2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole (BioDeep_00000017007)

   


代谢物信息卡片


2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole

化学式: C18H12N6OS (360.0793262)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(N(CC2=CC=CC=C2)N=N3)=C3C(SC4=NC5=C(C=CC=C5)O4)=NC=N1
InChI: InChI=1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2

描述信息

VAS2870 is a NADPH oxidase (NOX) inhibitor.

同义名列表

2 个代谢物同义名

2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole; VAS2870



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Mahtab Atashibarg, Masood Haghshenas. ROS scavenger, N-acetyl-l-cysteine and NOX specific inhibitor, VAS2870 reduce platelets apoptosis while enhancing their viability during storage. Transfusion. 2019 04; 59(4):1333-1343. doi: 10.1111/trf.15114. [PMID: 30609081]
  • Eleonora Cremonini, Patricia I Oteiza. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells. Archives of biochemistry and biophysics. 2018 05; 646(?):55-63. doi: 10.1016/j.abb.2018.03.027. [PMID: 29608879]
  • Jun Chen, Zhangzhe Peng, Miaomiao Lu, Xuan Xiong, Zhuo Chen, Qianbin Li, Zeneng Cheng, Dejian Jiang, Lijian Tao, Gaoyun Hu. Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy. Bioorganic & medicinal chemistry letters. 2018 01; 28(2):222-229. doi: 10.1016/j.bmcl.2017.07.001. [PMID: 29248299]
  • Katja Zappe, Angelika Pointner, Olivier J Switzeny, Ulrich Magnet, Elena Tomeva, Jutta Heller, George Mare, Karl-Heinz Wagner, Siegfried Knasmueller, Alexander G Haslberger. Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells. Oxidative medicine and cellular longevity. 2018; 2018(?):3734250. doi: 10.1155/2018/3734250. [PMID: 29854080]
  • Jong-Seok Moon, Kiichi Nakahira, Kuei-Pin Chung, Gina M DeNicola, Michael Jakun Koo, Maria A Pabón, Kristen T Rooney, Joo-Heon Yoon, Stefan W Ryter, Heather Stout-Delgado, Augustine M K Choi. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature medicine. 2016 09; 22(9):1002-12. doi: 10.1038/nm.4153. [PMID: 27455510]
  • Ting-Bo Li, Jie-Jie Zhang, Bin Liu, Wei-Qi Liu, Yan Wu, Xiao-Ming Xiong, Xiu-Ju Luo, Qi-Lin Ma, Jun Peng. Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitor cells in hyperlipidemia. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Mar; 389(3):289-302. doi: 10.1007/s00210-015-1198-y. [PMID: 26685858]
  • Zheng Lou, Kai-Di Ren, Bin Tan, Jing-Jie Peng, Xian Ren, Zhong-Bao Yang, Bin Liu, Jie Yang, Qi-Lin Ma, Xiu-Ju Luo, Jun Peng. Salviaolate Protects Rat Brain from Ischemia-Reperfusion Injury through Inhibition of NADPH Oxidase. Planta medica. 2015 Oct; 81(15):1361-9. doi: 10.1055/s-0035-1557774. [PMID: 26252829]
  • Mariam El Assar, Javier Angulo, Marta Santos-Ruiz, Paola Moreno, Anna Novials, María Luisa Villanueva-Peñacarrillo, Leocadio Rodríguez-Mañas. Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats. PloS one. 2015; 10(3):e0120479. doi: 10.1371/journal.pone.0120479. [PMID: 25807378]
  • Nina Queisser, Patricia I Oteiza, Samuel Link, Valentin Hey, Helga Stopper, Nicole Schupp. Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxidants & redox signaling. 2014 Nov; 21(15):2126-42. doi: 10.1089/ars.2013.5565. [PMID: 24512358]
  • Vidhya Munnamalai, Cory J Weaver, Corinne E Weisheit, Prahatha Venkatraman, Zeynep Sena Agim, Mark T Quinn, Daniel M Suter. Bidirectional interactions between NOX2-type NADPH oxidase and the F-actin cytoskeleton in neuronal growth cones. Journal of neurochemistry. 2014 Aug; 130(4):526-40. doi: 10.1111/jnc.12734. [PMID: 24702317]
  • Patricia Sancho, Isabel Fabregat. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochemical pharmacology. 2011 Apr; 81(7):917-24. doi: 10.1016/j.bcp.2011.01.007. [PMID: 21276422]
  • Ming-Ho Tsai, Meei Jyh Jiang. Reactive oxygen species are involved in regulating alpha1-adrenoceptor-activated vascular smooth muscle contraction. Journal of biomedical science. 2010 Aug; 17(?):67. doi: 10.1186/1423-0127-17-67. [PMID: 20727219]