DL-Mevalonolactone (BioDeep_00000016952)
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one
化学式: C6H10O3 (130.062991)
中文名称: DL-甲瓦龙酸内酯, 4-羟基-4-甲基四氢-2H-吡喃-2-酮
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 75%
分子结构信息
SMILES: CC1(CCOC(=O)C1)O
InChI: InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
描述信息
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:95115
- KEGG: C76125
- PubChem: 10428
- ChEMBL: CHEMBL4758470
- CAS: 503-48-0
- CAS: 674-26-0
- medchemexpress: HY-107855
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 178154 - Phaeosphaeria herpotrichoides: 10.1021/NP50099A034
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bin Chen, Nan Lu, KeeSuh Lee, Lei Ye, Chiho Hasegawa, Kazuhisa Maeda. Application of mevalonolactone prevents deterioration of epidermal barrier function by accelerating the lamellar granule lipid transport system.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2022 Nov; 28(6):804-814. doi:
10.1111/srt.13202. [PMID: 36148627] - Roberta Natália Cestari, Juciene Aparecida Caris, Adriana Rocha, Glauco Henrique Balthazar Nardotto, Renê Donizeti Ribeiro de Oliveira, Vera Lucia Lanchote. Plasma mevalonic acid exposure as a pharmacodynamic biomarker of fluvastatin/atorvastatin in healthy volunteers.
Journal of pharmaceutical and biomedical analysis.
2020 Apr; 182(?):113128. doi:
10.1016/j.jpba.2020.113128. [PMID: 32004772] - Tumelo M Satekge, Olivia Kiabilua, Alta J Terblanche, Meshack Bida, Tahir S Pillay. Mevalonate kinase deficiency masked by cytomegalovirus infection and obscure liver disease.
Clinica chimica acta; international journal of clinical chemistry.
2019 Nov; 498(?):122-125. doi:
10.1016/j.cca.2019.08.014. [PMID: 31430439] - Cristiane Cecatto, Alexandre Umpierrez Amaral, Janaína Camacho da Silva, Alessandro Wajner, Kálita Dos Santos Godoy, Rafael Teixeira Ribeiro, Aline de Mello Gonçalves, Carmen Regla Vargas, Moacir Wajner. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria.
Neurochemistry international.
2017 Sep; 108(?):133-145. doi:
10.1016/j.neuint.2017.03.005. [PMID: 28284974] - Adam Jozwiak, Agata Lipko, Magdalena Kania, Witold Danikiewicz, Liliana Surmacz, Agnieszka Witek, Jacek Wojcik, Konrad Zdanowski, Cezary Pączkowski, Tadeusz Chojnacki, Jaroslaw Poznanski, Ewa Swiezewska. Modeling of Dolichol Mass Spectra Isotopic Envelopes as a Tool to Monitor Isoprenoid Biosynthesis.
Plant physiology.
2017 Jun; 174(2):857-874. doi:
10.1104/pp.17.00036. [PMID: 28385729] - HaiKuan Wang, YanHua Yan, JiaMing Wang, HePing Zhang, Wei Qi. Production and characterization of antifungal compounds produced by Lactobacillus plantarum IMAU10014.
PloS one.
2012; 7(1):e29452. doi:
10.1371/journal.pone.0029452. [PMID: 22276116] - Nelson L Brock, Bettina Tudzynski, Jeroen S Dickschat. Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi.
Chembiochem : a European journal of chemical biology.
2011 Nov; 12(17):2667-76. doi:
10.1002/cbic.201100516. [PMID: 21990128] - Naciye Yaktubay Döndaş, Nehir Sucu, Banu Coşkun Yilmaz, Halil Mahir Kaplan, Murat Ozeren, Mehmet Kerem Karaca, Ozden Vezir, Ergin Singirik. Molecular mechanism of vasorelaxant and antiatherogenic effects of the statins in the human saphenous vein graft.
European journal of pharmacology.
2011 Sep; 666(1-3):150-7. doi:
10.1016/j.ejphar.2011.05.013. [PMID: 21620829] - Jenna Waldron, Craig Webster. Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins.
Annals of clinical biochemistry.
2011 May; 48(Pt 3):223-32. doi:
10.1258/acb.2010.010182. [PMID: 21355014] - Ioanna Vallianou, Nikolaos Peroulis, Panayotis Pantazis, Margarita Hadzopoulou-Cladaras. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity.
PloS one.
2011; 6(11):e20516. doi:
10.1371/journal.pone.0020516. [PMID: 22073134] - Diane M Martin, Sébastien Aubourg, Marina B Schouwey, Laurent Daviet, Michel Schalk, Omid Toub, Steven T Lund, Jörg Bohlmann. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays.
BMC plant biology.
2010 Oct; 10(?):226. doi:
10.1186/1471-2229-10-226. [PMID: 20964856] - Masaki Fujisawa, Hisashi Harada, Hiromichi Kenmoku, Satoru Mizutani, Norihiko Misawa. Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale.
Planta.
2010 Jun; 232(1):121-30. doi:
10.1007/s00425-010-1137-6. [PMID: 20229191] - Pierrette Bouvier-Navé, Anne Berna, Alexandre Noiriel, Vincent Compagnon, Anders S Carlsson, Antoni Banas, Sten Stymne, Hubert Schaller. Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence.
Plant physiology.
2010 Jan; 152(1):107-19. doi:
10.1104/pp.109.145672. [PMID: 19923239] - Ingrid Brucknerova, Darina Behulova, Claudia Sebova, Vladimir Bzduch, Mojmir Mach, Michal Dubovicky, Eduard Ujhazy. Conjugated hyperbilirubinaemia as the first manifestation of mevalonic aciduria in a term newborn.
Neuro endocrinology letters.
2009; 30 Suppl 1(?):29-31. doi:
NULL. [PMID: 20027140] - Masashi Suzuki, Shoko Nakagawa, Yukiko Kamide, Keiko Kobayashi, Kiyoshi Ohyama, Hiromi Hashinokuchi, Reiko Kiuchi, Kazuki Saito, Toshiya Muranaka, Noriko Nagata. Complete blockage of the mevalonate pathway results in male gametophyte lethality.
Journal of experimental botany.
2009; 60(7):2055-64. doi:
10.1093/jxb/erp073. [PMID: 19363204] - Svena M Lüdke, Ulrich Flenker, Wilhelm Schänzer, Dietmar Schomburg. Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Journal of lipid research.
2008 Dec; 49(12):2620-6. doi:
10.1194/jlr.m800313-jlr200. [PMID: 18669481] - Kazunori Okada, Hiroyuki Kasahara, Shinjiro Yamaguchi, Hiroshi Kawaide, Yuji Kamiya, Hideaki Nojiri, Hisakazu Yamane. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.
Plant & cell physiology.
2008 Apr; 49(4):604-16. doi:
10.1093/pcp/pcn032. [PMID: 18303110] - Tomoyuki Nishimoto, Eiichiro Ishikawa, Hisashi Anayama, Hitomi Hamajyo, Hirofumi Nagai, Masao Hirakata, Ryuichi Tozawa. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
Toxicology and applied pharmacology.
2007 Aug; 223(1):39-45. doi:
10.1016/j.taap.2007.05.005. [PMID: 17599378] - Akira Honda, Yuji Mizokami, Yasushi Matsuzaki, Tadashi Ikegami, Mikio Doy, Hiroshi Miyazaki. Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.
Journal of lipid research.
2007 May; 48(5):1212-20. doi:
10.1194/jlr.d600049-jlr200. [PMID: 17272831] - G S Saini, T A Wani, A Gautam, B Varshney, T Ahmed, K S Rajan, K K Pillai, J K Paliwal. Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect.
Journal of lipid research.
2006 Oct; 47(10):2340-5. doi:
10.1194/jlr.d600018-jlr200. [PMID: 16861623] - Daniela Hampel, Armin Mosandl, Matthias Wüst. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies.
Journal of agricultural and food chemistry.
2006 Feb; 54(4):1473-8. doi:
10.1021/jf0523972. [PMID: 16478276] - Monica P Polo, Margarita G de Bravo. Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2006 Feb; 84(1):102-11. doi:
10.1139/o05-160. [PMID: 16462894] - Rachel Harry, Matthew Gegg, Deborah Hankey, Hadi Zambarakji, Gareth Pryce, David Baker, Virginia Calder, Peter Adamson, John Greenwood. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.
Journal of immunology (Baltimore, Md. : 1950).
2005 Feb; 174(4):2327-2335. doi:
10.4049/jimmunol.174.4.2327. [PMID: 15699169] - A Berger, D Rein, E Kratky, I Monnard, H Hajjaj, I Meirim, C Piguet-Welsch, J Hauser, K Mace, P Niederberger. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Lipids in health and disease.
2004 Feb; 3(?):2. doi:
10.1186/1476-511x-3-2. [PMID: 14969592] - Joannis E Vamvakopoulos, Colin Green. HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection.
BMC cardiovascular disorders.
2003 Jul; 3(?):6. doi:
10.1186/1471-2261-3-6. [PMID: 12871602] - Mirjam Kreck, Susen Püschel, Matthias Wüst, Armin Mosandl. Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols.
Journal of agricultural and food chemistry.
2003 Jan; 51(2):463-9. doi:
10.1021/jf020845p. [PMID: 12517111] - Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Nobuyuki Yasuda, Toshimi Okada, Hironori Ikuta, Daisuke Shinmyo, Keigo Tanaka, Nobuyuki Kurusu, Ichiro Yoshida, Shinya Abe, Takao Saeki, Hiroshi Tanaka. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.
Journal of lipid research.
2003 Jan; 44(1):128-35. doi:
10.1194/jlr.m200316-jlr200. [PMID: 12518031] - Pattama Pittayakhajonwut, Man Theerasilp, Palangpon Kongsaeree, Amporn Rungrod, Morakot Tanticharoen, Yodhathai Thebtaranonth. Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878.
Planta medica.
2002 Nov; 68(11):1017-9. doi:
10.1055/s-2002-35653. [PMID: 12451493] - Elena Gubina, Trina Chen, Lei Zhang, Elaine F Lizzio, Steven Kozlowski. CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Blood.
2002 Apr; 99(7):2518-25. doi:
10.1182/blood.v99.7.2518. [PMID: 11895788] - T Funatsu, K Suzuki, M Goto, Y Arai, H Kakuta, H Tanaka, S Yasuda, M Ida, S Nishijima, K Miyata. Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells.
Atherosclerosis.
2001 Jul; 157(1):107-15. doi:
10.1016/s0021-9150(00)00714-0. [PMID: 11427209] - K Kojima, S Abe-Dohmae, R Arakawa, I Murakami, K Suzumori, S Yokoyama. Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein.
Biochimica et biophysica acta.
2001 Jun; 1532(3):173-84. doi:
10.1016/s1388-1981(01)00124-x. [PMID: 11470238] - I Vanhorebeek, M Baes, P E Declercq. Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model.
Biochimica et biophysica acta.
2001 May; 1532(1-2):28-36. doi:
10.1016/s1388-1981(01)00108-1. [PMID: 11420171] - E J Park, D Lee, Y G Shin, D D Lantvit, R B van Breemen, A D Kinghorn, J M Pezzuto. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(2):327-32. doi:
10.1016/s0378-4347(00)00620-4. [PMID: 11339276] - S Vaidya, R Bostedor, M M Kurtz, J D Bergstrom, V S Bansal. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.
Archives of biochemistry and biophysics.
1998 Jul; 355(1):84-92. doi:
10.1006/abbi.1998.0704. [PMID: 9647670] - R J Cenedella, P S Sexton. Probing cataractogenesis associated with mevalonic aciduria.
Current eye research.
1998 Feb; 17(2):153-8. doi:
10.1076/ceyr.17.2.153.5599. [PMID: 9523093] - P O Kwiterovich, M Motevalli. Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts.
Arteriosclerosis, thrombosis, and vascular biology.
1998 Jan; 18(1):57-64. doi:
10.1161/01.atv.18.1.57. [PMID: 9445257] - D E Nantais, M Schwemmle, J T Stickney, D J Vestal, J E Buss. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.
Journal of leukocyte biology.
1996 Sep; 60(3):423-31. doi:
10.1002/jlb.60.3.423. [PMID: 8830800] - A Komori, S Okabe, M Suganuma, M A Kerr, J Busch-Petersen, L M Oh, J Zhuo, G S Kannangara, X Zou, M A Tius, H Fujiki. Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation.
Japanese journal of cancer research : Gann.
1996 Sep; 87(9):875-81. doi:
10.1111/j.1349-7006.1996.tb02114.x. [PMID: 8878447] - F McTaggart, G R Brown, R G Davidson, S Freeman, G A Holdgate, K B Mallion, D J Mirrlees, G J Smith, W H Ward. Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines.
Biochemical pharmacology.
1996 Jun; 51(11):1477-87. doi:
10.1016/0006-2952(96)00089-5. [PMID: 8630089] - T J Rea, R B DeMattos, R Homan, R S Newton, M E Pape. Lack of correlation between ACAT mRNA expression and cholesterol esterification in primary liver cells.
Biochimica et biophysica acta.
1996 Jan; 1299(1):67-74. doi:
10.1016/0005-2760(95)00190-5. [PMID: 8555254] - N Latruffe, D Boscoboinik, A Azzi. Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Biochemical and biophysical research communications.
1995 Dec; 217(2):459-65. doi:
10.1006/bbrc.1995.2798. [PMID: 7503722] - P O Kwiterovich, M Motevalli. Inhibition of protein tyrosine kinase alters the effect of serum basic protein I on triacylglycerols and cholesterol differently in normal and hyperapoB fibroblasts.
Arteriosclerosis, thrombosis, and vascular biology.
1995 Aug; 15(8):1195-203. doi:
10.1161/01.atv.15.8.1195. [PMID: 7627714] - G Rogler, K J Lackner, G Schmitz. Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro.
The American journal of cardiology.
1995 Jul; 76(2):114A-116A. doi:
10.1016/s0002-9149(05)80031-1. [PMID: 7604784] - D C Crick, D A Andres, C J Waechter. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Biochemical and biophysical research communications.
1995 Jun; 211(2):590-9. doi:
10.1006/bbrc.1995.1854. [PMID: 7794274] - K C Doerner, E C Gurley, Z R Vlahcevic, P B Hylemon. Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures.
Journal of lipid research.
1995 Jun; 36(6):1168-77. doi:
. [PMID: 7665995] - B A Masters, M J Palmoski, O P Flint, R E Gregg, D Wang-Iverson, S K Durham. In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
Toxicology and applied pharmacology.
1995 Mar; 131(1):163-74. doi:
10.1006/taap.1995.1058. [PMID: 7878672] - R A Aspbury, M J Fisher, H H Rees. Lipid modification of signal-transducing polypeptides in the free-living nematode Caenorhabditis elegans.
Biochemical Society transactions.
1995 Feb; 23(1):3S. doi:
10.1042/bst023003s. [PMID: 7758740] - G Herold, R Jungwirth, G Rogler, I Geerling, E F Stange. Influence of cholesterol supply on cell growth and differentiation in cultured enterocytes (CaCo-2).
Digestion.
1995; 56(1):57-66. doi:
10.1159/000201223. [PMID: 7895934] - J B Roullet, H Xue, A S Pappu, C Roullet, S Holcomb, D A McCarron. Mevalonate availability and cardiovascular functions.
Proceedings of the National Academy of Sciences of the United States of America.
1993 Dec; 90(24):11728-32. doi:
10.1073/pnas.90.24.11728. [PMID: 8265617] - B M Hokland, J P Slotte, E L Bierman, J F Oram. Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.
The Journal of biological chemistry.
1993 Dec; 268(34):25343-9. doi:
10.1016/s0021-9258(19)74397-x. [PMID: 7503979] - S E Kasim, R C LeBoeuf, S Khilnani, L Tallapaka, D Dayananda, K L Jen. Mechanisms of triglyceride-lowering effect of an HMG-CoA reductase inhibitor in a hypertriglyceridemic animal model, the Zucker obese rat.
Journal of lipid research.
1992 Jan; 33(1):1-7. doi:
. [PMID: 1552226] - A Thelin, P Löw, T Chojnacki, G Dallner. Covalent binding of dolichyl phosphate to proteins in rat liver.
European journal of biochemistry.
1991 Feb; 195(3):755-61. doi:
10.1111/j.1432-1033.1991.tb15763.x. [PMID: 1999193] - J L Li, Y J Li, Y J Chao, L X Lin, M H Ouyang, Y B Peng, W S Chang. Cholesterol requirement for growth of IR983F and P3X63-Ag8-U1 myeloma cells in serum-free medium.
Cytobios.
1991; 68(272):15-22. doi:
NULL. [PMID: 1778091] - W M Pandak, Z R Vlahcevic, D M Heuman, P B Hylemon. Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis.
Journal of lipid research.
1990 Dec; 31(12):2149-58. doi:
. [PMID: 1708805] - S M Mumby, P J Casey, A G Gilman, S Gutowski, P C Sternweis. G protein gamma subunits contain a 20-carbon isoprenoid.
Proceedings of the National Academy of Sciences of the United States of America.
1990 Aug; 87(15):5873-7. doi:
10.1073/pnas.87.15.5873. [PMID: 2116011] - W M Pandak, D M Heuman, P B Hylemon, Z R Vlahcevic. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
Journal of lipid research.
1990 Jan; 31(1):79-90. doi:
. [PMID: 2313206] - P J Casey, P A Solski, C J Der, J E Buss. p21ras is modified by a farnesyl isoprenoid.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Nov; 86(21):8323-7. doi:
10.1073/pnas.86.21.8323. [PMID: 2682646] - S K Erickson, S Jaeckle, S R Lear, S M Brady, R J Havel. Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol-treated rats.
Journal of lipid research.
1989 Nov; 30(11):1763-71. doi:
". [PMID: 2614275] - S R Wang, M Pessah, J Infante, D Catala, C Salvat, R Infante. Lipid and lipoprotein metabolism in Hep G2 cells.
Biochimica et biophysica acta.
1988 Aug; 961(3):351-63. doi:
10.1016/0005-2760(88)90082-3. [PMID: 3042028] - T J Borgford, R A Hurta, D F Tough, D N Burton. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and lipid metabolism in a concanavalin A-resistant Chinese hamster ovary cell line.
Archives of biochemistry and biophysics.
1986 Feb; 244(2):502-16. doi:
10.1016/0003-9861(86)90619-3. [PMID: 3947077] - Z H Beg, D C Reznikov, J Avigan. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.
Archives of biochemistry and biophysics.
1986 Jan; 244(1):310-22. doi:
10.1016/0003-9861(86)90120-7. [PMID: 3004340] - G Steen, H Axelsson, M Bowallius, N Holthuis, B M Molander. Isoprenoid biosynthesis in multiple sclerosis.
Acta neurologica Scandinavica.
1985 Sep; 72(3):328-35. doi:
10.1111/j.1600-0404.1985.tb00879.x. [PMID: 4061053] - J E Cluette, J J Mulligan, R Noring, K Doyle, J Hojnacki. Ethanol enhances de novo synthesis of high density lipoprotein cholesterol.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1984 Sep; 176(4):508-11. doi:
10.3181/00379727-176-4-rc2. [PMID: 6463061] - R K Randolph, B P Smith, R W St Clair. Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway.
Journal of lipid research.
1984 Sep; 25(9):903-12. doi:
NULL. [PMID: 6491537] - J A Aguilera, A Linares, V Arce, E Garcia-Peregrin. Effect of dietary cholesterol on mevalonate metabolism by sterol and nonsterol pathways.
Biochemical and biophysical research communications.
1984 Aug; 122(3):945-8. doi:
10.1016/0006-291x(84)91182-3. [PMID: 6477574] - A M Heacock, P D Klinger, E B Seguin, B W Agranoff. Cholesterol synthesis and nerve regeneration.
Journal of neurochemistry.
1984 Apr; 42(4):987-93. doi:
10.1111/j.1471-4159.1984.tb12701.x. [PMID: 6699648] - B C Paton, A Poulos. Dolichol metabolism in cultured skin fibroblasts from patients with 'neuronal' ceroid lipofuscinosis (Batten's disease).
Journal of inherited metabolic disease.
1984; 7(3):112-6. doi:
10.1007/bf01801766. [PMID: 6438392] - R E Maxwell, J W Nawrocki, P D Uhlendorf. Some comparative effects of gemfibrozil, clofibrate, bezafibrate, cholestyramine and compactin on sterol metabolism in rats.
Atherosclerosis.
1983 Sep; 48(3):195-203. doi:
10.1016/0021-9150(83)90038-2. [PMID: 6579963] - F J Field, S N Mathur. Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells.
Journal of lipid research.
1983 Aug; 24(8):1049-59. doi:
". [PMID: 6631233] - R A Davis, W E Highsmith, M M McNeal, J A Schexnayder, J C Kuan. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids.
The Journal of biological chemistry.
1983 Apr; 258(7):4079-82. doi:
NULL. [PMID: 6550600] - W K Wilson, T J Scallen, C U Morrow. Determination of the enantiomeric purity of mevalonolactone via NMR using a chiral lanthanide shift reagent.
Journal of lipid research.
1982 May; 23(4):645-52. doi:
10.1016/s0022-2275(20)38130-x. [PMID: 7097129] - S L Perkins, S F Ledin, J D Stubbs. Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes. Effects of compactin on mitogen-induced lymphocytes in serum-free medium.
Biochimica et biophysica acta.
1982 Apr; 711(1):83-9. doi:
10.1016/0005-2760(82)90012-1. [PMID: 6279167] - C H Florén, A Nilsson. Effects of hypothyroidism and cholesterol feeding on the clearance of chylomicron remnants in vivo and by rat hepatocyte monolayers.
European journal of clinical investigation.
1981 Feb; 11(1):11-8. doi:
10.1111/j.1365-2362.1981.tb01759.x. [PMID: 6783423] - C A Drevon, S C Engelhorn, D Steinberg. Secretion of very low density lipoproteins enriched in cholesteryl esters by cultured rat hepatocytes during simulation of intracellular cholesterol esterification.
Journal of lipid research.
1980 Nov; 21(8):1065-71. doi:
10.1016/s0022-2275(20)34767-2. [PMID: 7462802] - S K Erickson, M A Shrewsbury, C Brooks, D J Meyer. Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro.
Journal of lipid research.
1980 Sep; 21(7):930-41. doi:
10.1016/s0022-2275(20)34791-x. [PMID: 7441061] - M Takahashi, A N Sarwal, R F Raicht, B I Cohen. Effect of colestipol on sterol metabolism in the rat.
Lipids.
1980 Jun; 15(6):434-8. doi:
10.1007/bf02534068. [PMID: 7401941]