JNJ-7777120 (BioDeep_00000016973)

   


代谢物信息卡片


(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone

化学式: C14H16ClN3O (277.0982)
中文名称: JNJ-7777120, （5-氯-1H-吲哚-2-基）（4-甲基-1-哌嗪基）甲酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1
InChI: InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3

描述信息

JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2].

同义名列表

4 个代谢物同义名

(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone; JNJ-7777120; 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine; (5-Chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Ahmed F Mohamed, Mohammed F El-Yamany, Fatma A El-Batrawy, Mohamed T Abdel-Aziz. JNJ7777120 Ameliorates Inflammatory and Oxidative Manifestations in a Murine Model of Contact Hypersensitivity via Modulation of TLR and Nrf2 Signaling. Inflammation. 2018 Mar; 41(2):378-389. doi: 10.1007/s10753-017-0693-3. [PMID: 29127662]
  • Sheikh Fayaz Ahmad, Khairy M A Zoheir, Mushtaq Ahmad Ansari, Ahmed Nadeem, Saleh A Bakheet, Ali R Al-Hoshani, Othman A Al-Shabanah, Mohammed M Al-Harbi, Sabry M Attia. Histamine 4 receptor promotes expression of costimulatory B7.1/B7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses. Journal of neuroimmunology. 2015 Dec; 289(?):30-42. doi: 10.1016/j.jneuroim.2015.10.008. [PMID: 26616869]
  • Eleonora Veglia, Cristina Grange, Alessandro Pini, Aldo Moggio, Cecilia Lanzi, Giovanni Camussi, Paul L Chazot, Arianna Carolina Rosa. Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2015 Apr; 64(3-4):261-70. doi: 10.1007/s00011-015-0807-z. [PMID: 25725698]
  • Adel R A Abd-Allah, Sheikh Fayaz Ahmad, Ibrahim Alrashidi, Hala E Abdel-Hamied, Khairy M A Zoheir, Abdelkader E Ashour, Saleh A Bakheet, Sabry M Attia. Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis. International immunology. 2014 Jun; 26(6):325-40. doi: 10.1093/intimm/dxt075. [PMID: 24402309]
  • Detlef Neumann, Silke Beermann, Heike Burhenne, Silke Glage, Christina Hartwig, Roland Seifert. The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma. Naunyn-Schmiedeberg's archives of pharmacology. 2013 Nov; 386(11):983-90. doi: 10.1007/s00210-013-0898-4. [PMID: 23820873]
  • Ayuko Matsushita, Masahiro Seike, Haruka Okawa, Yayoi Kadawaki, Hiroshi Ohtsu. Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis. Experimental dermatology. 2012 Sep; 21(9):714-5. doi: 10.1111/j.1600-0625.2012.01559.x. [PMID: 22897580]
  • Silke Beermann, Silke Glage, Danny Jonigk, Roland Seifert, Detlef Neumann. Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PloS one. 2012; 7(1):e30285. doi: 10.1371/journal.pone.0030285. [PMID: 22272324]
  • Eriko Suwa, Katsunori Yamaura, Manabu Oda, Takao Namiki, Koichi Ueno. Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model. European journal of pharmacology. 2011 Sep; 667(1-3):383-8. doi: 10.1016/j.ejphar.2011.05.037. [PMID: 21664903]
  • Zhi-qiang Yan, Ru-xin Zhang, Shao-qing Yu, Wu Wen, Jin-ke Hong, Jun Zhang, Xiao-li Shao, Sheng-hong Gao. [Effect of histamine H4 receptor and its antagonist on allergic rhinitis in rats]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. 2010 Jun; 45(6):477-80. doi: NULL. [PMID: 21055325]
  • Herman D Lim, Chris de Graaf, Wen Jiang, Payman Sadek, Patricia M McGovern, Enade P Istyastono, Remko A Bakker, Iwan J P de Esch, Robin L Thurmond, Rob Leurs. Molecular determinants of ligand binding to H4R species variants. Molecular pharmacology. 2010 May; 77(5):734-43. doi: 10.1124/mol.109.063040. [PMID: 20103609]
  • Tadashi Kohyama, Yasuhiro Yamauchi, Hajime Takizawa, Sumiko Kamitani, Shin Kawasaki, Takahide Nagase. Histamine stimulates human lung fibroblast migration. Molecular and cellular biochemistry. 2010 Apr; 337(1-2):77-81. doi: 10.1007/s11010-009-0287-y. [PMID: 19851834]
  • Yuji Takahashi, Yoto Kagawa, Kana Izawa, Rie Ono, Masaaki Akagi, Chiaki Kamei. Effect of histamine H4 receptor antagonist on allergic rhinitis in mice. International immunopharmacology. 2009 Jun; 9(6):734-8. doi: 10.1016/j.intimp.2009.02.011. [PMID: 19275949]
  • L G Morin. Improved separation of creatine kinase cardiac isoenzyme in serum by batch fractionation. Clinical chemistry. 1976 Jan; 22(1):92-7. doi: NULL. [PMID: 1160]