6-Hydroxychlorzoxazone (BioDeep_00000016961)

   


代谢物信息卡片


5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

化学式: C7H4ClNO3 (184.9879704)
中文名称: 6-.羟基氯唑沙宗
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C2C(=CC(=C1Cl)O)OC(=O)N2
InChI: InChI=1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)

描述信息

同义名列表

2 个代谢物同义名

5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one; 6-Hydroxychlorzoxazone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Sebastian Trousil, Patrizia Lee, Robert J Edwards, Lynn Maslen, Jingky P Lozan-Kuehne, Ramya Ramaswami, Eric O Aboagye, Stephen Clarke, Christopher Liddle, Rohini Sharma. Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation. British journal of pharmacology. 2019 09; 176(18):3712-3722. doi: 10.1111/bph.14776. [PMID: 31236938]
  • Nicolas Quesnot, Simon Bucher, Christina Gade, Manuel Vlach, Elise Vene, Samuel Valença, Thomas Gicquel, Helle Holst, Marie-Anne Robin, Pascal Loyer. Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes. Archives of toxicology. 2018 10; 92(10):3077-3091. doi: 10.1007/s00204-018-2300-2. [PMID: 30151596]
  • Nan Hu, Yanjuan Huang, Xuejiao Gao, Sai Li, Zhixiang Yan, Bin Wei, Ru Yan. Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine. Chemico-biological interactions. 2017 Jun; 271(?):48-58. doi: 10.1016/j.cbi.2017.04.018. [PMID: 28438436]
  • Lukas Witt, Yosuke Suzuki, Nicolas Hohmann, Gerd Mikus, Walter E Haefeli, Jürgen Burhenne. Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1027(?):207-13. doi: 10.1016/j.jchromb.2016.05.049. [PMID: 27300008]
  • Anaïs Michaut, Dounia Le Guillou, Caroline Moreau, Simon Bucher, Mitchell R McGill, Sophie Martinais, Thomas Gicquel, Isabelle Morel, Marie-Anne Robin, Hartmut Jaeschke, Bernard Fromenty. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicology and applied pharmacology. 2016 Feb; 292(?):40-55. doi: 10.1016/j.taap.2015.12.020. [PMID: 26739624]
  • Astrid Jordet Langhammer, Odd Georg Nilsen. Fennel and raspberry leaf as possible inhibitors of acetaminophen oxidation. Phytotherapy research : PTR. 2014 Oct; 28(10):1573-6. doi: 10.1002/ptr.5124. [PMID: 24458977]
  • Octavio Jiménez-Garza, Sergio Márquez-Gamiño, Arnulfo Albores, Cipriana Caudillo-Cisneros, Mariella Carrieri, Giovanni Battista Bartolucci, Maurizio Manno. CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene. Toxicology letters. 2012 Apr; 210(2):254-63. doi: 10.1016/j.toxlet.2012.01.021. [PMID: 22342293]
  • Imam H Shaik, Reza Mehvar. Effects of normothermic hepatic ischemia-reperfusion injury on the in vivo, isolated perfused liver, and microsomal disposition of chlorzoxazone, a cytochrome P450 2E1 probe, in rats. Journal of pharmaceutical sciences. 2011 Dec; 100(12):5281-92. doi: 10.1002/jps.22708. [PMID: 21780121]
  • Katsunori Yamaura, Maki Shimada, Noriyuki Nakayama, Koichi Ueno. Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats. Pharmacognosy research. 2011 Oct; 3(4):250-5. doi: 10.4103/0974-8490.89745. [PMID: 22224048]
  • P Piccoli, M Carrieri, L Padovano, M Di Mare, G B Bartolucci, M E Fracasso, J S Lepera, M Manno. In vivo CYP2E1 phenotyping as a new potential biomarker of occupational and experimental exposure to benzene. Toxicology letters. 2010 Jan; 192(1):29-33. doi: 10.1016/j.toxlet.2009.10.023. [PMID: 19900514]
  • Hye Y Jung, Hee E Kang, Young H Choi, So H Kim, Myung G Lee. Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. Biopharmaceutics & drug disposition. 2009 Nov; 30(8):485-93. doi: 10.1002/bdd.685. [PMID: 19753555]
  • Robert D Finn, Lesley A McLaughlin, Sebastien Ronseaux, Ian Rosewell, J Brian Houston, Colin J Henderson, C Roland Wolf. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. The Journal of biological chemistry. 2008 Nov; 283(46):31385-93. doi: 10.1074/jbc.m803496200. [PMID: 18805792]
  • M I Díaz Gómez, S L Fanelli, A M A Delgado de Layño, F M Bietto, J A Castro, G D Castro. Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet. Toxicology and industrial health. 2008 Nov; 24(10):625-34. doi: 10.1177/0748233708101207. [PMID: 19141567]
  • Choong Y Ahn, Soo K Bae, Young S Jung, Inchul Lee, Young C Kim, Myung G Lee, Wan G Shin. Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1233-41. doi: 10.1124/dmd.107.017442. [PMID: 18378564]
  • Nantaporn Prompila, Supeecha Wittayalertpanya, Piyawat Komolmit. Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2008 May; 91(5):733-8. doi: . [PMID: 18672640]
  • K Rajnarayana, A Venkatesham, M Nagulu, M Srinivas, D R Krishna. Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. Drug metabolism and drug interactions. 2008; 23(3-4):311-21. doi: 10.1515/dmdi.2008.23.3-4.311. [PMID: 19326774]
  • Phisit Khemawoot, Kousuke Nishino, Junko Ishizaki, Koichi Yokogawa, Ken-ichi Miyamoto. Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats. European journal of pharmacology. 2007 Nov; 574(1):71-6. doi: 10.1016/j.ejphar.2007.06.032. [PMID: 17651723]
  • Lena Ernstgård, Gunnar Johanson, Anne-Sophie Karlsson, Margareta Warholm. Phenotyping of cytochrome P450 2E1 in vitro and in vivo. Current drug metabolism. 2007 Jun; 8(5):493-8. doi: 10.2174/138920007780866843. [PMID: 17584020]
  • Phisit Khemawoot, Koichi Yokogawa, Tsutomu Shimada, Ken-Ichi Miyamoto. Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats. Biochemical pharmacology. 2007 Jan; 73(1):155-62. doi: 10.1016/j.bcp.2006.09.006. [PMID: 17049493]
  • Nantaporn Prompila, Supeecha Wittayalertpanya, Piyawat Komolmit. A study on the pharmacokinetics of chlorzoxazone in healthy Thai volunteers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2007 Jan; 90(1):160-6. doi: . [PMID: 17621748]
  • Nuntiya Somparn, Upa Kukongviriyapan, Wichittra Tassaneeyakul, Arunee Jetsrisuparb, Veerapol Kukongviriyapan. Modification of CYP2E1 and CYP3A4 activities in haemoglobin E-beta thalassemia patients. European journal of clinical pharmacology. 2007 Jan; 63(1):43-50. doi: 10.1007/s00228-006-0224-x. [PMID: 17119944]
  • Yu Chul Kim, Inchul Lee, Sang Geon Kim, Seong-Hee Ko, Myung Gull Lee, So Hee Kim. Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h. Life sciences. 2006 Nov; 79(23):2179-86. doi: 10.1016/j.lfs.2006.07.016. [PMID: 16914164]
  • Hye W Baek, Soo K Bae, Myung G Lee, Young T Sohn. Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation. Journal of pharmaceutical sciences. 2006 Nov; 95(11):2452-62. doi: 10.1002/jps.20698. [PMID: 16886191]
  • Ania Mendoza-Cantú, Fabiola Castorena-Torres, Mario Bermúdez de León, Bulmaro Cisneros, Lizbeth López-Carrillo, Aurora E Rojas-García, Alberto Aguilar-Salinas, Maurizio Manno, Arnulfo Albores. Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes. Environmental health perspectives. 2006 Apr; 114(4):494-9. doi: 10.1289/ehp.8192. [PMID: 16581535]
  • Robert A Moller, Jeannine M Fisher, Ann E Taylor, Sheela Kolluri, Mark J Gardner, R Scott Obach, Robert L Walsky. Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism. The Annals of pharmacotherapy. 2006 Jan; 40(1):32-7. doi: 10.1345/aph.1g347. [PMID: 16368922]
  • Ji-Young Park, Kyoung-Ah Kim, Pil-Whan Park, Jong-Myung Ha. Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe. Journal of clinical pharmacology. 2006 Jan; 46(1):109-14. doi: 10.1177/0091270005282635. [PMID: 16397290]
  • Jie Wan, Lena Ernstgård, Byoung J Song, Susan E Shoaf. Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. The Journal of pharmacy and pharmacology. 2006 Jan; 58(1):51-61. doi: 10.1211/jpp.58.1.0007. [PMID: 16393464]
  • S Muzeeb, M K Pasha, S J S Basha, R Mullangi, N R Srinivas. Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats. Xenobiotica; the fate of foreign compounds in biological systems. 2005 Aug; 35(8):825-38. doi: 10.1080/00498250500307301. [PMID: 16278194]
  • P H Roos, S Tschirbs, A Hack, P Welge, M Wilhelm. Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Xenobiotica; the fate of foreign compounds in biological systems. 2004 Sep; 34(9):781-95. doi: 10.1080/00498250400010880. [PMID: 15742974]
  • Lena Ernstgård, Margareta Warholm, Gunnar Johanson. Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. British journal of clinical pharmacology. 2004 Aug; 58(2):190-200. doi: 10.1111/j.1365-2125.2004.02132.x. [PMID: 15255802]
  • Samuel M Poloyac, Michael A Tortorici, Danielle I Przychodzin, Robert B Reynolds, Wen Xie, Reginald F Frye, Michael A Zemaitis. The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. Drug metabolism and disposition: the biological fate of chemicals. 2004 Jul; 32(7):727-33. doi: 10.1124/dmd.32.7.727. [PMID: 15205388]
  • Thomas D Nolin, Marc R Gastonguay, Robert R Bies, Gary R Matzke, Reginald F Frye. Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies. Clinical pharmacology and therapeutics. 2003 Dec; 74(6):555-68. doi: 10.1016/j.clpt.2003.09.003. [PMID: 14663458]
  • Choong Y Ahn, Eun J Kim, Inchul Lee, Jong W Kwon, Won B Kim, Sang G Kim, Myung G Lee. Effects of glucose on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Journal of pharmaceutical sciences. 2003 Aug; 92(8):1604-13. doi: 10.1002/jps.10426. [PMID: 12884247]
  • Won- Suk Chung, Eun Jung Kim, Inchul Lee, Sang Geon Kim, Myung Gull Lee, So Hee Kim. Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Life sciences. 2003 Jun; 73(3):253-63. doi: 10.1016/s0024-3205(03)00268-6. [PMID: 12757833]
  • Young Jin Moon, Ae Kyung Lee, Hye Chin Chung, Eun Jung Kim, So Hee Kim, Duk Chul Lee, Inchul Lee, Sang Geon Kim, Myung Gull Lee. Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats. Drug metabolism and disposition: the biological fate of chemicals. 2003 Jun; 31(6):776-84. doi: 10.1124/dmd.31.6.776. [PMID: 12756212]
  • Yu C Kim, Yoon G Kim, Eun J Kim, Min K Cho, Sang G Kim, Myung G Lee. Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: effects of food intakes. Biopharmaceutics & drug disposition. 2003 Mar; 24(2):53-61. doi: 10.1002/bdd.335. [PMID: 12619050]
  • M Reza Anari, Ray Bakhtiar, Ronald B Franklin, Paul G Pearson, Thomas A Baillie. Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s. Analytical chemistry. 2003 Feb; 75(3):469-78. doi: 10.1021/ac026157m. [PMID: 12585472]
  • Zaiqi Wang, Stephen D Hall, Juan F Maya, Lang Li, Ali Asghar, J C Gorski. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. British journal of clinical pharmacology. 2003 Jan; 55(1):77-85. doi: 10.1046/j.1365-2125.2003.01731.x. [PMID: 12534643]
  • Lanika A Brown, Linda M Arterburn, Ana P Miller, Nancy L Cowger, Sonya M Hartley, Annette Andrews, Paul M Silber, Albert P Li. Maintenance of liver functions in rat hepatocytes cultured as spheroids in a rotating wall vessel. In vitro cellular & developmental biology. Animal. 2003 Jan; 39(1-2):13-20. doi: 10.1290/1543-706x(2003)039<0013:molfir>2.0.co;2. [PMID: 12892522]
  • Xiao-Ping Chen, Xing-Mei Han, Chang-Hong Jiang, Song-Lin Huang, Zhao-Qian Liu, Bing Zhu, Gan Zhou, Hong-Hao Zhou. Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. Xenobiotica; the fate of foreign compounds in biological systems. 2002 Nov; 32(11):1053-62. doi: 10.1080/00498250210163270. [PMID: 12487734]
  • Yoon G Kim, Min K Cho, Jong W Kwon, Sang G Kim, Suk J Chung, Chang-K Shim, G Le Myung. Effects of cysteine on the pharmacokinetics of intravenous chlorzoxazone in rats with protein-calorie malnutrition. Biopharmaceutics & drug disposition. 2002 Apr; 23(3):121-9. doi: 10.1002/bdd.300. [PMID: 12173547]
  • E Tanaka. Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat. Human & experimental toxicology. 2001 Aug; 20(8):381-5. doi: 10.1191/096032701682692937. [PMID: 11727787]
  • H C Chung, S H Kim, M G Lee, C K Cho, T H Kim, D H Lee, S G Kim. Mitochondrial dysfunction by gamma-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver. Toxicology. 2001 Mar; 161(1-2):79-91. doi: 10.1016/s0300-483x(01)00332-8. [PMID: 11295257]
  • S M Poloyac, A Perez, S Scheff, R A Blouin. Tissue-specific alterations in the 6-hydroxylation of chlorzoxazone following traumatic brain injury in the rat. Drug metabolism and disposition: the biological fate of chemicals. 2001 Mar; 29(3):296-8. doi: NULL. [PMID: 11181498]
  • D Mizuno, E Tanaka, K Tanno, S Misawa. Chlorzoxazone: a probe drug whose metabolism can be used to monitor toluene exposure in rats. Archives of toxicology. 2000 May; 74(3):139-44. doi: 10.1007/s002040050666. [PMID: 10876999]
  • S M Poloyac, R T Tosheva, B M Gardner, S I Shedlofsky, R A Blouin. The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans. Clinical pharmacology and therapeutics. 1999 Dec; 66(6):554-62. doi: 10.1053/cp.1999.v66.103172001. [PMID: 10613610]
  • M G Emery, C Jubert, K E Thummel, E D Kharasch. Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. The Journal of pharmacology and experimental therapeutics. 1999 Oct; 291(1):213-9. doi: NULL. [PMID: 10490907]
  • L Li, Y Zhang. [Determination of chlorzoxazone and its metabolite 6-hydroxychlorzoxazone in plasma by HPLC and their pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica. 1998 Oct; 33(10):731-6. doi: NULL. [PMID: 12016924]
  • E S Vesell, Z Korsunsky. Pedigree analysis of a subject with abnormally slow renal elimination of 6-hydroxychlorzoxazone. Pharmacology. 1998 May; 56(5):262-6. doi: 10.1159/000028207. [PMID: 9597694]
  • G J Burckart, R F Frye, P Kelly, R A Branch, A Jain, J J Fung, T E Starzl, R Venkataramanan. Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation. Clinical pharmacology and therapeutics. 1998 Mar; 63(3):296-302. doi: 10.1016/s0009-9236(98)90161-8. [PMID: 9542473]
  • C B Eap, C Schnyder, L Savary. Determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma by gas chromatography--mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1998 Jan; 705(1):139-44. doi: 10.1016/s0378-4347(97)00501-x. [PMID: 9498681]
  • E Tanaka. Simultaneous determination of chlorzoxazone, indicator of CYP2E1, and its metabolite in human serum using a new reversed-phase chromatographic column of 2-microm porous microspherical silica-gel. Journal of pharmaceutical and biomedical analysis. 1998 Jan; 16(5):899-904. doi: 10.1016/s0731-7085(97)00105-2. [PMID: 9535202]
  • R F Frye, D D Stiff. Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Nov; 686(2):291-6. doi: 10.1016/s0378-4347(96)00227-7. [PMID: 8971612]
  • L Chen, C S Yang. Effects of cytochrome P450 2E1 modulators on the pharmacokinetics of chlorzoxazone and 6-hydroxychlorzoxazone in rats. Life sciences. 1996; 58(18):1575-85. doi: 10.1016/0024-3205(96)00132-4. [PMID: 8649187]
  • A W Dreisbach, N Ferencz, N E Hopkins, M G Fuentes, A B Rege, W J George, J J Lertora. Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity. Clinical pharmacology and therapeutics. 1995 Nov; 58(5):498-505. doi: 10.1016/0009-9236(95)90169-8. [PMID: 7586943]
  • E S Vesell, T D Seaton, Y I A-Rahim. Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe. Pharmacogenetics. 1995 Feb; 5(1):53-7. doi: 10.1097/00008571-199502000-00007. [PMID: 7773304]
  • J D de Vries, L Salphati, S Horie, C E Becker, B A Hoener. Variability in the disposition of chlorzoxazone. Biopharmaceutics & drug disposition. 1994 Oct; 15(7):587-97. doi: 10.1002/bdd.2510150706. [PMID: 7849234]
  • C Girre, D Lucas, E Hispard, C Menez, S Dally, J F Menez. Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochemical pharmacology. 1994 Apr; 47(9):1503-8. doi: 10.1016/0006-2952(94)90524-x. [PMID: 7910460]
  • D Lucas, F Berthou, C Girre, F Poitrenaud, J F Ménez. High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans. Journal of chromatography. 1993 Dec; 622(1):79-86. doi: 10.1016/0378-4347(93)80252-y. [PMID: 8120116]
  • D D Stiff, R F Frye, R A Branch. Sensitive high-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma. Journal of chromatography. 1993 Mar; 613(1):127-31. doi: 10.1016/0378-4347(93)80205-i. [PMID: 8458889]
  • J T Stewart, H K Carter. High-performance liquid chromatography with electrochemical detection of chlorzoxazone and its hydroxy metabolite in serum using solid-phase extraction. Journal of chromatography. 1986 Jul; 380(1):177-83. doi: 10.1016/s0378-4347(00)83640-3. [PMID: 3745381]
  • R K Desiraju, N L Renzi, R K Nayak, K T Ng. Pharmacokinetics of chlorzoxazone in humans. Journal of pharmaceutical sciences. 1983 Sep; 72(9):991-4. doi: 10.1002/jps.2600720905. [PMID: 6631711]
  • C Hipolito-Reis, M Sobrinho-Simões, A Ferraz, F Cerqueira-Magro. [Anti-insulin type urinary peptide in Lawrence's lipo-atrophic diabetes]. La Revue francaise d'endocrinologie clinique, nutrition, et metabolisme. 1968 Sep; 9(5):373-80. doi: NULL. [PMID: 5702099]