ketoconazole (BioDeep_00000016919)

 

Secondary id: BioDeep_00000018013

natural product


代谢物信息卡片


1-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

化学式: C26H28Cl2N4O4 (530.1487508)
中文名称: 酮康唑
谱图信息: 最多检出来源 Escherichia coli(natural_products) 90.91%

分子结构信息

SMILES: C1(=CC=C(C=C1)OC[C@@H]2O[C@@](OC2)(CN3C=CN=C3)C4=CC=C(C=C4Cl)Cl)N5CCN(CC5)C(=O)C
InChI: InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3

描述信息

G - Genito urinary system and sex hormones > G01 - Gynecological antiinfectives and antiseptics > G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids > G01AF - Imidazole derivatives
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02C - Antiadrenal preparations > H02CA - Anticorticosteroids
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use > J02AB - Imidazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
C254 - Anti-Infective Agent
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8051; ORIGINAL_PRECURSOR_SCAN_NO 8049
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8073; ORIGINAL_PRECURSOR_SCAN_NO 8071
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8091; ORIGINAL_PRECURSOR_SCAN_NO 8089
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8102; ORIGINAL_PRECURSOR_SCAN_NO 8100
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8082; ORIGINAL_PRECURSOR_SCAN_NO 8077
CONFIDENCE standard compound; INTERNAL_ID 373; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8103; ORIGINAL_PRECURSOR_SCAN_NO 8101
CONFIDENCE standard compound; INTERNAL_ID 2697
CONFIDENCE Parent Substance (Level 1); INTERNAL_ID 2600
CONFIDENCE standard compound; INTERNAL_ID 8574
CONFIDENCE standard compound; INTERNAL_ID 4100
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3262
Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

同义名列表

7 个代谢物同义名

ketoconazole; Ketocanazole; (+)-Ketoconazole; 1-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone; KET; Ketoconazol; R 41400



数据库引用编号

63 个数据库交叉引用编号

分类词条

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Çağrı Ergin, Özgür Kurt, Murat Türkoğlu, Hakan Sevinç, Göknur Akbaba. Evaluation of novel cosmetic shampoo formulations against Malassezia species: Preliminary results of anti-dandruff shampoo formulations. Journal of cosmetic dermatology. 2024 Jun; 23(6):2078-2083. doi: 10.1111/jocd.16219. [PMID: 38544350]
  • Shanshan Liu, Hailong Tian, Hui Ming, Tingting Zhang, Yajie Gao, Ruolan Liu, Lihua Chen, Chen Yang, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Mitochondrial-Targeted CS@KET/P780 Nanoplatform for Site-Specific Delivery and High-Efficiency Cancer Immunotherapy in Hepatocellular Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 Apr; 11(14):e2308027. doi: 10.1002/advs.202308027. [PMID: 38308137]
  • Fuxin Zhang, Jules Muhire, Xiao Sun, Dong Pei, Xinyi Huang. Comparison of two different multiple dual-mode counter-current chromatograph for separation of ketoconazole enantiomers. Journal of chromatography. A. 2024 Mar; 1718(?):464724. doi: 10.1016/j.chroma.2024.464724. [PMID: 38350351]
  • Zhenzhen Weng, Qi Wei, Cheng Ye, Yingying Xu, Jie Gao, Wei Zhang, Lubing Liu, Yue Zhang, Jiangnan Hu, Qin Zhong, Jian Sun, Xiaolei Wang. Traditional Herb (Moxa) Modified Zinc Oxide Nanosheets for Quick, Efficient and High Tissue Penetration Therapy of Fungal Infection. ACS nano. 2024 Feb; 18(6):5180-5195. doi: 10.1021/acsnano.3c13164. [PMID: 38299982]
  • Andreia Bento-Oliveira, Radosław Starosta, Rodrigo F M de Almeida. Interaction of the antifungal ketoconazole and its diphenylphosphine derivatives with lipid bilayers: Insights into their antifungal action. Archives of biochemistry and biophysics. 2024 Jan; ?(?):109919. doi: 10.1016/j.abb.2024.109919. [PMID: 38307316]
  • Yanxiong Gan, Yaxin Xu, Xue Zhang, Huiling Hu, Wenke Xiao, Zheng Yu, Tao Sun, Jinming Zhang, Chuanbiao Wen, Shichao Zheng. Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196962. [PMID: 37836805]
  • Mariana Elizabeth Troncoso, María José Germanó, Victoria J Arrieta, María Fernanda García Bustos, Diego Cifuente, Diego E Cargnelutti, Esteban S Lozano. Antiparasitic Activity of Two Natural Terpenes from Salvia cuspidata against Leishmania amazonensis. Journal of natural products. 2023 04; 86(4):797-803. doi: 10.1021/acs.jnatprod.2c00976. [PMID: 36857574]
  • Sadhana Raut, Nupur Gargate, Sharddha Ugale, K N Gujar, Harshad Kapare. Formulation and Development of Hyaluronic Acid based gel with Ketoconazole -Loaded Nanostructured Lipid Carriers in Fungal Infection. Pharmaceutical nanotechnology. 2023 Mar; ?(?):. doi: 10.2174/2211738511666230310103017. [PMID: 36896905]
  • Kun Ren, Ruijie Wang, Shinuo Fang, Shumeng Ren, Huiming Hua, Dongmei Wang, Yingni Pan, Xiaoqiu Liu. Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116005. doi: 10.1016/j.jep.2022.116005. [PMID: 36516906]
  • Muhammad Asyraf Abduraman, Nor Hidayah Mustafa, Nik Soriani Yaacob, Azimah Amanah, Mei Lan Tan. Cytochrome P450 inhibition activities of non-standardized botanical products. Journal of ethnopharmacology. 2022 Oct; 296(?):115406. doi: 10.1016/j.jep.2022.115406. [PMID: 35659627]
  • Sumit Arora, Amita Pansari, Peter J Kilford, Masoud Jamei, David B Turner, Iain Gardner. A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):483-495. doi: 10.1007/s13318-022-00765-w. [PMID: 35486324]
  • Mohhammad Ramzan, Samuel Gourion-Arsiquaud, Afzal Hussain, Jaspreet Singh Gulati, Qihong Zhang, Sonia Trehan, Vinam Puri, Bozena Michniak-Kohn, Indu Pal Kaur. In vitro release, ex vivo penetration, and in vivo dermatokinetics of ketoconazole-loaded solid lipid nanoparticles for topical delivery. Drug delivery and translational research. 2022 07; 12(7):1659-1683. doi: 10.1007/s13346-021-01058-6. [PMID: 34993923]
  • Maya Radeva-Llieva, Stanila Stoeva, Nadezhda Hvarchanova, Iliya Zhelev, Kaloyan D Georgiev. Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2022 Jun; 30(1):75-84. doi: 10.1007/s40199-022-00433-z. [PMID: 35146639]
  • Vinicius Goularte-Silva, Luciana Campos Paulino. Ketoconazole beyond antifungal activity: Bioinformatics-based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis. Experimental dermatology. 2022 05; 31(5):821-822. doi: 10.1111/exd.14505. [PMID: 34816495]
  • M Merlani, V Barbakadze, L Amiranashvili, L Gogilashvili, A Petrou, A Geronikaki, A Ćirić, J Glamočlija, M Soković. Caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid derivatives as antimicrobial agent: biological evaluation and molecular docking studies. SAR and QSAR in environmental research. 2022 Apr; 33(4):307-321. doi: 10.1080/1062936x.2022.2066173. [PMID: 35532307]
  • Yuan Jiang, Lin Qin, Anjing Lu, Juan Chen, Jianmei Wang, Qianru Zhang, Yanliu Lu, Qihai Gong, Jianmei Gao, Hong Ma, Daopeng Tan, Yuqi He. CYP3A1 metabolism-based neurotoxicity of strychnine in rat. Toxicology. 2022 Mar; 471(?):153156. doi: 10.1016/j.tox.2022.153156. [PMID: 35358606]
  • Sonia Saib, Sophie Hodin, Valérie Bin, Edouard Ollier, Xavier Delavenne. In Vitro Evaluation of P-gp-Mediated Drug-Drug Interactions Using the RPTEC/TERT1 Human Renal Cell Model. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):223-233. doi: 10.1007/s13318-021-00744-7. [PMID: 34935100]
  • Volodymyr Horishny, Athina Geronikaki, Victor Kartsev, Vasyl Matiychuk, Anthi Petrou, Pavel Pogodin, Vladimir Poroikov, Theodora A Papadopoulou, Ioannis S Vizirianakis, Marina Kostic, Marija Ivanov, Marina Sokovic. Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives. Molecules (Basel, Switzerland). 2022 Feb; 27(3):. doi: 10.3390/molecules27031068. [PMID: 35164333]
  • Jing Li, Mengyue Zhou, Xiaoqiong Lai, Yang Wang, Ying Zou, Kunna Li, Weiwei Li, Jiang Zheng. Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties. Biomedical chromatography : BMC. 2022 Feb; 36(2):e5270. doi: 10.1002/bmc.5270. [PMID: 34727371]
  • Hong Wei, Albert P Li. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone. Drug metabolism and disposition: the biological fate of chemicals. 2022 02; 50(2):140-149. doi: 10.1124/dmd.121.000645. [PMID: 34750194]
  • Johanna Weiss, Kathrin Isabelle Foerster, Maria Weber, Jürgen Burhenne, Gerd Mikus, Thorsten Lehr, Walter Emil Haefeli. Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound?. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Feb; 169(?):106076. doi: 10.1016/j.ejps.2021.106076. [PMID: 34856349]
  • Jin-Man Liu, Jun-Mei Chen, Ming-Jun Lin, Fan-Chang Wu, Cui-Ru Ma, Xue Zuo, Wen-Qian Yu, Ming-Jun Huang, Jian-Song Fang, Wei-Rong Li, Qi Wang, Yong Liang. Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. Journal of ethnopharmacology. 2022 Jan; 282(?):114643. doi: 10.1016/j.jep.2021.114643. [PMID: 34534597]
  • Mai Nagaoka, Tatsuki Fukami, Fumiya Kisui, Takuya Yamada, Yoshiyuki Sakai, Kiyomichi Tashiro, Takuo Ogiso, Keigo Konishi, Shiori Honda, Keiya Hirosawa, Masataka Nakano, Miki Nakajima. Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency. Biochemical pharmacology. 2022 01; 195(?):114842. doi: 10.1016/j.bcp.2021.114842. [PMID: 34798123]
  • Han Ju, N Arul Murugan, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan. Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability. Journal of medicinal chemistry. 2021 12; 64(24):17992-18009. doi: 10.1021/acs.jmedchem.1c01366. [PMID: 34735766]
  • Guoquan You, Ruopeng Yang, Yingjie Wei, Wanyu Hu, Lili Gan, Cong Xie, Zhijie Zheng, Zhongqiu Liu, Rongxin Liao, Ling Ye. The detoxification effect of cytochrome P450 3A4 on gelsemine-induced toxicity. Toxicology letters. 2021 Dec; 353(?):34-42. doi: 10.1016/j.toxlet.2021.10.003. [PMID: 34627953]
  • Jacky Bhagat, Liqing Zang, Hiroko Nakayama, Norihiro Nishimura, Yasuhito Shimada. Effects of nanoplastic on toxicity of azole fungicides (ketoconazole and fluconazole) in zebrafish embryos. The Science of the total environment. 2021 Dec; 800(?):149463. doi: 10.1016/j.scitotenv.2021.149463. [PMID: 34399343]
  • Ana Rita Sokolonski, Maísa Santos Fonseca, Bruna Aparecida Souza Machado, Kathleen Ramos Deegan, Roberto Paulo Correia Araújo, Marcelo Andrés Umsza-Guez, Roberto Meyer, Ricardo W Portela. Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp. BMC complementary medicine and therapies. 2021 Nov; 21(1):286. doi: 10.1186/s12906-021-03445-5. [PMID: 34814913]
  • Chunhua Ma, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu, Yuqin Jiang, Qingjie Ding. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors. Journal of medicinal chemistry. 2021 11; 64(21):16242-16270. doi: 10.1021/acs.jmedchem.1c01559. [PMID: 34672559]
  • Makoto Kataoka, Keiko Minami, Toshihide Takagi, Gregory E Amidon, Shinji Yamashita. In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior. Molecular pharmaceutics. 2021 11; 18(11):4122-4130. doi: 10.1021/acs.molpharmaceut.1c00537. [PMID: 34618448]
  • Shuo Yuan, Bo Wang, Qing-Qing Dai, Xiao-Nan Zhang, Jing-Ya Zhang, Jia-Hui Zuo, Hui Liu, Zhe-Sheng Chen, Guo-Bo Li, Shaomeng Wang, Hong-Min Liu, Bin Yu. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. Journal of medicinal chemistry. 2021 10; 64(19):14895-14911. doi: 10.1021/acs.jmedchem.1c01452. [PMID: 34546748]
  • Yi Xu, Hui Lu, Shuo Zhu, Wan-Qian Li, Yuan-Ying Jiang, Judith Berman, Feng Yang. Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans. Microbiology spectrum. 2021 09; 9(1):e0032121. doi: 10.1128/spectrum.00321-21. [PMID: 34160280]
  • Ying-Hao He, Qing Fang, Ling-Ling Yang, Si-Min Chen, Yan-Ping Luo, Hong Qian, Min-You Qi. [Effects of ketoconazole on physiological function of liver and testis in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2021 Sep; 37(5):475-479. doi: 10.12047/j.cjap.6110.2021.063. [PMID: 34816655]
  • Sara N Salerno, Fernando O Carreño, Andrea N Edginton, Michael Cohen-Wolkowiez, Daniel Gonzalez. Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population. Drug metabolism and disposition: the biological fate of chemicals. 2021 09; 49(9):844-855. doi: 10.1124/dmd.120.000318. [PMID: 34154994]
  • Ying-Chao Duan, Lin-Feng Jin, Hong-Mei Ren, Shao-Jie Zhang, Yue-Jiao Liu, Yong-Tao Xu, Zi-Hao He, Yu Song, Hang Yuan, Shu-Hui Chen, Yuan-Yuan Guan. Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer. European journal of medicinal chemistry. 2021 Aug; 220(?):113453. doi: 10.1016/j.ejmech.2021.113453. [PMID: 33957387]
  • Arti Nile, Shivraj Hariram Nile, Carlos L Cespedes-Acuña, Jae-Wook Oh. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Aug; 154(?):112327. doi: 10.1016/j.fct.2021.112327. [PMID: 34116102]
  • Jibin Li, Nicole Spivey, Svitlana Silchenko, Isabel Gonzalez-Alvarez, Marival Bermejo, Ismael J Hidalgo. A differential equation based modelling approach to predict supersaturation and in vivo absorption from in vitro dissolution-absorption system (idas2) data. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2021 Aug; 165(?):1-12. doi: 10.1016/j.ejpb.2021.05.003. [PMID: 33971275]
  • Alistair C Leitch, Ibrahim Ibrahim, Tarek M Abdelghany, Alex Charlton, Clair Roper, Dan Vidler, Jeremy M Palmer, Colin Wilson, David E Jones, Peter G Blain, Matthew C Wright. The methylimidazolium ionic liquid M8OI is detectable in human sera and is subject to biliary excretion in perfused human liver. Toxicology. 2021 07; 459(?):152854. doi: 10.1016/j.tox.2021.152854. [PMID: 34271081]
  • Frederic Castinetti, Lynnette K Nieman, Martin Reincke, John Newell-Price. Approach to the Patient Treated with Steroidogenesis Inhibitors. The Journal of clinical endocrinology and metabolism. 2021 06; 106(7):2114-2123. doi: 10.1210/clinem/dgab122. [PMID: 33675650]
  • Jacob W Greenberg, Hogyoung Kim, Ahmed A Moustafa, Amrita Datta, Pedro C Barata, A Hamid Boulares, Asim B Abdel-Mageed, Louis S Krane. Repurposing ketoconazole as an exosome directed adjunct to sunitinib in treating renal cell carcinoma. Scientific reports. 2021 05; 11(1):10200. doi: 10.1038/s41598-021-89655-w. [PMID: 33986386]
  • Wushuang Zeng, Lanlan Gui, Xianwen Tan, Pingping Zhu, Yiting Hu, Qingliang Wu, Xuejing Li, Lian Yang, Wei Jia, Changxiao Liu, Ke Lan. Tertiary Oxidation of Deoxycholate Is Predictive of CYP3A Activity in Dogs. Drug metabolism and disposition: the biological fate of chemicals. 2021 05; 49(5):369-378. doi: 10.1124/dmd.121.000385. [PMID: 33674269]
  • Jéssica Tauany Andrade, William Gustavo Lima, Jaqueline França Sousa, Aline Aparecida Saldanha, Nívea Pereira De Sá, Fernanda Barbara Morais, Mayra Karla Prates Silva, Gustavo Henrique Ribeiro Viana, Susana Johann, Adriana Cristina Soares, Leonardo Allan Araújo, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Jaqueline Maria Siqueira Ferreira. Design, synthesis, and biodistribution studies of new analogues of marine alkaloids: Potent in vitro and in vivo fungicidal agents against Candida spp. European journal of medicinal chemistry. 2021 Jan; 210(?):113048. doi: 10.1016/j.ejmech.2020.113048. [PMID: 33316690]
  • Dongying Li, Bridgett Knox, Binsheng Gong, Si Chen, Lei Guo, Zhichao Liu, Weida Tong, Baitang Ning. Identification of Translational microRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing. Toxicological sciences : an official journal of the Society of Toxicology. 2021 01; 179(1):31-43. doi: 10.1093/toxsci/kfaa162. [PMID: 33078836]
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  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
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