Salubrinal (BioDeep_00000016989)
代谢物信息卡片
Salubrinal
化学式: C21H17Cl3N4OS (478.0189)
中文名称: Salubrinal
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C=CC(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
InChI: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:131923
- ChEBI: CHEBI:91873
- KEGG: C75050
- PubChem: 5717801
- ChEMBL: CHEMBL180127
- CAS: 405060-95-9
- CAS: 304475-63-6
- MetaboLights: MTBLC131923
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yuan Yuan, Yang Guo, Zheng-Wang Guo, Hui-Feng Hao, Yan-Na Jiao, Xin-Xin Deng, Shu-Yan Han. Marsdenia tenacissima extract induces endoplasmic reticulum stress-associated immunogenic cell death in non-small cell lung cancer cells through targeting AXL.
Journal of ethnopharmacology.
2023 May; 314(?):116620. doi:
10.1016/j.jep.2023.116620. [PMID: 37207882] - Nicole H Lopez, Biaoru Li, Chithra Palani, Umapathy Siddaramappa, Mayuko Takezaki, Hongyan Xu, Wenbo Zhi, Betty S Pace. Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice.
PloS one.
2022; 17(5):e0261799. doi:
10.1371/journal.pone.0261799. [PMID: 35639781] - Tianhui Yang, Ruyi He, Gongzhe Li, Jia Liang, Liang Zhao, Xing Zhao, Liyang Li, Peng Wang. Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Neuroscience letters.
2021 07; 758(?):136004. doi:
10.1016/j.neulet.2021.136004. [PMID: 34098025] - Jie Li, Xinle Li, Daquan Liu, Shiqi Zhang, Nian Tan, Hiroki Yokota, Ping Zhang. Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner.
Cell death & disease.
2020 12; 11(12):1069. doi:
10.1038/s41419-020-03264-5. [PMID: 33318479] - Jian-Ri Li, Yen-Chuan Ou, Chih-Cheng Wu, Jiaan-Der Wang, Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen. Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Dec; 146(?):111828. doi:
10.1016/j.fct.2020.111828. [PMID: 33127495] - Asli Emincik, Zeynep Banu Gungor, Elif Guzel. Effects of salubrinal on ER stress in an experimental model of polycystic ovary syndrome.
Ultrastructural pathology.
2020 Nov; 44(4-6):422-435. doi:
10.1080/01913123.2020.1850963. [PMID: 33393432] - Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta. The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties.
Metallomics : integrated biometal science.
2020 06; 12(6):891-901. doi:
10.1039/d0mt00006j. [PMID: 32337526] - Mianli Bian, Jianlin He, Huanhuan Jin, Naqi Lian, Jiangjuan Shao, Qinglong Guo, Shijun Wang, Feng Zhang, Shizhong Zheng. Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress.
Apoptosis : an international journal on programmed cell death.
2019 12; 24(11-12):905-920. doi:
10.1007/s10495-019-01568-2. [PMID: 31538267] - Kazunori Aoi, Akiyoshi Nishio, Takashi Okazaki, Masahiro Takeo, Masataka Masuda, Toshiro Fukui, Kazushige Uchida, Kazuichi Okazaki. Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2019 Jun; 19(4):548-556. doi:
10.1016/j.pan.2019.04.005. [PMID: 31040063] - Sheng-Fan Wang, Chih-Hsuan Wung, Meng-Shian Chen, Chian-Feng Chen, Pen-Hui Yin, Tien-Shun Yeh, Yuh-Lih Chang, Yueh-Ching Chou, Hung-Hsu Hung, Hsin-Chen Lee. Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
International journal of molecular sciences.
2018 Oct; 19(11):. doi:
10.3390/ijms19113389. [PMID: 30380689] - Jia-Rong Jheng, Yuan-Siao Chen, Un Iong Ao, Ding-Cheng Chan, Jenq-Wen Huang, Kuang-Yu Hung, Der-Cheng Tarng, Chih-Kang Chiang. The double-edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation.
Journal of cachexia, sarcopenia and muscle.
2018 06; 9(3):570-584. doi:
10.1002/jcsm.12288. [PMID: 29380555] - Chao Ji, Bo Yang, Shu-Ying Huang, Jin-Wen Huang, Bo Cheng. Salubrinal protects human skin fibroblasts against UVB-induced cell death by blocking endoplasmic reticulum (ER) stress and regulating calcium homeostasis.
Biochemical and biophysical research communications.
2017 12; 493(4):1371-1376. doi:
10.1016/j.bbrc.2017.10.012. [PMID: 28988108] - Ziwei Huang, Min Zhou, Qian Wang, Mengjiao Zhu, Sheng Chen, Huang Li. Mechanical and hypoxia stress can cause chondrocytes apoptosis through over-activation of endoplasmic reticulum stress.
Archives of oral biology.
2017 Dec; 84(?):125-132. doi:
10.1016/j.archoralbio.2017.09.021. [PMID: 28987725] - Daquan Liu, Yunlong Zhang, Xinle Li, Jie Li, Shuang Yang, Xiaoxue Xing, Guanwei Fan, Hiroki Yokota, Ping Zhang. eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress.
Scientific reports.
2017 07; 7(1):5062. doi:
10.1038/s41598-017-05488-6. [PMID: 28698612] - Yue Zhang, Xiang Gao, Shuanggang Chen, Min Zhao, Jing Chen, Rui Liu, Shengyang Cheng, Mengyuan Qi, Shuo Wang, Wei Liu. Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy.
Cellular signalling.
2017 02; 31(?):31-40. doi:
10.1016/j.cellsig.2016.12.009. [PMID: 28024901] - Li-Li Huang, Xiao-Lin Zhu, Wei-Qian Deng, Na Duan, Xiu-Jie Liang, Yue Wang, Ting-Ting Guo, Shuang-Shuang Shu, Xiao-Hong Xiang, Ting-Ting Jiang, Xun Tang, Jun Zhang. [P38 MAPK signaling pathway mediates advanced oxidation protein product-induced epithelial-to-mesenchymal transition in tubular cells].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 Aug; 36(9):1209-1214. doi:
NULL. [PMID: 27687652] - Xiujie Liang, Na Duan, Yue Wang, Shuangshuang Shu, Xiaohong Xiang, Tingting Guo, Lei Yang, Shaojie Zhang, Xun Tang, Jun Zhang. Advanced oxidation protein products induce endothelial-to-mesenchymal transition in human renal glomerular endothelial cells through induction of endoplasmic reticulum stress.
Journal of diabetes and its complications.
2016 May; 30(4):573-9. doi:
10.1016/j.jdiacomp.2016.01.009. [PMID: 26861949] - Tony N Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G Dickhout, Joan C Krepinsky. SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.
Journal of the American Society of Nephrology : JASN.
2015 Aug; 26(8):1839-54. doi:
10.1681/asn.2013121332. [PMID: 25398788] - S Cao, B Yan, Y Lu, G Zhang, J Li, W Guo, Y Zhao, S Zhang. C/EBP homologous protein-mediated endoplasmic reticulum stress-related renal apoptosis is involved in rats with brain death.
Transplantation proceedings.
2015 Mar; 47(2):354-8. doi:
10.1016/j.transproceed.2014.10.012. [PMID: 25769572] - Linda L Wu, Darryl L Russell, Siew L Wong, Miaoxin Chen, Te-Sha Tsai, Justin C St John, Robert J Norman, Mark A Febbraio, John Carroll, Rebecca L Robker. Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors.
Development (Cambridge, England).
2015 Feb; 142(4):681-91. doi:
10.1242/dev.114850. [PMID: 25670793] - Zahraa Mohammed-Ali, Gaile L Cruz, Jeffrey G Dickhout. Crosstalk between the unfolded protein response and NF-κB-mediated inflammation in the progression of chronic kidney disease.
Journal of immunology research.
2015; 2015(?):428508. doi:
10.1155/2015/428508. [PMID: 25977931] - Qiaoqiao Wan, Wenxiao Xu, Jing-long Yan, Hiroki Yokota, Sungsoo Na. Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow.
PloS one.
2014; 9(8):e105699. doi:
10.1371/journal.pone.0105699. [PMID: 25157407] - Cristian González-Guerrero, Carlos Ocaña-Salceda, Sergio Berzal, Susana Carrasco, Beatriz Fernández-Fernández, Pablo Cannata-Ortiz, Jesús Egido, Alberto Ortiz, Adrián M Ramos. Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.
Toxicology and applied pharmacology.
2013 Nov; 272(3):825-41. doi:
10.1016/j.taap.2013.08.011. [PMID: 23958496] - Ting Yuan, Bai-ling Luo, Tian-hong Wei, Li Zhang, Bai-mei He, Rui-chao Niu. Salubrinal protects against cigarette smoke extract-induced HBEpC apoptosis likely via regulating the activity of PERK-eIF2α signaling pathway.
Archives of medical research.
2012 Oct; 43(7):522-9. doi:
10.1016/j.arcmed.2012.10.002. [PMID: 23072721] - Ping Zhang, Kazunori Hamamura, Chang Jiang, Liming Zhao, Hiroki Yokota. Salubrinal promotes healing of surgical wounds in rat femurs.
Journal of bone and mineral metabolism.
2012 Sep; 30(5):568-79. doi:
10.1007/s00774-012-0359-z. [PMID: 22610062] - Shaohua Zhu, Yan Wang, Jing Jin, Cuiwen Guan, Mei Li, Chen Xi, Zizhang Ouyang, Meiwan Chen, Yuwen Qiu, Min Huang, Zhiying Huang. Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2012 Aug; 26(5):663-71. doi:
10.1016/j.tiv.2012.03.005. [PMID: 22445861] - Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology.
2012 Jan; 258(2):275-87. doi:
10.1016/j.taap.2011.11.007. [PMID: 22155090] - Yuta Komoike, Hisako Inamura, Masato Matsuoka. Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells.
Archives of toxicology.
2012 Jan; 86(1):37-44. doi:
10.1007/s00204-011-0742-x. [PMID: 21809093] - Gwen Marie Taylor, Sandeep K Raghuwanshi, David T Rowe, Robert M Wadowsky, Adam Rosendorff. Endoplasmic reticulum stress causes EBV lytic replication.
Blood.
2011 Nov; 118(20):5528-39. doi:
10.1182/blood-2011-04-347112. [PMID: 21849482] - Cheng Tien Wu, Meei Ling Sheu, Keh Sung Tsai, Chih Kang Chiang, Shing Hwa Liu. Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model.
Free radical biology & medicine.
2011 Aug; 51(3):671-80. doi:
10.1016/j.freeradbiomed.2011.04.038. [PMID: 21616140] - Cheng T Wu, Meei L Sheu, Keh S Tsai, Te I Weng, Chih K Chiang, Shing H Liu. The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Apr; 114(2):295-301. doi:
10.1093/toxsci/kfq006. [PMID: 20071420] - Lene Sylvest, Christine Dam Bendiksen, Gunnar Houen. Phosphatase inhibitors with anti-angiogenic effect in vitro.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2010 Jan; 118(1):49-59. doi:
10.1111/j.1600-0463.2009.02561.x. [PMID: 20041871] - Ki Seong Eom, Hyung-Jin Kim, Hong-Seob So, Raekil Park, Tae Young Kim. Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction.
Biological & pharmaceutical bulletin.
2010; 33(10):1644-9. doi:
10.1248/bpb.33.1644. [PMID: 20930370] - Nicolas Bouvier, Jean Pierre Flinois, Jerome Gilleron, François-Ludovic Sauvage, Christophe Legendre, Philippe Beaune, Eric Thervet, Dany Anglicheau, Nicolas Pallet. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.
American journal of physiology. Renal physiology.
2009 Jan; 296(1):F160-9. doi:
10.1152/ajprenal.90567.2008. [PMID: 18987109] - N Pallet, N Bouvier, A Bendjallabah, M Rabant, J P Flinois, A Hertig, C Legendre, P Beaune, E Thervet, D Anglicheau. Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2008 Nov; 8(11):2283-96. doi:
10.1111/j.1600-6143.2008.02396.x. [PMID: 18785955] - M Yokouchi, N Hiramatsu, K Hayakawa, A Kasai, Y Takano, J Yao, M Kitamura. Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.
Cell death and differentiation.
2007 Aug; 14(8):1467-74. doi:
10.1038/sj.cdd.4402154. [PMID: 17464326] - Karen C Thomas, Ashwini S Sabnis, Mark E Johansen, Diane L Lanza, Philip J Moos, Garold S Yost, Christopher A Reilly. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.
The Journal of pharmacology and experimental therapeutics.
2007 Jun; 321(3):830-8. doi:
10.1124/jpet.107.119412. [PMID: 17332266] - G T Tucker. Plasma binding and disposition of local anesthetics.
International anesthesiology clinics.
1975; 13(4):33-59. doi:
10.1097/00004311-197513040-00005. [PMID: 1348]
