Saclofen (BioDeep_00000016991)

   


代谢物信息卡片


Saclofen

化学式: C9H12ClNO3S (249.0226392)
中文名称: β-(氨基甲基)-4 氯代苯乙烷磺酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C(CN)CS(=O)(=O)O)Cl
InChI: InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

描述信息

D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
Saclofen is a competitive antagonist of the GABAB receptor with an IC50 of 7.8 μM. Saclofen can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain[1].

同义名列表

1 个代谢物同义名

Saclofen



数据库引用编号

6 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marwa Y Sallam, Sahar M El-Gowilly, Abdel-Galil A Abdel-Galil, Mahmoud M El-Mas. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn-Schmiedeberg's archives of pharmacology. 2016 Mar; 389(3):279-88. doi: 10.1007/s00210-015-1201-7. [PMID: 26685896]
  • N Pozdnyakova, M Dudarenko, T Borisova. New effects of GABAB receptor allosteric modulator rac-BHFF on ambient GABA, uptake/release, Em and synaptic vesicle acidification in nerve terminals. Neuroscience. 2015 Sep; 304(?):60-70. doi: 10.1016/j.neuroscience.2015.07.037. [PMID: 26197223]
  • Nicolas Vallée, Jean-Jacques Rissoe, Jean-Eric Blatteau. Effect of an hyperbaric nitrogen narcotic ambience on arginine and citrulline levels, the precursor and co-product of nitric oxide, in rat striatum. Medical gas research. 2011 Jul; 1(1):16. doi: 10.1186/2045-9912-1-16. [PMID: 22146244]
  • Yukari Nakamura, Eiichi Hinoi, Takeshi Takarada, Yoshifumi Takahata, Tomomi Yamamoto, Hiroyuki Fujita, Saya Takada, Syota Hashizume, Yukio Yoneda. Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes. PloS one. 2011; 6(5):e20167. doi: 10.1371/journal.pone.0020167. [PMID: 21655283]
  • Kentaro Kaneko, Masashi Iwasaki, Masaaki Yoshikawa, Kousaku Ohinata. Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems. American journal of physiology. Gastrointestinal and liver physiology. 2010 Sep; 299(3):G799-805. doi: 10.1152/ajpgi.00081.2010. [PMID: 20616303]
  • Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to kava kava in the feline pulmonary vascular bed. Journal of medicinal food. 2006; 9(1):62-71. doi: 10.1089/jmf.2006.9.62. [PMID: 16579730]
  • Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to St. John's Wort in the feline pulmonary vascular bed. Journal of herbal pharmacotherapy. 2004; 4(3):47-62. doi: . [PMID: 15829469]
  • Aaron M Fields, Todd A Richards, Jason A Felton, Shaili K Felton, Erin Z Bayer, Ikhlass N Ibrahim, Alan David Kaye. Analysis of responses to valerian root extract in the feline pulmonary vascular bed. Journal of alternative and complementary medicine (New York, N.Y.). 2003 Dec; 9(6):909-18. doi: 10.1089/107555303771952253. [PMID: 14736362]
  • B Prieto-Gómez, J Tortoriello, A Vázquez-Alvarez, C Reyes-Vázquez. Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Planta medica. 2003 Jan; 69(1):38-43. doi: 10.1055/s-2003-37043. [PMID: 12567277]
  • Chun-Su Yuan, Lucy Dey, Anbao Wang, Sangeeta Mehendale, Jing-Tian Xie, Han H Aung, Michael K Ang-Lee. Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation. Planta medica. 2002 Dec; 68(12):1092-6. doi: 10.1055/s-2002-36338. [PMID: 12494336]
  • Marion Maus, Jacques Glowinski, Joel Premont. GABA is toxic for mouse striatal neurones through a transporter-mediated process. Journal of neurochemistry. 2002 Aug; 82(4):763-73. doi: 10.1046/j.1471-4159.2002.01011.x. [PMID: 12358781]
  • Gail D Zeevalk, Lawrence Manzino, Patricia K Sonsalla. Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum. Experimental neurology. 2002 Jul; 176(1):193-202. doi: 10.1006/exnr.2002.7917. [PMID: 12093096]