3-[({4-[4-({[1-(2-Chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid (BioDeep_00000017014)
代谢物信息卡片
3-[({4-[4-({[1-(2-Chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid
化学式: C23H23ClN2O5S (474.10161380000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
InChI: InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91194
- KEGG: C74828
- PubChem: 10367662
- ChEMBL: CHEMBL361501
- CAS: 355025-24-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rudolf G Abdelmessih, Jiaming Xu, Francisco R Hung, Debra T Auguste. Integration of an LPAR1 Antagonist into Liposomes Enhances Their Internalization and Tumor Accumulation in an Animal Model of Human Metastatic Breast Cancer.
Molecular pharmaceutics.
2023 11; 20(11):5500-5514. doi:
10.1021/acs.molpharmaceut.3c00348. [PMID: 37844135] - E Prakash, S Pavithra, D G Kishor Kumar, Manjit Panigrahi, Thakur Uttam Singh, Dinesh Kumar, Subhashree Parida. TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse.
Prostaglandins & other lipid mediators.
2023 Apr; 167(?):106736. doi:
10.1016/j.prostaglandins.2023.106736. [PMID: 37062326] - Vishal Kumar Gupta, Ajay Kumar. Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response.
Apoptosis : an international journal on programmed cell death.
2022 06; 27(5-6):382-400. doi:
10.1007/s10495-022-01723-2. [PMID: 35366141] - Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito. Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 04; 36(4):e22236. doi:
10.1096/fj.202101678r. [PMID: 35218596] - Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules.
Journal of physiology and biochemistry.
2021 May; 77(2):321-329. doi:
10.1007/s13105-021-00800-5. [PMID: 33704695] - Takashi Hirata, Stanley V Smith, Teisuke Takahashi, Noriyuki Miyata, Richard J Roman. Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
The Journal of pharmacology and experimental therapeutics.
2021 02; 376(2):240-249. doi:
10.1124/jpet.120.000353. [PMID: 33277348] - Aykut Deveci, Jessy Hasna, Alexandre Bouron. Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors.
Scientific reports.
2020 02; 10(1):2649. doi:
10.1038/s41598-020-59565-4. [PMID: 32060392] - Peng-Fei Zhao, Shuang Wu, Yan Li, Gegentuya Bao, Jing-Yuan Pei, Yue-Wu Wang, Qing Ma, Hong-Ju Sun, Alatangaole Damirin. LPA receptor1 antagonists as anticancer agents suppress human lung tumours.
European journal of pharmacology.
2020 Feb; 868(?):172886. doi:
10.1016/j.ejphar.2019.172886. [PMID: 31866407] - Nicole C Lummis, Paloma Sánchez-Pavón, Grace Kennedy, Aaron J Frantz, Yasuyuki Kihara, Victoria A Blaho, Jerold Chun. LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction.
Science advances.
2019 10; 5(10):eaax2011. doi:
10.1126/sciadv.aax2011. [PMID: 31633020] - Laura Sánchez-Marín, David Ladrón de Guevara-Miranda, M Carmen Mañas-Padilla, Francisco Alén, Román D Moreno-Fernández, Caridad Díaz-Navarro, José Pérez-Del Palacio, María García-Fernández, Carmen Pedraza, Francisco J Pavón, Fernando Rodríguez de Fonseca, Luis J Santín, Antonia Serrano, Estela Castilla-Ortega. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior.
Neuropharmacology.
2018 05; 133(?):189-201. doi:
10.1016/j.neuropharm.2018.01.033. [PMID: 29378212] - Geon Ho Bae, Sung Kyun Lee, Hyung Sik Kim, Mingyu Lee, Ha Young Lee, Yoe-Sik Bae. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury.
Experimental & molecular medicine.
2017 12; 49(12):e407. doi:
10.1038/emm.2017.203. [PMID: 29217823] - Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang. Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
Journal of lipid research.
2017 11; 58(11):2102-2113. doi:
10.1194/jlr.m075655. [PMID: 28874440] - Dong An, Feng Hao, Fuqiang Zhang, Wei Kong, Jerold Chun, Xuemin Xu, Mei-Zhen Cui. CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation.
The Journal of biological chemistry.
2017 09; 292(35):14391-14400. doi:
10.1074/jbc.m117.781807. [PMID: 28705936] - Hui Ying Li, Yoon Sin Oh, Ji-Woong Choi, Ji Yong Jung, Hee-Sook Jun. Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
Kidney international.
2017 06; 91(6):1362-1373. doi:
10.1016/j.kint.2016.11.010. [PMID: 28111010] - J J McDougall, S Albacete, N Schuelert, P G Mitchell, C Lin, J L Oskins, H H Bui, M G Chambers. Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
Osteoarthritis and cartilage.
2017 06; 25(6):926-934. doi:
10.1016/j.joca.2016.08.016. [PMID: 27651153] - Eva Kritikou, Gijs H M van Puijvelde, Thomas van der Heijden, Peter J van Santbrink, Maarten Swart, Frank H Schaftenaar, Mara J Kröner, Johan Kuiper, Ilze Bot. Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
Scientific reports.
2016 11; 6(?):37585. doi:
10.1038/srep37585. [PMID: 27883026] - J P Mansell, M Cooke, M Read, H Rudd, A I Shiel, K Wilkins, M Manso. Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3.
Biochimie.
2016 Sep; 128-129(?):193-200. doi:
10.1016/j.biochi.2016.08.011. [PMID: 27575987] - Estela Castilla-Ortega, Francisco Javier Pavón, Laura Sánchez-Marín, Guillermo Estivill-Torrús, Carmen Pedraza, Eduardo Blanco, Juan Suárez, Luis Santín, Fernando Rodríguez de Fonseca, Antonia Serrano. Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption.
Neuropharmacology.
2016 Apr; 103(?):92-103. doi:
10.1016/j.neuropharm.2015.12.010. [PMID: 26700247] - Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto, Yasuhito Onodera, Shotaro Furukawa, Haruka Handa, Tsukasa Oikawa, Yasunori Okada, Mototsugu Oya, Hisataka Sabe. Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
Nature communications.
2016 Feb; 7(?):10656. doi:
10.1038/ncomms10656. [PMID: 26854204] - Beatriz Orosa, Paula Martínez, Antonio González, David Guede, José R Caeiro, Juan J Gómez-Reino, Carmen Conde. Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.
Journal of bone and mineral metabolism.
2015 Jul; 33(4):383-91. doi:
10.1007/s00774-014-0607-5. [PMID: 24994065] - Jing Zhao, Jianxin Wei, Nathaniel Weathington, Anastasia M Jacko, Hai Huang, Allan Tsung, Yutong Zhao. Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis.
Translational research : the journal of laboratory and clinical medicine.
2015 Jul; 166(1):80-8. doi:
10.1016/j.trsl.2015.01.008. [PMID: 25701366] - Yoshishige Miyabe, Chie Miyabe, Yoshiko Iwai, Waka Yokoyama, Chiyoko Sekine, Kazutaka Sugimoto, Masayoshi Harigai, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki. Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade.
Arthritis research & therapy.
2014 Oct; 16(5):461. doi:
10.1186/s13075-014-0461-9. [PMID: 25273676] - Sun-Hye Choi, Byung-Hwan Lee, Hyeon-Joong Kim, Seok-Won Jung, Hyun-Sook Kim, Ho-Chul Shin, Jun-Hee Lee, Hyoung-Chun Kim, Hyewhon Rhim, Sung-Hee Hwang, Tal Soo Ha, Hyun-Ji Kim, Hana Cho, Seung-Yeol Nah. Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites.
Molecules and cells.
2014 Sep; 37(9):656-63. doi:
10.14348/molcells.2014.0087. [PMID: 25234465] - Marion David, Irma Machuca-Gayet, Junichi Kikuta, Penelope Ottewell, Fuka Mima, Raphael Leblanc, Edith Bonnelye, Johnny Ribeiro, Ingunn Holen, Rùben Lopez Vales, Pierre Jurdic, Jerold Chun, Philippe Clézardin, Masaru Ishii, Olivier Peyruchaud. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity.
The Journal of biological chemistry.
2014 Mar; 289(10):6551-6564. doi:
10.1074/jbc.m113.533232. [PMID: 24429286] - Sara Knowlden, Steve N Georas. The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
Journal of immunology (Baltimore, Md. : 1950).
2014 Feb; 192(3):851-7. doi:
10.4049/jimmunol.1302831. [PMID: 24443508] - Beatriz Orosa, Samuel García, Paula Martínez, Antonio González, Juan J Gómez-Reino, Carmen Conde. Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.
Annals of the rheumatic diseases.
2014 Jan; 73(1):298-305. doi:
10.1136/annrheumdis-2012-202832. [PMID: 23486415] - Marion David, Debashish Sahay, Florence Mege, Françoise Descotes, Raphaël Leblanc, Johnny Ribeiro, Philippe Clézardin, Olivier Peyruchaud. Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers.
PloS one.
2014; 9(5):e97771. doi:
10.1371/journal.pone.0097771. [PMID: 24828490] - Soo-Jin Park, Kyoung-Pil Lee, Saeromi Kang, Hae-Young Chung, Yoe-Sik Bae, Fumikazu Okajima, Dong-Soon Im. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells.
Cellular signalling.
2013 Nov; 25(11):2147-54. doi:
10.1016/j.cellsig.2013.07.001. [PMID: 23838008] - C Rancoule, C Attané, S Grès, A Fournel, R Dusaulcy, C Bertrand, C Vinel, K Tréguer, M Prentki, P Valet, J S Saulnier-Blache. Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice.
Diabetologia.
2013 Jun; 56(6):1394-402. doi:
10.1007/s00125-013-2891-3. [PMID: 23508306] - Sun-Hye Choi, Hyeon-Joong Kim, Bo-Ra Kim, Tae-Joon Shin, Sung-Hee Hwang, Byung-Hwan Lee, Sang-Mok Lee, Hyewhon Rhim, Seung-Yeol Nah. Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents.
Molecules and cells.
2013 Feb; 35(2):142-50. doi:
10.1007/s10059-013-2293-x. [PMID: 23456336] - Geun Ok Jeong, Sang Hun Shin, Eun Jin Seo, Yang Woo Kwon, Soon Chul Heo, Ki-Hyung Kim, Man-Soo Yoon, Dong-Soo Suh, Jae Ho Kim. TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 32(2):253-63. doi:
10.1159/000354434. [PMID: 23942151] - Shih-Lei Lai, Wan-Ling Yao, Ku-Chi Tsao, Anna J S Houben, Harald M H G Albers, Huib Ovaa, Wouter H Moolenaar, Shyh-Jye Lee. Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish.
Development (Cambridge, England).
2012 Dec; 139(23):4439-48. doi:
10.1242/dev.081745. [PMID: 23095890] - Joshua J Park, Maria V Rubio, Zhihong Zhang, Tae Um, Yuhuan Xie, Stewart M Knoepp, Ashley J Snider, Terra C Gibbs, Kathryn E Meier. Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells.
The Prostate.
2012 Nov; 72(15):1595-610. doi:
10.1002/pros.22513. [PMID: 22473839] - Yimin Qian, Matthew Hamilton, Achyutharao Sidduri, Stephen Gabriel, Yonglin Ren, Ruoqi Peng, Rama Kondru, Arjun Narayanan, Terry Truitt, Rachid Hamid, Yun Chen, Lin Zhang, Adrian J Fretland, Ruben Alvarez Sanchez, Kung-Ching Chang, Matthew Lucas, Ryan C Schoenfeld, Dramane Laine, Maria E Fuentes, Christopher S Stevenson, David C Budd. Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
Journal of medicinal chemistry.
2012 Sep; 55(17):7920-39. doi:
10.1021/jm301022v. [PMID: 22894757] - Detlef H Kozian, Andreas Evers, Peter Florian, Peter Wonerow, Sabrina Joho, Marc Nazare. Selective non-lipid modulator of LPA5 activity in human platelets.
Bioorganic & medicinal chemistry letters.
2012 Aug; 22(16):5239-43. doi:
10.1016/j.bmcl.2012.06.057. [PMID: 22801643] - Sung Hee Hwang, Tae-Joon Shin, Sun-Hye Choi, Hee-Jung Cho, Byung-Hwan Lee, Mi Kyung Pyo, Jun-Ho Lee, Jiyeon Kang, Hyeon-Joong Kim, Chan-Woo Park, Ho-Chul Shin, Seung-Yeol Nah. Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.
Molecules and cells.
2012 Feb; 33(2):151-62. doi:
10.1007/s10059-012-2216-z. [PMID: 22286231] - Sung Hee Hwang, Eun-Joo Shin, Tae-Joon Shin, Byung-Hwan Lee, Sun-Hye Choi, Jiyeon Kang, Hyeon-Joong Kim, Seung-Hwan Kwon, Choon-Gon Jang, Jun-Ho Lee, Hyoung-Chun Kim, Seung-Yeol Nah. Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Journal of Alzheimer's disease : JAD.
2012; 31(1):207-23. doi:
10.3233/jad-2012-120439. [PMID: 22543851] - Chi-Ling Chiang, Swey-Shen Alex Chen, Shyh Jye Lee, Ku-Chi Tsao, Pei-Lun Chu, Cheng-Hao Wen, Shiaw-Min Hwang, Chao-Ling Yao, Hsinyu Lee. Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.
Stem cells (Dayton, Ohio).
2011 Nov; 29(11):1763-73. doi:
10.1002/stem.733. [PMID: 21915944] - Jing Zhao, Donghong He, Yanlin Su, Evgeny Berdyshev, Jerold Chun, Viswanathan Natarajan, Yutong Zhao. Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.
American journal of physiology. Lung cellular and molecular physiology.
2011 Oct; 301(4):L547-56. doi:
10.1152/ajplung.00058.2011. [PMID: 21821728] - Adrienne E Dubin, Deron R Herr, Jerold Chun. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 May; 30(21):7300-9. doi:
10.1523/jneurosci.6151-09.2010. [PMID: 20505096] - Mosharraf H Sarker, De-En Hu, Paul A Fraser. Regulation of cerebromicrovascular permeability by lysophosphatidic acid.
Microcirculation (New York, N.Y. : 1994).
2010 Jan; 17(1):39-46. doi:
10.1111/j.1549-8719.2010.00001.x. [PMID: 20141599] - Lin Ma, Misaki Matsumoto, Weijiao Xie, Makoto Inoue, Hiroshi Ueda. Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.
Journal of neurochemistry.
2009 Apr; 109(2):603-10. doi:
10.1111/j.1471-4159.2009.05987.x. [PMID: 19222705] - Hiromi Nochi, Hideaki Tomura, Masayuki Tobo, Nobuyuki Tanaka, Koichi Sato, Tetsuya Shinozaki, Tsutomu Kobayashi, Kenji Takagishi, Hideo Ohta, Fumikazu Okajima, Koichi Tamoto. Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.
Journal of immunology (Baltimore, Md. : 1950).
2008 Oct; 181(7):5111-9. doi:
10.4049/jimmunol.181.7.5111. [PMID: 18802115] - Tadaaki Yamada, Seiji Yano, Hirokazu Ogino, Kenji Ikuta, Soji Kakiuchi, Masaki Hanibuchi, Takanori Kanematsu, Tetsuo Taniguchi, Yoshitaka Sekido, Saburo Sone. Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.
Cancer science.
2008 Aug; 99(8):1603-10. doi:
10.1111/j.1349-7006.2008.00848.x. [PMID: 18754873] - James I Fells, Ryoko Tsukahara, Yuko Fujiwara, Jianxiong Liu, Donna H Perygin, Daniel A Osborne, Gabor Tigyi, Abby L Parrill. Identification of non-lipid LPA3 antagonists by virtual screening.
Bioorganic & medicinal chemistry.
2008 Jun; 16(11):6207-17. doi:
10.1016/j.bmc.2008.04.035. [PMID: 18467108] - Nina Wiedmaier, Steffen Müller, Martin Köberle, Birgit Manncke, Juliane Krejci, Ingo B Autenrieth, Erwin Bohn. Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner.
International journal of medical microbiology : IJMM.
2008 Apr; 298(3-4):231-43. doi:
10.1016/j.ijmm.2007.06.001. [PMID: 17765657] - Kyungmoo Yea, Jaeyoon Kim, Seyoung Lim, Ho Seon Park, Kyong Soo Park, Pann-Ghill Suh, Sung Ho Ryu. Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
Journal of molecular medicine (Berlin, Germany).
2008 Feb; 86(2):211-20. doi:
10.1007/s00109-007-0269-z. [PMID: 17924084] - Jean-Philippe Pradère, Julie Klein, Sandra Grès, Charlotte Guigné, Eric Neau, Philippe Valet, Denis Calise, Jerold Chun, Jean-Loup Bascands, Jean-Sébastien Saulnier-Blache, Joost P Schanstra. LPA1 receptor activation promotes renal interstitial fibrosis.
Journal of the American Society of Nephrology : JASN.
2007 Dec; 18(12):3110-8. doi:
10.1681/asn.2007020196. [PMID: 18003779] - F D'Aquilio, M Procaccini, V Izzi, V Chiurchiu', V Giambra, F Carotenuto, P Di Nardo, P M Baldini. Activatory properties of lysophosphatidic acid on human THP-1 cells.
Inflammation.
2007 Oct; 30(5):167-77. doi:
10.1007/s10753-007-9034-2. [PMID: 17594136] - Young-Ja Chang, Yu-Lee Kim, Yun-Kyung Lee, Santosh J Sacket, Kyeok Kim, Hyo-Lim Kim, Mijin Han, Yoe-Sik Bae, Fumikazu Okajima, Dong-Soon Im. Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.
Prostaglandins & other lipid mediators.
2007 Jun; 83(4):268-76. doi:
10.1016/j.prostaglandins.2007.01.014. [PMID: 17499746] - Nobuyuki Fukushima, Shinya Shano, Ryutaro Moriyama, Jerold Chun. Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway.
Neurochemistry international.
2007 Jan; 50(2):302-7. doi:
10.1016/j.neuint.2006.09.008. [PMID: 17056154] - Lisa M Masiello, Joseph S Fotos, Deni S Galileo, Norman J Karin. Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells.
Bone.
2006 Jul; 39(1):72-82. doi:
10.1016/j.bone.2005.12.013. [PMID: 16487757] - J Gidley, S Openshaw, E T Pring, S Sale, J P Mansell. Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation.
Prostaglandins & other lipid mediators.
2006 Jul; 80(1-2):46-61. doi:
10.1016/j.prostaglandins.2006.04.001. [PMID: 16846786] - Zendra Lee, Ramona F Swaby, Yuewei Liang, Shuangxing Yu, Shuying Liu, Karen H Lu, Robert C Bast, Gordon B Mills, Xianjun Fang. Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
Cancer research.
2006 Mar; 66(5):2740-8. doi:
10.1158/0008-5472.can-05-2947. [PMID: 16510595] - Akihiro Sako, Joji Kitayama, Dai Shida, Rika Suzuki, Teruyuki Sakai, Hideo Ohta, Hirokazu Nagawa. Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
The Journal of surgical research.
2006 Jan; 130(1):94-101. doi:
10.1016/j.jss.2005.08.007. [PMID: 16171822] - F D'Aquilio, M Procaccini, V Izzi, V Chiurchiu', V Giambra, F Carotenuto, P Di Nardo, P M Baldini. Activatory properties of lysophosphatidic acid on human THP-1 cells.
Inflammation.
2005 Dec; 29(4-6):129-40. doi:
10.1007/s10753-006-9008-9. [PMID: 17089191] - Takayuki Yamada, Koichi Sato, Mayumi Komachi, Enkhzol Malchinkhuu, Masayuki Tobo, Takao Kimura, Atsushi Kuwabara, Yasuhiro Yanagita, Toshiro Ikeya, Yoshifumi Tanahashi, Tetsushi Ogawa, Susumu Ohwada, Yasuo Morishita, Hideo Ohta, Doon-Soon Im, Koichi Tamoto, Hideaki Tomura, Fumikazu Okajima. Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
The Journal of biological chemistry.
2004 Feb; 279(8):6595-605. doi:
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