lamotrigine (BioDeep_00000016920)
natural product
代谢物信息卡片
化学式: C9H7Cl2N5 (255.0078482)
中文名称: 拉莫三嗪
谱图信息:
最多检出来源 Escherichia coli(natural_products) 84.85%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
InChI: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 1528
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 86
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2676
同义名列表
1 个代谢物同义名
数据库引用编号
41 个数据库交叉引用编号
- ChEBI: CHEBI:6367
- KEGG: C07066
- KEGGdrug: D00354
- PubChem: 3878
- Metlin: METLIN917
- DrugBank: DB00555
- ChEMBL: CHEMBL741
- MeSH: Lamotrigine
- CAS: 84057-84-1
- CAS: 84057-84-1, 375347-20-9 (H2O), 493025-05-1 (HCl)
- MoNA: AU152805
- MoNA: AU152804
- MoNA: AU152803
- MoNA: AU152802
- MoNA: AU152801
- MoNA: WA001273
- MoNA: WA001272
- MoNA: WA001271
- MoNA: WA001270
- MoNA: WA001269
- MoNA: UA008601
- MoNA: FiehnHILIC002793
- MoNA: FiehnHILIC002044
- MoNA: FiehnHILIC000472
- MoNA: CCMSLIB00000078542
- MoNA: EA267614
- MoNA: EA267613
- MoNA: EA267612
- MoNA: EA267611
- MoNA: EA267610
- MoNA: EA267609
- MoNA: EA267608
- MoNA: EA267607
- MoNA: EA267606
- MoNA: EA267605
- MoNA: EA267604
- MoNA: EA267603
- MoNA: EA267602
- MoNA: EA267601
- MoNA: AU152806
- RefMet: Lamotrigine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Meriam N N Rezk, Sabreen Mahmoud Ahmed, Shereen S Gaber, Mostafa M Mohammed, Nada A Yousri, Nermeen N Welson. Curcumin protects against lamotrigine-induced chronic ovarian and uterine toxicity in rats by regulating PPAR-γ and ROS production.
Journal of biochemical and molecular toxicology.
2024 Jan; 38(1):e23599. doi:
10.1002/jbt.23599
. [PMID: 38050455] - Moran Madmon, Yifat Zvuluni, Vered Mordehay, Ariel Hindi, Tomer Malchi, Eyal Drug, Moshe Shenker, Avi Weissberg, Benny Chefetz. Pharmacokinetics of the Recalcitrant Drug Lamotrigine: Identification and Distribution of Metabolites in Cucumber Plants.
Environmental science & technology.
2023 Dec; 57(48):20228-20237. doi:
10.1021/acs.est.3c06685
. [PMID: 37935215] - Vasiliki G Beretsou, Maria-Christina Nika, Kyriakos Manoli, Costas Michael, Qian Sui, Lian Lundy, D Michael Revitt, Nikolaos S Thomaidis, Despo Fatta-Kassinos. Multiclass target analysis of contaminants of emerging concern including transformation products, soil bioavailability assessment and retrospective screening as tools to evaluate risks associated with reclaimed water reuse.
The Science of the total environment.
2022 Dec; 852(?):158391. doi:
10.1016/j.scitotenv.2022.158391
. [PMID: 36049679] - Jiaquan Li, Yangjia Huang, Qi An, Wenyu Li, Jianting Li, Hongji Liu, Dezhi Yang, Yang Lu, Zhengzheng Zhou. Discovered two polymorphs and two solvates of lamotrigine-tolfenamic acid salt: Thermal behavior and crystal morphological differences.
International journal of pharmaceutics.
2022 Nov; 628(?):122310. doi:
10.1016/j.ijpharm.2022.122310
. [PMID: 36270552] - Shan Zhou, Ruitong Li, Ziyi Chen, Ruina Ren, Xueding Wang, Qilin Dai, Dingshen Wen, Yanping Guan, Xiaoxu Zhang, Siyuan Tang, Liemin Zhou, Min Huang. LC-MS/MS quantification of levetiracetam, lamotrigine and 10-hydroxycarbazepine in TDM of epileptic patients.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5393. doi:
10.1002/bmc.5393
. [PMID: 35527473] - Yiqian Chen, Jingzhen Chen, Xiaorong Zhuang, Xingyu Chen, Jianqi Zeng, Ru Wang, Jiayin Miao. Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine.
Medicine.
2022 Jul; 101(26):e29780. doi:
10.1097/md.0000000000029780
. [PMID: 35776999] - Ivana Kacirova, Milan Grundmann, Hana Brozmanova. Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113167. doi:
10.1016/j.biopha.2022.113167
. [PMID: 35617804] - Mahmoud Abdelnabi, Marawan Elmssary, Jasmine Sekhon, Juthipong Benjanuwattra. Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome.
Lancet (London, England).
2022 05; 399(10338):1902. doi:
10.1016/s0140-6736(22)00464-0
. [PMID: 35569467] - Vaiva Petrenaite, Inger Öhman, Frederik Peter Thal Jantzen, Lena Ekström. Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients.
Epilepsy research.
2022 05; 182(?):106897. doi:
10.1016/j.eplepsyres.2022.106897
. [PMID: 35303539] - Page B Pennell, Ashwin Karanam, Kimford J Meador, Elizabeth Gerard, Laura Kalayjian, Patricia Penovich, Abigail Matthews, Thomas M McElrath, Angela K Birnbaum. Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.
JAMA neurology.
2022 04; 79(4):370-379. doi:
10.1001/jamaneurol.2021.5487
. [PMID: 35157004] - Naga Chalasani, Herbert L Bonkovsky, Jonathan G Stine, Jiezhun Gu, Huiman Barnhart, Elin Jacobsen, Einar Björnsson, Robert J Fontana, David E Kleiner, Jay H Hoofnagle. Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study.
Journal of hepatology.
2022 Apr; 76(4):832-840. doi:
10.1016/j.jhep.2021.12.013
. [PMID: 34953957] - Elkana Kohn, Natalie Dinavitser, Maya Berlin, Nurit Brandriss, Adina Bar-Chaim, Itai Gueta, Rimona Keidar, Ayelet Livne, David Stepensky, Matitiahu Berkovitch, Majdi Masarwi. Magnitude of Lamotrigine Exposure Through Breastfeeding.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2022 04; 17(4):341-348. doi:
10.1089/bfm.2021.0304
. [PMID: 35049332] - Giulia Liparoti, Beatrice Burchiani, Elisabetta Mencaroni, Domenico Tripodi, Giuseppe Di Cara, Alberto Verrotti. Individualizing doses of antiepileptic drugs.
Expert opinion on drug metabolism & toxicology.
2022 Mar; 18(3):219-233. doi:
10.1080/17425255.2022.2075342
. [PMID: 35523739] - Amir-Mohammad Yaryari, Mehrdokht Mazdeh, Mojdeh Mohammadi, Alireza Rastgoo Haghi, Masood Ghiasian, Maryam Mehrpooya. Evaluation of serum levels of asprosin and other metabolic profiles in patients with idiopathic tonic-clonic generalized epilepsy on treatment with valproic acid.
European journal of clinical pharmacology.
2022 Mar; 78(3):393-403. doi:
10.1007/s00228-022-03279-1
. [PMID: 35059757] - Yi Deng, Rachel W Li, Yong Liang Yang, Steven Weiss, Paul N Smith. Pharmacological prevention of renal ischemia-reperfusion injury in a rat model.
ANZ journal of surgery.
2022 03; 92(3):518-525. doi:
10.1111/ans.17381
. [PMID: 34820987] - Weixuan Zhao, Hongmei Meng. Effects of genetic polymorphism of drug-metabolizing enzymes on the plasma concentrations of antiepileptic drugs in Chinese population.
Bioengineered.
2022 03; 13(3):7709-7745. doi:
10.1080/21655979.2022.2036916
. [PMID: 35290166] - Kengo Hatanaka, Yoshito Kamijo, Takeshi Kitamoto, Tomoki Hanazawa, Tomohiro Yoshizawa, Hidenobu Ochiai, Yoshiyuki Haga. Effectiveness of multiple-dose activated charcoal in lamotrigine poisoning: a case series.
Clinical toxicology (Philadelphia, Pa.).
2022 Mar; 60(3):379-381. doi:
10.1080/15563650.2021.1953518
. [PMID: 34405740] - Kulanka Premachandra, Shweta Priyadarshini, Darren Roberts. Dialyzability of lamotrigine by continuous venovenous haemodiafiltration.
Clinical toxicology (Philadelphia, Pa.).
2022 02; 60(2):267. doi:
10.1080/15563650.2021.1916517
. [PMID: 33945365] - Li Yao, Liuli Ren, Qi Chen, Yuhan Wu, Jianguo Xu, Quan Xia, Chao Zhang, Wei Chen. Rapid and direct concentration range judgment of lamotrigine in plasma by the multi test lines with different detection limits on the same lateral flow strip.
Analytica chimica acta.
2022 Feb; 1192(?):339347. doi:
10.1016/j.aca.2021.339347
. [PMID: 35057924] - Ke-Yu Chen, Ruo-Yang Li. Efficacy and safety of different antidepressants and anticonvulsants in central poststroke pain: A network meta-analysis and systematic review.
PloS one.
2022; 17(10):e0276012. doi:
10.1371/journal.pone.0276012
. [PMID: 36227855] - Armando Criscuolo, Silvia Strumia, Giorgio Di Concetto, Ruggero M Corso. Acupuncture and lamotrigine for acute short unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome: a case report.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2021 12; 39(6):724-725. doi:
10.1177/09645284211009908
. [PMID: 34044624] - Rakesh Kumar, Nicolas A Nuñez, Larry J Prokop, Marin Veldic, Hannah Betcher, Balwinder Singh. Association of Optimal Lamotrigine Serum Levels and Therapeutic Efficacy in Mood Disorders: A Systematic Review.
Journal of clinical psychopharmacology.
2021 Nov; 41(6):681-686. doi:
10.1097/jcp.0000000000001475
. [PMID: 34459434] - Hüseyin Kurku, Bilge Çetin İlhan, Ömer Kaya, Semra Aydın Akfırat. Evaluation of the interference of lamotrigine on the analysis of synthetic cannabinoids in urine by the immunoassay method.
Scandinavian journal of clinical and laboratory investigation.
2021 Nov; 81(7):532-539. doi:
10.1080/00365513.2021.1961855
. [PMID: 34378475] - Meiyun Shi, Qiuhong Jiang, Qiushi Lyu, Zhengting Yuan, Lili Deng, Lei Yin. A LC-MS3 strategy to determine lamotrigine by Q-Q-trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity.
Analytical methods : advancing methods and applications.
2021 10; 13(38):4478-4484. doi:
10.1039/d1ay01372f
. [PMID: 34505603] - Ming-Lu Wang, Huan-Xin Wang, Ming-Ming Zhao, Yi-Yi Ma, Li-Mei Zhao. Redefining the age-specific therapeutic ranges of lamotrigine for patients with epilepsy: A step towards optimizing treatment and increasing cost-effectiveness.
Epilepsy research.
2021 10; 176(?):106728. doi:
10.1016/j.eplepsyres.2021.106728
. [PMID: 34339940] - Ingrid Fricke-Galindo, Helgi Jung-Cook, Iris E Martínez-Juárez, Nancy Monroy-Jaramillo, Alberto Ortega-Vázquez, Irma S Rojas-Tomé, Pedro Dorado, Eva Peñas-Lledó, Adrián Llerena, Marisol López-López. Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital.
Pharmacogenomics.
2021 10; 22(15):983-996. doi:
10.2217/pgs-2021-0081
. [PMID: 34612084] - Fatih Ozan Kahveci, Ramazan Kahveci, Emre Cemal Gokce, Aysun Gokce, Üçler Kısa, Mustafa Fevzi Sargon, Ramazan Fesli, Muhammed Fatih Sarı, Bora Gürer. Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury.
Injury.
2021 Oct; 52(10):2803-2812. doi:
10.1016/j.injury.2021.08.004
. [PMID: 34391576] - Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu. UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Oct; 51(10):1146-1154. doi:
10.1080/00498254.2021.1972492
. [PMID: 34423713] - Diane S Aschenbrenner. Lamotrigine may Increase Risk of Arrythmias.
The American journal of nursing.
2021 08; 121(8):23. doi:
10.1097/01.naj.0000767792.01749.bd
. [PMID: 34819469] - James R Phelps, Olivia R Pipitone, Kenneth Squires, Jonathan D Bale. Lamotrigine and lithium in primary care psychiatric consultation: adoption and adverse effects.
Family practice.
2021 07; 38(4):381-386. doi:
10.1093/fampra/cmaa131
. [PMID: 33367908] - Orlando Salinas-Jaramillo, Alejandra Monroy-Arreola, Sebastian Herrera-Noreña, Ana L Guzmán-Ortiz, Abrahan Hernández-Hernández, Silvia Méndez-Flores, Judith Domínguez-Cherit, Noe V Duran-Figueroa, Dean J Naisbitt, Pedro Cortes-Reynosa, Eduardo Perez Salazar, Héctor Quezada, J Luis Castrejón-Flores. Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions.
Chemical research in toxicology.
2021 07; 34(7):1738-1748. doi:
10.1021/acs.chemrestox.1c00047
. [PMID: 34142820] - Daniel W Griepp, David J Kim, Marc Ganz, Eugene J Dolphin, Nadia Sotudeh, Steven A Burekhovich, Qais Naziri. The effects of antiepileptic drugs on bone health: A systematic review.
Epilepsy research.
2021 Jul; 173(?):106619. doi:
10.1016/j.eplepsyres.2021.106619
. [PMID: 33774428] - Gordon Parker, Tahlia Ricciardi, Gabriela Tavella, Dusan Hadzi-Pavlovic. A Single-Blind Randomized Comparison of Lithium and Lamotrigine as Maintenance Treatments for Managing Bipolar II Disorder.
Journal of clinical psychopharmacology.
2021 Jul; 41(4):381-388. doi:
10.1097/jcp.0000000000001424
. [PMID: 34181361] - Dennis Klimpel, Anne Hagemann, Christian G Bien, Bertin Dufaux, Theodor W May, Christian Brandt. Therapeutic Drug Monitoring of Lamotrigine, Lacosamide, and Levetiracetam in Dried Capillary Blood-Determination of Conversion Factors for Serum-Based Reference Ranges.
Therapeutic drug monitoring.
2021 06; 43(3):394-400. doi:
10.1097/ftd.0000000000000890
. [PMID: 33851939] - Cindy H T Yeung, Shinya Ito, Julie Autmizguine, Andrea N Edginton. Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine.
The AAPS journal.
2021 05; 23(4):70. doi:
10.1208/s12248-021-00599-5
. [PMID: 34002327] - Ning Song, Chunsheng Zhang, Shu Wang, Yuguang Guan. Lamotrigine loaded nano-liposomes enhance brain selectivity in vivo.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3):875-882. doi:
"
. [PMID: 34602409] - Manon Tauzin, Jean-Marc Tréluyer, Rima Nabbout, Thierry Billette de Villemeur, Isabelle Desguerre, Radia Aboura, Ines Gana, Yi Zheng, Sihem Benaboud, Naim Bouazza, Camille Chenevier-Gobeaux, Cécile Freihuber, Déborah Hirt. Dosing Recommendations for Lamotrigine in Children: Evaluation Based on Previous and New Population Pharmacokinetic Models.
Journal of clinical pharmacology.
2021 05; 61(5):677-687. doi:
10.1002/jcph.1791
. [PMID: 33244764] - R M Müller, B Herziger, S Jeschke, M P Neininger, T Bertsche, A Bertsche. Knowledge of epilepsy among German pharmacists.
Epilepsy research.
2021 05; 172(?):106587. doi:
10.1016/j.eplepsyres.2021.106587
. [PMID: 33647738] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Ting Zhao, Lu-Hai Yu, Ting-Ting Wang, Jie Feng, Long Ma, Jing Yu, Li Sun, Hong-Jian Li, Yan Sun. Development and validation of an innovative UPLC method to quantify lacosamide, oxcarbazepine, and lamotrigine in the serum of children with epilepsy in China.
Biomedical chromatography : BMC.
2021 Apr; 35(4):e5022. doi:
10.1002/bmc.5022
. [PMID: 33169403] - Alicia Mastrocco, Alex L Blutinger, Samantha A Baine, Jennifer E Prittie. Use of injectable lipid emulsion and sodium bicarbonate to treat severe cardiovascular collapse secondary to lamotrigine toxicosis in a dog.
Journal of the American Veterinary Medical Association.
2021 Mar; 258(5):510-514. doi:
10.2460/javma.258.5.510
. [PMID: 33620240] - Ai Goto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama. Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs.
Heart and vessels.
2021 Mar; 36(3):424-429. doi:
10.1007/s00380-020-01716-8
. [PMID: 33136260] - Hassan Heidari, Chiman Mammostafaei. Spectrophotometric determination of lamotrigine in plasma samples: Ultrasound-assisted emulsification-microextraction based on a hydrophobic deep eutectic solvent followed by back-extraction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Feb; 247(?):119098. doi:
10.1016/j.saa.2020.119098
. [PMID: 33161272] - Yvonne Bigott, Soumitra Paul Chowdhury, Sandra Pérez, Nicola Montemurro, Rayana Manasfi, Peter Schröder. Effect of the pharmaceuticals diclofenac and lamotrigine on stress responses and stress gene expression in lettuce (Lactuca sativa) at environmentally relevant concentrations.
Journal of hazardous materials.
2021 Feb; 403(?):123881. doi:
10.1016/j.jhazmat.2020.123881
. [PMID: 33264951] - Reem Odi, Valentina Franco, Emilio Perucca, Meir Bialer. Bioequivalence and switchability of generic antiseizure medications (ASMs): A re-appraisal based on analysis of generic ASM products approved in Europe.
Epilepsia.
2021 02; 62(2):285-302. doi:
10.1111/epi.16802
. [PMID: 33426641] - Johan Fernström, Lars Ohlsson, Marie Asp, Eva Lavant, Amanda Holck, Cécile Grudet, Åsa Westrin, Daniel Lindqvist. Plasma circulating cell-free mitochondrial DNA in depressive disorders.
PloS one.
2021; 16(11):e0259591. doi:
10.1371/journal.pone.0259591
. [PMID: 34735532] - Rosa Sabença, Joana Bicker, Rui Silva, Andreia Carona, Ana Silva, Isabel Santana, Francisco Sales, Amílcar Falcão, Ana Fortuna. Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jan; 1162(?):122491. doi:
10.1016/j.jchromb.2020.122491
. [PMID: 33360678] - Alessandro Cuomo, Mario Amore, Claudio Vampini, Andrea Fagiolini. [Lamotrigine in bipolar disorder: preventing depression to treat the disease].
Rivista di psichiatria.
2021 Jan; 56(1):1-11. doi:
10.1708/3546.35215
. [PMID: 33560270] - Samuel J Toll, Fiona Qiu, Yifan Huang, Mark D Habgood, Katarzyna M Dziegielewska, Shuai Nie, Norman R Saunders. Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain.
F1000Research.
2021; 10(?):384. doi:
10.12688/f1000research.52607.2
. [PMID: 34249340] - Wanshu Li, Jie Wang, Hangjuan Lin, Gang Shen. HLA-A∗24:02 associated with lamotrigine-induced cutaneous adverse drug reactions: A systematic review and meta-analysis.
Medicine.
2020 Dec; 99(52):e23929. doi:
10.1097/md.0000000000023929
. [PMID: 33350798] - Yi Guo, Zhonghua Lin, Yulan Huang, Liang Yu. Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy.
Epilepsy & behavior : E&B.
2020 12; 113(?):107489. doi:
10.1016/j.yebeh.2020.107489
. [PMID: 33220583] - Alberto Ortega-Vázquez, Ingrid Fricke-Galindo, Pedro Dorado, Helgi Jung-Cook, Iris E Martínez-Juárez, Nancy Monroy-Jaramillo, Irma S Rojas-Tomé, Eva Peñas-Lledó, Adrián Llerena, Marisol López-López. Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy.
The pharmacogenomics journal.
2020 12; 20(6):845-856. doi:
10.1038/s41397-020-0173-2
. [PMID: 32483200] - Soma Das, Ananya Ghosh, Abhijit Changder, Gouranga Nandi, Lakshmi Kanta Ghosh. Quality-by-design approach for development of sustained-release multiple-unit beads of lamotrigine based on ion-cross-linked composite of pectin and okra mucilage: An in vitro appraisal.
International journal of biological macromolecules.
2020 Nov; 163(?):842-853. doi:
10.1016/j.ijbiomac.2020.07.033
. [PMID: 32653379] - Sandra Ventura, Márcio Rodrigues, Amílcar Falcão, Gilberto Alves. Safety evidence on the administration of Fucus vesiculosus L. (bladderwrack) extract and lamotrigine: data from pharmacokinetic studies in the rat.
Drug and chemical toxicology.
2020 Nov; 43(6):560-566. doi:
10.1080/01480545.2018.1518454
. [PMID: 30332899] - Sheng Feng, Brandi Bridgewater, Erin C Strickland, Gregory McIntire. A Rapid LC-MS-MS Method for the Quantitation of Antiepileptic Drugs in Urine.
Journal of analytical toxicology.
2020 Oct; 44(7):688-696. doi:
10.1093/jat/bkaa095
. [PMID: 32744607] - Patsy Ramey, Melissa Osborn, Howard Kirshner, Bassel Abou-Khalil. Misdiagnosis of lamotrigine toxicity as posterior circulation transient ischemic attack or stroke.
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Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
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"
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Molecular pharmacology.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
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Basic & clinical pharmacology & toxicology.
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Brain and behavior.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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European journal of drug metabolism and pharmacokinetics.
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Therapeutic drug monitoring.
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Analytical and bioanalytical chemistry.
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Clinical pharmacokinetics.
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The Journal of dermatology.
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Neuropsychopharmacology reports.
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Colloids and surfaces. B, Biointerfaces.
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Therapeutic drug monitoring.
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Toxicology and applied pharmacology.
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
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PloS one.
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Therapeutic drug monitoring.
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Zhonghua yi xue za zhi.
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Pakistan journal of pharmaceutical sciences.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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Therapeutic drug monitoring.
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