Tritoqualine (BioDeep_00000169719)

   

human metabolite


代谢物信息卡片


7-amino-4,5,6-triethoxy-3-{4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl}-1,3-dihydro-2-benzofuran-1-one

化学式: C26H32N2O8 (500.21585519999996)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=C(C(=C(C2=C1C(OC2=O)C3C4=C(C5=C(C=C4CCN3C)OCO5)OC)N)OCC)OCC
InChI: InChI=1S/C26H32N2O8/c1-6-31-23-17-16(18(27)24(32-7-2)25(23)33-8-3)26(29)36-21(17)19-15-13(9-10-28(19)4)11-14-20(22(15)30-5)35-12-34-14/h11,19,21H,6-10,12,27H2,1-5H3

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
Tritoqualine is an H1-antihistamine.
C471 - Enzyme Inhibitor

同义名列表

13 个代谢物同义名

7-amino-4,5,6-triethoxy-3-{4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl}-1,3-dihydro-2-benzofuran-1-one; 4,5,6-Triethoxy-7-amino-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)phthalide; Chiesi brand OF tritoqualine; Tritoqualine; Inhibostamin; Tritoqualin; Tritocaline; Hypostamine; Hypostamin; Livalfa; L 554; 35NZ; 554l



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Matthias Unger, Stefanie Laug, Ulrike Holzgrabe. Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts. Electrophoresis. 2005 Jun; 26(12):2430-6. doi: 10.1002/elps.200410322. [PMID: 15912542]
  • D Rehn, H J Reimann, M von der Ohe, U Schmidt, G Hennings. The influence of tritoqualin (Inhibostamin) on the plasma histamine level and its biorhythmic variations. Agents and actions. 1987 Dec; 22(3-4):209-13. doi: 10.1007/bf02009048. [PMID: 3445817]
  • S Yuasa, Y Nakao, K Umezu. Suppressive effect of tritoqualine on enzyme leakage induced by D-galactosamine in rat primary-cultured hepatocytes. Japanese journal of pharmacology. 1987 Mar; 43(3):263-6. doi: 10.1254/jjp.43.263. [PMID: 3586415]
  • S Yuasa, A Sudoh, Y Nakao, K Umezu. Suppressive effect of tritoqualine on lipid peroxidation and enzyme leakage induced by carbon tetrachloride in rat hepatocytes. Japanese journal of pharmacology. 1986 Jun; 41(2):205-10. doi: 10.1254/jjp.41.205. [PMID: 2875205]
  • C Maśliński, W A Fogel, J Wyczółkowska, J Z Nowak. Tritoqualine and some aspects of histamine metabolism. Arzneimittel-Forschung. 1986 May; 36(5):822-5. doi: NULL. [PMID: 2425817]
  • K Umezu, S Yuasa, A Sudoh, M Inagaki. [Suppressive effect of tritoqualine (TRQ) on the acceleration of fibrosis in the liver]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1986 Mar; 87(3):291-300. doi: 10.1254/fpj.87.291. [PMID: 3710312]
  • G Albertini, R Davalli, P Moroni, V Oberhauser. Clinical pharmacology of tritoqualine: a comparative study against dexchlorpheniramine in allergic rhinitis. International journal of clinical pharmacology research. 1986; 6(2):113-8. doi: NULL. [PMID: 2873107]
  • S Yuasa, A Sudoh, K Umezu. [Effect of tritoqualine on liver regeneration after partial hepatectomy in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1985 May; 85(5):387-95. doi: 10.1254/fpj.85.387. [PMID: 4029809]
  • S Yuasa, A Sudoh, K Toshida, M Takechi, K Umezu. [Therapeutic effect of TRQ on chronic liver injury model in rats induced by CCl4]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1985 Apr; 85(4):249-57. doi: 10.1254/fpj.85.249. [PMID: 4007708]
  • K Umezu, S Yuasa, A Sudoh. [Prophylactic effect of tritoqualine (TRQ) on the CCl4-induced chronic liver injury model in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1985 Mar; 85(3):185-92. doi: 10.1254/fpj.85.185. [PMID: 4007707]
  • K Ishii, O Suzuki, K Maruyama, H Nagata, Y Kiryu, M Tsuchiya. Therapeutic effect of histidine decarboxylase inhibitor on chronic active hepatitis. Gastroenterologia Japonica. 1978; 13(2):105-10. doi: 10.1007/bf02773855. [PMID: 669195]