Temelastine (BioDeep_00000169714)

   

human metabolite


代谢物信息卡片


2-{[4-(5-bromo-3-methylpyridin-2-yl)butyl]amino}-5-[(6-methylpyridin-3-yl)methyl]-3,4-dihydropyrimidin-4-one

化学式: C21H24BrN5O (441.1164114)
中文名称: 替美斯汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(CC2=CN=C(NCCCCC3=C(C)C=C(Br)C=N3)NC2=O)C=N1
InChI: InChI=1S/C21H24BrN5O/c1-14-9-18(22)13-25-19(14)5-3-4-8-23-21-26-12-17(20(28)27-21)10-16-7-6-15(2)24-11-16/h6-7,9,11-13H,3-5,8,10H2,1-2H3,(H2,23,26,27,28)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Temelastine is a second-generation H1-antihistamine.

同义名列表

6 个代谢物同义名

2-{[4-(5-bromo-3-methylpyridin-2-yl)butyl]amino}-5-[(6-methylpyridin-3-yl)methyl]-3,4-dihydropyrimidin-4-one; SK And F 93944; SK And F-93944; Temelastine; SK&F 93944; SKF 93944



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G Coelho-Palermo Cunha, B van Ravenzwaay. Evaluation of mechanisms inducing thyroid toxicity and the ability of the enhanced OECD Test Guideline 407 to detect these changes. Archives of toxicology. 2005 Jul; 79(7):390-405. doi: 10.1007/s00204-004-0644-2. [PMID: 15692820]
  • A Kjaer, U Knigge, E L Madsen, P Søe-Jensen, F W Bach, J Warberg. Insulin/hypoglycemia-induced adrenocorticotropin and beta-endorphin release: involvement of hypothalamic histaminergic neurons. Endocrinology. 1993 May; 132(5):2213-20. doi: 10.1210/endo.132.5.8386615. [PMID: 8386615]
  • E Doyle, A M Mitchell, V S Picot, S J Rogers. Determination of temelastine and a hydroxymethyl-pyridyl metabolite in biological fluid by high-performance liquid chromatography. Journal of pharmaceutical sciences. 1990 Jun; 79(6):524-6. doi: 10.1002/jps.2600790614. [PMID: 2395097]
  • A Poole, G R Betton, G Salmon, T Sutton, C K Atterwill. Comparative toxicology of temelastine. A novel H1 antagonist in dog, rat, and monkey. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1990 Jan; 14(1):71-83. doi: 10.1016/0272-0590(90)90232-9. [PMID: 1968406]
  • T J Blake, I G Beattie. The analysis and characterization of isomeric metabolites of temelastine by the combined use of thermospray liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry. Biomedical & environmental mass spectrometry. 1989 Oct; 18(10):860-6. doi: 10.1002/bms.1200181004. [PMID: 2804433]
  • U Knigge, S Matzen, F W Bach, P Bang, J Warberg. Involvement of histaminergic neurons in the stress-induced release of pro-opiomelanocortin-derived peptides in rats. Acta endocrinologica. 1989 Apr; 120(4):533-9. doi: 10.1530/acta.0.1200533. [PMID: 2566249]
  • U Knigge, S Matzen, J Warberg. Histaminergic mediation of the stress-induced release of prolactin in male rats. Neuroendocrinology. 1988 Jan; 47(1):68-74. doi: 10.1159/000124893. [PMID: 3340272]
  • E Doyle, J C Pearce, V S Picot, R M Lee. Analysis of drugs from biological fluids using disposable solid phase columns. Journal of chromatography. 1987 Dec; 411(?):325-33. doi: 10.1016/s0021-9673(00)93983-9. [PMID: 2895114]
  • B G Charles, J J Schneider, R L Norris, P J Ravenscroft. Temelastine does not affect theophylline pharmacokinetics in normal subjects. British journal of clinical pharmacology. 1987 Nov; 24(5):673-5. doi: 10.1111/j.1365-2125.1987.tb03229.x. [PMID: 2893638]
  • T J Blake. Structure elucidation of drug metabolites using thermospray liquid chromatography-mass spectrometry. Journal of chromatography. 1987 May; 394(1):171-81. doi: 10.1016/s0021-9673(01)94170-6. [PMID: 3597616]
  • C de Mey, I Meineke, H Wesche. Temelastine, a novel histamine H1-receptor antagonist, does not induce oxidative hepatic enzyme activity in man. European journal of drug metabolism and pharmacokinetics. 1987 Jan; 12(1):65-9. doi: 10.1007/bf03189863. [PMID: 2886338]
  • M J Mattila, M Mattila, K Konno. Acute and subacute actions on human performance and interactions with diazepam of temelastine (SK&F93944) and diphenhydramine. European journal of clinical pharmacology. 1986; 31(3):291-8. doi: 10.1007/bf00981126. [PMID: 2878812]
  • F Alexander, R M Stote, N Allison, R G Familiar, D Tatoian, J W Dubb. Temelastine, a new H1-receptor antagonist. The Journal of international medical research. 1986; 14(4):200-4. doi: 10.1177/030006058601400406. [PMID: 2875907]