.06.031. [PMID: 20675090]
  • Lokesh Jain, Erin R Gardner, Jürgen Venitz, Giuseppe Giaccone, Brett E Houk, William D Figg. Determination of PF-04928473 in human plasma using liquid chromatography with tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Nov; 878(30):3187-92. doi: 10.1016/j.jchromb.2010.09.017. [PMID: 20951100]
  • J A Morris, R H Cagan. Effects of denaturants on the sweet-tasting protein monellin. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1975 Nov; 150(2):265-70. doi: 10.3181/00379727-150-39017. [PMID: 1790]