N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (BioDeep_00000016975)

   


代谢物信息卡片


N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

化学式: C15H11Cl2NO3 (323.0116)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1OC2=C(O1)C=C(C=C2)CNC(=O)C3=C(C=CC=C3Cl)Cl
InChI: InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)

描述信息

Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.

同义名列表

2 个代谢物同义名

N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide; Alda-1



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Romina Deza-Ponzio, Paula A Albrecht, Lucia E Fernandez-Hubeid, Tuany Eichwald, Romina B Cejas, Yohana C Garay, Mario Rivera-Meza, Alexandra Latini, Fernando J Irazoqui, Miriam B Virgolini. ALDH2 Inhibition by Lead and Ethanol Elicits Redox Imbalance and Mitochondrial Dysfunction in SH-SY5Y Human Neuroblastoma Cell Line: Reversion by Alda-1. Neurotoxicology. 2023 May; ?(?):. doi: 10.1016/j.neuro.2023.05.001. [PMID: 37142061]
  • Ling Chen, Yu-Ting Wu, Xuan-Ye Gu, Ling-Peng Xie, Hui-Jie Fan, Zhang-Bin Tan, Wen-Tong Zhang, Hong-Mei Chen, Jun Li, Gui-Qiong Huang, Bin Liu, Ying-Chun Zhou, Xiao-Min Sun. Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):128045. doi: 10.1016/j.bmcl.2021.128045. [PMID: 33865968]
  • Leonardo da Cunha Menezes Souza, Fábio Henrique Fernandes, Paula Torres Presti, Ana Lucia Anjos Ferreira, Daisy Maria Fávero Salvadori. Effect of doxorubicin on cardiac lipid metabolism-related transcriptome and the protective activity of Alda-1. European journal of pharmacology. 2021 May; 898(?):173955. doi: 10.1016/j.ejphar.2021.173955. [PMID: 33617823]
  • Hereward J Wimborne, Jiangting Hu, Kenji Takemoto, Nga T Nguyen, Hartmut Jaeschke, John J Lemasters, Zhi Zhong. Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization. Toxicology and applied pharmacology. 2020 06; 396(?):114982. doi: 10.1016/j.taap.2020.114982. [PMID: 32240663]
  • Shengchuan Cao, Yuan Bian, Xin Zhou, Qiuhuan Yuan, Shujian Wei, Li Xue, Feihong Yang, Qianqian Dong, Wenjun Wang, Boyuan Zheng, Jian Zhang, Zheng Wang, Ziqi Han, Kehui Yang, Haiying Rui, Ying Zhang, Feng Xu, Yuguo Chen. A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis. Biochemical and biophysical research communications. 2020 02; 522(2):518-524. doi: 10.1016/j.bbrc.2019.11.128. [PMID: 31784085]
  • Hereward J Wimborne, Kenji Takemoto, Patrick M Woster, Don C Rockey, John J Lemasters, Zhi Zhong. Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice. Free radical biology & medicine. 2019 12; 145(?):136-145. doi: 10.1016/j.freeradbiomed.2019.09.026. [PMID: 31557514]
  • Fayez T Hammad, Suhail Al-Salam, Priya Yuvaraju, Loay Lubbad. Alda-1, an aldehyde dehydrogenase-2 agonist, causes deterioration in renal functions following ischemia-reperfusion injury due to crystalline nephropathy. Drug development research. 2018 11; 79(7):315-323. doi: 10.1002/ddr.21454. [PMID: 30291750]
  • Yue Hua, Hongmei Chen, Xinyun Zhao, Min Liu, Wen Jin, Wen Yan, Yifen Wu, Zhangbin Tan, Huijie Fan, Yuting Wu, Lingpeng Xie, Wentong Zhang, Bin Liu, Yingchun Zhou. Alda‑1, an aldehyde dehydrogenase‑2 agonist, improves long‑term survival in rats with chronic heart failure following myocardial infarction. Molecular medicine reports. 2018 Sep; 18(3):3159-3166. doi: 10.3892/mmr.2018.9309. [PMID: 30066916]
  • Wenwen Liu, Xiaoxuan Zhai, Wenjun Wang, Boyuan Zheng, Zhenxiao Zhang, Xinhui Fan, Yuguo Chen, Jiali Wang. Aldehyde dehydrogenase 2 activation ameliorates cyclophosphamide-induced acute cardiotoxicity via detoxification of toxic aldehydes and suppression of cardiac cell death. Journal of molecular and cellular cardiology. 2018 08; 121(?):134-144. doi: 10.1016/j.yjmcc.2018.07.006. [PMID: 29981795]
  • Arnau Panisello-Roselló, Alexandre Lopez, Emma Folch-Puy, Teresa Carbonell, Anabela Rolo, Carlos Palmeira, René Adam, Marc Net, Joan Roselló-Catafau. Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update. World journal of gastroenterology. 2018 Jul; 24(27):2984-2994. doi: 10.3748/wjg.v24.i27.2984. [PMID: 30038465]
  • Mei-Yan Yang, Ya-Bin Wang, Bo Han, Bo Yang, Yu-Wei Qiang, Yan Zhang, Zhao Wang, Xu Huang, Jie Liu, Yun-Dai Chen, Jun Ren, Feng Cao, Yong Xu. Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells. Acta pharmacologica Sinica. 2018 Jan; 39(1):48-58. doi: 10.1038/aps.2017.81. [PMID: 28858301]
  • Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia. Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. Journal of immunology research. 2018; 2018(?):9807139. doi: 10.1155/2018/9807139. [PMID: 30671488]
  • Tao Xu, Shuangyue Liu, Tingting Ma, Ziyi Jia, Zhifei Zhang, Aimei Wang. Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension. Redox biology. 2017 04; 11(?):286-296. doi: 10.1016/j.redox.2016.12.019. [PMID: 28030785]
  • Aneta Stachowicz, Rafał Olszanecki, Maciej Suski, Katarzyna Głombik, Agnieszka Basta-Kaim, Dariusz Adamek, Ryszard Korbut. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). International journal of molecular sciences. 2017 Feb; 18(2):. doi: 10.3390/ijms18020435. [PMID: 28218653]
  • Monika Mittal, Subhashis Pal, Shyamsundar Pal China, Konica Porwal, Kapil Dev, Richa Shrivastava, Kanumuri Siva Rama Raju, Mamunur Rashid, Arun Kumar Trivedi, Sabyasachi Sanyal, Muhammad Wahajuddin, Smrati Bhaduria, Rakesh Maurya, Naibedya Chattopadhyay. Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect. Toxicology and applied pharmacology. 2017 02; 316(?):63-73. doi: 10.1016/j.taap.2016.12.013. [PMID: 28017615]
  • Naim Stiti, Balakumaran Chandrasekar, Laura Strubl, Shabaz Mohammed, Dorothea Bartels, Renier A L van der Hoorn. Nicotinamide Cofactors Suppress Active-Site Labeling of Aldehyde Dehydrogenases. ACS chemical biology. 2016 06; 11(6):1578-86. doi: 10.1021/acschembio.5b00784. [PMID: 26990764]
  • Aneta Stachowicz, Katarzyna Głombik, Rafał Olszanecki, Agnieszka Basta-Kaim, Maciej Suski, Władysław Lasoń, Ryszard Korbut. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain, behavior, and immunity. 2016 Jan; 51(?):144-153. doi: 10.1016/j.bbi.2015.08.004. [PMID: 26254233]
  • Wei Zhong, Wenliang Zhang, Qiong Li, Guoxiang Xie, Qian Sun, Xiuhua Sun, Xiaobing Tan, Xinguo Sun, Wei Jia, Zhanxiang Zhou. Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice. Journal of hepatology. 2015 Jun; 62(6):1375-81. doi: 10.1016/j.jhep.2014.12.022. [PMID: 25543082]
  • Katia M S Gomes, Luiz R G Bechara, Vanessa M Lima, Márcio A C Ribeiro, Juliane C Campos, Paulo M Dourado, Alicia J Kowaltowski, Daria Mochly-Rosen, Julio C B Ferreira. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. International journal of cardiology. 2015 Jan; 179(?):129-38. doi: 10.1016/j.ijcard.2014.10.140. [PMID: 25464432]
  • Aneta Stachowicz, Rafał Olszanecki, Maciej Suski, Anna Wiśniewska, Justyna Totoń-Żurańska, Józef Madej, Jacek Jawień, Magdalena Białas, Krzysztof Okoń, Mariusz Gajda, Katarzyna Głombik, Agnieszka Basta-Kaim, Ryszard Korbut. Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Journal of the American Heart Association. 2014 Nov; 3(6):e001329. doi: 10.1161/jaha.114.001329. [PMID: 25392542]
  • P R Steinmetz, Q Al-Awqati, W J Lawton. Nephrology rounds, University of Iowa Hospitals: renal tubular acidosis. The American journal of the medical sciences. 1976 Jan; 271(1):40-54. doi: 10.1097/00000441-197601000-00006. [PMID: 3970]