Aminosalicylic Acid (BioDeep_00000001699)

 

Secondary id: BioDeep_00000409330

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


p-Aminosalicylic acid, monosodium salt, dihydrate

化学式: C7H7NO3 (153.0425912)
中文名称: 4-氨基水杨酸, 对氨基水杨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 14.56%

分子结构信息

SMILES: C1=CC(=C(C=C1N)O)C(=O)O
InChI: InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

描述信息

Aminosalicylic Acid is only found in individuals that have used or taken this drug. It is an antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid. [PubChem]There are two mechanisms responsible for aminosalicylic acids bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slows. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis.
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AA - Aminosalicylic acid and derivatives
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
COVID info from PDB, Protein Data Bank
KEIO_ID A129
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

38 个代谢物同义名

p-Aminosalicylic acid, monosodium salt, dihydrate; p-Aminosalicylic acid, aluminum (2:1) salt; p-Aminosalicylic acid, calcium (2:1) salt; p-Aminosalicylic acid monopotassium salt; p Aminosalicylic acid monopotassium salt; p Aminosalicylic acid monolithium salt; p-Aminosalicylic acid monolithium salt; p-Aminosalicylic acid monosodium salt; p Aminosalicylic acid monosodium salt; 4-amino-2-hydroxybenzoic acid; 2-HYDROXY-4-aminobenzoIC ACID; Alumino-4-aminosalicylic acid; Alumino 4 aminosalicylic acid; 2-HYDROXY-4-aminobenzoate; Para-amino salicylic acid; Para-aminosalicylic acid; Para aminosalicylic acid; Aminosalicylate Sodium; 4 Aminosalicylic acid; p-Aminosalicylic acid; p Aminosalicylic acid; 4-Aminosalicylic acid; Para-amino salicylate; Acid, aminosalicylic; Aminosalicylic Acid; p-Aminosalicylate; 4-Aminosalicylate; Aminosalicylate; Amino-pas; Rezipas; Pamisyl; Paser; 4-ASA; PASK; APAS; PAS; 4-Aminosalicylate; 4-Aminosalicylic acid



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaocui Wu, Guangkun Tan, Wei Sha, Haican Liu, Jinghui Yang, Yinjuan Guo, Xin Shen, Zheyuan Wu, Hongbo Shen, Fangyou Yu. Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures. Microbiology spectrum. 2022 04; 10(2):e0251621. doi: 10.1128/spectrum.02516-21. [PMID: 35311541]
  • Md Masud Parvez, Said Kalkisim, Phuong Thi Thu Nguyen, Jin Ah Jung, Jeong-Kon Park, Jong-Lyul Ghim, Eun-Young Kim, Yong-Soon Cho, Melih O Babaoglu, Jae-Gook Shin. Para-aminosalicylic acid significantly reduced tenofovir exposure in human subjects: Mismatched findings from in vitro to in vivo translational research. British journal of clinical pharmacology. 2022 03; 88(3):1159-1169. doi: 10.1111/bcp.15056. [PMID: 34432302]
  • Denny L Cottle, Gloria M A Ursino, Lynelle K Jones, Ming Shen Tham, Allara K Zylberberg, Ian M Smyth. Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis. Cell reports. Medicine. 2020 11; 1(8):100129. doi: 10.1016/j.xcrm.2020.100129. [PMID: 33294854]
  • Ahmed A Abulfathi, Peter R Donald, Kim Adams, Elin M Svensson, Andreas H Diacon, Helmuth Reuter. The pharmacokinetics of para-aminosalicylic acid and its relationship to efficacy and intolerance. British journal of clinical pharmacology. 2020 11; 86(11):2123-2132. doi: 10.1111/bcp.14395. [PMID: 32470182]
  • Julia Wohl, Maike Petersen. Phenolic metabolism in the hornwort Anthoceros agrestis: 4-coumarate CoA ligase and 4-hydroxybenzoate CoA ligase. Plant cell reports. 2020 Sep; 39(9):1129-1141. doi: 10.1007/s00299-020-02552-w. [PMID: 32405654]
  • Kim T Adams, Peter R Donald, Ahmed A Abulfathi, Andreas H Diacon, Marietjie A Stander, Helmuth Reuter. Pharmacokinetics of Para-Aminosalicylic Acid and Its 2 Major Metabolites: A Potential Relationship to the Development of Gastrointestinal Intolerance. Journal of clinical pharmacology. 2020 04; 60(4):489-494. doi: 10.1002/jcph.1542. [PMID: 31682027]
  • Dong-Jie Peng, Yu-Wen Zhang, Zhao-Cong Li, Shao-Jun Li, Mei Cai, Wen-Xia Qin, Shi-Yan Ou, Xiao-Wei Huang, Zong-Xiang Yuan, Yue-Ming Jiang. Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2019 Jul; 54(?):134-141. doi: 10.1016/j.jtemb.2019.04.013. [PMID: 31109603]
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  • Tarek Baati, Patricia Horcajada, Ruxandra Gref, Patrick Couvreur, Christian Serre. Quantification of fumaric acid in liver, spleen and urine by high-performance liquid chromatography coupled to photodiode-array detection. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(4):758-62. doi: 10.1016/j.jpba.2011.07.011. [PMID: 21820831]
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  • Xinfeng Zhang, Yuelan Xuan, Aimin Sun, Yi Lv, Xiandeng Hou. Simultaneous determination of isoniazid and p-aminosalicylic acid by capillary electrophoresis using chemiluminescence detection. Luminescence : the journal of biological and chemical luminescence. 2009 Jul; 24(4):243-9. doi: 10.1002/bio.1107. [PMID: 19248184]
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