N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide (BioDeep_00000017003)
代谢物信息卡片
N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
化学式: C15H9F6N5OS (421.04319760000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
InChI: InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kevin Munoz, Samiksha Wasnik, Amir Abdipour, Hongzheng Bi, Sean M Wilson, Xiaolei Tang, Mahdis Ghahramanpouri, David J Baylink. The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury.
International journal of molecular sciences.
2021 May; 22(10):. doi:
10.3390/ijms22105244. [PMID: 34063554] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Purvi Mehrotra, Michael Sturek, Javier A Neyra, David P Basile. Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury.
The Journal of clinical investigation.
2019 11; 129(11):4951-4961. doi:
10.1172/jci126108. [PMID: 31415242] - Swagat Sharma, Corey R Hopkins. Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Journal of medicinal chemistry.
2019 09; 62(17):7589-7602. doi:
10.1021/acs.jmedchem.8b01954. [PMID: 30943030] - Maya Miyoshi, Shuang Liu, Asuka Morizane, Erika Takemasa, Yashuyuki Suzuki, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi. Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis.
European journal of pharmacology.
2018 Apr; 824(?):89-98. doi:
10.1016/j.ejphar.2018.02.006. [PMID: 29428471] - Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G Nelson, Wenjun Ju, Matthias Kretzler, Stephen L Atkin, Maria F Gomez, Shang-Zhong Xu. ORAI channels are critical for receptor-mediated endocytosis of albumin.
Nature communications.
2017 12; 8(1):1920. doi:
10.1038/s41467-017-02094-y. [PMID: 29203863] - Yueh-Lin Wu, Jian Xie, Sung-Wan An, Noelynn Oliver, Nestor X Barrezueta, Mei-Hsiang Lin, Lutz Birnbaumer, Chou-Long Huang. Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.
Kidney international.
2017 04; 91(4):830-841. doi:
10.1016/j.kint.2016.09.039. [PMID: 27979597] - Jessica Sabourin, Fiona Bartoli, Fabrice Antigny, Ana Maria Gomez, Jean-Pierre Benitah. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
The Journal of biological chemistry.
2016 Jun; 291(25):13394-409. doi:
10.1074/jbc.m115.693911. [PMID: 27129253] - A Ambily, W J Kaiser, C Pierro, E V Chamberlain, Z Li, C I Jones, N Kassouf, J M Gibbins, K S Authi. The role of plasma membrane STIM1 and Ca(2+)entry in platelet aggregation. STIM1 binds to novel proteins in human platelets.
Cellular signalling.
2014 Mar; 26(3):502-11. doi:
10.1016/j.cellsig.2013.11.025. [PMID: 24308967] - Ying-Ting Chen, Yih-Fung Chen, Wen-Tai Chiu, Yang-Kao Wang, Hsien-Chang Chang, Meng-Ru Shen. The ER Ca²⁺ sensor STIM1 regulates actomyosin contractility of migratory cells.
Journal of cell science.
2013 Mar; 126(Pt 5):1260-7. doi:
10.1242/jcs.121129. [PMID: 23378028] - Lintao Qu, Yumei Li, Xinghua Pan, Pu Zhang, Robert H LaMotte, Chao Ma. Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Jul; 32(28):9554-62. doi:
10.1523/jneurosci.6355-11.2012. [PMID: 22787041] - Monu Goel, William P Schilling. Role of TRPC3 channels in ATP-induced Ca2+ signaling in principal cells of the inner medullary collecting duct.
American journal of physiology. Renal physiology.
2010 Jul; 299(1):F225-33. doi:
10.1152/ajprenal.00670.2009. [PMID: 20410214] - Yankun Shi, Mingbao Song, Ruiwei Guo, Hong Wang, Pan Gao, Weibin Shi, Lan Huang. Knockdown of stromal interaction molecule 1 attenuates hepatocyte growth factor-induced endothelial progenitor cell proliferation.
Experimental biology and medicine (Maywood, N.J.).
2010 Mar; 235(3):317-25. doi:
10.1258/ebm.2009.009237. [PMID: 20404049] - Keiko Ohga, Ryuichi Takezawa, Taiji Yoshino, Toshimitsu Yamada, Yasuaki Shimizu, Jun Ishikawa. The suppressive effects of YM-58483/BTP-2, a store-operated Ca2+ entry blocker, on inflammatory mediator release in vitro and airway responses in vivo.
Pulmonary pharmacology & therapeutics.
2008; 21(2):360-9. doi:
10.1016/j.pupt.2007.09.003. [PMID: 17977764] - François-Xavier Boittin, Olivier Petermann, Carole Hirn, Peggy Mittaud, Olivier M Dorchies, Emmanuelle Roulet, Urs T Ruegg. Ca2+-independent phospholipase A2 enhances store-operated Ca2+ entry in dystrophic skeletal muscle fibers.
Journal of cell science.
2006 Sep; 119(Pt 18):3733-42. doi:
10.1242/jcs.03184. [PMID: 16926189]