Desethylchloroquine (BioDeep_00000016971)

   


代谢物信息卡片


Desethyl Chloroquine

化学式: C16H22ClN3 (291.1502162)
中文名称: 去乙基氯喹
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNCCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
InChI: InChI=1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

描述信息

同义名列表

2 个代谢物同义名

Desethyl Chloroquine; Desethylchloroquine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • R J Brüggemann, D J A R Moes, K P van Rhee, N E van 't Veer, B C P Koch, M van Rossum, A Vermeulen Windsant-van den Tweel, M H E Reijers, R R J van Kimmenade, J C Rahamat-Langedoen, T C D Rettig, R van Raalte, J van Paassen, F N Polderman, P D van der Linden, T Frenzel, Q de Mast, D M Burger, J Schouten, F L van de Veerdonk, P Pickkers, R Ter Heine. Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals. International journal of antimicrobial agents. 2021 Mar; 57(3):106293. doi: 10.1016/j.ijantimicag.2021.106293. [PMID: 33515687]
  • Azrin N Abd-Rahman, Louise Marquart, Nathalie Gobeau, Anne Kümmel, Julie A Simpson, Stephan Chalon, Jörg J Möhrle, James S McCarthy. Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study. Clinical pharmacology and therapeutics. 2020 11; 108(5):1055-1066. doi: 10.1002/cpt.1893. [PMID: 32415986]
  • James A Watson, Joel Tarning, Richard M Hoglund, Frederic J Baud, Bruno Megarbane, Jean-Luc Clemessy, Nicholas J White. Concentration-dependent mortality of chloroquine in overdose. eLife. 2020 07; 9(?):. doi: 10.7554/elife.58631. [PMID: 32639233]
  • Luann Wendel Pereira de Sena, Amanda Gabryelle Nunes Cardoso Mello, Michelle Valéria Dias Ferreira, Marcieni Andrade de Ataide, Rosa Maria Dias, José Luiz Fernandes Vieira. Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin. Malaria journal. 2019 Dec; 18(1):439. doi: 10.1186/s12936-019-3072-8. [PMID: 31864358]
  • Esteban Mesa-Echeverry, Mayra Niebles-Bolívar, Alberto Tobón-Castaño. Chloroquine-Primaquine Therapeutic Efficacy, Safety, and Plasma Levels in Patients with Uncomplicated Plasmodium vivax Malaria in a Colombian Pacific Region. The American journal of tropical medicine and hygiene. 2019 01; 100(1):72-77. doi: 10.4269/ajtmh.18-0655. [PMID: 30457097]
  • Matthew M Ippolito, Jeffrey M Jacobson, Michael M Lederman, Markus Winterberg, Joel Tarning, Theresa A Shapiro, Charles Flexner. Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018 10; 67(10):1617-1620. doi: 10.1093/cid/ciy405. [PMID: 29771277]
  • Sam Salman, Francesca Baiwog, Madhu Page-Sharp, Kay Kose, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis. Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. International journal of antimicrobial agents. 2017 Oct; 50(4):542-551. doi: 10.1016/j.ijantimicag.2017.05.011. [PMID: 28669839]
  • Toi Van Pham, Phuong Pham Nguyen, Tho Nguyen Duc Khanh, Nhien Nguyen Thanh Thuy, Ca Nguyen Thuy Nha, Thomas Pouplin, Jeremy Farrar, Guy E Thwaites, Hien Tran Tinh. An HPLC method with diode array detector for the simultaneous quantification of chloroquine and desethylchloroquine in plasma and whole blood samples from Plasmodium vivax patients in Vietnam, using quinine as an internal standard. Biomedical chromatography : BMC. 2016 Jul; 30(7):1104-1111. doi: 10.1002/bmc.3657. [PMID: 26578224]
  • Lina Zuluaga-Idárraga, Natalia Yepes-Jiménez, Carlos López-Córdoba, Silvia Blair-Trujillo. Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD. Journal of pharmaceutical and biomedical analysis. 2014 Jul; 95(?):200-6. doi: 10.1016/j.jpba.2014.03.006. [PMID: 24682018]
  • Marly M Marques, Monica R F Costa, Franklin S Santana Filho, José L F Vieira, Margareth T S Nascimento, Larissa W Brasil, Fátima Nogueira, Henrique Silveira, Roberto C Reyes-Lecca, Wuelton M Monteiro, Marcus V G Lacerda, Maria G C Alecrim. Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon. Antimicrobial agents and chemotherapy. 2014; 58(1):342-7. doi: 10.1128/aac.02279-12. [PMID: 24165179]
  • Praveena Chiowchanwisawakit, Surasak Nilganuwong, Varalak Srinonprasert, Rasada Boonprasert, Weerawadee Chandranipapongse, Somruedee Chatsiricharoenkul, Wanruchada Katchamart, Piyapat Pongnarin, Wimonrat Danwiriyakul, Ajchara Koolvisoot, Emvalee Arromdee, Ngamkae Ruangvaravate. Prevalence and risk factors for chloroquine maculopathy and role of plasma chloroquine and desethylchloroquine concentrations in predicting chloroquine maculopathy. International journal of rheumatic diseases. 2013 Feb; 16(1):47-55. doi: 10.1111/1756-185x.12029. [PMID: 23441772]
  • Anurak Cheomung, Kesara Na-Bangchang. HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):1031-40. doi: 10.1016/j.jpba.2011.03.001. [PMID: 21466937]
  • Harin A Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law, Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F Ilett, Timothy M E Davis. Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy. Antimicrobial agents and chemotherapy. 2010 Mar; 54(3):1186-92. doi: 10.1128/aac.01269-09. [PMID: 20086162]
  • Harin A Karunajeewa, Kenneth F Ilett, Ivo Mueller, Peter Siba, Irwin Law, Madhu Page-Sharp, Enmoore Lin, Jovitha Lammey, Kevin T Batty, Timothy M E Davis. Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria. Antimicrobial agents and chemotherapy. 2008 Jan; 52(1):237-43. doi: 10.1128/aac.00555-07. [PMID: 17967917]
  • Anderson Rodrigo Moraes de Oliveira, Pierina Sueli Bonato. Stereoselective determination of hydroxychloro-quine and its major metabolites in human urine by solid-phase microextraction and HPLC. Journal of separation science. 2007 Oct; 30(15):2351-9. doi: 10.1002/jssc.200700121. [PMID: 17722190]
  • I A Yakasai. An improved high-performance liquid chromatographic determination of chloroquine and its major metabolite, desethylchloroquine, in human plasma. European journal of drug metabolism and pharmacokinetics. 2006 Jan; 31(1):1-4. doi: 10.1007/bf03190634. [PMID: 16715775]
  • Jens Rengelshausen, Jürgen Burhenne, Margit Fröhlich, Yorki Tayrouz, Shio Kumar Singh, Klaus-Dieter Riedel, Olaf Müller, Torsten Hoppe-Tichy, Walter E Haefeli, Gerd Mikus, Ingeborg Walter-Sack. Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria. European journal of clinical pharmacology. 2004 Dec; 60(10):709-15. doi: 10.1007/s00228-004-0818-0. [PMID: 15619134]
  • Mercilina C Chukwuani, Oluseye O Bolaji, Cyprian O Onyeji, O N Makinde, Festus A Ogunbona. Evidence for increased metabolism of chloroquine during the early third trimester of human pregnancy. Tropical medicine & international health : TM & IH. 2004 May; 9(5):601-5. doi: 10.1111/j.1365-3156.2004.01227.x. [PMID: 15117305]
  • D Müller, G Blaschke. Enantioselective assay of chloroquine and its main metabolite deethyl chloroquine in human plasma by capillary electrophoresis. Journal of chromatographic science. 2000 Oct; 38(10):435-40. doi: 10.1093/chromsci/38.10.435. [PMID: 11048780]
  • O G Ademowo, O Sodeinde, O Walker. The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without chloroquine-induced pruritus: evidence for decreased chloroquine metabolism in volunteers with pruritus. Clinical pharmacology and therapeutics. 2000 Mar; 67(3):237-41. doi: 10.1067/mcp.2000.104257. [PMID: 10741626]
  • V K Dua, P K Kar, N C Gupta, V P Sharma. Determination of chloroquine and desethylchloroquine in plasma and blood cells of Plasmodium vivax malaria cases using liquid chromatography. Journal of pharmaceutical and biomedical analysis. 1999 Oct; 21(1):199-205. doi: 10.1016/s0731-7085(99)00097-7. [PMID: 10701928]
  • V K Dua, N C Gupta, V P Sharma. Chloroquine concentration profile in the community of Mewat region, district Gurgaon (Haryana), India. The Southeast Asian journal of tropical medicine and public health. 1999 Jun; 30(2):232-4. doi: NULL. [PMID: 10774683]
  • H Wu. [Determination of chloroquine in human urine]. Fa yi xue za zhi. 1998; 14(4):201-2, 251. doi: NULL. [PMID: 11938897]
  • B Traore, E Lazaro, F Gay. A bioassay for evaluating antimalarial activity and for measuring concentration in plasma. Tropical medicine & international health : TM & IH. 1997 Oct; 2(10):929-33. doi: 10.1046/j.1365-3156.1997.d01-150.x. [PMID: 9357482]
  • O Walker, O G Ademowo. A rapid, cost-effective liquid chromatographic method for the determination of chloroquine and desethylchloroquine in biological fluids. Therapeutic drug monitoring. 1996 Feb; 18(1):92-6. doi: 10.1097/00007691-199602000-00015. [PMID: 8848828]
  • B M Kotecka, K H Rieckmann. In vivo-in vitro model to assess chloroquine activity in monkeys. Chemotherapy. 1995 Mar; 41(2):134-40. doi: 10.1159/000239334. [PMID: 7758357]
  • A M Vigário, T A Eggelte, A Costa, E Seixas, V E Rosário. Investigation of chloroquine intake in Biombo region, Guinea Bissau. Applied parasitology. 1994 Nov; 35(4):237-41. doi: NULL. [PMID: 7812310]
  • K Croes, P T McCarthy, R J Flanagan. Simple and rapid HPLC of quinine, hydroxychloroquine, chloroquine, and desethylchloroquine in serum, whole blood, and filter paper-adsorbed dry blood. Journal of analytical toxicology. 1994 Sep; 18(5):255-60. doi: 10.1093/jat/18.5.255. [PMID: 7990442]
  • J Iredale, H Fieger, I W Wainer. Determination of the stereoisomers of hydroxychloroquine and its major metabolites in plasma and urine following a single oral administration of racemic hydroxychloroquine. Seminars in arthritis and rheumatism. 1993 Oct; 23(2 Suppl 1):74-81. doi: 10.1016/s0049-0172(10)80011-3. [PMID: 8278822]
  • J F Chaulet, Y Robet, J M Prevosto, O Soares, J L Brazier. Simultaneous determination of chloroquine and quinine in human biological fluids by high-performance liquid chromatography. Journal of chromatography. 1993 Apr; 613(2):303-10. doi: 10.1016/0378-4347(93)80146-u. [PMID: 8491817]
  • P Augustijns, N Verbeke. Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans. Clinical pharmacokinetics. 1993 Mar; 24(3):259-69. doi: 10.2165/00003088-199324030-00007. [PMID: 8462231]
  • A J McLachlan, D J Cutler, S E Tett. Plasma protein binding of the enantiomers of hydroxychloroquine and metabolites. European journal of clinical pharmacology. 1993; 44(5):481-4. doi: 10.1007/bf00315548. [PMID: 8359187]
  • H Fieger, J Iredale, I W Wainer. Enantioselective determination of hydroxychloroquine and its major metabolites in urine and the observation of a reversal in the (+)/(-)-hydroxychloroquine ratio. Chirality. 1993; 5(2):65-70. doi: 10.1002/chir.530050205. [PMID: 8343344]
  • E A Karim, K E Ibrahim, M A Hassabalrasoul, B O Saeed, R A Bayoumi. A study of chloroquine and desethylchloroquine plasma levels in patients infected with sensitive and resistant malaria parasites. Journal of pharmaceutical and biomedical analysis. 1992 Feb; 10(2-3):219-23. doi: 10.1016/0731-7085(92)80032-i. [PMID: 1391103]
  • J Iredale, I W Wainer. Determination of hydroxychloroquine and its major metabolites in plasma using sequential achiral-chiral high-performance liquid chromatography. Journal of chromatography. 1992 Jan; 573(2):253-8. doi: 10.1016/0378-4347(92)80126-b. [PMID: 1601957]
  • D R Miller, S K Khalil, G A Nygard. Steady-state pharmacokinetics of hydroxychloroquine in rheumatoid arthritis patients. DICP : the annals of pharmacotherapy. 1991 Dec; 25(12):1302-5. doi: 10.1177/106002809102501202. [PMID: 1815421]
  • C Escande, P Chevalier, F Verdier, R Bourdon. Sensitive radioimmunoassay and enzyme-linked immunosorbent assay for the simultaneous determination of chloroquine and its metabolites in biological fluids. Journal of pharmaceutical sciences. 1990 Jan; 79(1):23-7. doi: 10.1002/jps.2600790107. [PMID: 2313570]
  • K H Rieckmann, D R Davis, D C Hutton. Plasmodium vivax resistance to chloroquine?. Lancet (London, England). 1989 Nov; 2(8673):1183-4. doi: 10.1016/s0140-6736(89)91792-3. [PMID: 2572903]
  • F O Ajayi, L A Salako, J O Kuye. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. African journal of medicine and medical sciences. 1989 Jun; 18(2):95-100. doi: NULL. [PMID: 2547293]
  • M Estadieu, A Durand, A Viala, P P Rop, M Fornaris, J Quicke. A rapid HPLC procedure for the simultaneous determination of chloroquine, monodesethylchloroquine, diazepam, and nordiazepam in blood. Journal of analytical toxicology. 1989 Mar; 13(2):89-93. doi: 10.1093/jat/13.2.89. [PMID: 2499732]
  • N J White, K D Miller, F C Churchill, C Berry, J Brown, S B Williams, B M Greenwood. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. The New England journal of medicine. 1988 Dec; 319(23):1493-500. doi: 10.1056/nejm198812083192301. [PMID: 3054558]
  • R W Steketee, D L Mount, L C Patchen, S B Williams, F C Churchill, J M Roberts, D C Kaseje, A D Brandling-Bennett. Field application of a colorimetric method of assaying chloroquine and desethylchloroquine in urine. Bulletin of the World Health Organization. 1988; 66(4):485-90. doi: NULL. [PMID: 3262448]
  • D L Mount, B L Nahlen, L C Patchen, F C Churchill. Field-adapted method for high-performance thin-layer chromatographic detection and estimation of chloroquine and desethylchloroquine in urine. Journal of chromatography. 1987 Dec; 423(?):261-9. doi: 10.1016/0378-4347(87)80349-3. [PMID: 3443657]
  • L A Salako, F O Ajayi. Distribution and urinary excretion of the desethylmetabolites of chloroquine in the rat. The Journal of pharmacy and pharmacology. 1987 Oct; 39(10):859-60. doi: 10.1111/j.2042-7158.1987.tb05136.x. [PMID: 2891831]
  • L L Gustafsson, B Lindström, A Grahnén, G Alván. Chloroquine excretion following malaria prophylaxis. British journal of clinical pharmacology. 1987 Aug; 24(2):221-4. doi: 10.1111/j.1365-2125.1987.tb03165.x. [PMID: 3620297]
  • F A Ogunbona, C O Onyeji, O O Bolaji, S E Torimiro. Excretion of chloroquine and desethylchloroquine in human milk. British journal of clinical pharmacology. 1987 Apr; 23(4):473-6. doi: 10.1111/j.1365-2125.1987.tb03078.x. [PMID: 3580253]
  • A U Orjih. Increased accumulation of chloroquine and desethylchloroquine in homozygous sickle cells. Bulletin of the World Health Organization. 1987; 65(1):51-5. doi: NULL. [PMID: 3495366]
  • L A Salako, A F Aderounmu, O Walker. Influence of route of administration on the pharmaco-kinetics of chloroquine and desethylchloroquine. Bulletin of the World Health Organization. 1987; 65(1):47-50. doi: NULL. [PMID: 3495365]
  • D L Mount, L C Patchen, S B Williams, F C Churchill. Colorimetric and thin-layer chromatographic methods for field assay of chloroquine and its metabolites in urine. Bulletin of the World Health Organization. 1987; 65(5):615-23. doi: NULL. [PMID: 3501342]
  • A F Aderounmu, L A Salako, B Lindström, O Walker, L Ekman. Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans. British journal of clinical pharmacology. 1986 Nov; 22(5):559-64. doi: 10.1111/j.1365-2125.1986.tb02935.x. [PMID: 3790402]
  • D Ofori-Adjei, O Ericsson, B Lindström, F Sjöqvist. Protein binding of chloroquine enantiomers and desethylchloroquine. British journal of clinical pharmacology. 1986 Sep; 22(3):356-8. doi: 10.1111/j.1365-2125.1986.tb02900.x. [PMID: 3768249]
  • F A Ogunbona, C O Onyeji, A A Lawal, C M Chukwuani, O O Bolaji. Liquid chromatographic analysis of chloroquine and desethylchloroquine in human plasma, saliva and urine. Journal of chromatography. 1986 Aug; 380(2):425-30. doi: 10.1016/s0378-4347(00)83674-9. [PMID: 3760072]
  • B Betschart, S Steiger. Quantitative determination of chloroquine and desethylchloroquine in biological fluids by high performance thin layer chromatography. Acta tropica. 1986 Jun; 43(2):125-30. doi: NULL. [PMID: 2874709]
  • R R Brown, R M Stroshane, D P Benziger. High-performance liquid chromatographic assay for hydroxychloroquine and three of its major metabolites, desethylhydroxychloroquine, desethylchloroquine and bidesethylchloroquine, in human plasma. Journal of chromatography. 1986 Apr; 377(?):454-9. doi: 10.1016/s0378-4347(00)80809-9. [PMID: 3711242]
  • D Ofori-Adjei, O Ericsson, B Lindström, J Hermansson, K Adjepon-Yamoah, F Sjöqvist. Enantioselective analysis of chloroquine and desethylchloroquine after oral administration of racemic chloroquine. Therapeutic drug monitoring. 1986; 8(4):457-61. doi: 10.1097/00007691-198612000-00014. [PMID: 3824433]
  • K K Adjepon-Yamoah, D Ofori-Adjei, N M Woolhouse, B Lindström. Whole-blood single-dose kinetics of chloroquine and desethylchloroquine in Africans. Therapeutic drug monitoring. 1986; 8(2):195-9. doi: 10.1097/00007691-198606000-00012. [PMID: 3726934]
  • L Rombo, O Ericsson, G Alván, B Lindström, L L Gustafsson, F Sjöqvist. Chloroquine and desethylchloroquine in plasma, serum, and whole blood: problems in assay and handling of samples. Therapeutic drug monitoring. 1985; 7(2):211-5. doi: 10.1097/00007691-198506000-00013. [PMID: 4024216]
  • F Verdier, F Clavier, P Deloron, M C Blayo. [Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC]. Pathologie-biologie. 1984 May; 32(5):359-61. doi: NULL. [PMID: 6739145]
  • Y Bergqvist, S Eckerbom. An improved gas chromatographic method for the simultaneous determination of chloroquine and two metabolites using capillary columns. Journal of chromatography. 1984 Mar; 306(?):147-53. doi: 10.1016/s0378-4347(00)80877-4. [PMID: 6715455]
  • M Frisk-Holmberg, Y Bergqvist, E Termond, B Domeij-Nyberg. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. European journal of clinical pharmacology. 1984; 26(4):521-30. doi: 10.1007/bf00542151. [PMID: 6610555]
  • O Walker, A H Dawodu, A A Adeyokunnu, L A Salako, G Alvan. Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. British journal of clinical pharmacology. 1983 Dec; 16(6):701-5. doi: 10.1111/j.1365-2125.1983.tb02244.x. [PMID: 6661356]
  • A Viala, E Deturmeny, C Aubert, M Estadieu, A Durand, J P Cano, J Delmont. Determination of chloroquine and monodesethylchloroquine in hair. Journal of forensic sciences. 1983 Oct; 28(4):922-8. doi: NULL. [PMID: 6631371]
  • L L Gustafsson, L Rombo, G Alván, A Björkman, M Lind, O Walker. On the question of dose-dependent chloroquine elimination of a single oral dose. Clinical pharmacology and therapeutics. 1983 Sep; 34(3):383-5. doi: 10.1038/clpt.1983.183. [PMID: 6883914]
  • L L Gustafsson, O Walker, G Alván, B Beermann, F Estevez, L Gleisner, B Lindström, F Sjöqvist. Disposition of chloroquine in man after single intravenous and oral doses. British journal of clinical pharmacology. 1983 Apr; 15(4):471-9. doi: 10.1111/j.1365-2125.1983.tb01532.x. [PMID: 6849784]
  • Y Bergqvist, B Domeij-Nyberg. Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma. Journal of chromatography. 1983 Jan; 272(1):137-48. doi: 10.1016/s0378-4347(00)86110-1. [PMID: 6841533]