N2N2-Dimethylguanosine (BioDeep_00000016965)
Main id: BioDeep_00000018473
PANOMIX_OTCML-2023
代谢物信息卡片
N2,N2-Dimethylguanosine
化学式: C12H17N5O5 (311.123)
中文名称: N2,N2-二甲基鸟苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C12H17N5O5/c1-16(2)12-14-9-6(10(21)15-12)13-4-17(9)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,18-20H,3H2,1-2H3,(H,14,15,21)/t5-,7-,8-,11-/m1/s1
描述信息
CONFIDENCE standard compound; INTERNAL_ID 311
N2,N2-Dimethylguanosine is an urinary nucleoside, a primary degradation product of tRNA.
N2,N2-Dimethylguanosine is an urinary nucleoside, a primary degradation product of tRNA.
同义名列表
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 4896 - Schizosaccharomyces pombe: 10.1039/C4MB00346B
- 29760 - Vitis vinifera: 10.1016/J.DIB.2020.106469
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh. Metabolomic Alterations Associated with Cause of CKD.
Clinical journal of the American Society of Nephrology : CJASN.
2017 Nov; 12(11):1787-1794. doi:
10.2215/cjn.02560317. [PMID: 28971980] - Daniel G Beach, Wojciech Gabryelski. Linear and nonlinear regimes of electrospray signal response in analysis of urine by electrospray ionization-high field asymmetric waveform ion mobility spectrometry-MS and implications for nontarget quantification.
Analytical chemistry.
2013 Feb; 85(4):2127-34. doi:
10.1021/ac3027542. [PMID: 23297652] - Danijel Djukovic, Hamid R Baniasadi, Ravi Kc, Zane Hammoud, Daniel Raftery. Targeted serum metabolite profiling of nucleosides in esophageal adenocarcinoma.
Rapid communications in mass spectrometry : RCM.
2010 Oct; 24(20):3057-62. doi:
10.1002/rcm.4739. [PMID: 20872639] - Sung-Hee Cho, Man Ho Choi, Won-Yong Lee, Bong Chul Chung. Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal.
Clinical biochemistry.
2009 Apr; 42(6):540-3. doi:
10.1016/j.clinbiochem.2008.12.026. [PMID: 19186175] - Sung-Hee Cho, Byung Hwa Jung, Sang Hee Lee, Won-Yong Lee, Gu Kong, Bong Chul Chung. Direct determination of nucleosides in the urine of patients with breast cancer using column-switching liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2006 Nov; 20(11):1229-36. doi:
10.1002/bmc.689. [PMID: 16799933] - Heinrich Topp, Susanne Unverzagt, Silvia Rudloff, Gerhard Schöch, Friedrich Manz, Christoph Fusch. Diurnal variation in the renal excretion of modified RNA catabolites in humans.
Clinical science (London, England : 1979).
2003 Aug; 105(2):195-202. doi:
10.1042/cs20020253. [PMID: 12708967] - J Jankowski, H Luftmann, M Tepel, D Leibfritz, W Zidek, H Schlüter. Characterization of dimethylguanosine, phenylethylamine, and phenylacetic acid as inhibitors of Ca2+ ATPase in end-stage renal failure.
Journal of the American Society of Nephrology : JASN.
1998 Jul; 9(7):1249-57. doi:
10.1681/asn.v971249. [PMID: 9644635] - J I Langridge, T D McClure, S el-Shakawi, A Fielding, K H Schram, R P Newton. Gas chromatography/mass spectrometric analysis of urinary nucleosides in cancer patients; potential of modified nucleosides as tumour markers.
Rapid communications in mass spectrometry : RCM.
1993 Jun; 7(6):427-34. doi:
10.1002/rcm.1290070605. [PMID: 8329765] - H Topp, G Sander, G Heller-Schöch, G Schöch. Determination of 7-methylguanine, N2,N2-dimethylguanosine, and pseudouridine in ultrafiltrated serum of healthy adults by high-performance liquid chromatography.
Analytical biochemistry.
1987 Feb; 161(1):49-56. doi:
10.1016/0003-2697(87)90650-6. [PMID: 2437827] - G Sander, H Topp, G Heller-Schöch, J Wieland, G Schöch. Ribonucleic acid turnover in man:RNA catabolites in urine as measure for the metabolism of each of the three major species of RNA.
Clinical science (London, England : 1979).
1986 Oct; 71(4):367-74. doi:
10.1042/cs0710367. [PMID: 2428556] - G Sander, H Topp, J Wieland, G Heller-Schöch, G Schöch. Possible use of urinary modified RNA metabolites in the measurement of RNA turnover in the human body.
Human nutrition. Clinical nutrition.
1986 Mar; 40(2):103-18. doi:
NULL. [PMID: 2420752] - L D Szabo, P Keresztes, J P Pallos, E Csato, T Predmerszky. Study of nucleic acid metabolism in two astronauts.
Advances in space research : the official journal of the Committee on Space Research (COSPAR).
1984; 4(10):15-8. doi:
10.1016/0273-1177(84)90219-9. [PMID: 11539621] - D A Heldman, M R Grever, J S Miser, R W Trewyn. Relationship of urinary excretion of modified nucleosides to disease status in childhood acute lymphoblastic leukemia.
Journal of the National Cancer Institute.
1983 Aug; 71(2):269-73. doi:
. [PMID: 6576186] - D A Heldman, M R Grever, C E Speicher, R W Trewyn. Urinary excretion of modified nucleosides in chronic myelogenous leukemia.
The Journal of laboratory and clinical medicine.
1983 May; 101(5):783-92. doi:
NULL. [PMID: 6572681] - D A Heldman, M R Grever, R W Trewyn. Differential excretion of modified nucleosides in adult acute leukemia.
Blood.
1983 Feb; 61(2):291-6. doi:
NULL. [PMID: 6571786] - P Clemens, G Schöch, G Ziemer, J Altenhoff, N Erb, H Lorenz, J Müller, R Grüttner. [Excretion of methylated nucleosides in the initial therapy phase in a case of anorexia nervosa].
Padiatrie und Padologie.
1982; 17(2):157-63. doi:
NULL. [PMID: 7099674] - D C Tormey, T P Waalkes, C W Gehrke. Biological markers in breast carcinoma--clinical correlations with pseudouridine, N2,N2-dimethylguanosine, and 1-methylinosine.
Journal of surgical oncology.
1980; 14(3):267-73. doi:
10.1002/jso.2930140313. [PMID: 7392649] - T P Waalkes, C W Gehrke, R W Zumwalt, S Y Chang, D B Lakings, D C Tormey, D L Ahmann, C G Moertel. The urinary excretion of nucleosides of ribonucleic acid by patients with advanced cancer.
Cancer.
1975 Aug; 36(2):390-8. doi:
10.1002/1097-0142(197508)36:2<390::aid-cncr2820360214>3.0.co;2-c. [PMID: 1157009] - L Levine, T P Waalkes, L Stolbach. Serum levels of N2, N2-dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy.
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1975 Feb; 54(2):341-3. doi:
. [PMID: 1117461]
